Several lipid disorders are without known genetic origin. The scope of this project is to sequence genes superior involved in lipid and carbohydrate metabolism in patients with severe lipid disorders. The resulting mutations will be tested in suitable in vitro systems to detect their part in development of the specific disease.

Condition	Phase
Lipid Disorder	Phase I

Further study details as provided by University of Oslo:

See "brief summary" above.

Ages Eligible for Study:  18 Years   -   54 Years,  Genders Eligible for Study:  Both

Accepts Healthy Volunteers

Criteria

Inclusion Criteria:

• proven written informed consent prior to recruitment
• male or female
• 18-55 years old
• patients with severe lipid disorders
• fasting plasma cholesterol, triglyceride or glucose, blood pressure or waist circumference/BMI out of normal range

Exclusion Criteria:

-

Please refer to this study by ClinicalTrials.gov identifier  NCT00277121

Hilde Irene Nebb, PhD      +47-22851510    h.i.nebb@medisin.uio.no
Kjetil Retterstøl, Dr Med      +47-23075603    kjetil.retterstol@rikshospitalet.no

Norway
      Department of Nutrition, University of Oslo, Oslo,  NO-0316,  Norway

Study chairs or principal investigators

Hilde I Nebb, PhD,  Study Chair,  Department of Nutrition, University of Oslo   
Karianne Solaas, PhD,  Principal Investigator,  Department of Nutrition, University of Oslo   
Monica H Carlsen,  Principal Investigator,  Department of Nutrition, University of Oslo   
Leiv Ose, Dr med,  Principal Investigator,  Lipid Clinic, The National Hospital   
Marit S Nenseter, PhD,  Principal Investigator,  Research Institute of Internal Medicine, The National Hospital   
Kirsten Holven, PhD,  Principal Investigator,  Research Institute of Internal Medicine, The National Hospital   
Bente Halvorsen, PhD,  Principal Investigator,  Research Institute of Internal Medicine, The National Hospital   
Serena Tonstad, Dr med,  Principal Investigator,  Department of Preventive Medicine, Ullevål university hospital   
Håkon Gjessing, PhD,  Principal Investigator,  Norwegian Institute of Public Health   
Per Thorsby, Dr med,  Principal Investigator,  Hormone laboratory, Aker university hospital   
Sigbjørn Lien, PhD,  Principal Investigator,  Agricultural university of Norway   
Paul Berg, PhD,  Principal Investigator,  Agricultural university of Norway   
Kjetil Retterstøl, Dr med,  Principal Investigator,  Lipid Clinic, The National Hospital   

Study ID Numbers:  S-03150 (REK); 02/4746 (SHdir); 10163 (NSD)
Last Updated:  January 12, 2006
Record first received:  January 12, 2006
ClinicalTrials.gov Identifier:  NCT00277121
Health Authority: Norway: Regional Committee for Medical Research Ethics, Sothern Region (REK); Norway: Norwegian Social Science Data Services; Norway: Directorate for Health and Social Affairs
ClinicalTrials.gov processed this record on 2006-01-17