Article: Diltiazem

Diltiazem
Systematic (IUPAC) name
[2-(2-dimethylaminoethyl)-5-(4-methoxyphenyl) -3-oxo-6-thia-2-azabicyclo[5.4.0]undeca-7,9, 11-trien-4-yl]ethanoate
Identifiers
CAS number	42399-41-7
ATC code	C08DB01
PubChem	39186
DrugBank	APRD00473
Chemical data
Formula	C22H26N2O4S
Mol. weight	414.519 g/mol
Pharmacokinetic data
Bioavailability	40%
Metabolism	Hepatic
Half life	3-4.5 hours
Excretion	Renal Biliary Lactic (in lactiferous females)
Therapeutic considerations
Pregnancy cat.	D: (USA)
Legal status
Routes	Oral

Diltiazem is a member of the group of drugs known as Benzothiapines, which are a class of calcium channel blockers, used in the treatment of hypertension, angina pectoris, and some types of arrhythmia. It is a class 3 anti anginal drug. It incites very minimal reflex sympathetic changes.

Diltiazem's is a potent vasodilator, increasing blood flow and variably decreasing the heart rate via strong depression of A-V node conduction.

Diltiazem is metabolized by and acts as an inhibitor of the CYP3A4 enzyme.

Diltiazem is contraindicated in the presence of Sick sinus syndrome, Atrioventricular node conduction disturbances, Bradycardia, impaired Left ventricle function, Peripheral artery occlusive disease, Chronic obstructive pulmonary disease, and Prinzmetal's angina.

Brand names

• Cardizem®
• Cartia XT®
• Tiazac®
• Tiamate®

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