Methylphenidate ER |
Concerta; Metadate CD; Metadate ER; Methylin ER; Ritalin SR |
Methylphenidate Systematic (IUPAC) name methyl 2-phenyl-2-(2-piperidyl)acetate Identifiers CAS number 113-45-1 ATC code N06BA04 PubChem 4158 DrugBank APRD00657 Chemical data Formula C14H19NO2 Mol. weight 233.306 g/mol Pharmacokinetic data Bioavailability 11–52% (Oral) Metabolism Liver Half life 2–4 hours Excretion Urine Therapeutic considerations Pregnancy cat. C Legal status Schedule II USA, Schedule 2 UK Routes ? Indicated ...
Wikipedia - [full article]
Methylphenidate ER Clinical Trials
- Effects of Methylphenidate Versus Sustained Release Methylphenidate on Cognitive Functioning
ClinicalTrials.gov Identifier: NCT00418691 - Recruiting
Brain Tumor
- Ritaline
ClinicalTrials.gov Identifier: NCT00273741 - Recruiting
Palliative Care; Asthenia; Neoplasms; Methylphenidate
- A Study of Repeat Dosing of OROS® Methylphenidate Hydrochloride (CONCERTA®) and Immediate Release Methylphenidate Hydrochloride in Healthy Adults
ClinicalTrials.gov Identifier: NCT00302458 - Recruiting
Healthy
- Multiphase Efficacy Study of venlafaxine ER to Treat Recurrent Depression
ClinicalTrials.gov Identifier: NCT00046020 - Active, not recruiting
Depression
- Methylphenidate in the Treatment of Cocaine Dependent Patients with Adult Attention Deficit Hyperactivity Disorder - 5
ClinicalTrials.gov Identifier: NCT00015223 - Active, not recruiting
Cocaine-Related Disorders; Substance-Related Disorders
- Study Examining Repeat Dosing of OROS® Methylphenidate (CONCERTA®) and Immediate Release Methylphenidate in Healthy Adults
ClinicalTrials.gov Identifier: NCT00302393 - Not yet recruiting
Healthy
- Methylphenidate Treatment for Cocaine Abuse and ADHD - 1
ClinicalTrials.gov Identifier: NCT00136734 - Active, not recruiting
Attention Deficit Disorder with Hyperactivity; Cocaine-Related Disorders
- Methylphenidate in Treating Patients With Melanoma
ClinicalTrials.gov Identifier: NCT00003266 - Active, not recruiting
unspecified adult solid tumor, protocol specific; Fatigue; Quality of Life
- The Genetic Bases for Vulnerability to Substance Abuse in Individuals With Different Acute Responses to Methylphenidate
ClinicalTrials.gov Identifier: NCT00247689 - Not yet recruiting
Substance Abuse
- Safety and Tolerability of MTS in Children Aged 6-12 Diagnosed with ADHD and Previously Treated with Extended-Release Methylphenidate Therapy
ClinicalTrials.gov Identifier: NCT00151983 - Completed
Attention Deficit Disorder with Hyperactivity
- Study of DVS-233 SR and Venlafaxine ER in Adult Outpatients With Major Depressive Disorder
ClinicalTrials.gov Identifier: NCT00087737 - Active, not recruiting
Major Depressive Disorder
- Study Of DVS-233 SR And Venlafaxine ER In Adult Outpatients With Major Depressive Disorder
ClinicalTrials.gov Identifier: NCT00090649 - Active, not recruiting
Major Depressive Disorder
- Methylphenidate for Apathy in Alzheimer’s Dementia: A Controlled Study
ClinicalTrials.gov Identifier: NCT00495820 - Not yet recruiting
ALZHEIMER’S DISEASE; APATHY; Dementia; Methylphenidate
- Methylphenidate for Depressed Cancer Patients in Hospice
ClinicalTrials.gov Identifier: NCT00129467 - Recruiting
Depression; Hospice Care; Cancer; Mental Disorder
- Cetuximab and Carbo for ER/PR/HER2 Negative BC
ClinicalTrials.gov Identifier: NCT00420329 - Active, not recruiting
Breast Cancer
- Study Evaluating the Pharmacokinetics of Venlafaxine ER and Desvenlafaxine SR in Healthy Subjects
ClinicalTrials.gov Identifier: NCT00329186 - Active, not recruiting
Depressive Disorder, Major
- Methylphenidate for Treating Children With ADHD and Tourette Syndrome
ClinicalTrials.gov Identifier: NCT00441649 - Active, not recruiting
Attention Deficit Disorder With Hyperactivity; Tourette Syndrome
- The Effect of Methylphenidate on Motor Learning in Stroke Patients
ClinicalTrials.gov Identifier: NCT00396058 - Recruiting
Cerebrovascular Accident
- Preoperative Cisplatin in Early Stage Breast Cancer
ClinicalTrials.gov Identifier: NCT00148694 - Active, not recruiting
Breast Cancer; ER Negative Breast Cancer; PR Negative Breast Cancer; HER-2 Negative Breast Cancer
- An Open-Label Study of Quetiapine Added to Oros Methylphenidate in the Treatment of ADHD and Aggressive Behavior
ClinicalTrials.gov Identifier: NCT00198211 - Active, not recruiting
Attention-Deficit/Hyperactivity Disorder, Combined Type; Disruptive Behavior Disorder
- Methylphenidate Study in Young Children With Developmental Disorders
ClinicalTrials.gov Identifier: NCT00517504 - Recruiting
Attention Deficit Hyperactivity Disorder
- Risperidone Vs. Bupropion ER Augmentation of SSRIs in Treatment-Resistant Depression
ClinicalTrials.gov Identifier: NCT00179244 - Active, not recruiting
Unipolar Depression
- A Case Management Intervention to Prevent ER Visits in HIV-Infected Persons
ClinicalTrials.gov Identifier: NCT00187590 - Active, not recruiting
HIV
- A Study to Evaluate Effectiveness and Safety of ER OROS Paliperidone in Patients With Schizophrenia
ClinicalTrials.gov Identifier: NCT00396565 - Active, not recruiting
Schizophrenia
- Depakote-ER for Depressive and Bipolar Depression
ClinicalTrials.gov Identifier: NCT00226343 - Active, not recruiting
Bipolar Disorder
- Methylphenidate Transdermal System (MTS) in the Treatment of Adult ADHD
ClinicalTrials.gov Identifier: NCT00506285 - Recruiting
Attention Deficit Hyperactivity Disorder
- Treatment of Adult Attention Deficit Hyperactivity Disorder (ADHD) in Methadone Patients - 1
ClinicalTrials.gov Identifier: NCT00061087 - Active, not recruiting
Opioid-Related Disorders
- Genetic Measurements in Blood Cells of Children Taking Adderall or Methylphenidate
ClinicalTrials.gov Identifier: NCT00341029 - Recruiting
Attention Deficit Hyperactivity Disorder; ADHD
- Double-Blind, Placebo-Controlled Divalproex Sodium ER in Bipolar I or Bipolar II Depression
ClinicalTrials.gov Identifier: NCT00194116 - Active, not recruiting
Bipolar Disorder
- Comparative Study of Oestradiol Suppression: Zoladex 10.8mg/3 Month vs. 3.6mg/Month in ER +ve EBC Pre-Menopausal Patients
ClinicalTrials.gov Identifier: NCT00303524 - Active, not recruiting
Breast Cancer
- Efficacy Study of PR OROS Methylphenidate and Psychosocial Interventions in Swedish Imprisoned Men With ADHD
ClinicalTrials.gov Identifier: NCT00482313 - Recruiting
Attention Deficit Hyperactivity Disorder
- A Long-Term Safety Study to Evaluate Methylphenidate HCL Tablets at Multiple Dose Levels in Adults With Attention Deficit Hyperactivity Disorder
ClinicalTrials.gov Identifier: NCT00326300 - Active, not recruiting
Attention Deficit Hyperactivity Disorder
- A Double-Blind Randomized, Placebo-Controlled, Crossover Study of Single Doses of OROS Methylphenidate Hydrochloride (CONCERTA) and Long-Acting Methylphenidate Hydrochloride (RITALIN LA) in Healthy Adults
ClinicalTrials.gov Identifier: NCT00302354 - Completed
Healthy Volunteers
- An Effectiveness and Safety Study of CONCERTA* Vs. Immediate Release Methylphenidate (IR MPH) in Attention Deficit Hyperactivity Disorder Children
ClinicalTrials.gov Identifier: NCT00304681 - Active, not recruiting
Attention Deficit Hyperactivity Disorder
- Methylphenidate and a Nursing Telephone Intervention for Fatigue
ClinicalTrials.gov Identifier: NCT00424099 - Recruiting
Advanced Cancer; Fatigue
- Safety And Efficacy Study Of Depakote ER To Treat Pediatric Bipolar Disorder
ClinicalTrials.gov Identifier: NCT00199966 - Active, not recruiting
Bipolar Disorder
- Study of the Effects of OROS Methylphenidate (Concerta) on Attention and Memory
ClinicalTrials.gov Identifier: NCT00530257 - Recruiting
Attention Deficit Hyperactivity Disorder
- Pediatric Traumatic Brain Injury: Methylphenidate Effects on Early Recovery
ClinicalTrials.gov Identifier: NCT00035139 - Completed
Brain Injuries
- Paliperidone ER Study of Economic, Functional, and Clinical Outcomes.
ClinicalTrials.gov Identifier: NCT00488891 - Recruiting
Schizophrenia
- Evaluate the Safety and Efficacy of Methylphenidate Transdermal System (MTS) in Adolescents Aged 13-17 Years With ADHD
ClinicalTrials.gov Identifier: NCT00501293 - Recruiting
ADHD
- Effects of Methylphenidate on Cellular Abnormalities in Children With Attention Deficit Hyperactivity Disorder
ClinicalTrials.gov Identifier: NCT00409708 - Active, not recruiting
Attention Deficit Hyperactivity Disorder
- Study of Gabapentin Extended Release (G-ER) in the Treatment of Vasomotor (Hot Flashes/Hot Flushes) Symptoms in Postmenopausal Women
ClinicalTrials.gov Identifier: NCT00511953 - Active, not recruiting
Hot Flashes
- Evaluate the Efficacy &Safety of Methylphenidate Transdermal System (MTS) in Adolescents Aged 13-17 Years With ADHD
ClinicalTrials.gov Identifier: NCT00499863 - Recruiting
ADHD
- Placebo Controlled Trial of Depakote ER in Alcohol Dependent Patients With Mood and/or Anxiety Symptoms
ClinicalTrials.gov Identifier: NCT00202514 - Active, not recruiting
Alcoholism; Alcohol Related Disorders; Mood Disorders
- Study of Depakote ER for the Treatment of Mania in Children Ages 6-12 With Bipolar Disorder
ClinicalTrials.gov Identifier: NCT00181727 - Active, not recruiting
Bipolar Disorder; Mania
- Brief Intervention to Reduce STDs in ER Drug Users - 1
ClinicalTrials.gov Identifier: NCT00218400 - Recruiting
Substance-Related Disorders; Sexual Risk Behaviors
- Comparison of Modafinil and Methylphenidate in Treatment of Excessive Daytime Sleepiness in Patients With Parkinson's Disease
ClinicalTrials.gov Identifier: NCT00393562 - Recruiting
Parkinson's Disease
- A Study to Evaluate the Efficacy and Safety of Adjustable Doses of Extended-Release (ER) Paliperidone Compared With Placebo, in Combination With Lithium or Valproate, to Treat Manic and Mixed Episodes in Patients With Bipolar I Disorder
ClinicalTrials.gov Identifier: NCT00309686 - Active, not recruiting
Affective Psychosis, Bipolar; Bipolar Disorder; Mania
- Naturalistic Study, Comparison of Divalproex ER and Quetiapine for Adults With Acute Mania or Mixed Episodes
ClinicalTrials.gov Identifier: NCT00397020 - Recruiting
Bipolar Disorder
- NF1-Attention: Study of Children With Neurofibromatosis Type 1 Treated by Methylphenidate
ClinicalTrials.gov Identifier: NCT00169611 - Recruiting
Neurofibromatosis Type 1
- Methylphenidate (Ritalin) and Memory/Attention in Traumatic Brain Injury (TBI)
ClinicalTrials.gov Identifier: NCT00453921 - Recruiting
Brain Injury
- A Study to Evaluate the Efficacy and Safety of Flexible Doses of Extended-Release (ER) Paliperidone Compared With Flexible Doses of Quetiapine and Placebo in Patients With Bipolar I Disorder
ClinicalTrials.gov Identifier: NCT00309699 - Active, not recruiting
Bipolar Disorder; Mood Disorders
- Efficacy, Safety and Tolerability of SPD485 in Children Aged 6-12 Diagnosed with ADHD
ClinicalTrials.gov Identifier: NCT00151970 - Completed
Attention Deficit Disroder with Hyperactivity
- Comparing Compliance, Tolerability, Efficacy and Adverse Events in Bipolar Tients From Valproic Acid to Depakote ER.
ClinicalTrials.gov Identifier: NCT00211250 - Recruiting
Mood Disorder
- Depakote ER in Bipolar Depression
ClinicalTrials.gov Identifier: NCT00186186 - Active, not recruiting
Depression, Bipolar
- Safety and Tolerability of SPD485 in Children Aged 6-12 Diagnosed with ADHD and Previously Participated in MTS Trials
ClinicalTrials.gov Identifier: NCT00151957 - Completed
Attention Deficit Disorder with Hyyperactivity.
- Study to Measure the Safety of Paliperidone ER (Extended-Release) in Patients With Liver Disease
ClinicalTrials.gov Identifier: NCT00535145 - Recruiting
Schizophrenia; Psychotic Disorders; Schizoaffective Disorder
- Panic Disorder Study
ClinicalTrials.gov Identifier: NCT00038896 - Active, not recruiting
Panic Disorder
- Panic Disorder Study
ClinicalTrials.gov Identifier: NCT00044772 - Active, not recruiting
Panic Disorder
- Evaluate the Effect of Nebulized Budesonide and Oral Corticosteroids on Wheezing Episode Relapse in Children Following Discharge From the ER/Outpatient Care Facility
ClinicalTrials.gov Identifier: NCT00189436 - Recruiting
Asthma
- Aripiprazole Associated With Methylphenidate in Children and Adolescents With Bipolar Disorder and ADHD
ClinicalTrials.gov Identifier: NCT00305370 - Recruiting
Bipolar Disorder; Attention Deficit Hyperactivity Disorder
- Methylphenidate Study in Breast Cancer Patients
ClinicalTrials.gov Identifier: NCT00516269 - Recruiting
Breast Cancer; Fatigue
- Tolerability and Efficacy of Depakote-ER in the Elderly
ClinicalTrials.gov Identifier: NCT00318929 - Recruiting
Elderly; Epilepsy; Seizures
- Study of Paliperidone ER in Adolescents and Young Adults With Autism
ClinicalTrials.gov Identifier: NCT00549562 - Recruiting
Autism
- Valproic Acid (Depakote ER) in Patients With Advanced Thyroid Cancer
ClinicalTrials.gov Identifier: NCT00525135 - Recruiting
Head and Neck Cancer
- An Open Label Multicentre Study to Determine the Dose Distribution of Paliperidone ER in Patients With Schizophrenia
ClinicalTrials.gov Identifier: NCT00473434 - Recruiting
Schizophrenia
- A Study of the Efficacy and Safety of One Dosage of Paliperidone Extended Release (ER) in Treating Patients With Schizophrenia
ClinicalTrials.gov Identifier: NCT00524043 - Recruiting
Schizophrenia
- Study to Evaluate Symptoms in Patients Treated With Nebivolol or Metoprolol Extended-Release (ER) for Hypertension
ClinicalTrials.gov Identifier: NCT00547300 - Recruiting
Hypertension
- Divalproex Sodium ER in Adult Autism
ClinicalTrials.gov Identifier: NCT00211796 - Recruiting
Autism
- A Trial to Explore the Tolerability, Safety and Effectiveness of Paliperidone ER (Extended Release) Flexible Dosing in Patients With Schizophrenia
ClinicalTrials.gov Identifier: NCT00460512 - Recruiting
Schizophrenia
- Depakote Extended Release (ER) Versus Seroquel for Agitated Behaviors in Nursing Home Care Unit Patients With Dementia
ClinicalTrials.gov Identifier: NCT00315900 - Recruiting
Agitation; Dementia
- A Double-Blind, Placebo-Controlled Study of the Safety and Efficacy of Paliperidone Extended Release (ER) in the Treatment of Schizophrenia in Adolescent Patients.
ClinicalTrials.gov Identifier: NCT00518323 - Recruiting
Schizophrenia
- A Multicenter Study Comparing the Efficacy and Safety of OROS® Methylphenidate HCl, Ritalin® (Methylphenidate HCl) and Placebo in Children With Attention Deficit Hyperactivity Disorder
ClinicalTrials.gov Identifier: NCT00269802 - Completed
Attention Deficit Hyperactivity Disorder
- A Comparative Effectiveness Study Evaluating OROS® Methylphenidate HCl, Ritalin® (Methylphenidate HCl), and Placebo for the Treatment of Attention Deficit Hyperactivity Disorder in Children
ClinicalTrials.gov Identifier: NCT00269789 - Completed
Attention Deficit Hyperactivity Disorder
- A Trial to Explore the Tolerability, Safety and Treatment Response of the Antipsychotic Paliperidone ER (Extended Release) Using Flexible Dosing in Patients With Acute Schizophrenia
ClinicalTrials.gov Identifier: NCT00566631 - Recruiting
Schizophrenia
- Pain Study to See if Ultram ER Will Provide Relief to Subjects Whose Pain is Not Well Controlled by Narcotics
ClinicalTrials.gov Identifier: NCT00505531 - Recruiting
Chronic Pain
- An Effectiveness and Safety Study Evaluating OROS® Methylphenidate HCl, Ritalin® (Methylphenidate HCl) and Placebo in Children With Attention Deficit Hyperactivity Disorder
ClinicalTrials.gov Identifier: NCT00269776 - Completed
Attention Deficit Hyperactivity Disorder
- Open-Label Depakote ER in Patients With Bipolar I or II Depression and Alcohol Abuse or Dependence
ClinicalTrials.gov Identifier: NCT00204503 - Active, not recruiting
Bipolar I or II Depression and Alcohol Abuse or Dependence
- Efficacy, Safety, Tolerability of Pramipexol ER Versus Pramipexol IR Versus Placebo in Early PD Patients
ClinicalTrials.gov Identifier: NCT00479401 - Recruiting
Parkinson Disease
- Preoperative Cisplatin and Bevacizumab in ER-, PR-, Her-2 Negative Breast Cancer
ClinicalTrials.gov Identifier: NCT00580333 - Recruiting
Breast Cancer
- Trial Evaluating the Safety and Efficacy of 2 Doses of ER OROS Paliperidone in Acute Adult Schizophrenics
ClinicalTrials.gov Identifier: NCT00077714 - Completed
Schizophrenia
- Methylphenidate in Treating Patients With Fatigue Caused by Cancer
ClinicalTrials.gov Identifier: NCT00376675 - Not yet recruiting
Fatigue; Unspecified Adult Solid Tumor, Protocol Specific
- Open-Label Study of Flexible-Dose Paliperidone ER (Extended Release) to Treat Adolescent Schizophrenia.
ClinicalTrials.gov Identifier: NCT00488319 - Recruiting
Dementia Praecox.; Schizophrenia; Psychotic Disorders; Schizophrenic Disorders
- ADHD in Adolescents With Substance Use Disorders
ClinicalTrials.gov Identifier: NCT00264797 - Recruiting
ADHD; Substance Abuse
- An Open-Label Extension Study With Flexible Dosing of Extended-Release (ER) Tapentadol (CG5503) to Treat Patients With Moderate to Severe Chronic Pain
ClinicalTrials.gov Identifier: NCT00487435 - Recruiting
Low Back Pain; Pain; Osteoarthritis
- Phase II Letrozole + Herceptin in Her2neu Positive, ER and/or PR Receptor (+),Metastatic Breast Cancer
ClinicalTrials.gov Identifier: NCT00134680 - Active, not recruiting
Metastatic breast cancer
- Methylphenidate Raclopride Positron Emission Tomography (PET) Test - 11
ClinicalTrials.gov Identifier: NCT00015301 - Completed
Cocaine-Related Disorders; Substance-Related Disorders
- Treatment of Youth with ADHD and Anxiety
ClinicalTrials.gov Identifier: NCT00012584 - Active, not recruiting
Attention Deficit Hyperactivity Disorder; Anxiety, Separation; Social Phobia; Generalized Anxiety Disorder
- Testing Methylphenidate for Smoking Abstinence
ClinicalTrials.gov Identifier: NCT00549640 - Not yet recruiting
Smoking
- Breathing Meditation With Methylphenidate for the Treatment of Attention Deficit Hyperactivity Disorder
ClinicalTrials.gov Identifier: NCT00310986 - Recruiting
Attention Deficit Disorder With Hyperactivity
- A 12-Week Study of Pramipexole ER in Patients With Parkinson?s Disease, Followed by a 52-Week Long-Term Treatment Period
ClinicalTrials.gov Identifier: NCT00560508 - Recruiting
Parkinson Disease
- Androgen Therapy for Management of Estrogen/Progesterone Receptor Negative ER(-)PR(-) Metastatic Breast Cancer
ClinicalTrials.gov Identifier: NCT00303615 - Recruiting
Metastatic Breast Cancer
- A Study to Evaluate the Effectiveness and Safety of Tapentadol(CG5503) Extended Release (ER) in Patients With Moderate to Severe Chronic Low Back Pain
ClinicalTrials.gov Identifier: NCT00449176 - Recruiting
Low Back Pain
- An Open-Label Study to Compare the Lipid Effects of Niacin ER and Simvastatin (NS) to Atorvastatin in Subjects With Hyperlipidemia or Mixed Dyslipidemia (SUPREME)
ClinicalTrials.gov Identifier: NCT00465088 - Recruiting
Hyperlipidemia; Mixed Dyslipidemia
- Phase II Trial of Cetuximab Alone and in Combination With Carboplatin in ER-Negative, PR-Negative, HER-2 Nonoverexpressing Metastatic Breast Cancers (LCCC 0403)
ClinicalTrials.gov Identifier: NCT00492375 - Recruiting
Metastatic Breast Cancer
- Does The Addition Of Divalproex Sodium ER To An Atypical Antipsychotic Drug (APD) Improve Cognition And Psychopathology In Outpatients With Schizophrenia (SCH) Or Schizoaffective Disorder (SAD)?
ClinicalTrials.gov Identifier: NCT00306475 - Recruiting
Schizophrenia; Schizoaffective Disorder
- Overnight Switch Trial From Pramipexole IR to Pramipexole ER in Patients With Early Parkinson Disease
ClinicalTrials.gov Identifier: NCT00558025 - Recruiting
Parkinson Disease
- Trial of Letrozole Plus OSI-774 (Tarceva) in Post-Menopausal Women With Estrogen Receptor (ER) and/or Progesterone Receptor (PR)-Positive Metastatic Breast Cancer
ClinicalTrials.gov Identifier: NCT00179296 - Recruiting
Breast Cancer; Neoplasm Metastasis
- A Phase III Trial to Evaluate the Effectiveness and Safety of Tapentadol(CG5503) Extended Release (ER) in Patients With Moderate to Severe Chronic Pain Due to Osteoarthritis of the Knee
ClinicalTrials.gov Identifier: NCT00421928 - Recruiting
Pain; Osteoarthritis, Knee
- Methylphenidate in ADHD With Trichotillomania
ClinicalTrials.gov Identifier: NCT00552266 - Recruiting
ADHD; Trichotillomania

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