Losartan and Hydrochlorothiazide |
Hyzaar |
Losartan Systematic (IUPAC) name (1-((2'-(2H-tetrazol-5-yl)biphenyl-4-yl)methyl)- 2-butyl-4-chloro-1H-imidazol-5-yl)methanol Identifiers CAS number 114798-26-4 ATC code C09CA01 PubChem 3961 DrugBank APRD00052 Chemical data Formula C22H23ClN6O Mol. weight 422.91 Pharmacokinetic data Bioavailability 25–35% Metabolism Hepatic (CYP2C9, CYP3A4) Half life 1.5–2 hours Excretion Renal 13–25%, biliary 50–60% Therapeutic considerations Pregnancy cat. D ...
Wikipedia - [full article]
Losartan and Hydrochlorothiazide Clinical Trials
- A Randomized, Double-Blind, Parallel-Group Assessment of the Safety and Efficacy of Telmisartan 40mg Plus Hydrochlorothiazide 12.5mg (Micardis Plus) in Comparison with Losartan 50mg Plus Hydrochlorothiazide 12.5mg in Taiwanese Patients with Mild to Modera
ClinicalTrials.gov Identifier: NCT00133185 - Completed
Hypertension
- Hydrochlorothiazide (+) Losartan Potassium Vs. Amlodipine Comparative Study
ClinicalTrials.gov Identifier: NCT00157963 - Completed
Essential Hypertension
- An Open Label Study to Assess the Efficacy, Safety and Tolerability of COZAAR Plus (Losartan Potassium 50mg/Hydrochlorothiazide 12.5mg) Possibly Titrated up to COZAAR Plus-F (Losartan Potassium 100mg/Hydrochlorothiazide 25mg) in Patients With Essential Hy
ClinicalTrials.gov Identifier: NCT00449111 - Terminated
Hypertension
- Losartan vs. Hydrochlorothiazide in Reversing Remodeling of Small Arteries in Pre-Hypertensive Pre-Diabetic Subjects
ClinicalTrials.gov Identifier: NCT00388388 - Recruiting
Pre-Hypertension; Pre-Diabetes
- Efficacy and Safety of Valsartan in Combination With Amlodipine Compared to Losartan Plus Hydrochlorothiazide in Patients With Hypertension and Left Ventricular Hypertrophy
ClinicalTrials.gov Identifier: NCT00446563 - Active, not recruiting
Hypertension; Hypertrophy, Left Ventricular
- Safety/Efficacy of Valsartan/Hydrochlorothiazide Combination Compared to Hydrochlorothiazide in Obese Hypertensive Adults
ClinicalTrials.gov Identifier: NCT00439738 - Active, not recruiting
Hypertension
- Losartan and HCTZ and Amlopidine Vs Atenolol and Amlodipine
ClinicalTrials.gov Identifier: NCT00140959 - Active, not recruiting
Hypertension
- PPARgamma Activation by Losartan in Hypertensive Patients: The Importance of Losartan-Metabolites
ClinicalTrials.gov Identifier: NCT00561327 - Recruiting
Hypertension
- Efficacy of Valsartan/Hydrochlorothiazide Versus Amlodipine and Hydrochlorothiazide in Patients Hypertension
ClinicalTrials.gov Identifier: NCT00425997 - Active, not recruiting
Hypertension
- A Study to Evaluate the Renal Protective Effects of Losartan in Patients with Renal Transplant.
ClinicalTrials.gov Identifier: NCT00140907 - Active, not recruiting
Renal Disorder
- Antiproteinuric Efficacy of Losartan Potassium in Patients with Non-Diabetic Proteinuric Renal Diseases
ClinicalTrials.gov Identifier: NCT00140985 - Active, not recruiting
Renal disorder
- Safety/Efficacy of Combo Therapy With Aliskiren & Hydrochlorothiazide vs Therapy With Hydrochlorothiazide Alone in Patients With Hypertension
ClinicalTrials.gov Identifier: NCT00387517 - Active, not recruiting
Hypertension
- Efficacy of Irbesartan/Hydrochlorothiazide Versus Valsartan/Hydrochlorothiazide in Mild to Moderate Hypertension
ClinicalTrials.gov Identifier: NCT00500604 - Recruiting
Hypertension
- A Randomised, Double-Blind, Placebo-Controlled, 3 x 3 Factorial Trial of Telmisartan and Hydrochlorothiazide in Patients With Essential Hypertension.
ClinicalTrials.gov Identifier: NCT00153049 - Completed
Hypertension
- Safety and Efficacy of Valsartan Plus Hydrochlorothiazide and Amlodipine in Hypertensive Patients
ClinicalTrials.gov Identifier: NCT00426478 - Active, not recruiting
Hypertension
- Antihypertensive Effectiveness of the Associations of Hydrochlorothiazide and Amiloride and Hydrochlorothiazide and Enalapril
ClinicalTrials.gov Identifier: NCT00394394 - Completed
Hypertension
- Safety and Efficacy of Valsartan Versus Atenolol and Hydrochlorothiazide Combination on Blood Flow in Hypertensive Patients
ClinicalTrials.gov Identifier: NCT00396656 - Active, not recruiting
Hypertension
- Study Comparing SPP100 (Aliskiren) 150mg to Placebo and to Losartan 50mg in Patients With Mild to Moderate Essential Hypertension
ClinicalTrials.gov Identifier: NCT00344110 - Active, not recruiting
Hypertension
- Double-Blind Randomized Cross-Over Trial Comparing Metabolic Effects of Candesartan, Hydrochlorothiazide and Placebo
ClinicalTrials.gov Identifier: NCT00282178 - Active, not recruiting
Hypertension; Obesity
- Efficacy and Safety of Valsartan/Hydrochlorothiazide Combination Therapy in Patients With Hypertension
ClinicalTrials.gov Identifier: NCT00277472 - Active, not recruiting
Hypertension
- Efficacy and Safety of Valsartan/Hydrochlorothiazide Combination Therapy in Patients With Hypertension
ClinicalTrials.gov Identifier: NCT00280540 - Active, not recruiting
Hypertension
- Efficacy and Safety of Valsartan, Hydrochlorothiazide and Amlodipine Combination Therapy in Hypertension
ClinicalTrials.gov Identifier: NCT00400777 - Active, not recruiting
Hypertension
- A Clinical Study to Evaluate the Long-Term Safety (12 Months) of the Combination of Aliskiren 300 mg and Hydrochlorothiazide 25 mg
ClinicalTrials.gov Identifier: NCT00171405 - Active, not recruiting
Hypertension
- A Clinical Study to Evaluate Safety & Efficacy of the Combination of Aliskiren, Valsartan & Hydrochlorothiazide in Diabetic Hypertensive Nonresponder Patients
ClinicalTrials.gov Identifier: NCT00219102 - Active, not recruiting
Hypertension; Diabetes
- Efficacy and Safety of Valsartan Plus Hydrochlorothiazide in Fixed Dose Combination in Hypertensive Patients Not Controlled by the Free Combination of an Angiotensin Receptor Blocker Plus Hydrochlorothiazide
ClinicalTrials.gov Identifier: NCT00360178 - Completed
Hypertension
- Effect of Lacidipine and Losartan on 24 Hour Systolic Blood Pressure Variability in Elderly Hypertensive Patients
ClinicalTrials.gov Identifier: NCT00533858 - Recruiting
Hypertension
- Renin Angiotensin System Study (RASS/B-RASS)
ClinicalTrials.gov Identifier: NCT00143949 - Active, not recruiting
Type 1 Diabetes
- Effect of Losartan on Retinal Endothelial Function in Patients with Essential Hypertension
ClinicalTrials.gov Identifier: NCT00152633 - Completed
Hypertension
- Irbesartan/Hydrochlorothiazide National Taiwan University Hospital Listing
ClinicalTrials.gov Identifier: NCT00443612 - Recruiting
Hypertension
- Effectiveness Study on Fosinopril and/or Losartan in Patients With Chronic Kidney Disease Stage 3
ClinicalTrials.gov Identifier: NCT00565396 - Active, not recruiting
Chronic Kidney Insufficiency; Angiotensin-Converting Enzyme Inhibitors; Angiotensin II Type 1 Receptor Blockers; Proteinuria
- A Randomized, Double-Blind, Placebo-Controlled, Forced-Titration, Phase IV Study Comparing Telmisartan 80 Mg + Hydrochlorothiazide 25 Mg [Micardis HCT] Versus Valsartan 160 Mg + Hydrochlorothiazide 25 Mg [Diovan HCT] Taken Orally for Eight Weeks in Patien
ClinicalTrials.gov Identifier: NCT00168779 - Completed
Hypertension
- Pharmacodynamic Influences of Candesartan, Atenolol, Hydrochlorothiazide and Drug Combinations in Hypertensive Patients.
ClinicalTrials.gov Identifier: NCT00232882 - Recruiting
Hypertension
- Evaluation of Effect of Combination With Telmisartan and Hydrochlorothiazide in Hypertensives Uncontrolled on Amlodipine
ClinicalTrials.gov Identifier: NCT00509470 - Recruiting
Essential Hypertension
- Losartan Anti-Atherosclerosis Study
ClinicalTrials.gov Identifier: NCT00496834 - Not yet recruiting
Hypertension
- A Prospective, Randomised, Double-Blind, Double-Dummy, Forced-Titration, Multicentre, Parallel Group, One Year Treatment Trial to Compare Telmisartan (MICARDIS) 80 mg Versus Losartan (COZAAR) 100 mg, in Hypertensive Type 2 Diabetic Patients With Overt Nep
ClinicalTrials.gov Identifier: NCT00168857 - Active, not recruiting
Hypertension; Diabetic Nephropathies
- Kallikrein-Kinin (KKS) and Renin-Angiotension-Aldosterone System (RAAS)in Primary Aldosteronism
ClinicalTrials.gov Identifier: NCT00155064 - Recruiting
Hyperaldosteronism
- A Safety and Tolerability Study of the Combination of Aliskiren/Valsartan in Patients With High Blood Pressure, Followed by Long-Term Safety and Tolerability of Aliskiren, Valsartan and Hydrochlorothiazide.
ClinicalTrials.gov Identifier: NCT00386607 - Active, not recruiting
Hypertension
- A 16 Week Study to Evaluate the Effect on Insulin Sensitivity of Valsartan (320 mg) and Hydrochlorothiazide (25 mg) Combined and Alone, in Patients With Metabolic Syndrome
ClinicalTrials.gov Identifier: NCT00170937 - Active, not recruiting
Metabolic Syndrome; Hypertension; Pre-Hypertension
- Pharmacokinetic Drug Interaction Study Following co-Administration of Valsartan, Hydrochlorothiazide and Amlodipine in Patients With Hypertension
ClinicalTrials.gov Identifier: NCT00548067 - Recruiting
Hypertension
- Efficacy of the New Closure Device in Improving Patient Compliance in Treatment of Hypertension With Valsartan+/-Hydrochlorothiazide (HCTZ) at 6 Months
ClinicalTrials.gov Identifier: NCT00487123 - Recruiting
Hypertension
- Effect of Enalapril and Losartan Association Therapy on Proteinuria and Inflammatory Biomarkers in Diabetic Nephropathy: a Clinical Trial on Type 2 Diabetes Mellitus
ClinicalTrials.gov Identifier: NCT00419835 - Recruiting
Macroalbuminuric Diabetic Nephropathy
- The Vascular Effects of Carvedilol CR + Lisinopril Versus Lisinopril + Hydrochlorothiazide in Abdominally Obese Hypertensive Patients
ClinicalTrials.gov Identifier: NCT00459056 - Recruiting
Abdominal Obesity; Hypertension
- A Comparison of Telmisartan 80 mg + Hydrochlorothiazide 12.5 mg With Amlodipine 10 mg + Hydrochlorothiazide 12.5 mg in the Control of Blood Pressure in Older Patients With Predominantly Systolic Hypertension. A Prospective, Randomised, Open-Label, Blinded
ClinicalTrials.gov Identifier: NCT00240474 - Completed
Hypertension
- Aliskiren in Combination With Losartan Compared to Losartan on the Regression of Left Ventricular Hypertrophy in Overweight Patients With Essential Hypertension
ClinicalTrials.gov Identifier: NCT00219141 - Completed
Hypertension; Left Ventricular Hypertrophy; Overweight
- Angiotensin II Blockade
ClinicalTrials.gov Identifier: NCT00067990 - Recruiting
Kidney Disease; Proteinuria
- Study to Determine the Effects of Losartan on Proteinuria in Pediatric Patients
ClinicalTrials.gov Identifier: NCT00568178 - Not yet recruiting
Proteinuria
- A Study of Losartan Compared to Losartan/HCTZ in Pediatric Patients With Hypertension
ClinicalTrials.gov Identifier: NCT00447603 - Terminated
Hypertension
- Open-Label Trial of the Efficacy and Safety of Combination of Telmisartan 80 Mg + Hydrochlorothiazide 25 Mg Tablets in Patients With Hypertension.
ClinicalTrials.gov Identifier: NCT00267943 - Completed
Hypertension
- Effectiveness of Losartan 50 mg/HCTZ 12.5 mg Versus Valsartan 80 mg/HCTZ 12.5 mg Titrated as Needed in Patients With Hypertension Not Controlled on Monotherapy
ClinicalTrials.gov Identifier: NCT00546754 - Recruiting
Hypertension
- Long Term Effects of Enalapril and Losartan on Genetic Heart Disease
ClinicalTrials.gov Identifier: NCT00001534 - Completed
Hypertrophic Cardiomyopathy; Left Ventricular Hypertrophy; Myocardial Ischemia
- Olmesartan Alone or in Combination With Hydrochlorothiazide in Subjects With Mild to Moderate Essential Hypertension
ClinicalTrials.gov Identifier: NCT00139698 - Completed
Essential Hypertension
- Use of the Combination of Olmesartan and Hydrochlorothiazide in Essential Hypertension
ClinicalTrials.gov Identifier: NCT00430508 - Not yet recruiting
Essential Hypertension
- Combination of Olmesartan and Hydrochlorothiazide in Essential Hypertension
ClinicalTrials.gov Identifier: NCT00430950 - Not yet recruiting
Essential Hypertension
- Glucose Optimisation With Angiotensin II Antagonist Losartan (GOAAL)
ClinicalTrials.gov Identifier: NCT00237588 - Completed
Hypertension
- Pioglitazone and Losartan Provides Additional Renoprotection
ClinicalTrials.gov Identifier: NCT00364988 - Completed
Type 2 Diabetes; Diabetic Nephropathy
- Telmisartan and Losartan in Hypertensive IGT
ClinicalTrials.gov Identifier: NCT00407862 - Completed
Hypertension; Impaired Glucose Tolerance
- Rural Andhra Pradesh Cardiovascular Prevention Study (RAPCAPS)
ClinicalTrials.gov Identifier: NCT00263393 - Recruiting
* Myocardial Infarction; Angina Pectoris; Cerebrovascular Accidents; Diabetes Mellitus
- Avoiding Cardiovascular Events through Combination therapy in patients with Systolic Hypertension ACCOMPLISH
ClinicalTrials.gov Identifier: NCT00097864 - No longer recruiting
Heart Disease
- A Research Study to Evaluate the Renal (Kidney) Protective Effects of Losartan in Patients With Non-Insulin Dependent Diabetes
ClinicalTrials.gov Identifier: NCT00308347 - Completed
Type 2 Diabetes and Nephropathy
- Losartan Intervention For Endpoint Reduction in Hypertension (LIFE) Study
ClinicalTrials.gov Identifier: NCT00338260 - Completed
Hypertension and Left Ventricular Hypertrophy (Thickening of the Main Pumping Chamber of the Heart)
- Valsartan/Hydrochlorothiazide Combination vs Amlodipine in Patients With Hypertension, Diabetes, and Albuminuria.
ClinicalTrials.gov Identifier: NCT00171561 - Completed
Hypertension
- Valsartan/Hydrochlorothiazide Combination in Hypertensive Patients Not Controlled With Valsartan Alone
ClinicalTrials.gov Identifier: NCT00170989 - Completed
Hypertension
- Ramipril and Hydrochlorothiazide Alone and in Combination for the Treatment of Essential Hypertension
ClinicalTrials.gov Identifier: NCT00355589 - Completed
Hypertension; Blood Pressure, High
- Combination of Benazepril Plus Hydrochlorothiazide in Chinese Patients With Mild to Moderate Essential Hypertension
ClinicalTrials.gov Identifier: NCT00367094 - Completed
Hypertension
- Long Term Safety of Aliskiren Alone or With the Optional Addition of Hydrochlorothiazide in Patients With Essential Hypertension
ClinicalTrials.gov Identifier: NCT00219037 - Completed
Hypertension
- A Study Comparing Valsartan With And Without Hydrochlorothiazide In Patients With Hypertension
ClinicalTrials.gov Identifier: NCT00241007 - Completed
Hypertension
- Valsartan/Hydrochlorothiazide Combination in the Treatment of Severe Hypertension
ClinicalTrials.gov Identifier: NCT00273299 - Completed
Hypertension
- A Comparison of the Effect of Olmesartan Medoxomil, Losartan Potassium, and Atenolol on the Ability of Overweight Patients With High Blood Pressure to Respond to Insulin
ClinicalTrials.gov Identifier: NCT00185094 - Completed
Hypertension; Insulin Resistance; Metabolic Syndrome
- Clinical Study to Evaluate the Efficacy and Safety of Aliskiren Alone and in Combination With Hydrochlorothiazide in Patients With Essential Hypertension.
ClinicalTrials.gov Identifier: NCT00219024 - Completed
Hypertension
- Study of Inherited Changes of Receptors Located on Blood Vessels
ClinicalTrials.gov Identifier: NCT00001741 - Completed
Cardiovascular Disease
- A 52 Week Study to Evaluate the Effects of Losartan With or Without HCTZ on Plasma Glucose, Metabolic Parameters, Blood Pressure in Hypertensive Patients With Metabolic Syndrome
ClinicalTrials.gov Identifier: NCT00546052 - Completed
Hypertension; Metabolic Disorder
- Effects of Losartan on Hepatic Fibrogenesis in Chronic Hepatitis C
ClinicalTrials.gov Identifier: NCT00298714 - Completed
Chronic Hepatitis C; Liver Fibrosis
- PROBE Parallel 6-wk Treatment Comparing Telmisartan/HCT (40/12.5 or 80/12.5) With Losartan/HCT (50/12.5) Using ABPM
ClinicalTrials.gov Identifier: NCT00274638 - Completed
Hypertension
- Study to Evaluate the Efficacy and Safety of Daglutril Compared to Placebo on Top of Losartan in Type 2 Diabetics with Overt Nephropathy and Well Controlled Hypertension
ClinicalTrials.gov Identifier: NCT00160225 - Completed
Hypertension
- Effects of Losartan on Insulin Sensitivity and Secretion in Type 2 Diabetes and Nephropathy
ClinicalTrials.gov Identifier: NCT00361023 - Completed
Type 2 Diabetes; Diabetic Nephropathy
- A Clinical Study to Compare Long-Term Efficacy and Safety of an Aliskiren Based Regimen to a Hydrochlorothiazide Based Treatment Regimen With Optional Addition of Amlodipine
ClinicalTrials.gov Identifier: NCT00294710 - Completed
Hypertension
- Treatment of High Blood Pressure Using Olmesartan with Hydrochlorothiazide Compared to an ACE Inhibitor with a Calcium Channel Blocker
ClinicalTrials.gov Identifier: NCT00185120 - Completed
Hypertension
- Irbesartan/Hydrochlorothiazide and Irbesartan in the Treatment of Mild to Moderate Hypertension
ClinicalTrials.gov Identifier: NCT00263003 - Completed
Hypertension
- Losartan Therapy in Pulmonary Hypertension
ClinicalTrials.gov Identifier: NCT00519870 - Completed
Pulmonary Hypertension
- Irbesartan/Hydrochlorothiazide (HCTZ) Combination Therapy as First Line Treatment for Severe Hypertension
ClinicalTrials.gov Identifier: NCT00095394 - Completed
Hypertension
- Irbesartan/Hydrochlorothiazide (HCTZ) Combination Therapy for Patients with Moderate Hypertension
ClinicalTrials.gov Identifier: NCT00095550 - Completed
Hypertension
- A Safety and Efficacy Trial of the Combination of Aliskiren / Hydrochlorothiazide (HCTZ)(300/12.5 mg and 300/25 mg) Compared to Aliskiren 300 mg in Hypertensive Patients
ClinicalTrials.gov Identifier: NCT00386139 - Completed
Hypertension
- Olmesartan as an Add-on to Amlodipine in Hypertension
ClinicalTrials.gov Identifier: NCT00220233 - Completed
Essential Hypertension
- Irbesartan in the Treatment of Hypertensive Patients with Metabolic Syndrome
ClinicalTrials.gov Identifier: NCT00110422 - Completed
Metabolic Syndrome X; Hypertension
- Olmesartan Medoxomil in Hypertension and Renal Impairment
ClinicalTrials.gov Identifier: NCT00151827 - Completed
Essential Hypertension; Renal impairment
- A Randomised, Double-Blind Study Comparing a Fixed Dose Combination of Telmisartan 40 Mg Plus Hydrochlorothiazide 12.5 Mg to Telmisartan 40 Mg (Micardis®) in Patients Who Fail to Respond Adequately to Treatment with Telmisartan (Micardis®) 40 Mg
ClinicalTrials.gov Identifier: NCT00144222 - Completed
Hypertension
- Diuretics, Hypertension, and Arrhythmias Clinical Trial
ClinicalTrials.gov Identifier: NCT00000525 - Completed
Cardiovascular Diseases; Death, Sudden, Cardiac; Heart Arrest; Heart Diseases; Hypertension
- Long-Term Renoprotection of Optimal Antiproteinuric Doses of Benazepril and Losartan in Chronic Renal Insufficiency
ClinicalTrials.gov Identifier: NCT00338091 - Terminated
Renal Insufficiency,Chronic; Disease Progression; Proteinuria; Dose-Response Relationship,Drug; ACE Inhibitor; Angiotensin II Type 1 Receptor Blockers

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