Losartan and Hydrochlorothiazide

Hyzaar

... LOSARTAN-HYDROCHLOROTHIAZIDE (Hyzaar^®) is a combination of two drugs used to lower blood pressure. Losartan controls high blood pressure (hypertension) by relaxing blood vessels. Hydrochlorothiazide is a diuretic. High blood pressure can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. By lowering blood pressure, losartan-hydrochlorothiazide can help reduce your risk of having damage to your kidneys, heart, or other organs. This medicine does not cure high blood pressure. Generic losartan-hydrochlorothiazide tablets are not yet available. ...

Losartan Systematic (IUPAC) name (1-((2'-(2H-tetrazol-5-yl)biphenyl-4-yl)methyl)- 2-butyl-4-chloro-1H-imidazol-5-yl)methanol Identifiers CAS number 114798-26-4 ATC code C09CA01 PubChem 3961 DrugBank APRD00052 Chemical data Formula C22H23ClN6O Mol. weight 422.91 Pharmacokinetic data Bioavailability 25–35% Metabolism Hepatic (CYP2C9, CYP3A4) Half life 1.5–2 hours Excretion Renal 13–25%, biliary 50–60% Therapeutic considerations Pregnancy cat. D ...