Esomeprazole |
Nexium |
Esomeprazole Systematic (IUPAC) name (S)-5-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl) methylsulfinyl]-3H-benzoimidazole Identifiers CAS number 161796-78-7 ATC code A02BC05 PubChem 4594 DrugBank APRD00363 Chemical data Formula C17H19N3O3S Mol. weight 345.417 Pharmacokinetic data Bioavailability 50–90% Metabolism Hepatic (CYP2C19, CYP3A4) Half life 1–1.5 hours Excretion 80% Renal 20% Faecal Therapeutic considerations Pregnancy cat. B3 (Austral ...
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Esomeprazole Clinical Trials
- Comparison of Esomeprazole to Aerosolized, Swallowed Fluticasone for Eosinophilic Esophagitis
ClinicalTrials.gov Identifier: NCT00123656 - Recruiting
Esophagitis
- High Dosage Esomeprazole and Baclofen for Therapy of Gastroesophageal Reflux Disease
ClinicalTrials.gov Identifier: NCT00461604 - Recruiting
Patients With Persistent Objectified Gastroesophageal Reflux and Reflux-Associated Symptoms Despite PPI-Therapy With 40mg Esomeprazole
- Inhibition of Gastric Acid is the Key to Satisfactory Relief of Symptoms With Esomeprazole in NUD Patients
ClinicalTrials.gov Identifier: NCT00222131 - Active, not recruiting
Indigestion
- Esomeprazole and Symptomatic Response in Patients With or Without an Elevated Risk for NSAID-Associated GI Damage
ClinicalTrials.gov Identifier: NCT00524329 - Active, not recruiting
Heartburn; Bloating; Regurgitation
- Proton Pump Inhibitor Treatment Stop
ClinicalTrials.gov Identifier: NCT00120315 - Active, not recruiting
Dyspepsia
- An Open-Label Study of Once-Daily Oral Administration of Esomeprazole 40 Mg in Patients With Symptoms of Gastroesophageal Reflux Disease (GERD)
ClinicalTrials.gov Identifier: NCT00242736 - Completed
GERD
- Effect of Acid Suppression With Esomeprazole on Vocal Cord Granulomas
ClinicalTrials.gov Identifier: NCT00567658 - Recruiting
Larynx Disease
- Phase 3/Safety & Efficacy of Esomeprazole in Infants
ClinicalTrials.gov Identifier: NCT00468559 - Recruiting
Gastroesophageal Reflux Disease (GERD)
- A Comparison of Gastric pH Control With High Dose Intravenous or Oral Esomeprazole
ClinicalTrials.gov Identifier: NCT00164788 - Recruiting
Gastrointestinal Hemorrhage
- Evaluation of Esomeprazole in Treating GERD in Head and Neck Cancer Patients Exposed to Radiation Therapy.
ClinicalTrials.gov Identifier: NCT00222079 - Recruiting
Gastro-Esophageal Reflux
- Efficacy and Safety of Esomeprazole Once Daily for the Treatment of GERD in Neonatal Patients
ClinicalTrials.gov Identifier: NCT00427635 - Recruiting
GERD
- Nexium (Esomeprazole) in Symptom Adapted Therapy in GERD Patients
ClinicalTrials.gov Identifier: NCT00444275 - Recruiting
GERD
- Efficacy and Safety Study of Esomeprazole vs Omeprazole to Treat Acute Non-Variceal Upper Gastrointestinal Bleeding
ClinicalTrials.gov Identifier: NCT00402259 - Recruiting
Gastrointestinal Hemorrhage
- Safety and Efficacy Study to Determine Anti-Asthmatic Effect of Esomeprazole Magnesium; Nexium Reflux Asthma
ClinicalTrials.gov Identifier: NCT00317044 - Recruiting
Asthma; GERD
- In Vivo Quantification of Dental Demineralisation Using Optical Coherence Tomography Before and After Double-Blind, Randomised Treatment With Esomeprazole or Placebo of Patients With Dental Erosions
ClinicalTrials.gov Identifier: NCT00564330 - Recruiting
Tooth Erosion
- Esomeprazole With or Without Aspirin in Preventing Esophageal Cancer in Patients With Barrett's Metaplasia
ClinicalTrials.gov Identifier: NCT00357682 - Recruiting
Esophageal Cancer; Precancerous/Nonmalignant Condition
- Esomeprazole With or Without Aspirin in Preventing Esophageal Cancer in Patients With Barrett Esophagus
ClinicalTrials.gov Identifier: NCT00474903 - Recruiting
Esophageal Cancer; Precancerous/Nonmalignant Condition
- Compare Efficacy of Gastric Acid Suppression by Oral and Intravenous Administration of Esomeprazole in Patients With Peptic Ulcer
ClinicalTrials.gov Identifier: NCT00471029 - Recruiting
Peptic Ulcer
- Efficacy and Safety Study of Esomeprazole 20mg qd vs Ranitidine 150mg Bid in Patients With an NSAID-Induced Gastric Ulcer
ClinicalTrials.gov Identifier: NCT00401752 - Recruiting
Gastric Ulcer
- Study of Esomeprazole 20 mg or 40 mg vs Placebo Effectiveness on the Occurrence of Peptic Ulcers in Subjects on LDA
ClinicalTrials.gov Identifier: NCT00441727 - Recruiting
Gastric Ulcer; Duodenal Ulcer
- Comparison of the Gastric Acid Suppressive Effects of Esomeprazole and Generic Omeprazole
ClinicalTrials.gov Identifier: NCT00542347 - Recruiting
Gastric Acid
- Esomeprazole In Patients With Gastric Acid Hypersecretory States Including Idiopathic Hypersecretion and Zollinger-Ellison Syndrome
ClinicalTrials.gov Identifier: NCT00079833 - Completed
Zollinger-Ellison Syndrome
- A Study To Evaluate The Effects Of Repeat Dosing Of Esomeprazole On The Pharmacokinetics Of SB-751689 In Healthy People
ClinicalTrials.gov Identifier: NCT00508534 - Not yet recruiting
Osteoporosis
- Esomeprazole, Moxifloxacin and Amoxicilin for Rescue Therapy of Helicobacter Pylori Infection
ClinicalTrials.gov Identifier: NCT00455806 - Recruiting
Helicobacter Pylori Infection; Chronic Gastritis
- Esomeprazole Treatment for Patients With Lymphocytic Gastritis
ClinicalTrials.gov Identifier: NCT00455754 - Recruiting
Lymphocytic Gastritis
- APE-Study: Ablation of Barrett's Mucosa vs. Surveillance Without Ablation in Patients Cured From Barrett's Cancer Combined With Randomization of Esomeprazole vs. Placebo for Symptomatic Reflux Control After Successful Barrett's Ablation
ClinicalTrials.gov Identifier: NCT00546065 - Recruiting
Barrett's Esophagus
- A Study to Compare the Number of Patients With Gastro-Oesophageal Reflux Disease (GORD) Achieving Heartburn and Regurgitation Symptom Resolution After Treatment With Either Rabeprazole Sodium 20mg, Esomeprazole 20mg or Esomperazole 40m
ClinicalTrials.gov Identifier: NCT00464308 - Recruiting
Gastro-Oesophageal Reflux
- Clinical Trial of Acid Reflux Therapy in Asthma
ClinicalTrials.gov Identifier: NCT00069823 - Recruiting
Asthma; Lung Diseases; Lung Diseases, Obstructive
- The Effect of Nexium on Transmucosal Esophageal Leak
ClinicalTrials.gov Identifier: NCT00216788 - Not yet recruiting
Reflux; Esophagitis; Barrett''s Esophagus
- Esomeprazole in PPI Failures - IMPROVE
ClinicalTrials.gov Identifier: NCT00272701 - Completed
Gastroesophageal Reflux Disease
- Esomeprazole and Gastric Emptying of Beer
ClinicalTrials.gov Identifier: NCT00472550 - Completed
Gastroesophageal Reflux; Heartburn
- Esomeprazole for Prevention of Upper Gastrointestinal Symptoms Associated With Continuous Use of NSAIDs
ClinicalTrials.gov Identifier: NCT00241514 - Completed
GERD
- Esomeprazole for Relief of Upper Gastrointestinal Symptoms Associated With Continuous Use of NSAIDs
ClinicalTrials.gov Identifier: NCT00241540 - Completed
GERD
- Evaluation of 24-Hour Intragastric pH Using Esomeprazole, Lansoprazole, and Pantoprazole in Hispanic Patients With GERD
ClinicalTrials.gov Identifier: NCT00410592 - Completed
Gastroesophageal Reflux Disease
- Study to Assess Management Strategies for the Use of Esomeprazole (Nexium) in Helicobacter Pylori Infected Patients
ClinicalTrials.gov Identifier: NCT00574925 - Completed
Gastroesophageal Reflux Disease (GERD)
- AGN 201904 Versus Esomeprazole in the Prevention of Aspirin-Induced Stomach or Upper Intestinal Damage in Healthy Volunteers
ClinicalTrials.gov Identifier: NCT00325715 - Completed
Peptic Ulcer
- Safety of Daily Dose Esomeprazole for GERD for Pediatric and Adolescent Patients
ClinicalTrials.gov Identifier: NCT00241501 - Completed
Gastroesophageal Reflux Disease (GERD)
- Acid-Associated Heartburn Symptoms and Dose of Esomeprazole
ClinicalTrials.gov Identifier: NCT00206024 - Completed
Heartburn
- An Open Label pH Comparison of Esomeprazole and Lansoprazole in Barrett's Esophagus Patients
ClinicalTrials.gov Identifier: NCT00352261 - Completed
Barrett's Esophagus
- Study of 24-Hour Intragastric pH Profiles of Esomeprazole 40 Mg and Lansoprazole 30 Mg in Healthy Volunteer Subjects
ClinicalTrials.gov Identifier: NCT00230516 - Completed
Healthy
- A Dose-Finding Phase IIb Study With AZD0865 and Esomeprazole in GERD Patients With Erosive Esophagitis.
ClinicalTrials.gov Identifier: NCT00206245 - Completed
GERD With Erosive Esophagitis
- A Dose-Finding Phase IIb Study With AZD0865 and Esomeprazole in GERD Patients Without Erosive Esophagitis.
ClinicalTrials.gov Identifier: NCT00206284 - Completed
GERD Without Erosive Esophagitis
- Esomeprazole for Treatment of GERD in Pediatric Patients
ClinicalTrials.gov Identifier: NCT00228527 - Completed
Gastroesophageal Reflux Disease (GERD); Erosive Esophagitis; Non-Erosive Esophagitis
- Esomeprazole for Prevention of Upper Gastrointestinal Symptoms Associated With Continuous Use of NSAIDs
ClinicalTrials.gov Identifier: NCT00241553 - Completed
NSAIDs; Upper GI Symptoms
- Esomeprazole for Relief of Upper Gastrointestinal Symptoms Associated With Continuous Use of NSAIDs
ClinicalTrials.gov Identifier: NCT00241527 - Completed
NSAIDs; Upper GI Symptoms
- Preventing Recurrent Ulcer Bleeding in Arthritis Patients Using Esomeprazole Plus Celecoxib
ClinicalTrials.gov Identifier: NCT00365313 - Completed
Arthritis; Bleeding Ulcer
- Study of Intragastric pH Profile After 5 Days Pantoprazole 40 Mg Iv Followed by Oral Esomeprazole 40 Mg Po or Oral Pantoprazole 40 Mg Po
ClinicalTrials.gov Identifier: NCT00206050 - Completed
Healthy
- Total Antioxidant Effects of Esomeprazole in Dyspeptic Patients Receiving Non-Steroidal Anti-Inflammatory Drugs
ClinicalTrials.gov Identifier: NCT00443963 - Terminated
Dyspepsia
- A Phase I Study of BMS-275183 (Oral Taxane) Given on a Daily Schedule in Combination With Esomeprazole (Nexium) in Patients With Advanced Cancer
ClinicalTrials.gov Identifier: NCT00332748 - Terminated
Cancer

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