Methylphenidate |
Methylin; Ritalin |
Methylphenidate Systematic (IUPAC) name methyl 2-phenyl-2-(2-piperidyl)acetate Identifiers CAS number 113-45-1 ATC code N06BA04 PubChem 4158 DrugBank APRD00657 Chemical data Formula C14H19NO2 Mol. weight 233.306 g/mol Pharmacokinetic data Bioavailability 11–52% (Oral) Metabolism Liver Half life 2–4 hours Excretion Urine Therapeutic considerations Pregnancy cat. C Legal status Schedule II USA, Schedule 2 UK Routes ? Indicated ...
Wikipedia - [full article]
Methylphenidate Clinical Trials
- Effects of Methylphenidate Versus Sustained Release Methylphenidate on Cognitive Functioning
ClinicalTrials.gov Identifier: NCT00418691 - Recruiting
Brain Tumor
- Ritaline
ClinicalTrials.gov Identifier: NCT00273741 - Recruiting
Palliative Care; Asthenia; Neoplasms; Methylphenidate
- A Study of Repeat Dosing of OROS® Methylphenidate Hydrochloride (CONCERTA®) and Immediate Release Methylphenidate Hydrochloride in Healthy Adults
ClinicalTrials.gov Identifier: NCT00302458 - Recruiting
Healthy
- Methylphenidate in the Treatment of Cocaine Dependent Patients with Adult Attention Deficit Hyperactivity Disorder - 5
ClinicalTrials.gov Identifier: NCT00015223 - Active, not recruiting
Cocaine-Related Disorders; Substance-Related Disorders
- Study Examining Repeat Dosing of OROS® Methylphenidate (CONCERTA®) and Immediate Release Methylphenidate in Healthy Adults
ClinicalTrials.gov Identifier: NCT00302393 - Not yet recruiting
Healthy
- Methylphenidate Treatment for Cocaine Abuse and ADHD - 1
ClinicalTrials.gov Identifier: NCT00136734 - Active, not recruiting
Attention Deficit Disorder with Hyperactivity; Cocaine-Related Disorders
- Methylphenidate in Treating Patients With Melanoma
ClinicalTrials.gov Identifier: NCT00003266 - Active, not recruiting
unspecified adult solid tumor, protocol specific; Fatigue; Quality of Life
- The Genetic Bases for Vulnerability to Substance Abuse in Individuals With Different Acute Responses to Methylphenidate
ClinicalTrials.gov Identifier: NCT00247689 - Not yet recruiting
Substance Abuse
- Safety and Tolerability of MTS in Children Aged 6-12 Diagnosed with ADHD and Previously Treated with Extended-Release Methylphenidate Therapy
ClinicalTrials.gov Identifier: NCT00151983 - Completed
Attention Deficit Disorder with Hyperactivity
- Methylphenidate for Apathy in Alzheimer’s Dementia: A Controlled Study
ClinicalTrials.gov Identifier: NCT00495820 - Not yet recruiting
ALZHEIMER’S DISEASE; APATHY; Dementia; Methylphenidate
- Methylphenidate for Depressed Cancer Patients in Hospice
ClinicalTrials.gov Identifier: NCT00129467 - Recruiting
Depression; Hospice Care; Cancer; Mental Disorder
- Methylphenidate for Treating Children With ADHD and Tourette Syndrome
ClinicalTrials.gov Identifier: NCT00441649 - Active, not recruiting
Attention Deficit Disorder With Hyperactivity; Tourette Syndrome
- The Effect of Methylphenidate on Motor Learning in Stroke Patients
ClinicalTrials.gov Identifier: NCT00396058 - Recruiting
Cerebrovascular Accident
- An Open-Label Study of Quetiapine Added to Oros Methylphenidate in the Treatment of ADHD and Aggressive Behavior
ClinicalTrials.gov Identifier: NCT00198211 - Active, not recruiting
Attention-Deficit/Hyperactivity Disorder, Combined Type; Disruptive Behavior Disorder
- Methylphenidate Study in Young Children With Developmental Disorders
ClinicalTrials.gov Identifier: NCT00517504 - Recruiting
Attention Deficit Hyperactivity Disorder
- Methylphenidate Transdermal System (MTS) in the Treatment of Adult ADHD
ClinicalTrials.gov Identifier: NCT00506285 - Recruiting
Attention Deficit Hyperactivity Disorder
- Treatment of Adult Attention Deficit Hyperactivity Disorder (ADHD) in Methadone Patients - 1
ClinicalTrials.gov Identifier: NCT00061087 - Active, not recruiting
Opioid-Related Disorders
- Genetic Measurements in Blood Cells of Children Taking Adderall or Methylphenidate
ClinicalTrials.gov Identifier: NCT00341029 - Recruiting
Attention Deficit Hyperactivity Disorder; ADHD
- Efficacy Study of PR OROS Methylphenidate and Psychosocial Interventions in Swedish Imprisoned Men With ADHD
ClinicalTrials.gov Identifier: NCT00482313 - Recruiting
Attention Deficit Hyperactivity Disorder
- A Long-Term Safety Study to Evaluate Methylphenidate HCL Tablets at Multiple Dose Levels in Adults With Attention Deficit Hyperactivity Disorder
ClinicalTrials.gov Identifier: NCT00326300 - Active, not recruiting
Attention Deficit Hyperactivity Disorder
- A Double-Blind Randomized, Placebo-Controlled, Crossover Study of Single Doses of OROS Methylphenidate Hydrochloride (CONCERTA) and Long-Acting Methylphenidate Hydrochloride (RITALIN LA) in Healthy Adults
ClinicalTrials.gov Identifier: NCT00302354 - Completed
Healthy Volunteers
- An Effectiveness and Safety Study of CONCERTA* Vs. Immediate Release Methylphenidate (IR MPH) in Attention Deficit Hyperactivity Disorder Children
ClinicalTrials.gov Identifier: NCT00304681 - Active, not recruiting
Attention Deficit Hyperactivity Disorder
- Methylphenidate and a Nursing Telephone Intervention for Fatigue
ClinicalTrials.gov Identifier: NCT00424099 - Recruiting
Advanced Cancer; Fatigue
- Study of the Effects of OROS Methylphenidate (Concerta) on Attention and Memory
ClinicalTrials.gov Identifier: NCT00530257 - Recruiting
Attention Deficit Hyperactivity Disorder
- Pediatric Traumatic Brain Injury: Methylphenidate Effects on Early Recovery
ClinicalTrials.gov Identifier: NCT00035139 - Completed
Brain Injuries
- Evaluate the Safety and Efficacy of Methylphenidate Transdermal System (MTS) in Adolescents Aged 13-17 Years With ADHD
ClinicalTrials.gov Identifier: NCT00501293 - Recruiting
ADHD
- Effects of Methylphenidate on Cellular Abnormalities in Children With Attention Deficit Hyperactivity Disorder
ClinicalTrials.gov Identifier: NCT00409708 - Active, not recruiting
Attention Deficit Hyperactivity Disorder
- Evaluate the Efficacy &Safety of Methylphenidate Transdermal System (MTS) in Adolescents Aged 13-17 Years With ADHD
ClinicalTrials.gov Identifier: NCT00499863 - Recruiting
ADHD
- Comparison of Modafinil and Methylphenidate in Treatment of Excessive Daytime Sleepiness in Patients With Parkinson's Disease
ClinicalTrials.gov Identifier: NCT00393562 - Recruiting
Parkinson's Disease
- NF1-Attention: Study of Children With Neurofibromatosis Type 1 Treated by Methylphenidate
ClinicalTrials.gov Identifier: NCT00169611 - Recruiting
Neurofibromatosis Type 1
- Methylphenidate (Ritalin) and Memory/Attention in Traumatic Brain Injury (TBI)
ClinicalTrials.gov Identifier: NCT00453921 - Recruiting
Brain Injury
- Efficacy, Safety and Tolerability of SPD485 in Children Aged 6-12 Diagnosed with ADHD
ClinicalTrials.gov Identifier: NCT00151970 - Completed
Attention Deficit Disroder with Hyperactivity
- Safety and Tolerability of SPD485 in Children Aged 6-12 Diagnosed with ADHD and Previously Participated in MTS Trials
ClinicalTrials.gov Identifier: NCT00151957 - Completed
Attention Deficit Disorder with Hyyperactivity.
- Aripiprazole Associated With Methylphenidate in Children and Adolescents With Bipolar Disorder and ADHD
ClinicalTrials.gov Identifier: NCT00305370 - Recruiting
Bipolar Disorder; Attention Deficit Hyperactivity Disorder
- Methylphenidate Study in Breast Cancer Patients
ClinicalTrials.gov Identifier: NCT00516269 - Recruiting
Breast Cancer; Fatigue
- A Multicenter Study Comparing the Efficacy and Safety of OROS® Methylphenidate HCl, Ritalin® (Methylphenidate HCl) and Placebo in Children With Attention Deficit Hyperactivity Disorder
ClinicalTrials.gov Identifier: NCT00269802 - Completed
Attention Deficit Hyperactivity Disorder
- A Comparative Effectiveness Study Evaluating OROS® Methylphenidate HCl, Ritalin® (Methylphenidate HCl), and Placebo for the Treatment of Attention Deficit Hyperactivity Disorder in Children
ClinicalTrials.gov Identifier: NCT00269789 - Completed
Attention Deficit Hyperactivity Disorder
- An Effectiveness and Safety Study Evaluating OROS® Methylphenidate HCl, Ritalin® (Methylphenidate HCl) and Placebo in Children With Attention Deficit Hyperactivity Disorder
ClinicalTrials.gov Identifier: NCT00269776 - Completed
Attention Deficit Hyperactivity Disorder
- Methylphenidate in Treating Patients With Fatigue Caused by Cancer
ClinicalTrials.gov Identifier: NCT00376675 - Not yet recruiting
Fatigue; Unspecified Adult Solid Tumor, Protocol Specific
- ADHD in Adolescents With Substance Use Disorders
ClinicalTrials.gov Identifier: NCT00264797 - Recruiting
ADHD; Substance Abuse
- Methylphenidate Raclopride Positron Emission Tomography (PET) Test - 11
ClinicalTrials.gov Identifier: NCT00015301 - Completed
Cocaine-Related Disorders; Substance-Related Disorders
- Treatment of Youth with ADHD and Anxiety
ClinicalTrials.gov Identifier: NCT00012584 - Active, not recruiting
Attention Deficit Hyperactivity Disorder; Anxiety, Separation; Social Phobia; Generalized Anxiety Disorder
- Testing Methylphenidate for Smoking Abstinence
ClinicalTrials.gov Identifier: NCT00549640 - Not yet recruiting
Smoking
- Breathing Meditation With Methylphenidate for the Treatment of Attention Deficit Hyperactivity Disorder
ClinicalTrials.gov Identifier: NCT00310986 - Recruiting
Attention Deficit Disorder With Hyperactivity
- Methylphenidate in ADHD With Trichotillomania
ClinicalTrials.gov Identifier: NCT00552266 - Recruiting
ADHD; Trichotillomania
- Methylphenidate for Treating Attention Deficit Hyperactivity Disorder in Children With Both ADHD and Epilepsy
ClinicalTrials.gov Identifier: NCT00323947 - Recruiting
Attention Deficit Disorder With Hyperactivity; Epilepsy
- CONCERTA® (OROS® Methylphenidate Hydrochloride) for the Treatment of Attention Deficit Hyperactivity Disorder in Adults
ClinicalTrials.gov Identifier: NCT00246207 - Completed
Attention Deficit Disorder With Hyperactivity
- Methylphenidate for Attention Deficit Hyperactivity Disorder and Autism in Children
ClinicalTrials.gov Identifier: NCT00178503 - Recruiting
Autism; Attention Deficit Disorder With Hyperactivity
- Adverse Effect of Prolonged Methylphenidate Treatment on Cardiac Functions
ClinicalTrials.gov Identifier: NCT00372359 - Recruiting
Attention Deficit Disorder With Hyperactivity; Attention Deficit Disorder; Attention Deficit Hyperactivity Disorder; Attention Deficit Disorders With Hyperactivity; Attention Deficit Hyperactivity Disorders
- Dextroamphetamine-Amphetamine Compared With Methylphenidate in Treating Children With Depression and Problems With Memory, Attention, and Thinking Caused By Cancer Treatment
ClinicalTrials.gov Identifier: NCT00069927 - Completed
unspecified childhood solid tumor, protocol specific; Depression; neurotoxicity
- Methylphenidate in Children and Adolescents with Pervasive Developmental Disorders
ClinicalTrials.gov Identifier: NCT00025779 - Completed
Attention Deficit Disorder with Hyperactivity; Autistic Disorder; Pervasive Development Disorders
- Methylphenidate for the Treatment of Gait Impairment in Parkinson's Disease
ClinicalTrials.gov Identifier: NCT00526630 - Not yet recruiting
Parkinson's Disease; Gait Impairment
- Methylphenidate and Driving Ability in Adult Patients With Attention-Deficit Hyperactivity Disorder
ClinicalTrials.gov Identifier: NCT00223561 - Completed
ADHD
- Naturalistic Substitution of Concerta in Adult Subject With ADHD Receiving Immediate Release Methylphenidate
ClinicalTrials.gov Identifier: NCT00302406 - Completed
Attention Deficit Hyperactivity Disorder
- A PET Study Examining Pharmacokinetics and Dopamine Transporter Receptor Occupancy Of Two Long-Acting Formulations of Methylphenidate in Adults
ClinicalTrials.gov Identifier: NCT00301639 - Completed
Healthy Volunteers
- Safety and Efficacy of Methylphenidate Transdermal System (MTS) Versus Concerta in Pediatric Patients (Aged 6-12 Years) With ADHD
ClinicalTrials.gov Identifier: NCT00444574 - Completed
Attention Deficit Hyperactivity Disorder
- An Open Label Phase I/II Study of Dopamine Transporter Receptor Occupancy With OROS and Immediate Release Methylphenidate as Measured With C-11 Altropane in Human Subjects
ClinicalTrials.gov Identifier: NCT00302367 - Completed
Healthy Volunteers
- Methylphenidate to Improve Quality of Life in Patients Undergoing Radiation Therapy for Brain Tumors
ClinicalTrials.gov Identifier: NCT00031798 - Completed
adult brain tumor; brain metastases; cognitive and functional effects; Depression; Fatigue; Quality of Life
- CONCERTA® (Methylphenidate Hydrochloride) as Add-on Therapy in the Treatment of Adult Major Depressive Disorder.
ClinicalTrials.gov Identifier: NCT00246233 - Completed
Depressive Disorder, Major
- Methylphendidate Treatment of Cocaine Dependent Patients with Attention Deficit Hyperactivity Disorder - 3
ClinicalTrials.gov Identifier: NCT00015054 - Completed
Cocaine-Related Disorders
- Smoking Cessation for Adults With ADHD
ClinicalTrials.gov Identifier: NCT00253747 - Completed
ADHD; Smoking
- A Study of the Effectiveness and Safety of Prolonged-Release Methylphenidate Hydrochloride in Adult Patients With Attention Deficit/Hyperactivity Disorder.
ClinicalTrials.gov Identifier: NCT00246220 - Completed
Attention Deficit Disorder With Hyperactivity
- A Safety and Effectiveness Study of Methylphenidate HCl Extended-Release Tablets in Adults With Attention Deficit Hyperactivity Disorder
ClinicalTrials.gov Identifier: NCT00326391 - Completed
Attention Deficit Disorder With Hyperactivity
- A Study to Determine Effective and Tolerable Titration Scheme for OROS-Methylphenidate in Children With Attention-Deficit Hyperactivity Disorder
ClinicalTrials.gov Identifier: NCT00518232 - Completed
Attention-Deficit Hyperactivity Disorder
- An Effectiveness and Safety Study of CONCERTA® (Methylphenidate Hydrochloride) in the Treatment of Adolescents With Attention Deficit Hyperactivity Disorder
ClinicalTrials.gov Identifier: NCT00249353 - Completed
Attention Deficit Disorder With Hyperactivity
- Long-Term Safety and Effectiveness of OROS® Methylphenidate HCl in Children With Attention Deficit Hyperactivity Disorder
ClinicalTrials.gov Identifier: NCT00269815 - Completed
Attention Deficit Hyperactivity Disorder
- Efficacy and Safety of Dex-Methylphenidate Extended Release 20 mg Versus Placebo in Children (6-12 Years) With Attention-Deficit/Hyperactivity Disorder (ADHD) in a Laboratory Classroom Setting
ClinicalTrials.gov Identifier: NCT00564954 - Completed
Attention Deficit Hyperactivity Disorder
- Cocaine-Methylphendidate Interaction Study - 4
ClinicalTrials.gov Identifier: NCT00015067 - Completed
Cocaine-Related Disorders
- Safety and Efficacy of Methylphenidate in Children With Attention-Deficit Hyperactivity Disorder (ADHD)
ClinicalTrials.gov Identifier: NCT00428792 - Completed
Attention Deficit Hyperactivity Disorder
- Methylphenidate and Parkinson's Disease
ClinicalTrials.gov Identifier: NCT00359723 - Completed
Parkinson's Disease
- Treatment of Attention Deficit Hyperactivity Disorder in Preschool-Age Children (PATS)
ClinicalTrials.gov Identifier: NCT00018863 - Completed
Attention Deficit Disorder with Hyperactivity
- Clonidine in Attention Deficit Hyperactivity Disorder (ADHD) in Children
ClinicalTrials.gov Identifier: NCT00031395 - Completed
Attention Deficit Disorder with Hyperactivity
- Behavioral Treatment, Drug Treatment, and Combined Treatment for Attention Deficit Hyperactivity Disorder (ADHD)
ClinicalTrials.gov Identifier: NCT00050622 - Completed
Attention Deficit Hyperactivity Disorder

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