Montelukast

montelukast sodium; Singulair

Article: Montelukast

Image:Singulair.jpg
Montelukast
Systematic (IUPAC) name
2-[1-[[(1R)-1-[3-[2-(7-chloroquinolin-2-yl)ethenyl] phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl] sulfanylmethyl]cyclopropyl]acetic acid
Identifiers
CAS number	158966-92-8
ATC code	R03DC03
PubChem	60951
DrugBank	APRD00434
Chemical data
Formula	C₃₅H₃₆NClO₃S
Mol. weight	586.184 g/mol
Pharmacokinetic data
Bioavailability	?
Protein binding	99%
Metabolism	Hepatic (CYP3A4 and CYP2C9-mediated)
Half life	2.7-5.5 hours
Excretion	Biliary
Therapeutic considerations
Pregnancy cat.	B (U.S.), B1 (Au)
Legal status	℞-only (U.S.), POM (UK), S4 (Au)
Routes	Oral

Montelukast is an oral leukotriene receptor antagonist (LTRA) for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies. It is not useful for the treatment of acute asthma attacks, so patients should also be supplied with rescue medication, such as an albuterol inhaler. Montelukast blocks the action of leukotriene D4 on the cysteinyl leukotriene receptor CysLT₁, thus inhibiting bronchoconstriction.

Montelukast is marketed by Merck & Co. with the brand name Singulair®. It is available as oral tablets, chewable tablets, and oral granules.

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