Olanzapine |
Zyprexa; Zyprexa Zydis |
Olanzapine Systematic (IUPAC) name 2-methyl-4-(4-methyl-1-piperazinyl)- 10H-thieno[2,3-b][1,5]benzodiazepine Identifiers CAS number 132539-06-1 ATC code N05AH03 PubChem 4585 DrugBank 132539-06-1 Chemical data Formula C17H20N4S Mol. weight 312.439 Pharmacokinetic data Bioavailability ? Metabolism Hepatic Half life 21-54 hours Excretion ? Therapeutic considerations Pregnancy cat. C Legal status Rx only Routes oral Olanzapine ...
Wikipedia - [full article]
Olanzapine Clinical Trials
- Patient's Preference Between Conventional Oral Olanzapine Tablet vs Olanzapine Orodispersible Tablet
ClinicalTrials.gov Identifier: NCT00324051 - Active, not recruiting
Schizophrenia
- Comparing the Effect of Under the Tongue Olanzapine Versus Swallowed Olanzapine on Body Mass Index (A Ratio of Weight to Height)
ClinicalTrials.gov Identifier: NCT00303602 - Active, not recruiting
Schizophrenia; Schizoaffective Disorder; Bipolar Disorder
- Olanzapine Pamoate Depot Versus Oral Olanzapine on Treatment Outcomes in Outpatients With Schizophrenia
ClinicalTrials.gov Identifier: NCT00320489 - Recruiting
Schizophrenia
- Intramuscular Olanzapine Depot in Patients With Schizophrenia or Schizoaffective Disorder
ClinicalTrials.gov Identifier: NCT00088465 - Active, not recruiting
Schizophrenic Disorders
- A Controlled Study of Olanzapine in Children with Autism
ClinicalTrials.gov Identifier: NCT00057408 - Recruiting
Autistic Disorder
- Optimal Duration of Olanzapine Add-on Therapy in Major Depression
ClinicalTrials.gov Identifier: NCT00568672 - Recruiting
Relapse Rate of a Major Depressive Episode; Safety of Olanzapine in Subjects With Major Depression
- Validation of Multidimensional Assessment of THYmic States (MATHYS): A Study in a Population of Bipolar Patients Treated With Olanzapine
ClinicalTrials.gov Identifier: NCT00259272 - Recruiting
Bipolar Disorder I or II
- Glucose regulation during risperidone and olanzapine treatment
ClinicalTrials.gov Identifier: NCT00006195 - Recruiting
Schizophrenia
- Comparison of Clozapine or Olanzapine in Childhood-Onset Psychotic Disorders
ClinicalTrials.gov Identifier: NCT00001656 - Active, not recruiting
Mental Disorder Diagnosed in Childhood; Psychotic Disorder; Schizophrenia
- Subcutaneous Olanzapine for Hyperactive or Mixed Delirium
ClinicalTrials.gov Identifier: NCT00512291 - Active, not recruiting
Advanced Cancer
- Pfizer/IVGTT/Ziprasidone/Olanzapine
ClinicalTrials.gov Identifier: NCT00205725 - Active, not recruiting
Schizophrenia; Type 2 Diabetes Mellitus
- Determining the Safety and Effectiveness of Olanzapine in Children and Adolescents
ClinicalTrials.gov Identifier: NCT00183612 - Active, not recruiting
Bipolar Disorder; Psychotic Disorders
- A Study of Treatment Success in Changing From Olanzapine to Long-Acting Injectable Risperidone (RISPERDAL® CONSTA™)
ClinicalTrials.gov Identifier: NCT00216632 - Active, not recruiting
Psychotic Disorders; Schizophrenia
- Comparison of Intramuscular Olanzapine Depot to Oral Olanzapine and Low-Dose Depot in the Maintenance Therapy of Patients With Schizophrenia
ClinicalTrials.gov Identifier: NCT00088491 - Completed
Schizophrenic Disorders
- Double-Blind Trial of Olanzapine in Patients with Manic or Mixed Episode of Bipolar I Disorder
ClinicalTrials.gov Identifier: NCT00129220 - Recruiting
Manic or mixed episode associated with bipolar I disorder
- The Effect of a Weight Management Program During Treatment With Olanzapine
ClinicalTrials.gov Identifier: NCT00169702 - Recruiting
Schizophrenia
- Short Term Rescue Study of Olanzapine
ClinicalTrials.gov Identifier: NCT00186017 - Recruiting
Bipolar Disorders
- An Evaluation of Divalproex Vs. Olanzapine for Alcohol Abuse Relapse Prevention in Patients With Bipolar Disorder
ClinicalTrials.gov Identifier: NCT00221481 - Active, not recruiting
Bipolar Disorder
- Atomoxetine for Treatment of Weight Gain in Olanzapine or Clozapine Patients
ClinicalTrials.gov Identifier: NCT00176436 - Recruiting
Schizophrenia
- 3 Fixed Dosages of Extended Release OROS Paliperidone and Olanzapine in the Treatment of Subjects with Schizophrenia
ClinicalTrials.gov Identifier: NCT00078039 - Active, not recruiting
Schizophrenia
- Extended Release OROS Paliperidone in Treatment of Schizophrenia (double blind, placebo-controlled trial, with Olanzapine arm)
ClinicalTrials.gov Identifier: NCT00083668 - Active, not recruiting
Schizophrenia
- Assessment of Safety and Efficacy of Therapy for the Prevention of Weight Gain Associated With Olanzapine
ClinicalTrials.gov Identifier: NCT00401973 - Recruiting
Schizophrenia; Schizoaffective Disorders
- Study Comparing Patients Taking Olanzapine and Patients Taking Aripiprazole on Learning of Vocational Skills
ClinicalTrials.gov Identifier: NCT00223418 - Active, not recruiting
Schizophenia Disorder; Schizoaffective Disorder
- Treatment and Outcome of Early Onset Bipolar Disorder
ClinicalTrials.gov Identifier: NCT00048802 - Active, not recruiting
Bipolar Disorder
- Comparative Effects of Chronic Treatment With Olanzapine and Risperidone on Glucose and Lipid Metabolism
ClinicalTrials.gov Identifier: NCT00287820 - Recruiting
Schizophrenia; Diabetes; Metabolic Syndrome; Hyperglycemia
- Olanzapine Versus An Active Comparator in the Treatment of Schizophrenia
ClinicalTrials.gov Identifier: NCT00036088 - Completed
Schizophrenia
- Olanzapine versus Placebo in the Treatment of Adolescents with Schizophrenia
ClinicalTrials.gov Identifier: NCT00051298 - Completed
Schizophrenia
- Treatment of Schizophrenia and Comorbid Cannabis Use Disorder: Comparing Clozapine to Risperidone and Olanzapine.
ClinicalTrials.gov Identifier: NCT00149955 - Recruiting
Schizophrenia; Dual Diagnosis; Schizoaffective Disorder; Psychotic Disorder; Substance Abuse; Cannabis Abuse
- Energy Homoeostasis Under Treatment with Atypical Antipsychotics
ClinicalTrials.gov Identifier: NCT00148564 - Recruiting
Schizophrenia
- Olanzapine Treatment of Patients With Bipolar I Disorder
ClinicalTrials.gov Identifier: NCT00510146 - Recruiting
Depression, Bipolar
- An Observational Study of Olanzapine Coated and Orodispersible Tablets Effectiveness in Schizophrenic and Bipolar Outpatients.
ClinicalTrials.gov Identifier: NCT00510211 - Recruiting
Schizophrenia; Bipolar Disorder
- Comparison of Continuing Olanzapine to Switching to Quetiapine in Overweight or Obese Patients with Schizophrenia and Schizoaffective Disorder
ClinicalTrials.gov Identifier: NCT00090012 - Completed
Schizophrenia
- An Investigation of the Sleep Architecture and Consequent Cognitive Changes in Olanzapine-Treated Depressed Patients
ClinicalTrials.gov Identifier: NCT00520507 - Recruiting
Bipolar Disorder, Depression; Depressive Disorder, Major
- BMI and Metabolic Changes Following Switch to Aripiprazole From Olanzapine, Risperidone and Quetiapine.
ClinicalTrials.gov Identifier: NCT00312598 - Recruiting
Schizophrenia; Schizoaffective Disorder; Schizophreniform Disorder; Mood Disorders With Psychotic Features
- Treating Drug-Resistant Childhood Schizophrenia
ClinicalTrials.gov Identifier: NCT00048828 - Recruiting
Schizophrenia
- Switching Medication to Treat Schizophrenia
ClinicalTrials.gov Identifier: NCT00044655 - Recruiting
Schizophrenia
- Study of Amantadine for Weight Stabilization During Olanzapine Treatment
ClinicalTrials.gov Identifier: NCT00287352 - Recruiting
Psychotic Disorder; Schizophreniform Disorder; Schizophrenia; Schizoaffective Disorder
- Olanzapine versus Aripiprazole in the Treatment of Acutely Ill Patients with Schizophrenia
ClinicalTrials.gov Identifier: NCT00103571 - Completed
Schizophrenia
- The Study of Olanzapine Plus Fluoxetine in Combination for Treatment-Resistant Depression Without Psychotic Features
ClinicalTrials.gov Identifier: NCT00035321 - Completed
Depressive Disorders
- 6-Month Extension Trial of Asenapine With Olanzapine in Negative Symptom Patients Who Completed the First 6-Month Trial.
ClinicalTrials.gov Identifier: NCT00174265 - Recruiting
Schizophrenia
- 6-Month Extension Trial of Asenapine With Olanzapine in Negative Symptom Patients Who Completed the First 6-Month Trial
ClinicalTrials.gov Identifier: NCT00265343 - Recruiting
Schizophrenia
- Study to Examine the Effect of Betahistine on Body Weight Gain Due to Olanzapine Treatment
ClinicalTrials.gov Identifier: NCT00428168 - Recruiting
Weight Gain
- Comparison of Combination Olanzapine+Lithium or Chlorpromazine+Lithium in Treatment of First Manic Episode With Psychotic Features
ClinicalTrials.gov Identifier: NCT00202293 - Recruiting
Bipolar Disorder; Schizoaffective Disorder
- Olanzapine Versus Active Comparator in the Treatment of Bipolar I Disorder
ClinicalTrials.gov Identifier: NCT00034580 - Completed
Bipolar Disorder
- Schizophrenia Risperidone vs Olanzapine Study HGMN
ClinicalTrials.gov Identifier: NCT00373321 - Recruiting
Schizophrenia; Schizoaffective Disorder; Schizophreniform Disorder
- Olanzapine Versus Placebo in the Treatment of Mania in Adolescents with Bipolar I Disorder
ClinicalTrials.gov Identifier: NCT00050206 - Completed
Bipolar Disorder
- Study Comparing Olanzapine with Haloperidol for the Relief of Nausea and Vomitting in Patients with Advanced Cancer
ClinicalTrials.gov Identifier: NCT00124930 - Recruiting
Refractory Nausea
- Melatonin Metabolism Abnormality in Patients With Schizophrenia or Schizoaffective Disorder Treated With Olanzapine
ClinicalTrials.gov Identifier: NCT00512070 - Recruiting
Schizophrenia; Schizoaffective Disorder; Obesity; Metabolic Syndrome
- Study of Olanzapine vs. Aripiprazole in the Treatment of Schizophrenia
ClinicalTrials.gov Identifier: NCT00088049 - Completed
Schizophrenia
- Olanzapine Augmentation Therapy in Treatment-Resistant Depression: a Double-Blind Placebo-Controlled Trial
ClinicalTrials.gov Identifier: NCT00273624 - Recruiting
Therapy-Resistant Depression
- Comparison of Intramuscular Olanzapine Depot with Placebo in the Treatment of Patients with Schizophrenia
ClinicalTrials.gov Identifier: NCT00088478 - Completed
Schizophrenia
- Olanzapine in the Treatment of Patients With Anorexia Nervosa
ClinicalTrials.gov Identifier: NCT00260962 - Recruiting
Anorexia Nervosa
- Olanzapine Compared to Divalproex and Placebo in the Treatment of Mild to Moderate Mania Associated with Bipolar I Disorder
ClinicalTrials.gov Identifier: NCT00094549 - Completed
Bipolar Disorder
- A Comparison of Olanzapine in Combination With a Mood Stabilizer vs Mood Stabilizer Alone, in Mixed Bipolar Patients
ClinicalTrials.gov Identifier: NCT00402324 - Recruiting
Bipolar I Disorder
- Safety Study of Olanzapine and a Comparator in Patients With Schizophrenia and Schizoaffective Disorder
ClinicalTrials.gov Identifier: NCT00190749 - Recruiting
Schizophrenia; Schizoaffective Disorder
- PET Imaging and Olanzapine Treatment in Borderline Personality Disorder
ClinicalTrials.gov Identifier: NCT00275301 - Recruiting
Borderline Personality Disorder
- Pilot Study of Topiramate and Olanzapine in the Prevention of Weight Gain in Children and Adolescents With Bipolar Disorder
ClinicalTrials.gov Identifier: NCT00394095 - Recruiting
Bipolar Disorder; Weight Gain
- Olanzapine Versus Active Comparator in the Treatment of Depression in Patients with Schizophrenia
ClinicalTrials.gov Identifier: NCT00034801 - Completed
Depression; Schizophrenia; Schizoaffective Disorder
- Medication Treatment for Psychotic Depression
ClinicalTrials.gov Identifier: NCT00056472 - Recruiting
Depression; Major Depressive Disorder
- Population Pharmacokinetic Study in Adolescent Patients with Schizophrenia or Bipolar I Disorder with Olanzapine
ClinicalTrials.gov Identifier: NCT00113594 - Completed
Schizophrenia; Bipolar Disorder
- Efficacy and Safety of Olanzapine in Patients with Borderline Personality Disorder
ClinicalTrials.gov Identifier: NCT00088036 - Completed
Borderline Personality Disorder
- Efficacy of High Dose Olanzapine for the Treatment of Schizophrenia and Schizoaffective Disorder
ClinicalTrials.gov Identifier: NCT00100776 - Completed
Schizophrenia; Schizoaffective Disorder
- The Effects on Thinking of Risperidone and Olanzapine
ClinicalTrials.gov Identifier: NCT00108368 - Completed
Schizophrenia; Psychotic Disorders
- Efficacy and Safety of Olanzapine in the Extended Treatment for Manic or Mixed Episode of Bipolar I Disorder
ClinicalTrials.gov Identifier: NCT00266630 - Recruiting
Manic or Mixed Episode Associated With Bipolar I Disorder
- Olanzapine in Patients With Advanced Cancer and Weight Loss
ClinicalTrials.gov Identifier: NCT00489593 - Recruiting
Advanced Cancer; Weight Loss
- Olanzapine in Patients with Borderline Personality Disorder
ClinicalTrials.gov Identifier: NCT00091650 - Completed
Borderline Personality Disorder
- A Study of Zonisamide to Prevent Olanzapine-Associated Weight Gain
ClinicalTrials.gov Identifier: NCT00363376 - Not yet recruiting
Weight Gain
- Pharmacokinetic Characterization of Intramuscular Olanzapine Depot
ClinicalTrials.gov Identifier: NCT00094640 - Completed
Schizophrenia; Schizoaffective Disorder
- To Determine If Olanzapine Is More Cost Effective Than Haloperidol for the Treatment of Schizophrenia
ClinicalTrials.gov Identifier: NCT00007774 - Completed
Schizophrenia; Schizoaffective Disorder
- Depakote Monotherapy, Olanzapine Monotherapy, and Combination Therapy of Depakote Plus Olanzapine in Stable Subjects during the Maintenance Phase of Bipolar Illness
ClinicalTrials.gov Identifier: NCT00071253 - Terminated
Bipolar Disorder
- Ziprasidone for Clozapine- or Olanzapine-Associated Diabetes Mellitus
ClinicalTrials.gov Identifier: NCT00351000 - Completed
Schizophrenia
- Large Simple Trial (LST) Of Cardiovascular Safety Of Ziprasidone And Olanzapine- (Zodiac)
ClinicalTrials.gov Identifier: NCT00418171 - Completed
Schizophrenia
- Optimal Length of Treatment Continuation With Olanzapine After Remission of Manic or Mixed Episode
ClinicalTrials.gov Identifier: NCT00191997 - Completed
Bipolar Disorder
- Risperidone and Olanzapine for the Schizophrenic Patients With Neuroleptic-Induced Acute Dystonia or Parkinsonism
ClinicalTrials.gov Identifier: NCT00331825 - Completed
Schizophrenia; Extrapyramidal Syndrome
- Influence of Treatment With Olanzapine or Ziprasidone on Transcapillary Glucose Transport in Human Skeletal Muscle
ClinicalTrials.gov Identifier: NCT00297960 - Completed
Healthy Male Volunteers
- Olanzapine Versus Clozapine in Treatment Refractory Schizophrenia
ClinicalTrials.gov Identifier: NCT00179231 - Completed
Schizophrenia; Schizoaffective Disorder
- A Study Using Rapid Acting Intramuscular Olanzapine in Agitated Patients With Schizophrenia
ClinicalTrials.gov Identifier: NCT00316238 - Completed
Schizophrenia
- Study Comparing the Affect of Bifeprunox Vs Olanzapine on Weight During the Treatment of Outpatients With Schizophrenia.
ClinicalTrials.gov Identifier: NCT00380224 - Completed
Schizophrenia
- Olanzapine/Fluoxetine Combination Versus Comparator in the Treatment of Bipolar I Depression
ClinicalTrials.gov Identifier: NCT00485771 - Completed
Bipolar Disorder
- Examining Rapid Acting Intra-Muscular Olanzapine in Japanese Patients With Schizophrenia
ClinicalTrials.gov Identifier: NCT00485810 - Completed
Schizophrenia
- Efficacy and Safety of Asenapine Compared With Olanzapine in Patients With Persistent Negative Symptoms of Schizophrenia
ClinicalTrials.gov Identifier: NCT00212836 - Completed
Schizophrenia
- A Placebo-Controlled Trial Ampakine Added to Clozapine, Olanzapine or Risperidone in Patients With Schizophrenia
ClinicalTrials.gov Identifier: NCT00235352 - Completed
Schizophrenia
- Olanzapine Plus Carbamazepine in the Treatment of Bipolar I Mania
ClinicalTrials.gov Identifier: NCT00190892 - Completed
Bipolar Disorder
- The Effectiveness of Supplementing Supported Employment With Behavioral Skills Training in Schizophrenia Patients Taking Risperidone or Olanzapine
ClinicalTrials.gov Identifier: NCT00183625 - Completed
Schizophrenia
- Olanzapine in the Treatment of Hair Pulling (Trichotillomania)
ClinicalTrials.gov Identifier: NCT00182507 - Completed
Trichotillomania
- Ziprasidone Versus Olanzapine In The Treatment Of Schizophrenia.
ClinicalTrials.gov Identifier: NCT00239109 - Completed
Schizophrenia
- A Study of the Effects of Risperidone and Olanzapine on Blood Glucose (Sugar) in Patients With Schizophrenia or Schizoaffective Disorder
ClinicalTrials.gov Identifier: NCT00236379 - Completed
Schizophrenia; Diabetes Mellitus
- A Study Comparing the Efficacy of Long-Acting Injectable Risperidone and Olanzapine Tablets in the Treatment of Patients With Schizophrenia or Schizoaffective Disorder
ClinicalTrials.gov Identifier: NCT00236457 - Completed
Schizophrenia; Psychotic Disorders
- Antipsychotic Response in Schizophrenia
ClinicalTrials.gov Identifier: NCT00018668 - Completed
Schizophrenia
- CATIE- Schizophrenia Trial
ClinicalTrials.gov Identifier: NCT00014001 - Completed
Schizophrenia
- Treatment for First-Episode Schizophrenia
ClinicalTrials.gov Identifier: NCT00000374 - Completed
Schizophrenia
- Open label trial exploring a switch from oral medications, to risperidone depot microspheres
ClinicalTrials.gov Identifier: NCT00034775 - Completed
Schizophrenia
- Safety and Efficacy Trial of Olanzapine in Outpatients With Pathological Gambling
ClinicalTrials.gov Identifier: NCT00438776 - Completed
Pathological Gambling
- Olanzapine Versus Comparator in the Treatment of Bipolar Disorder
ClinicalTrials.gov Identifier: NCT00485680 - Completed
Bipolar Disorder
- Comparison of Intramuscular Olanzapine and Intramuscular Haloperidol in Patients With Schizophrenia
ClinicalTrials.gov Identifier: NCT00485901 - Completed
Schizophrenia
- A Study Comparing Three Strategies to Switch Patients With Schizophrenia or Schizoaffective Disorder to Risperidone After Unsuccessful Treatment With Olanzapine.
ClinicalTrials.gov Identifier: NCT00378183 - Completed
Schizoaffective Disorder; Schizophrenia
- Risperidone Versus Olanzapine for Mania in Preschool Children 4 to 6 Years of Age With Bipolar Disorder
ClinicalTrials.gov Identifier: NCT00181935 - Completed
Bipolar Disorder; Mania
- A Two-Week Study of the Efficacy and Safety of Mifepristone in the Prevention of Olanzapine-Induced Weight Gain
ClinicalTrials.gov Identifier: NCT00455442 - Completed
Weight-Gain Prevention
- Kahn Study
ClinicalTrials.gov Identifier: NCT00145444 - Completed
Schizophrenia; Psychotic Disorders
- A First In Human Study Of PF-00184562 In Healthy Volunteers
ClinicalTrials.gov Identifier: NCT00150215 - Completed
Schizophrenia

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