Isotretinoin |
Accutane; Amnesteem; Claravis; Sotret |
Isotretinoin Systematic (IUPAC) name 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)- nona-2,4,6,8-tetraenoic acid Identifiers CAS number 4759-48-2 ATC code D10AD04 PubChem 5538 DrugBank APRD00140 Chemical data Formula C20H28O2 Mol. weight 300.44 Pharmacokinetic data Bioavailability ? Metabolism Liver Half life 10–20 hours Excretion Feces and Urine Therapeutic considerations Pregnancy cat. X (Au), X (U.S.) Legal status S4 (Au), POM ...
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Isotretinoin Clinical Trials
- Vitamin E in Preventing the Side Effects of Isotretinoin in Former and Current Smokers Who Are Receiving Isotretinoin to Prevent Lung Cancer
ClinicalTrials.gov Identifier: NCT00003599 - Active, not recruiting
Lung Cancer; prevention of lung cancer
- Phase I Study of Isotretinoin in Patients With Recessive Dystrophic Epidermolysis Bullosa
ClinicalTrials.gov Identifier: NCT00014729 - Active, not recruiting
Epidermolysis Bullosa
- MS-275 and Isotretinoin in Treating Patients With Metastatic or Advanced Solid Tumors or Lymphomas
ClinicalTrials.gov Identifier: NCT00098891 - Active, not recruiting
adult solid tumor; Leukemia; Lymphoma; small intestine cancer
- Interferon alfa, Isotretinoin, and Paclitaxel in Treating Patients With Recurrent Small Cell Lung Cancer
ClinicalTrials.gov Identifier: NCT00062010 - Active, not recruiting
Recurrent Small Cell Lung Cancer
- Isotretinoin With or Without Vitamin E for Prevention of Lung Cancer
ClinicalTrials.gov Identifier: NCT00002586 - Active, not recruiting
Non-small cell lung cancer; Small Cell Lung Cancer; Drug Toxicity
- Interferon alfa With or Without Isotretinoin in Treating Patients With Metastatic Kidney Cancer
ClinicalTrials.gov Identifier: NCT00002737 - Active, not recruiting
Stage IV Renal Cell Cancer; recurrent renal cell cancer; Renal Cell Adenocarcinoma
- Isotretinoin, Interferon alfa, and Vitamin E in Treating Patients With Stage III or Stage IV Head and Neck Cancer
ClinicalTrials.gov Identifier: NCT00054561 - Active, not recruiting
Hypopharyngeal Cancer; Laryngeal Cancer; lip and oral cavity cancer; Oropharyngeal Cancer
- Procarbazine and Isotretinoin in Treating Patients With Recurrent Primary Malignant Gliomas
ClinicalTrials.gov Identifier: NCT00003564 - Active, not recruiting
adult glioblastoma multiforme; adult anaplastic astrocytoma; adult anaplastic oligodendroglioma; recurrent adult brain tumor; Mixed Gliomas
- Temozolomide Alone or in Combination With Thalidomide and/or Isotretinoin and/or Celecoxib in Treating Patients Who Have Undergone Radiation Therapy for Glioblastoma Multiforme
ClinicalTrials.gov Identifier: NCT00112502 - Recruiting
adult giant cell glioblastoma; adult gliosarcoma; adult glioblastoma
- Isotretinoin, Interferon Alfa-2b, and Paclitaxel in Treating Patients With Stage IV, Recurrent, or Persistent Cervical Cancer
ClinicalTrials.gov Identifier: NCT00138151 - Recruiting
recurrent cervical cancer; stage IVB cervical cancer
- Isotretinoin Plus Dexamethasone in Treating Patients With Multiple Myeloma
ClinicalTrials.gov Identifier: NCT00021359 - Active, not recruiting
stage I multiple myeloma; stage II multiple myeloma; stage III multiple myeloma
- Isotretinoin, Interferon Alfa-2b, Docetaxel, and Estramustine in Treating Patients With Metastatic Prostate Cancer That Did Not Respond to Hormone Therapy
ClinicalTrials.gov Identifier: NCT00176527 - Active, not recruiting
Prostate Cancer
- Isotretinoin Plus Interferon in Treating Patients With Recurrent Cancer
ClinicalTrials.gov Identifier: NCT00002506 - Active, not recruiting
recurrent non-small cell lung cancer; recurrent cervical cancer; recurrent squamous cell carcinoma of the lip and oral cavity; ...
- Isotretinoin With or Without Monoclonal Antibody, Interleukin-2, and Sargramostim Following Stem Cell Transplantation in Treating Patients With Neuroblastoma
ClinicalTrials.gov Identifier: NCT00026312 - Recruiting
regional neuroblastoma; disseminated neuroblastoma; stage 4S neuroblastoma; localized resectable neuroblastoma; localized unresectable neuroblastoma
- Combination Chemotherapy and Surgery With or Without Isotretinoin in Treating Young Patients With Neuroblastoma
ClinicalTrials.gov Identifier: NCT00499616 - Recruiting
Neuroblastoma
- Combination Chemotherapy Followed by Stem Cell Transplant and Isotretinoin in Treating Young Patients With High-Risk Neuroblastoma
ClinicalTrials.gov Identifier: NCT00526318 - Recruiting
Neuroblastoma
- PXD101 and Isotretinoin in Treating Patients With Solid Tumors That Are Metastatic or That Cannot Be Removed by Surgery
ClinicalTrials.gov Identifier: NCT00334789 - Recruiting
Unspecified Adult Solid Tumor, Protocol Specific
- Combination Chemotherapy With or Without Filgrastim Before Surgery, High-Dose Chemotherapy, and Radiation Therapy Followed by Isotretinoin With or Without Monoclonal Antibody in Treating Patients With Neuroblastoma
ClinicalTrials.gov Identifier: NCT00030719 - Recruiting
regional neuroblastoma; disseminated neuroblastoma; stage 4S neuroblastoma; localized unresectable neuroblastoma
- Vorinostat, Isotretinoin and Carboplatin in Adults With Recurrent Glioblastoma Multiforme (GBM)
ClinicalTrials.gov Identifier: NCT00555399 - Recruiting
Glioblastoma Multiforme; Anaplastic Glioma
- Safety and Effectiveness of Giving Isotretinoin to HIV-Infected Women to Treat Cervical Tumors
ClinicalTrials.gov Identifier: NCT00001073 - Completed
HIV Infections; Cervix, Dysplasia
- Vorinostat and Isotretinoin in Treating Patients With Advanced Kidney Cancer
ClinicalTrials.gov Identifier: NCT00324740 - Recruiting
Kidney Cancer
- Study of Isotretinoin for the Prevention of Skin Cancer in Patients With Xeroderma Pigmentosum or Nevoid Basal Cell Carcinoma Syndrome
ClinicalTrials.gov Identifier: NCT00025012 - Completed
prevention of skin cancer
- Vorinostat With or Without Isotretinoin in Treating Young Patients With Recurrent or Refractory Solid Tumors, Lymphoma, or Leukemia
ClinicalTrials.gov Identifier: NCT00217412 - Recruiting
Brain and Central Nervous System Tumors; Leukemia; Lymphoma; Unspecified Childhood Solid Tumor, Protocol Specific
- Biological Therapy Plus Chemotherapy in Treating Patients With Metastatic or Recurrent Kidney Cancer
ClinicalTrials.gov Identifier: NCT00003585 - Active, not recruiting
Stage IV Renal Cell Cancer; recurrent renal cell cancer
- Chemotherapy With or Without Biological Therapy in Treating Patients With Metastatic Prostate Cancer That Has Not Responded to Hormone Therapy
ClinicalTrials.gov Identifier: NCT00005847 - Active, not recruiting
adenocarcinoma of the prostate; stage IV prostate cancer; recurrent prostate cancer
- Monoclonal Antibody Therapy Plus Etoposide in Treating Patients With Neuroblastoma
ClinicalTrials.gov Identifier: NCT00004110 - Active, not recruiting
regional neuroblastoma; disseminated neuroblastoma; recurrent neuroblastoma; localized unresectable neuroblastoma
- Multiple Therapies in Treating Patients With Advanced Neuroblastoma
ClinicalTrials.gov Identifier: NCT00040872 - Active, not recruiting
regional neuroblastoma; disseminated neuroblastoma; recurrent neuroblastoma; localized unresectable neuroblastoma
- Combination Chemotherapy Plus Biological Therapy in Treating Patients With Acute Myelogenous Leukemia
ClinicalTrials.gov Identifier: NCT00003405 - Active, not recruiting
untreated adult acute myeloid leukemia; childhood acute megakaryocytic leukemia (M7); adult acute differentiated monocytic leukemia (M5b); ...
- Combination Chemotherapy Followed By Peripheral Stem Cell Transplantation or Isotretinoin in Treating Patients With Acute Myeloid Leukemia, Myelodysplastic Syndrome, or Acute Lymphocytic Leukemia
ClinicalTrials.gov Identifier: NCT00003619 - Completed
Polycythemia Vera; Thrombocytopenia; Refractory Anemia; Previously Treated Myelodysplastic Syndrome; secondary myelodysplastic syndrome; ...
- High-Dose Chemotherapy Plus Autologous Stem Cell Transplantation Compared With Intermediate-Dose Chemotherapy Plus Autologous Stem Cell Transplantation With or Without Isotretinoin in Treating Young Patients With Recurrent High-Grade Gliomas
ClinicalTrials.gov Identifier: NCT00078988 - Completed
high-grade childhood cerebral astrocytoma; recurrent childhood cerebellar astrocytoma; recurrent childhood cerebral astrocytoma
- Chemoprevention of Anal Neoplasia Arising Secondary to Anogenital Human Papillomavirus Infection in Persons With HIV Infection.
ClinicalTrials.gov Identifier: NCT00000764 - Completed
HIV Infections; Anus Neoplasms
- Use of Isotretinoin for Prevention of Skin Cancer in Patients with Xeroderma Pigmentosum or Nevoid Basal Cell Carcinoma Syndrome
ClinicalTrials.gov Identifier: NCT00005661 - Completed
Basal Cell Nevus Syndrome; Xeroderma Pigmentosum
- Combination Chemotherapy Followed By Donor Bone Marrow or Umbilical Cord Blood Transplantation in Treating Children With Newly Diagnosed Juvenile Myelomonocytic Leukemia
ClinicalTrials.gov Identifier: NCT00025038 - Completed
juvenile myelomonocytic leukemia
- Biological Therapy in Treating Patients With Neuroblastoma That Has Not Responded to Previous Treatment
ClinicalTrials.gov Identifier: NCT00089258 - Completed
localized unresectable neuroblastoma; disseminated neuroblastoma; regional neuroblastoma; stage 4S neuroblastoma; recurrent neuroblastoma
- Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Children With Newly Diagnosed Neuroblastoma
ClinicalTrials.gov Identifier: NCT00017368 - Completed
regional neuroblastoma; disseminated neuroblastoma; localized unresectable neuroblastoma; stage 4S neuroblastoma
- Monoclonal Antibody Therapy With Sargramostim and Interleukin-2 in Treating Children With Neuroblastoma
ClinicalTrials.gov Identifier: NCT00005576 - Completed
disseminated neuroblastoma; regional neuroblastoma; recurrent neuroblastoma
- Induction Chemotherapy Using Cyclophosphamide and Topotecan in Treating Patients Who Are Undergoing Autologous Peripheral Stem Cell Transplantation for Newly Diagnosed or Progressive Neuroblastoma
ClinicalTrials.gov Identifier: NCT00070200 - Completed
recurrent neuroblastoma; stage 4S neuroblastoma; localized unresectable neuroblastoma; localized resectable neuroblastoma; regional neuroblastoma; ...
- Combination Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Neuroblastoma
ClinicalTrials.gov Identifier: NCT00004188 - Completed
localized resectable neuroblastoma; regional neuroblastoma; disseminated neuroblastoma; stage 4S neuroblastoma; localized unresectable neuroblastoma

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