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Ibuprofen and Pseuodoephedrine |
Advil Cold |
Clinical Trial: The Effects of AZT and Ibuprofen on HIV-Infected Patients with Hemophilia
This study has been completed.
|
Purpose
To determine if platelet dysfunction and/or pharmacologic drug interaction occurs in patients taking both AZT and ibuprofen, which might account for enhanced bleeding tendency.
| Condition | Treatment or Intervention |
|---|---|
| HIV Infections Hemophilia A | Drug: Ibuprofen Drug: Zidovudine |
MedlinePlus related topics: AIDS; Hemophilia
Study Type: Interventional
Study Design: Treatment
Official Title: Study of Bleeding Tendency, Platelet Function, and Pharmacokinetics of Azidothymidine (AZT) and Motrin (Ibuprofen) in HIV-Infected Hemophiliacs
Eligibility
Ages Eligible for Study: 12 Years and above, Genders Eligible for Study: Both
Criteria
Inclusion Criteria
Patients must have:
- Hemophilia.
- HIV-seropositivity confirmed by Western Blot. Prior Medication: Required:
AZT for study patients. Allowed:
Ibuprofen.
Exclusion Criteria
Co-existing Condition: Patients with the following symptoms and conditions are excluded: Hospitalization for opportunistic infection, bacterial infection or malignancy. Concurrent Medication: Excluded:
- AZT (for control group).
- Antibiotics or other medication for opportunistic infection, bacterial infection, or malignancy. Patients with the following prior conditions are excluded: Hospitalization for opportunistic infection, bacterial infection, or malignancy. Required:
- Ibuprofen.
- AZT 1-2 gm daily (for study patient) or not taking AZT (for control).
Location Information
Pennsylvania
Hemophilia Ctr of Western PA / Univ of Pittsburgh, Pittsburgh, Pennsylvania, 15219, United States
More Information
Publications
Ragni MV, Miller BJ, Whalen R, Ptachcinski R. Bleeding tendency, platelet function, and pharmacokinetics of ibuprofen and zidovudine in HIV(+) hemophilic men. Am J Hematol. 1992 Jul;40(3):176-82.
Record last reviewed: June 1990
Last Updated: October 13, 2004
Record first received: November 2, 1999
ClinicalTrials.gov Identifier: NCT00002276
Health Authority: United States: Food and Drug Administration
ClinicalTrials.gov processed this record on 2005-04-08
Source: ClinicalTrials.gov
Cache Date: April 9, 2005
Resources
- Advil Cold & Sinus (Drug Digest)
- Advil Flu & Body Ache (Drug Digest)
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