Article: Bisoprolol

Bisoprolol
Systematic (IUPAC) name
1-[4-[2-(1-methylethoxy)ethoxymethyl] phenoxy]-3-(1-methylethylamino)propan-2-ol
Identifiers
CAS number	66722-44-9
ATC code	C07AB07
PubChem	2405
DrugBank	APRD00257
Chemical data
Formula	C18H31NO4
Mol. weight	325.443 g/mol
Pharmacokinetic data
Bioavailability	>90%
Metabolism	Hepatic
Half life	9-12hours
Excretion	Renal
Therapeutic considerations
Pregnancy cat.	C(AU) C(US)
Legal status	℞ Prescription only
Routes	oral

Bisoprolol is a drug belonging to the group of beta blockers, a class of drugs used primarily in cardiovascular diseases.

Indications

Bisoprolol can be used to treat cardiovascular diseases such as hypertension, coronary heart disease, arrhythmias, and treatment of myocardial infarction after the acute event. Patients with compensated congestive heart failure may be treated with Bisoprolol as a comedication (usually together with an ACE inhibitor, a diuretic and a digitalis-glycosid, if indicated). In patients with congestive heart failure, it reduces the need for and the consumption of oxygen of the heart muscle. It is very important to start with low doses, as bisoprolol reduces also the muscular power of the heart, which is an undesired effect in congestive heart failure.

The drug is also used to treat other conditions, including dysautonomia, anxiety and hyperthyroidism (overfunction of the thyroid gland).

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