Article: Cromoglicate

Cromoglicate
Systematic (IUPAC) name
5-[3-(2-carboxy-4-oxo-chromen-6-yl) oxy-2-hydroxy-propoxy]- 4-oxo-chromene-2-carboxylic acid
Identifiers
CAS number	16110-51-3
ATC code	?
PubChem	27686
DrugBank	APRD00336
Chemical data
Formula	C23H16O11
Mol. weight	468.367 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	1.3 hours
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Cromoglicate (INN) (also referred to as cromolyn (USAN) or cromoglycate (former BAN)) is traditionally described as a mast cell stabilizing drug, and is commonly marketed as the sodium salt sodium cromoglicate. This drug prevents the release of chemicals such as histamine from mast cells. It is available as a nasal spray (Nasalcrom®) to treat allergic rhinitis, as an inhaler (Intal®) to treat asthma, as eye drops (Opticrom®, Crolom®, Cromolux(UK))) for allergic conjunctivitis, or in an oral form (Gastrocrom®) to treat mastocytosis).

Although cromoglycate stabilizes mast cells, this mechanism is probably not why it works in asthma. Pharmaceutical companies have produced 20 related compounds that are equally or more potent at stabilising mast cells and none of them have shown any anti-asthmatic effect.

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