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Didanosine |
DDI; Videx |
Didanosine Systematic (IUPAC) name 9-[5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one Identifiers CAS number 69655-05-6 ATC code J05AF02 PubChem 50599 DrugBank APRD00240 Chemical data Formula C10H12N4O3 Mol. weight 236.227 g/mol Pharmacokinetic data Bioavailability ? Metabolism Renal elimination Half life ? Excretion ? Therapeutic considerations Pregnancy cat. B (USA) B2 (Aus) Legal status Routes ? Didanosine (2'-3'-dideo ...
Wikipedia - [full article]
Didanosine Clinical Trials
- A Comparison of Zidovudine (AZT) Used Alone or in Combination with Didanosine (ddI) or Dideoxycytidine (ddC) in HIV-Infected Patients
ClinicalTrials.gov Identifier: NCT00001022 - Active, not recruiting
HIV Infections
- A Phase I Study to Evaluate the Safety and Toxicity of the Combination of Zidovudine and 2',3'-Dideoxyinosine (Didanosine) in Children With HIV Infection
ClinicalTrials.gov Identifier: NCT00000652 - Active, not recruiting
HIV Infections
- Differences Between Women and Men Taking a Combination of Indinavir, Ritonavir, Enteric-Coated Didanosine, and Stavudine Who Previously Took Anti-HIV Drugs
ClinicalTrials.gov Identifier: NCT00006397 - Active, not recruiting
HIV Infections
- Phase II/III Study of the Tolerance and Efficacy of Combined Use of Didanosine (2',3'-Dideoxyinosine; ddI) and Lentinan in HIV-Positive Patients
ClinicalTrials.gov Identifier: NCT00002099 - Active, not recruiting
HIV Infections
- A Phase I Trial to Evaluate Didanosine (ddI) in HIV-Infected Pregnant Women
ClinicalTrials.gov Identifier: NCT00000839 - Active, not recruiting
HIV Infections; Pregnancy
- A Comparison of Emtricitabine and Stavudine Used with Didanosine Plus Efavirenz in HIV-Infected Patients Who Have Not Taken Anti-HIV Drugs
ClinicalTrials.gov Identifier: NCT00006208 - Active, not recruiting
HIV Infections
- Safety and Effectiveness of Emtricitabine, Efavirenz, and Didanosine in HIV Infected Children Who Have Taken Few or No Anti-HIV Drugs
ClinicalTrials.gov Identifier: NCT00016718 - Active, not recruiting
HIV Infections
- A Comparative Study of a Combination of Zidovudine, Didanosine, and Double-Blinded Nevirapine Versus a Combination of Zidovudine and Didanosine
ClinicalTrials.gov Identifier: NCT00000770 - Completed
HIV Infections
- Comparing Side Effects of Two Forms of Videx in HIV-Infected Adults
ClinicalTrials.gov Identifier: NCT00008489 - Active, not recruiting
HIV Infections
- A Study to Compare Two Different Anti-HIV Drug Regimens
ClinicalTrials.gov Identifier: NCT00000924 - Active, not recruiting
HIV Infections
- Safety and Effectiveness of a Three-Drug Combination Treatment for Recently Infected or Converted HIV Patients
ClinicalTrials.gov Identifier: NCT00007202 - Active, not recruiting
HIV Infections
- Treatment with Interleukin-2 (IL-2) Plus Combination Anti-HIV-Drug Therapy (HAART) for Patients Formerly in ACTG 328
ClinicalTrials.gov Identifier: NCT00000923 - Active, not recruiting
HIV Infections
- A Study of the Safety and Effectiveness of Treating Advanced AIDS Patients between Ages 4 and 22 with 7 Drugs, Some at Higher than Usual Doses
ClinicalTrials.gov Identifier: NCT00001108 - Active, not recruiting
HIV Infections
- A Prospective, Randomized, Open-Label, Comparative Trial of Dideoxyinosine (ddI) Versus Dideoxycytidine (ddC) in HIV-Infected Patients Who Are Intolerant of or Who Have Failed Zidovudine (AZT) Therapy
ClinicalTrials.gov Identifier: NCT00000969 - Active, not recruiting
HIV Infections
- Anti-HIV Drugs for Treating Infants Who Acquired HIV Infection at Birth
ClinicalTrials.gov Identifier: NCT00102960 - Active, not recruiting
HIV Infections
- Once-Daily HAART Regimen Administration in HIV-1 Infected Children in Burkina Faso
ClinicalTrials.gov Identifier: NCT00122538 - Active, not recruiting
HIV Infection; AIDS
- A Comparison of Two Anti-HIV Drug Regimens for Youth Who Have Failed Prior Therapy
ClinicalTrials.gov Identifier: NCT00102206 - Active, not recruiting
HIV Infections
- A Study on the Management of Combination Anti-HIV Drug Therapy in HIV-Positive Children with Prior Treatment
ClinicalTrials.gov Identifier: NCT00000902 - Active, not recruiting
HIV Infections
- Anti-HIV Drugs During Pregnancy
ClinicalTrials.gov Identifier: NCT00042289 - Active, not recruiting
HIV Infections
- Once-Daily PI/NNRTI Therapy Combinations for Treatment Naive, HIV Infected Patients in Resource-limited Conditions
ClinicalTrials.gov Identifier: NCT00084136 - Active, not recruiting
HIV Infections
- Antiretroviral Switch From Didanosine to Tenofovir in HIV/HCV Co-Infected Patients
ClinicalTrials.gov Identifier: NCT00358696 - Recruiting
HIV
- One Month Dual Antiretroviral Prophylaxis to Prevent Resistance Mutations in Mothers Exposed to Single Dose Nevirapine
ClinicalTrials.gov Identifier: NCT00142337 - Active, not recruiting
HIV; Postpartum Period
- Treatment with Nelfinavir or Efavirenz of HIV-Infected Patients Who Have Never Received Anti-HIV Drugs
ClinicalTrials.gov Identifier: NCT00005000 - Active, not recruiting
HIV Infections
- Comparison of Two Anti-HIV Regimens that Include One of Two Forms of Didanosine (ddI)
ClinicalTrials.gov Identifier: NCT00002224 - Completed
HIV Infections
- Effectiveness of Directly Observed Therapy in Combined HIV and Tuberculosis Treatment in Resource-limited Settings
ClinicalTrials.gov Identifier: NCT00091936 - Active, not recruiting
HIV Infections; Tuberculosis
- Treatment of Hepatitis B Virus (HBV) Before Beginning Anti-HIV Drugs in Patients with Both HBV and HIV
ClinicalTrials.gov Identifier: NCT00051090 - Active, not recruiting
HIV Infections; Hepatitis B
- Combination Chemotherapy in Treating Patients With HIV-Related Non-Hodgkin's Lymphoma
ClinicalTrials.gov Identifier: NCT00002905 - Active, not recruiting
AIDS-related peripheral/systemic lymphoma
- A Study Comparing Two Forms of Didanosine in HIV-infected Patients
ClinicalTrials.gov Identifier: NCT00002360 - Completed
HIV Infections
- Study of Anti-HIV Therapy Intensification
ClinicalTrials.gov Identifier: NCT00034086 - Active, not recruiting
HIV Infections
- A Phase I/II, Open Label Study to Evaluate the Antiviral Potential of Combination Zidovudine and 2' 3'-Dideoxyinosine (Didanosine) in Patients With Asymptomatic HIV Disease
ClinicalTrials.gov Identifier: NCT00000656 - Completed
HIV Infections
- Comparison of Stavudine Used Alone or in Combination with Didanosine in HIV-Infected Children
ClinicalTrials.gov Identifier: NCT00000851 - Completed
HIV Infections
- A Comparison of Two Dose Levels of Didanosine Used in Combination with Stavudine in HIV-Infected Patients
ClinicalTrials.gov Identifier: NCT00002207 - Completed
HIV Infections
- A Study of Didanosine Use Alone or in Combination with Zidovudine in Infants Exposed to or Infected with HIV
ClinicalTrials.gov Identifier: NCT00001049 - Completed
HIV Infections
- Phase I/II Study of the Tolerance and Efficacy of Combined Use of Didanosine (2',3'-Dideoxyinosine; ddI) and Lentinan in HIV-Positive Patients
ClinicalTrials.gov Identifier: NCT00002098 - Completed
HIV Infections
- A Phase I Open-Label Study of the Safety, Tolerance, and Pharmacokinetic Interactions of Combination Didanosine and Ribavirin in HIV-Positive Individuals
ClinicalTrials.gov Identifier: NCT00000772 - Completed
HIV Infections
- Safety and Effectiveness of Combining Hydroxyurea (HU) with Didanosine (ddI) and Stavudine (d4T) for Treatment of HIV-Infected Adults
ClinicalTrials.gov Identifier: NCT00002427 - Completed
HIV Infections
- Evaluation of an Anti-HIV Drug Combination That Includes a Coated Form of Didanosine (ddI EC) Compared to a Typical Anti-HIV Drug Regimen
ClinicalTrials.gov Identifier: NCT00002429 - Completed
HIV Infections
- Evaluation of Four Anti-HIV Treatment Strategies in Resource-Limited South African Communities
ClinicalTrials.gov Identifier: NCT00255840 - Active, not recruiting
HIV Infections
- A Multicenter Phase II Double-Blind Exploratory Study to Evaluate Differences Among Various Zidovudine/Didanosine Regimens on Quantitative Measures of Viral Burden in Relatively Early HIV-1 Infection
ClinicalTrials.gov Identifier: NCT00000823 - Completed
HIV Infections
- A Randomized, Placebo-Controlled Study of the Safety and Efficacy of Efavirenz, Didanosine, and Stavudine in Combination With or Without Hydroxyurea in Antiretroviral Naive or Experienced HIV-Infected Patients
ClinicalTrials.gov Identifier: NCT00002230 - Completed
HIV Infections
- A Double-Blind, Randomized, Comparative Study of Delavirdine Mesylate (U-90152S) in Combination With Didanosine (ddI) Versus ddI Alone in HIV-1 Infected Individuals With CD4 Counts of <= 300/mm3
ClinicalTrials.gov Identifier: NCT00002123 - Completed
HIV Infections
- Reducing the Incidence of Nevirapine Resistance Mutations in Pregnant HIV Infected Women Who Receive Anti-HIV Drugs Prior to and After Giving Birth
ClinicalTrials.gov Identifier: NCT00109590 - Recruiting
HIV Infections
- A Phase I Study of Combination Therapy With Didanosine (ddI) and Ribavirin in HIV-Infected Children.
ClinicalTrials.gov Identifier: NCT00000833 - Completed
HIV Infections
- A Study of Efavirenz in Combination with Stavudine and Didanosine
ClinicalTrials.gov Identifier: NCT00002225 - Completed
HIV Infections
- A Pilot Open Label Trial of HIV Therapy with d4T (Stavudine), ddI (Didanosine), Nelfinavir and Hydroxyurea in Subjects with Early Asymptomatic HIV Infection
ClinicalTrials.gov Identifier: NCT00002176 - Completed
HIV Infections
- Antiviral Activity of and Resistance to Lamivudine in Combination with Zidovudine, Stavudine, or Didanosine
ClinicalTrials.gov Identifier: NCT00000838 - Completed
HIV Infections
- A Pilot Open Label Trial of HIV Therapy with d4T (Stavudine), ddI (Didanosine), Nelfinavir and Hydroxyurea in Subjects with Recent HIV Infection
ClinicalTrials.gov Identifier: NCT00002177 - Completed
HIV Infections
- A Phase I Concentration-Controlled Trial to Assess the Safety, Tolerance, Pharmacokinetics and Development of Decreased HIV-1 Susceptibility to the Combination of Atevirdine Mesylate (U-87201E), Zidovudine (AZT), and Didanosine (ddI)
ClinicalTrials.gov Identifier: NCT00000742 - Completed
HIV Infections
- Safety and Effectiveness of Giving an Anti-HIV Drug Combination of Adefovir Dipivoxil Plus Didanosine Plus Efavirenz Plus Lamivudine Once Daily to HIV-Infected Patients
ClinicalTrials.gov Identifier: NCT00002234 - Completed
HIV Infections
- Effectiveness of Early or Delayed Addition of Hydroxyurea to a Three-Drug Anti-HIV Drug Combination Including Didanosine, in Advanced HIV Patients Who Failed a First or Second Anti-HIV Triple-Drug Therapy
ClinicalTrials.gov Identifier: NCT00008866 - Completed
HIV Infections
- Comparison of 2',3'-Dideoxyinosine (Didanosine, ddI) and Zidovudine in Therapy of Patients With the AIDS Dementia Complex
ClinicalTrials.gov Identifier: NCT00000657 - Completed
AIDS Dementia Complex; HIV Infections
- A Phase I Pharmacokinetic Study in HIV-Positive Subjects of Oral Ganciclovir and Concomitant Antiretroviral Zidovudine and Didanosine
ClinicalTrials.gov Identifier: NCT00002096 - Completed
Cytomegalovirus Infections; HIV Infections
- The Safety and Effectiveness of Interferon Alfa-2B Plus Didanosine in Patients with Kaposi's Sarcoma
ClinicalTrials.gov Identifier: NCT00001114 - Completed
Sarcoma, Kaposi; HIV Infections
- A Study to Evaluate the Use of a Protease Inhibitor and of Interleukin-2 (IL-2) in the Treatment of Early HIV Infection
ClinicalTrials.gov Identifier: NCT00006154 - Not yet recruiting
HIV Infections
- A Phase II Double-Blind Study of Delavirdine Mesylate ( U-90152 ) in Combination With Zidovudine ( AZT ) and/or Didanosine ( ddI ) Versus AZT and ddI Combination Therapy
ClinicalTrials.gov Identifier: NCT00000803 - Completed
HIV Infections
- To Assess Compliance With a Once-Daily Regimen of Lamivudine, Efavirenz and Didanosine
ClinicalTrials.gov Identifier: NCT00207168 - Completed
AIDS
- The Safety and Effectiveness of Didanosine Plus Stavudine Plus Nevirapine Combined with MKC-442 in HIV-Infected Patients Who Have Not Had Success with Protease Inhibitors
ClinicalTrials.gov Identifier: NCT00002418 - Terminated
HIV Infections
- The Safety and Effectiveness of Didanosine Plus Stavudine Plus Delavirdine Mesylate Plus MKC-442 in HIV-Infected Patients Who Have Not Had Success with Protease Inhibitors
ClinicalTrials.gov Identifier: NCT00002420 - Terminated
HIV Infections
- A Study of ddI in Children with AIDS Who Have Not Had Success with Zidovudine
ClinicalTrials.gov Identifier: NCT00002280 - Completed
HIV Infections
- Virologic Responses To New Nucleoside Regimens After Prolonged ZDV or ddI Monotherapy
ClinicalTrials.gov Identifier: NCT00000831 - Completed
HIV Infections
- Feasibility Study of a Once Daily Antiretroviral Regimen in Vietnam (ANRS 1210 VIETAR)
ClinicalTrials.gov Identifier: NCT00158470 - Completed
HIV Infection
- A Study of MKC-442 in Combination with Other Anti-HIV Drugs
ClinicalTrials.gov Identifier: NCT00002412 - Completed
HIV Infections
- A Comparative Study of Combination Antiretroviral Therapy in Children and Adolescents with Advanced HIV Disease
ClinicalTrials.gov Identifier: NCT00000814 - Completed
HIV Infections
- Safety and Effectiveness of a Combination Anti-HIV Drug Treatment
ClinicalTrials.gov Identifier: NCT00005018 - Completed
HIV Infections
- Correlation of HIV Levels with Clinical and Immunologic Outcome in Children Treated with Didanosine
ClinicalTrials.gov Identifier: NCT00026676 - Completed
HIV Infection
- A Comparison of Three Treatments for Advanced HIV Disease in Patients Who Have Received Nucleoside Therapy in the Past
ClinicalTrials.gov Identifier: NCT00001029 - Completed
HIV Infections
- A Comparison of Two Triple-Drug Combinations in Patients Who Have Never Been Treated with Anti-HIV Drugs
ClinicalTrials.gov Identifier: NCT00002411 - Completed
HIV Infections
- Study of a New Protease Inhibitor, BMS-232632, in Combination with Other Anti-HIV Drugs
ClinicalTrials.gov Identifier: NCT00002240 - Completed
HIV Infections
- Comparison of Three Anti-HIV Drug Combinations in HIV-Infected Patients with No Symptoms of the Disease
ClinicalTrials.gov Identifier: NCT00001045 - Completed
HIV Infections
- A Comparison of Two Anti-HIV Triple-Drug Combinations in HIV-Infected Patients
ClinicalTrials.gov Identifier: NCT00002168 - Completed
HIV Infections
- The Effectiveness of Two Anti-HIV Treatments in HIV-Infected Patients
ClinicalTrials.gov Identifier: NCT00001057 - Completed
HIV Infections
- A Study of an Adherence Plan to Help HIV-Positive Patients Take Their First Anti-HIV Medications Correctly
ClinicalTrials.gov Identifier: NCT00001122 - Completed
HIV Infections
- A Study of Three Drug Combination Therapies in HIV-Infected Patients Who Have Never Been Treated with Anti-HIV Drugs
ClinicalTrials.gov Identifier: NCT00002407 - Completed
HIV Infections
- The Safety and Effects of 1592U89 Used Alone or in Combination with Other Anti-HIV Drugs in HIV-Infected Infants and Children
ClinicalTrials.gov Identifier: NCT00000865 - Completed
HIV Infections
- A Study to Compare the Effectiveness of Different Anti-HIV Drug Regimens in Keeping Levels of HIV in the Blood as Low as Possible
ClinicalTrials.gov Identifier: NCT00000939 - Completed
HIV Infections
- The Effects of Anti-HIV Drugs in HIV-Infected Patients Who Do Not Have AIDS
ClinicalTrials.gov Identifier: NCT00001024 - Completed
HIV Infections
- The Effectiveness of HIV RNA Viral Load Testing in Determining Treatment Type in HIV-Infected Patients
ClinicalTrials.gov Identifier: NCT00002376 - Completed
HIV Infections
- Evaluation of Patients Who Have Not Had Success with Zidovudine
ClinicalTrials.gov Identifier: NCT00001025 - Completed
HIV Infections
- The Effectiveness of Three Drug Combinations in HIV-Infected Patients Who Have Taken Zidovudine for More than 12 Weeks
ClinicalTrials.gov Identifier: NCT00001063 - Completed
HIV Infections
- An Efficacy Study of 2',3'-Dideoxyinosine (ddI) (BMY-40900) Administered Orally Twice Daily to Zidovudine Intolerant Patients With AIDS or AIDS-Related Complex
ClinicalTrials.gov Identifier: NCT00000672 - Completed
HIV Infections
- A Phase I Safety and Pharmacokinetics Study of 2',3'-Dideoxyinosine (ddI) Administered Twice Daily to Infants and Children With AIDS or Symptomatic HIV Infection
ClinicalTrials.gov Identifier: NCT00000669 - Completed
HIV Infections
- A Study of Dideoxyinosine (ddI) in HIV-Infected Children Who Have Not Had Success with Zidovudine or Who Cannot Take Zidovudine
ClinicalTrials.gov Identifier: NCT00000963 - Completed
HIV Infections
- Comparison of ddI Versus Zidovudine in HIV-Infected Patients
ClinicalTrials.gov Identifier: NCT00000979 - Completed
HIV Infections
- The Safety and Effectiveness of Hydroxyurea and ddI Used Individually or Together in HIV-Infected Patients
ClinicalTrials.gov Identifier: NCT00001074 - Completed
HIV Infections
- A Study of Azidothymidine in HIV-Infected Children
ClinicalTrials.gov Identifier: NCT00000982 - Completed
Encephalopathy; HIV Infections
- A Randomized, Parallel Arm, Comparative, Open Label, Multicenter Study of the Activity and Safety of Two Formulations of Saquinavir in Combination With Other Antiretroviral Drugs
ClinicalTrials.gov Identifier: NCT00002162 - Completed
HIV Infections
- A Treatment IND (Investigational New Drug) Protocol for the Use of Videx (2',3'-dideoxyinosine, ddI) in Patients With Acquired Immunodeficiency Syndrome (AIDS) or AIDS- Related Complex (ARC) Who Are Intolerant to Zidovudine (Retrovir)
ClinicalTrials.gov Identifier: NCT00002028 - Completed
HIV Infections
- Safety and Effectiveness of Giving Combinations of Three or Four Anti-HIV Drugs to HIV-Infected Patients
ClinicalTrials.gov Identifier: NCT00002211 - Completed
HIV Infections
- Once a Day (QD) - Twice a Day (BID) Clinical Trial: Didanosine, Lamivudine and Efavirenz Versus Zidovudine, Lamivudine and Efavirenz in the Starting Treatment of HIV
ClinicalTrials.gov Identifier: NCT00256828 - Completed
HIV Infections
- A Phase I Safety, Efficacy, and Pharmacokinetic Study of 2',3'-Dideoxyinosine (ddI) Administered Twice Daily to Patients With AIDS or AIDS Related Complex
ClinicalTrials.gov Identifier: NCT00000710 - Completed
HIV Infections
- 3 Antiretroviral Medicines in Combination, in HIV Patients who Have Not Been Previously Treated with Antiretroviral Therapy
ClinicalTrials.gov Identifier: NCT00116415 - Completed
HIV Infections; AIDS
- Immunologic and Virologic Consequences of Long-Term Highly Active Antiretroviral Therapy (HAART) in Subjects with Moderately Advanced HIV-1 Disease: A Follow-Up Study to ACTG 315
ClinicalTrials.gov Identifier: NCT00000891 - Completed
HIV Infections
- The Safety and Effectiveness of a Two-Drug Combination in the Treatment of Patients with Hepatitis C Plus Advanced HIV Infections
ClinicalTrials.gov Identifier: NCT00001035 - Completed
HIV Infections; Hepatitis C
- A Phase I Study to Evaluate the Pharmacokinetics, Safety and Antiviral Effects of Concurrent Administration of Zidovudine (AZT) and 2'3'-Dideoxyinosine (ddI) in Patients With Human Immunodeficiency Virus (HIV)
ClinicalTrials.gov Identifier: NCT00002014 - Completed
HIV Infections
- A Randomized, Double-Blind, Four-Arm Study Comparing Combination Nucleoside, Alternating Nucleoside, and Triple-Drug Therapy for the Treatment of Advanced HIV Disease (CD4 <= 50/mm3)
ClinicalTrials.gov Identifier: NCT00000781 - Completed
HIV Infections
- A Study of Nystatin in HIV-Infected Patients
ClinicalTrials.gov Identifier: NCT00002313 - Completed
HIV Infections
- The Antiviral Efficacy of Concurrent Zidovudine and 2',3'-dideoxyinosine or 2',3'-dideoxycytidine in Patients with Human Immunodeficiency Virus Disease
ClinicalTrials.gov Identifier: NCT00002001 - Completed
HIV Infections
- A Phase I Concentration-Targeted Multidose Study of Atevirdine Mesylate ( U-87201E ), AZT, and ddI or ddC
ClinicalTrials.gov Identifier: NCT00000753 - Completed
HIV Infections
- A Randomized, Double-Blind Phase II/III Trial of Monotherapy vs. Combination Therapy With Nucleoside Analogs in HIV-Infected Persons With CD4 Cells of 200-500/mm3
ClinicalTrials.gov Identifier: NCT00000625 - Completed
HIV Infections
- A Study to Evaluate the Long-Term Effectiveness of Three Anti-HIV Drug Treatments in HIV-Positive Patients Who Have Never Been Exposed to Highly Active Antiretroviral Therapy (HAART)
ClinicalTrials.gov Identifier: NCT00000922 - Completed
HIV Infections
Resources
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