The purpose of this trial is to study the clinical safety, tolerability, and efficacy of zoledronic acid compared to an oral bisphosphonate in postmenopausal women with osteoporosis.

Condition	Treatment or Intervention	Phase
Osteoporosis	Drug: zoledronic acid	Phase III

Further Study Details: 

Primary Outcomes: Bone markers

Ages Eligible for Study:  45 Years   -   79 Years,  Genders Eligible for Study:  Female

Criteria

Inclusion Criteria:

• Postmenopausal women between 45 and 79 years of age
• Must be osteopenic/osteoporotic

Exclusion Criteria:

• Any women of child-bearing potential

Alabama
      Univ. of Alabama/Division of Clinical Immunology and Rheumatology, Birmingham,  Alabama,  35294,  United States
California
      Radiant Research, San Diego,  California,  92108,  United States
Colorado
      Denver Arthritis Clinic, Denver,  Colorado,  80230,  United States
Florida
      Florida Medical Research Institute, Gainesville,  Florida,  32605,  United States
Illinois
      Northwestern Center for Clinical Research, Chicago,  Illinois,  60611,  United States
Maryland
      The Center for Rheumatology and Bone Research, Wheaton,  Maryland,  20902,  United States
Michigan
      Midwest Arthritis Center, Kalamazoo,  Michigan,  49048-1634,  United States
Missouri
      St. John's Medical Research, Springfield,  Missouri,  65807,  United States
Montana
      Deaconess Billings Clinic Research Division, Billings,  Montana,  59101,  United States
New Jersey
      UMDNJ-Robert Wood Johnson Medical School, New Brunswick,  New Jersey,  08903,  United States
New York
      Helen Hayes Hospital - Regional Bone Clinic, West Haverstraw,  New York,  10993,  United States
Ohio
      Private Practice, Mayfield Village,  Ohio,  44143,  United States
Tennessee
      The Arthritis Clinic of Jackson, Jackson,  Tennessee,  38305,  United States
Texas
      Radiant Research, Dallas,  Texas,  75235,  United States
      Univ. of North Texas Health Science Center at Fort Worth, Fort Worth,  Texas,  76107,  United States
      St. Luke's Episcopal Hospital Ctr for Ortho. Res. and Education, Houston,  Texas,  77030,  United States
Utah
      Women's Health Center, Salt Lake City,  Utah,  84117,  United States
West Virginia
      Valley Medical Associates, Lewisburg,  West Virginia,  24901,  United States

Study ID Numbers:  CZOL446H2315
Record last reviewed:  December 2004
Last Updated:  January 4, 2005
Record first received:  January 3, 2005
ClinicalTrials.gov Identifier:  NCT00100555
Health Authority: United States: Food and Drug Administration
ClinicalTrials.gov processed this record on 2005-04-08