RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Monoclonal antibodies can locate tumor cells and deliver tumor-killing substances to them without harming normal cells. Combining chemotherapy with monoclonal antibody therapy may kill more tumor cells. PURPOSE: Phase II trial to study the effectiveness of combining docetaxel and monoclonal antibody therapy in treating women who have metastatic or recurrent breast cancer.

OBJECTIVES: I. Determine the toxicity and safety profile of doxorubicin-monoclonal antibody BR96 immunoconjugate (SGN-15) and docetaxel in women with metastatic or recurrent breast cancer. II. Determine the clinical response rate and duration of response of patients treated with this regimen.

PROTOCOL OUTLINE: Patients receive doxorubicin-monoclonal antibody BR96 immunoconjugate (SGN-15) IV over 2 hours and docetaxel IV over 30 minutes on day 1 of weeks 1-6. Treatment repeats every 8 weeks for up to 6 courses in the absence of disease progression or unacceptable toxicity. Patients are followed at 4 weeks.

PROJECTED ACCRUAL: A maximum of 45 patients will be accrued for this study within 18-24 months.

Ages Eligible for Study:  18 Years and above

Criteria

PROTOCOL ENTRY CRITERIA:

--Disease Characteristics--

Histologically confirmed metastatic or recurrent breast carcinoma

• Unresectable disease
• Previously treated with no more than 2 chemotherapy regimens for metastatic disease

OR

• Recurrent within 6 months of adjuvant chemotherapy

Measurable disease OR Positive bone scan and elevation of serum tumor marker for adenocarcinoma

• Serum levels must have increased over 2 consecutive measurements and exceed at least 2 times upper limit of normal

Lewis-y antigen expression documented by immunohistochemistry

No brain metastases that are uncontrolled or require active treatment (including steroids)

Hormone receptor status: Not specified

--Prior/Concurrent Therapy--

Biologic therapy: At least 8 weeks since prior therapeutic or diagnostic murine/humanized/human chimeric antibodies

Chemotherapy:

• See Disease Characteristics
• At least 4 weeks since prior chemotherapy (6 weeks for nitrosoureas, carboplatin, mitomycin, or anthracyclines)
• No prior cumulative anthracycline of 300 mg/m2 or more
• No concurrent antineoplastic agents

Endocrine therapy:

• See Disease Characteristics
• At least 4 weeks since prior hormonal therapy
• No concurrent hormonal therapy except estrogen replacement

Radiotherapy: At least 4 weeks since prior radiotherapy

Surgery: See Disease Characteristics

Other:

• No other concurrent experimental agents
• No concurrent immunosuppressive medications

--Patient Characteristics--

Age: 18 and over

Sex: Female

Menopausal status: Not specified

Performance status: ECOG 0-2

Life expectancy: At least 3 months

Hematopoietic:

• Hemoglobin at least 10 g/dL
• Absolute neutrophil count at least 1,500/mm3
• Platelet count at least 100,000/mm3
• No bleeding diathesis

Hepatic:

• Bilirubin no greater than 1.5 mg/dL
• SGOT no greater than 2.5 times normal
• Alkaline phosphatase no greater than 2.5 times normal (unless documented bony metastasis present)
• Amylase/lipase less than 1.5 times normal
• Hepatitis B and C negative
• No hepatic failure

Renal:

• Creatinine no greater than 1.5 times upper limit of normal
• No renal failure

Cardiovascular:

• LVEF greater than 50% by echocardiogram or MUGA scan
• No congestive heart failure

Other:

• HIV negative
• No antibody present that detects monoclonal antibody BR96 in serum
• No peripheral neuropathy grade 2 or greater
• No dementia or altered mental status
• No other serious underlying medical condition that would preclude study
• No prior allergic reactions to recombinant human or murine proteins
• No uncontrolled peptic ulcer disease
• No active viral, bacterial, or systemic fungal infections
• No other primary malignancy except nonmelanoma skin cancer or carcinoma in situ of the cervix
• No serious nonmalignant disease
• Not pregnant or nursing
• Negative pregnancy test
• Fertile patients must use effective contraception