Dornase Alfa

Pulmozyme

... DORNASE ALFA (Pulmozyme^®) helps to manage the lung problems caused by cystic fibrosis. Dornase alfa helps the lungs function better and decreases the number of lung infections that require treatment with intravenous antibiotics. Generic dornase alfa inhalation solution is not yet available. ...

A box of Pulmozyme Dornase alfa (proprietary name Pulmozyme® from Genentech) is a highly purified solution of recombinant human deoxyribonuclease I (rhDNase), an enzyme which selectively cleaves DNA. Dornase alfa hydrolyzes the DNA present in sputum/mucus of CF patients and reduces viscoelasticity in the lungs, promoting improved clearance of secretions. This protein therapeutic agent is produced in Chinese hamster ovary cells. Dornase alfa is the most recent therapeutic agent develop ...