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Efavirenz |
Sustiva |
Efavirenz Systematic (IUPAC) name 8-chloro-5-(2-cyclopropylethynyl)- 5-(trifluoromethyl)- 4-oxa-2-azabicyclo [4.4.0]deca- 7,9,11-trien-3-one Identifiers CAS number 154598-52-4 ATC code J05AG03 PubChem 64139 DrugBank APRD00059 Chemical data Formula C14H9NClF3O2 Mol. weight 315.675 g/mol Pharmacokinetic data Bioavailability ? Protein binding 99.5-99.75% Metabolism Hepatic (CYP3A4 and CYP2B6-mediated) Half life 40-55 hours Excretion Renal and f ...
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Efavirenz Clinical Trials
- Study of Treatment of Antiretroviral-Naive, HIV-1-Infected Patients Comparing Tenofovir Disoproxil Fumarate Administered in Combination with Lamivudine and Efavirenz Vs. Stavudine, Lamivudine and Efavirenz.
ClinicalTrials.gov Identifier: NCT00158821 - Active, not recruiting
HIV-1
- Tenofovir Disoproxil Fumarate (DF)/Emtricitabine/Efavirenz Versus Combivir/Efavirenz in Antiretroviral-Naive HIV-1 Infected Subjects
ClinicalTrials.gov Identifier: NCT00112047 - Active, not recruiting
HIV Infections
- Comparison of Elvucitabine/Efavirenz/Tenofovir Versus Lamivudine/Efavirenz/Tenofovir in HIV-1 Infected, Treatment Naive Subjects
ClinicalTrials.gov Identifier: NCT00350272 - Active, not recruiting
HIV Infections
- Treatment with Nelfinavir or Efavirenz of HIV-Infected Patients Who Have Never Received Anti-HIV Drugs
ClinicalTrials.gov Identifier: NCT00005000 - Active, not recruiting
HIV Infections
- Safety, Tolerability, and Anti-HIV Activity of DMP 266 (Efavirenz) in Combination with Nelfinavir in HIV-Positive Children
ClinicalTrials.gov Identifier: NCT00000893 - Active, not recruiting
HIV Infections
- Safety and Effectiveness of TRIZIVIR (Abacavir/Lamivudine/Zidovudine) with Efavirenz in HIV-Infected Patients Who Have Never Taken Anti-HIV Drugs
ClinicalTrials.gov Identifier: NCT00011895 - Active, not recruiting
HIV Infections
- A Comparison of Emtricitabine and Stavudine Used with Didanosine Plus Efavirenz in HIV-Infected Patients Who Have Not Taken Anti-HIV Drugs
ClinicalTrials.gov Identifier: NCT00006208 - Active, not recruiting
HIV Infections
- Safety and Effectiveness of Emtricitabine, Efavirenz, and Didanosine in HIV Infected Children Who Have Taken Few or No Anti-HIV Drugs
ClinicalTrials.gov Identifier: NCT00016718 - Active, not recruiting
HIV Infections
- Efavirenz Or Atazanazir/Ritonavir Given with Emtricitabine/Tenofovir Disoproxil Fumarate Or Abacavir/Lamivudine in HIV Infected Treatment-Naive Adults
ClinicalTrials.gov Identifier: NCT00118898 - Active, not recruiting
HIV Infections
- Efficacy of Tenofovir-Emtricitabine and Efavirenz in HIV Infected Patients with Tuberculosis
ClinicalTrials.gov Identifier: NCT00115609 - Recruiting
HIV Infections; Tuberculosis
- Pharmacokinetics of Efavirenz in HIV-1 Invected Subjects with Hepatic Impairment
ClinicalTrials.gov Identifier: NCT00162097 - Recruiting
HIV Infections; Hepatic Impairment
- Comparing the Effectiveness Between Ritonavir Boosted Atazanavir and Efavirenz for the First HIV Treatment
ClinicalTrials.gov Identifier: NCT00280969 - Active, not recruiting
HIV Infection
- Efavirenz and Lamivudine/Zidovudine for Treatment-Naive HIV Infected Adults and Adolescents in Senegal
ClinicalTrials.gov Identifier: NCT00100568 - Not yet recruiting
HIV Infections
- Modification of Doses of Efavirenz According to Its Blood Concentration in HIV Patients Initiating Treatment With Sustiva
ClinicalTrials.gov Identifier: NCT00299091 - Active, not recruiting
HIV Infections
- Effect of Genetics on Metabolism of Efavirenz
ClinicalTrials.gov Identifier: NCT00245986 - Active, not recruiting
Metabolism
- A Study to Evaluate the Safety and Antiretroviral Activity of MK0518 Versus Efavirenz in Treatment Naive HIV-Infected Patients, Each in Combination With TRUVADA(TM)
ClinicalTrials.gov Identifier: NCT00369941 - Active, not recruiting
HIV Infections
- Incidence and Severity of Neuropsychiatric Adverse Events of Efavirenz Given as a Stepped Dosage vs. the Usual Dosage
ClinicalTrials.gov Identifier: NCT00556634 - Active, not recruiting
HIV-1 Infections; HIV Infections
- Anti-HIV Drugs for Treating Infants Who Acquired HIV Infection at Birth
ClinicalTrials.gov Identifier: NCT00102960 - Active, not recruiting
HIV Infections
- Comparing the Safety, Effectiveness, and Tolerability of Three Anti-HIV Drug Regimens for Treatment-Naive Patients
ClinicalTrials.gov Identifier: NCT00050895 - Active, not recruiting
HIV Infections
- Once-Daily HAART Regimen Administration in HIV-1 Infected Children in Burkina Faso
ClinicalTrials.gov Identifier: NCT00122538 - Active, not recruiting
HIV Infection; AIDS
- Randomized Clinical Trial to Assess the Efficacy and Safety of Concomitant Use of Rifampicin and Efavirenz 600 X 800mg
ClinicalTrials.gov Identifier: NCT00533390 - Recruiting
Tuberculosis; HIV Infections
- Blood Levels of Anti-HIV Drugs Used in Combination Regimens in HIV Infected Children
ClinicalTrials.gov Identifier: NCT00260078 - Active, not recruiting
HIV Infections
- Once-Daily PI/NNRTI Therapy Combinations for Treatment Naive, HIV Infected Patients in Resource-limited Conditions
ClinicalTrials.gov Identifier: NCT00084136 - Active, not recruiting
HIV Infections
- Safety, Tolerability and Pharmacokinetics of Efavirenz in HIV-Infected Children
ClinicalTrials.gov Identifier: NCT00364793 - Recruiting
HIV Infections
- Effectiveness of Directly Observed Therapy in Combined HIV and Tuberculosis Treatment in Resource-limited Settings
ClinicalTrials.gov Identifier: NCT00091936 - Active, not recruiting
HIV Infections; Tuberculosis
- Comparative Pharmacokinetics (PK) Study of Efavirenz or Lopinavir/Ritonavir Between Older and Younger HIV-Infected Adults
ClinicalTrials.gov Identifier: NCT00179335 - Recruiting
HIV Infections
- Treatment of Hepatitis B Virus (HBV) Before Beginning Anti-HIV Drugs in Patients with Both HBV and HIV
ClinicalTrials.gov Identifier: NCT00051090 - Active, not recruiting
HIV Infections; Hepatitis B
- Once a Day (QD) - Twice a Day (BID) Clinical Trial: Didanosine, Lamivudine and Efavirenz Versus Zidovudine, Lamivudine and Efavirenz in the Starting Treatment of HIV
ClinicalTrials.gov Identifier: NCT00256828 - Completed
HIV Infections
- Anti-HIV Drug Regimens With or Without Protease Inhibitors and Drug Level Monitoring in HIV Infected Adolescents
ClinicalTrials.gov Identifier: NCT00075907 - Active, not recruiting
HIV Infections
- A Study of Efavirenz in HIV-Infected Patients Who Have Never Taken Anti-HIV Drugs
ClinicalTrials.gov Identifier: NCT00002227 - Completed
HIV Infections
- A Pharmacokinetic Study of Once Daily Efavirenz 400 mg Versus 600 mg in Thai HIV-1 Infected Subjects
ClinicalTrials.gov Identifier: NCT00476424 - Recruiting
HIV Infections
- Efavirenz-Based Versus Nevirapine-Based Antiretroviral Therapy Among HIV-Infected Patients Receiving Rifampin
ClinicalTrials.gov Identifier: NCT00483054 - Recruiting
HIV Infections; Tuberculosis
- Drug Interactions of Amprenavir and Efavirenz, in Combination with a Second Protease Inhibitor, in HIV-Negative Volunteers
ClinicalTrials.gov Identifier: NCT00005762 - Completed
HIV Infections
- ABT-378/Ritonavir and Efavirenz in HIV-Infected Patients Who Have Taken More Than One Protease Inhibitor in the Past
ClinicalTrials.gov Identifier: NCT00004582 - Completed
HIV Infections
- Once Daily 3TC, Efavirenz and ddI for HIV Infection
ClinicalTrials.gov Identifier: NCT00214435 - Recruiting
HIV Infection; AIDS
- FOTO: Five Consecutive Days on Treatment With Efavirenz, Tenofovir, and Emtricitabine Followed by Two Days Off Treatment Versus Continuous Treatment
ClinicalTrials.gov Identifier: NCT00414635 - Recruiting
HIV Infections
- When to Start Anti-HIV Drugs in Children Infected With HIV
ClinicalTrials.gov Identifier: NCT00234091 - Recruiting
HIV Infections
- An Expanded Access Study of Oral Liquid Efavirenz in the Treatment of Children with HIV Infection
ClinicalTrials.gov Identifier: NCT00162227 - Recruiting
HIV Infection
- Effectiveness and Safety of Epivir/Ziagen/Zerit (3TC/ABC/d4T) Versus Epivir/Ziagen/Sustiva (3TC/ABC/EFV) Versus Epivir/Ziagen/Agenerase/Norvir (3TC/ABC/APV/RTV) in HIV Patients Who Have Never Received Treatment
ClinicalTrials.gov Identifier: NCT00005017 - Active, not recruiting
HIV Infections
- A Comparison of BMS-232632 with Efavirenz, Each in Combination with Zidovudine-Lamivudine
ClinicalTrials.gov Identifier: NCT00013897 - Completed
HIV Infections
- A Pilot Study of Atazanavir/Ritonavir/Efavirenz as a Nucleoside Sparing Regimen.
ClinicalTrials.gov Identifier: NCT00135343 - Completed
HIV/AIDS
- Simple Once Daily Triple Regimen Including Tenofovir, Emtricitabine and Efavirenz in HIV-1 Infected Patients (ANRS 1207)
ClinicalTrials.gov Identifier: NCT00158457 - Completed
HIV Infection
- Trial of UK-427,857 in Combination with Zidovudine/Lamivudine versus Efavirenz in Combination with Zidovudine/Lamivudine for the Treatment of HIV-1 Infected Subjects
ClinicalTrials.gov Identifier: NCT00098293 - Active, not recruiting
HIV Infection
- Early Versus Standard Start of Anti-HIV Therapy for Treatment-Naive Adults in Haiti
ClinicalTrials.gov Identifier: NCT00120510 - Recruiting
HIV Infections; Tuberculosis
- Pharmacokinetics of Intermittent Rifabutin and Isoniazid with Daily Efavirenz
ClinicalTrials.gov Identifier: NCT00023413 - Completed
HIV Infections; Tuberculosis
- Efavirenz and Lamivudine/Zidovudine for Treatment-Naive HIV Infected People in Wenxi County, Shanxi Province, China
ClinicalTrials.gov Identifier: NCT00100594 - Completed
HIV Infections
- Evaluation of Four Anti-HIV Treatment Strategies in Resource-Limited South African Communities
ClinicalTrials.gov Identifier: NCT00255840 - Active, not recruiting
HIV Infections
- A Randomized, Placebo-Controlled Study of the Safety and Efficacy of Efavirenz, Didanosine, and Stavudine in Combination With or Without Hydroxyurea in Antiretroviral Naive or Experienced HIV-Infected Patients
ClinicalTrials.gov Identifier: NCT00002230 - Completed
HIV Infections
- A Study to Compare Three Doses of T-20 When Given in Combination with Abacavir, Amprenavir, Ritonavir, and Efavirenz to HIV-Infected Adults
ClinicalTrials.gov Identifier: NCT00002239 - Completed
HIV Infections
- A Study of Efavirenz in Combination with Stavudine and Didanosine
ClinicalTrials.gov Identifier: NCT00002225 - Completed
HIV Infections
- PI Vs. NNRTI Based Therapy for HIV Advanced Disease
ClinicalTrials.gov Identifier: NCT00162643 - Recruiting
Acquired Immunodeficiency Syndrome
- The Effectiveness of Nelfinavir and Efavirenz, Used Alone or Together, Combined with Other Anti-HIV Drugs in Patients Who Have Taken Anti-HIV Drugs
ClinicalTrials.gov Identifier: NCT00001087 - Completed
HIV Infections
- The Effect of Efavirenz and Nelfinavir on the Blood Levels of Certain Lipid-Lowering Drugs
ClinicalTrials.gov Identifier: NCT00017758 - Completed
HIV Infections; HIV Seronegativity; Lipodystrophy
- Comparison of Nevirapine and Efavirenz for the Treatment of HIV-TB co-Infected Patients (ANRS 12146)
ClinicalTrials.gov Identifier: NCT00495326 - Not yet recruiting
Tuberculosis; AIDS; HIV Infections
- Indinavir Plus Efavirenz Plus Adefovir Dipivoxil in HIV-Infected Patients Who Have Not Had Success with Nelfinavir
ClinicalTrials.gov Identifier: NCT00002220 - Completed
HIV Infections
- An Expanded Access Study of Oral Liquid Efavirenz in the Treatment of Children with HIV Infection: Canada
ClinicalTrials.gov Identifier: NCT00162188 - Recruiting
HIV Infection
- Safety and Effectiveness of Giving Adefovir Dipivoxil Plus Abacavir Plus Efavirenz Plus Amprenavir to HIV-Infected Patients Who Have Failed to Respond to Previous Protease Inhibitor Treatment
ClinicalTrials.gov Identifier: NCT00002419 - Completed
HIV Infections
- A Study on the Safety and Effectiveness of Twice-Daily Nelfinavir Plus Twice-Daily Indinavir Plus Efavirenz in HIV-Positive Patients Who Have Never Taken Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) or Protease Inhibitors
ClinicalTrials.gov Identifier: NCT00002235 - Completed
HIV Infections
- Intensive Pharmacokinetics of the Nelfinavir-Rifabutin Interaction in Patients with HIV-Related Tuberculosis Treated with a Rifabutin-Based Regimen
ClinicalTrials.gov Identifier: NCT00018083 - Recruiting
Tuberculosis; HIV Infections
- Amprenavir/Ritonavir, Saquinavir/Ritonavir or Efavirenz in HIV-Infected Patients Following Failure with Kaletra (ABT-378/Ritonavir) as Their First Protease Inhibitor Based HAART
ClinicalTrials.gov Identifier: NCT00038532 - Completed
HIV Infections
- Safety and Effectiveness of Giving an Anti-HIV Drug Combination of Adefovir Dipivoxil Plus Didanosine Plus Efavirenz Plus Lamivudine Once Daily to HIV-Infected Patients
ClinicalTrials.gov Identifier: NCT00002234 - Completed
HIV Infections
- Effectiveness of ABT-378/Ritonavir Plus Lamivudine Plus Efavirenz Plus Tenofovir DF in HIV-Infected Patients
ClinicalTrials.gov Identifier: NCT00038220 - Completed
HIV Infections
- Pharmacokinetics of Emtricitabine/Tenofovir + Efavirenz in HIV-Infected Patients With Tuberculosis
ClinicalTrials.gov Identifier: NCT00474435 - Not yet recruiting
Tuberculosis; HIV Infections
- Addition of Efavirenz or Nelfinavir to a Lamivudine/Zidovudine/Indinavir HIV Treatment Regimen
ClinicalTrials.gov Identifier: NCT00000903 - Completed
HIV Infections
- The Safety and Effectiveness of Indinavir Sulfate Plus Efavirenz
ClinicalTrials.gov Identifier: NCT00002387 - Completed
HIV Infections
- A Study of Abacavir Plus Indinavir Sulfate Plus Efavirenz in HIV-Infected Patients
ClinicalTrials.gov Identifier: NCT00001086 - Completed
HIV Infections
- TMC278-TiDP6-C215: A Clinical Trial in Treatment naïve HIV-1 Patients Comparing TMC278 to Efavirenz in Combination With Abacavir + Lamivudine
ClinicalTrials.gov Identifier: NCT00543725 - Not yet recruiting
HIV-1; HIV Infections
- Immediate Versus Deferred Start of Anti-HIV Therapy in HIV Infected Adults Being Treated for Tuberculosis
ClinicalTrials.gov Identifier: NCT00108862 - Recruiting
HIV Infections; Tuberculosis
- TMC278-TiDP6-C209: A Clinical Trial in Treatment naïve HIV-1 Patients Comparing TMC278 to Efavirenz in Combination With Tenofovir + Emtricitabine.
ClinicalTrials.gov Identifier: NCT00540449 - Not yet recruiting
HIV-1; HIV Infections; Human Immunodeficiency Virus Type 1
- A simplified Kaletra® (lopinavir/ritonavir)-based therapy versus a Sustiva® (efavirenz)-based standard of care in previously non-treated HIV-infected subjects
ClinicalTrials.gov Identifier: NCT00075231 - Completed
HIV Infections
- A Study to Evaluate the Use of a Protease Inhibitor and of Interleukin-2 (IL-2) in the Treatment of Early HIV Infection
ClinicalTrials.gov Identifier: NCT00006154 - Not yet recruiting
HIV Infections
- A Study Exploring an Induction-Maintenance Kaletra-Based Therapy Versus a Sustiva-Based Regimen in Previously Non-Treated, HIV-1/HCV Co-Infected Subjects
ClinicalTrials.gov Identifier: NCT00121017 - Not yet recruiting
HIV Infection; Hepatitis C
- Combination of Efavirenz and Truvada - COMET Study
ClinicalTrials.gov Identifier: NCT00224458 - Completed
HIV Infections
- To Assess Compliance With a Once-Daily Regimen of Lamivudine, Efavirenz and Didanosine
ClinicalTrials.gov Identifier: NCT00207168 - Completed
AIDS
- KIVEXA Vs TRUVADA, Both Administered With Efavirenz, In ART-Naive Subjects
ClinicalTrials.gov Identifier: NCT00549198 - Completed
HIV Infections
- Antiretroviral Treatment Simplification Study With Efavirenz + Abacavir + 3TC Once Daily
ClinicalTrials.gov Identifier: NCT00314626 - Completed
HIV Infections
- Dose Finding Confirmation of Atazanavir With Ritonavir and Efavirenz (ATV/RTV + EFV) in Healthy Subjects
ClinicalTrials.gov Identifier: NCT00357188 - Completed
HIV Infections; Protease Inhibitor
- 2NN & CHARM Long-Term Follow-Up Study
ClinicalTrials.gov Identifier: NCT00127972 - Completed
HIV-1
- Continued Antiretroviral Therapy with Abacavir, Amprenavir and Efavirenz
ClinicalTrials.gov Identifier: NCT00001758 - Completed
HIV Infection
- Feasibility Study of a Once Daily Antiretroviral Regimen in Vietnam (ANRS 1210 VIETAR)
ClinicalTrials.gov Identifier: NCT00158470 - Completed
HIV Infection
- Drug Interactions Among Anti-HIV Agents
ClinicalTrials.gov Identifier: NCT00001766 - Completed
HIV Infection
- A Study to Compare Two Anti-HIV Drug Combinations
ClinicalTrials.gov Identifier: NCT00002447 - Completed
HIV Infections
- Safety and Effectiveness of a Combination Anti-HIV Drug Treatment
ClinicalTrials.gov Identifier: NCT00005018 - Completed
HIV Infections
- Pilot Study on Once Daily FTC, ddI, Efavirenz Combination in Antiretroviral Naive HIV Infected Adults
ClinicalTrials.gov Identifier: NCT00196599 - Completed
HIV Infections; Antiretroviral Naive
- The Safety and Effectiveness of 1592U89 Plus 141W94 Plus DMP 266 in Patients with HIV Who Developed a Resistance to Protease Inhibitors
ClinicalTrials.gov Identifier: NCT00002213 - Completed
HIV Infections
- A Comparison of Two Drug Combinations Used in HIV-Infected Patients Who Never Have Taken Anti-HIV Drugs
ClinicalTrials.gov Identifier: NCT00005573 - Completed
HIV Infections
- A Study of an Adherence Plan to Help HIV-Positive Patients Take Their First Anti-HIV Medications Correctly
ClinicalTrials.gov Identifier: NCT00001122 - Completed
HIV Infections
- A Study to Compare the Effects of Two Anti-HIV Drug Combinations on the Immune Systems of HIV-Infected Patients
ClinicalTrials.gov Identifier: NCT00002448 - Completed
HIV Infections
- A Study to Compare the Effectiveness of Different Anti-HIV Drug Regimens in Keeping Levels of HIV in the Blood as Low as Possible
ClinicalTrials.gov Identifier: NCT00000939 - Completed
HIV Infections
- A Study of Indinavir Taken with or without DMP 266
ClinicalTrials.gov Identifier: NCT00002393 - Completed
HIV Infections
- A Study of the Effectiveness of Different Anti-HIV Treatments in HIV-Positive Individuals Who Have Been on a Protease Inhibitor-Containing Drug Regimen for at Least 16 Weeks
ClinicalTrials.gov Identifier: NCT00000914 - Completed
HIV Infections
- Effectiveness and Safety of Two Forms of Stavudine in HIV-Infected Patients
ClinicalTrials.gov Identifier: NCT00005918 - Completed
HIV Infections
- Rollover Study for Zerit (Stavudine) ER Studies (-096, -099)
ClinicalTrials.gov Identifier: NCT00116298 - Completed
HIV Infections; AIDS
- A Study to determine how and why HIV-Infected subjects on anti-viral treatment develop Lipodystrophy
ClinicalTrials.gov Identifier: NCT00006190 - Completed
HIV Infections; Lipodystrophy
- 3 Antiretroviral Medicines in Combination, in HIV Patients who Have Not Been Previously Treated with Antiretroviral Therapy
ClinicalTrials.gov Identifier: NCT00116415 - Completed
HIV Infections; AIDS
- Potent Antiviral Therapy for Critically Ill HIV Infected Patients Admitted to Intensive Care
ClinicalTrials.gov Identifier: NCT00028327 - Completed
HIV Infections
- DART II - Study of 3 Antiretroviral Medicines in Combination, in HIV Patients who Have Not Been Previously Treated with Antiretroviral Therapy
ClinicalTrials.gov Identifier: NCT00116116 - Completed
HIV Infections; AIDS
- Effects of Anti-HIV Therapy on Treatment for Hepatitis C in HCV/HIV Infected Adults
ClinicalTrials.gov Identifier: NCT00100581 - Completed
HIV Infections; Hepatitis C
- Changing to Nonprotease Inhibitor Treatment to Improve Side Effects
ClinicalTrials.gov Identifier: NCT00021463 - Completed
HIV Infections; Lipodystrophy
- A Study on Amprenavir in Combination with Other Anti-HIV Drugs in HIV-Positive Patients
ClinicalTrials.gov Identifier: NCT00000912 - Completed
HIV Infections
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