Rasburicase

Elitek

Article: Rasburicase


Rasburicase
Systematic (IUPAC) name
Aspergillus urate oxidase
Identifiers
CAS number	134774-45-1
ATC code	V03AF07
PubChem	?
DrugBank	BIOD00090
Chemical data
Formula	C₁₅₂₁H₂₃₈₁N₄₁₇O₄₆₁S₇
Mol. weight	34109.5
Pharmacokinetic data
Bioavailability	N/A
Metabolism	?
Half life	8 hrs
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status	RX/POM
Routes	Intravenous

Rasburicase (brand names: Fasturtec and Elitek) is a recombinant urate oxidase enzyme. It is used for the prevention and treatment of tumor lysis syndrome in patients receiving chemotherapy for hematologic cancers such as leukemias and lymphomas.

It catalyses the conversion of uric acid to allantoin. Allantoin is much more soluble than uric acid, so renal excretion is more effective.

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Retrieved from "http://en.wikipedia.org/wiki/Rasburicase"

Categories: Enzyme stubs | Pharmacology stubs | Chemotherapeutic adjuvants

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Rasburicase (Drug Digest)

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