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L-Asparaginase |
Elspar |
Asparaginase (EC 3.5.1.1) is an enzyme which is used to treat acute lymphoblastic leukemia (ALL). It is marketed under the brand name Elspar®. It can be given intramuscularly or intravenously. Mechanism of action The rationale behind asparaginase is that it takes advantage of the fact that ALL cells are unable to synthesize the non-essential amino acid asparagine whereas normal cells are able to make their own asparagine. These leukemic cells depend on circulating asparagine. Asparaginase ...
Wikipedia - [full article]
L-Asparaginase Clinical Trials
- Erwinia Asparaginase After Allergy to PEG-Asparaginase in Treating Young Patients With Acute Lymphoblastic Leukemia
ClinicalTrials.gov Identifier: NCT00537030 - Not yet recruiting
Leukemia
- PEG-Asparaginase During Two Treatment Courses
ClinicalTrials.gov Identifier: NCT00192673 - Recruiting
Acute Lymphoblastic Leukemia
- Intensified Post Remission Therapy Containing PEG-Asparaginase
ClinicalTrials.gov Identifier: NCT00184041 - Recruiting
Acute Lymphoblastic Leukemia
- Combination Chemotherapy in Treating Patients With Acute B-Lymphoblastic Leukemia or Non-Hodgkin's Lymphoma
ClinicalTrials.gov Identifier: NCT00002471 - Active, not recruiting
Lymphoma; Leukemia
- Pegasparaginase or Asparaginase and Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Lymphoblastic Leukemia
ClinicalTrials.gov Identifier: NCT00400946 - Recruiting
Drug Toxicity; Leukemia
- Chemotherapy in Treating Patients With Acute Lymphoblastic Leukemia and Diffuse Non-Hodgkin's Lymphoma
ClinicalTrials.gov Identifier: NCT00018954 - Active, not recruiting
Lymphoma; Leukemia
- Association of L-Asparaginase-Methotrexate–Dexamethasone for Nasal and Nasal-Type Natural Killer (NK)-T-Cell Lymphoma
ClinicalTrials.gov Identifier: NCT00283985 - Recruiting
Lymphoma, Non-Hodgkin
- Combination Chemotherapy With or Without Bone Marrow Transplantation in Treating Patients With Previously Untreated Acute Lymphocytic Leukemia
ClinicalTrials.gov Identifier: NCT00002665 - Active, not recruiting
Thrombocytopenia; Leukemia, Lymphocytic; Neutropenia
- Combination Chemotherapy in Treating Patients With Relapsed or Refractory Acute Lymphocytic Leukemia
ClinicalTrials.gov Identifier: NCT00002532 - Active, not recruiting
recurrent adult acute lymphoblastic leukemia
- Combination Chemotherapy in Treating Children With Relapsed Acute Lymphocytic Leukemia
ClinicalTrials.gov Identifier: NCT00002499 - Active, not recruiting
recurrent childhood acute lymphocytic leukemia
- LAMPP Trial for Peripheral and Cutaneous T-Cell Lymphoma
ClinicalTrials.gov Identifier: NCT00161239 - Recruiting
T-Cell Lymphoma
- Combination Chemotherapy in Treating Children With Newly Diagnosed Acute Lymphocytic Leukemia
ClinicalTrials.gov Identifier: NCT00003671 - Active, not recruiting
B-cell childhood acute lymphocytic leukemia; untreated childhood acute lymphocytic leukemia
- Combination Chemotherapy in Treating Patients With Newly Diagnosed Acute Lymphoblastic Leukemia
ClinicalTrials.gov Identifier: NCT00016302 - Active, not recruiting
untreated childhood acute lymphoblastic leukemia; T-cell childhood acute lymphoblastic leukemia
- Combination Chemotherapy in Treating Children With Acute Lymphoblastic Leukemia
ClinicalTrials.gov Identifier: NCT00005603 - Active, not recruiting
childhood acute lymphoblastic leukemia in remission; B-cell childhood acute lymphoblastic leukemia
- Randomized Controlled Trial to Test Efficacy of High-Dose MTX for Adult Acute Lymphoblastic Leukemia (ALL)
ClinicalTrials.gov Identifier: NCT00131027 - Recruiting
Acute Lymphoblastic Leukemia
- Combination Chemotherapy and Radiation Therapy in Treating Children With Acute Lymphoblastic Leukemia
ClinicalTrials.gov Identifier: NCT00004034 - Active, not recruiting
L2 childhood acute lymphoblastic leukemia; untreated childhood acute lymphoblastic leukemia; cardiac toxicity; ...
- Combination Chemotherapy in Treating Adults With Acute Lymphocytic Leukemia
ClinicalTrials.gov Identifier: NCT00002531 - Active, not recruiting
non-T, non-B adult acute lymphoblastic leukemia; untreated adult acute lymphoblastic leukemia; B-cell adult acute lymphoblastic leukemia; ...
- Combination Chemotherapy in Treating Children With Very High Risk Acute Lymphocytic Leukemia
ClinicalTrials.gov Identifier: NCT00003783 - Active, not recruiting
L2 childhood acute lymphoblastic leukemia; untreated childhood acute lymphoblastic leukemia; L1 childhood acute lymphoblastic leukemia; ...
- Phase 2 Study of Applying Pediatric Regimens to Younger Adult Patients with Acute Lymphoblastic Leukemia (ALL)
ClinicalTrials.gov Identifier: NCT00131053 - Recruiting
Acute Lymphoblastic Leukemia
- Hormone Therapy Plus Chemotherapy in Treating Children With Acute Lymphocytic Leukemia
ClinicalTrials.gov Identifier: NCT00003437 - Active, not recruiting
recurrent childhood acute lymphoblastic leukemia; untreated childhood acute lymphoblastic leukemia
- Combination Chemotherapy in Treating Patients With Untreated Acute Lymphoblastic Leukemia
ClinicalTrials.gov Identifier: NCT00003700 - Active, not recruiting
L1 adult acute lymphoblastic leukemia; L2 adult acute lymphoblastic leukemia; untreated adult acute lymphoblastic leukemia
- Combination Chemotherapy in Treating Children or Adolescents With Newly Diagnosed Lymphoblastic Lymphoma
ClinicalTrials.gov Identifier: NCT00004228 - Active, not recruiting
stage I childhood lymphoblastic lymphoma; stage II childhood lymphoblastic lymphoma; stage III childhood lymphoblastic lymphoma; ...
- Radiation Therapy to the Head or Intrathecal Chemotherapy Plus High Dose Cytarabine in Preventing CNS Disease in Children With Acute Lymphoblastic Leukemia
ClinicalTrials.gov Identifier: NCT00019409 - Active, not recruiting
L2 childhood acute lymphoblastic leukemia; untreated childhood acute lymphoblastic leukemia; L1 childhood acute lymphoblastic leukemia; ...
- Radiation Therapy and Chemotherapy in Treating Children With CNS Relapse From Acute Lymphoblastic Leukemia
ClinicalTrials.gov Identifier: NCT00002704 - Active, not recruiting
B-cell childhood acute lymphocytic leukemia; TdT positive childhood acute lymphocytic leukemia; recurrent childhood acute lymphocytic leukemia; ...
- Comparison of Different Combination Chemotherapy Regimens in Treating Infants With Acute Lymphoblastic Leukemia
ClinicalTrials.gov Identifier: NCT00015873 - Active, not recruiting
untreated childhood acute lymphoblastic leukemia
- Combination Chemotherapy in Treating Children With Non-Hodgkin's Lymphoma
ClinicalTrials.gov Identifier: NCT00003650 - Active, not recruiting
stage I childhood lymphoblastic lymphoma; stage II childhood lymphoblastic lymphoma; stage III childhood lymphoblastic lymphoma; ...
- Combination Chemotherapy Followed by Melphalan and Peripheral Stem Cell Transplantation in Treating Children With Newly Diagnosed Acute Myeloid Leukemia
ClinicalTrials.gov Identifier: NCT00004056 - Active, not recruiting
childhood acute megakaryocytic leukemia (M7); untreated childhood acute myeloid leukemia; ...
- A Multicenter Phase II Study in Adults with Untreated Acute Lymphoblastic Leukemia
ClinicalTrials.gov Identifier: NCT00136435 - Recruiting
Acute Lymphoblastic Leukemia
- Alemtuzumab and Combination Chemotherapy in Treating Patients With Untreated Acute Lymphoblastic Leukemia
ClinicalTrials.gov Identifier: NCT00061945 - Active, not recruiting
B-cell adult acute lymphoblastic leukemia; L1 adult acute lymphoblastic leukemia; L2 adult acute lymphoblastic leukemia; ...
- Combination Chemotherapy in Treating Children With Non-Hodgkin's Lymphoma
ClinicalTrials.gov Identifier: NCT00003423 - Active, not recruiting
stage I childhood large cell lymphoma; stage III childhood lymphoblastic lymphoma; stage III childhood large cell lymphoma; ...
- Combination Chemotherapy With or Without Donor Bone Marrow Transplantation in Treating Infants With Previously Untreated Acute Lymphoblastic Leukemia
ClinicalTrials.gov Identifier: NCT00022126 - Active, not recruiting
untreated childhood acute lymphoblastic leukemia; L1 childhood acute lymphoblastic leukemia; L2 childhood acute lymphoblastic leukemia; ...
- Combination Chemotherapy and Alemtuzumab in Treating Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia
ClinicalTrials.gov Identifier: NCT00262925 - Recruiting
Recurrent Adult Acute Lymphoblastic Leukemia
- Chemotherapy With or Without Bone Marrow Transplantation in Treating Patients With Acute Lymphoblastic Leukemia
ClinicalTrials.gov Identifier: NCT00002700 - Active, not recruiting
untreated adult acute lymphoblastic leukemia; stage I adult lymphoblastic lymphoma; stage III adult lymphoblastic lymphoma; ...
- Combination Chemotherapy With or Without Bone Marrow Transplantation in Treating Children With Acute Myeloid Leukemia
ClinicalTrials.gov Identifier: NCT00003436 - Active, not recruiting
refractory anemia with excess blasts in transformation; refractory anemia with excess blasts; childhood acute promyelocytic leukemia (M3); ...
- Combination Chemotherapy With or Without Peripheral Stem Cell Transplantation in Treating Children With Acute Lymphoblastic Leukemia
ClinicalTrials.gov Identifier: NCT00022737 - Active, not recruiting
recurrent childhood acute lymphoblastic leukemia; childhood acute lymphoblastic leukemia in remission
- Epratuzumab and Combination Chemotherapy in Treating Young Patients With Relapsed Acute Lymphoblastic Leukemia
ClinicalTrials.gov Identifier: NCT00098839 - Recruiting
recurrent childhood acute lymphoblastic leukemia
- Combination Chemotherapy Plus Steroid Therapy in Treating Children With Acute Lymphoblastic Leukemia or Lymphoblastic Non-Hodgkin's Lymphoma
ClinicalTrials.gov Identifier: NCT00003728 - Recruiting
acute undifferentiated leukemia; childhood acute lymphoblastic leukemia; childhood lymphoblastic lymphoma
- Combination Chemotherapy, Bone Marrow Transplantation, and Radiation Therapy in Treating Infants With Acute Lymphoblastic Leukemia
ClinicalTrials.gov Identifier: NCT00002785 - Completed
untreated childhood acute lymphoblastic leukemia
- Induction Intensification in Treating Infants With Newly Diagnosed Acute Lymphoblastic Leukemia
ClinicalTrials.gov Identifier: NCT00002756 - Completed
untreated childhood acute lymphoblastic leukemia; acute undifferentiated leukemia
- Combination Chemotherapy in Treating Children With Newly Diagnosed Acute Lymphoblastic Leukemia
ClinicalTrials.gov Identifier: NCT00002744 - Completed
L1 childhood acute lymphocytic leukemia; L2 childhood acute lymphocytic leukemia; untreated childhood acute lymphocytic leukemia
- Combination Chemotherapy in Treating Children With Acute Lymphocytic Leukemia
ClinicalTrials.gov Identifier: NCT00002812 - Completed
L2 childhood acute lymphoblastic leukemia; untreated childhood acute lymphoblastic leukemia; L1 childhood acute lymphoblastic leukemia
- Combination Chemotherapy With or Without Bone Marrow Transplantation in Treating Children With Acute Myelogenous Leukemia or Myelodysplastic Syndrome
ClinicalTrials.gov Identifier: NCT00002798 - Completed
Myeloid Leukemia; Refractory Anemia
- Chemotherapy in Treating Children With Down Syndrome and Myeloproliferative Disorder, Acute Myelogenous Leukemia, or Myelodysplastic Syndrome
ClinicalTrials.gov Identifier: NCT00003593 - Completed
childhood acute monocytic leukemia; childhood acute myeloid leukemia and other myeloid malignancies; Chronic Myelomonocytic Leukemia; ...
- Combination Chemotherapy in Treating Pediatric Patients With Stage III or IV Non-Hodgkin's Lymphoma
ClinicalTrials.gov Identifier: NCT00002691 - Completed
stage III childhood lymphoblastic lymphoma; stage III childhood large cell lymphoma; stage IV childhood large cell lymphoma; ...
- Monoclonal Antibody Plus Chemotherapy in Treating Young Patients With Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndromes
ClinicalTrials.gov Identifier: NCT00028899 - Completed
recurrent childhood acute myeloid leukemia; secondary acute myeloid leukemia; previously treated myelodysplastic syndromes
- Combination Chemotherapy and Imatinib Mesylate in Treating Children With Relapsed Acute Lymphoblastic Leukemia
ClinicalTrials.gov Identifier: NCT00049569 - Completed
recurrent childhood acute lymphoblastic leukemia; non-T, non-B childhood acute lymphoblastic leukemia; T-cell childhood acute lymphoblastic leukemia; ...
- Gemtuzumab Ozogamicin in Treating Young Patients With Newly Diagnosed Acute Myeloid Leukemia Undergoing Remission Induction and Intensification Therapy
ClinicalTrials.gov Identifier: NCT00070174 - Completed
childhood acute monocytic leukemia; childhood acute myeloid leukemia
- Stem Cell Transplantation Compared With Standard Chemotherapy in Treating Patients With Acute Lymphoblastic Leukemia in First Remission
ClinicalTrials.gov Identifier: NCT00002514 - Completed
adult acute lymphoblastic leukemia in remission
Resources
- Elspar (Drug Digest)
- L-Asparaginase (Drug Digest)
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