Lamivudine |
3TC; Epivir; Epivir-HBV |
Lamivudine Systematic (IUPAC) name L-2',3'-dideoxy-3'-thiacytidine Identifiers CAS number 134678-17-4 ATC code J05AF05 PubChem 60825 DrugBank APRD00681 Chemical data Formula C8H11N3O3S Mol. weight 229.26 Pharmacokinetic data Bioavailability ? Metabolism Renal elimination (ca.70%) Half life ? Excretion ? Therapeutic considerations Pregnancy cat. C (USA) B3 (Aus) Legal status Routes ? Lamivudine (2',3'-dideoxy-3'-thia ...
Wikipedia - [full article]
Lamivudine Clinical Trials
- Study of Treatment of Antiretroviral-Naive, HIV-1-Infected Patients Comparing Tenofovir Disoproxil Fumarate Administered in Combination with Lamivudine and Efavirenz Vs. Stavudine, Lamivudine and Efavirenz.
ClinicalTrials.gov Identifier: NCT00158821 - Active, not recruiting
HIV-1
- Comparison of Anti-HIV Drug Combinations to Prevent Mother-to-Child Transmission of HIV
ClinicalTrials.gov Identifier: NCT00086359 - Active, not recruiting
HIV Infections
- A Study to Evaluate the Safety and Tolerance of Stavudine (d4T) in Combination with Lamivudine (3TC) in HIV-Positive Pregnant Women and Their Infants
ClinicalTrials.gov Identifier: NCT00000878 - Active, not recruiting
HIV Infections; Pregnancy
- Safety and Effectiveness of Giving Indinavir Plus Stavudine Plus Lamivudine to HIV-Infected Children
ClinicalTrials.gov Identifier: NCT00000901 - Active, not recruiting
HIV Infections
- Zidovudine and Lamivudine Given Once Versus Twice Daily
ClinicalTrials.gov Identifier: NCT00014014 - Active, not recruiting
HIV Infections
- A Study to Evaluate the Safety and Tolerance of Nelfinavir (NFV) Given with Zidovudine (ZDV) and Lamivudine (3TC) in HIV-Positive Pregnant Women and Their Infants
ClinicalTrials.gov Identifier: NCT00000887 - Active, not recruiting
HIV Infections; Pregnancy
- Zidovudine / Lamivudine + Nevirapine Twice Daily, Versus Tenofovir + Lamivudine + Nevirapine Once Daily in ARV-Naive Patients
ClinicalTrials.gov Identifier: NCT00199979 - Recruiting
Hiv Infection With Antiretroviral Therapy Indication; CD4 Below 350/µL or Below 15%
- A Study to Evaluate the Safety and Tolerance of Combination Anti-HIV Drug Therapy (Indinavir, Lamivudine, and Zidovudine) in HIV-Positive Pregnant Women and Their Infants
ClinicalTrials.gov Identifier: NCT00000944 - Active, not recruiting
HIV Infections; Pregnancy
- Safety and Effectiveness of Three Anti-HIV Drugs Combined in One Pill (Trizivir)
ClinicalTrials.gov Identifier: NCT00004981 - Active, not recruiting
HIV Infections
- Safety and Effectiveness of Giving Indinavir, Ritonavir, Stavudine, and Lamivudine to HIV-Infected Patients Who Have Never Received Anti-HIV Drugs
ClinicalTrials.gov Identifier: NCT00002451 - Active, not recruiting
HIV Infections
- Four-Drug Combination Therapy with Zidovudine, Lamivudine, 1592U89 (Abacavir), and 141W94 (Amprenavir) in HIV-Infected Patients
ClinicalTrials.gov Identifier: NCT00006617 - Active, not recruiting
HIV Infections
- Switching Study From Lamivudine to Clevudine Versus Continued Lamivudine in the Chronic Hepatitis B Patients
ClinicalTrials.gov Identifier: NCT00558493 - Recruiting
Chronic Hepatitis B
- Safety and Effectiveness of TRIZIVIR (Abacavir/Lamivudine/Zidovudine) with Efavirenz in HIV-Infected Patients Who Have Never Taken Anti-HIV Drugs
ClinicalTrials.gov Identifier: NCT00011895 - Active, not recruiting
HIV Infections
- Study of Anti-HIV Therapy Intensification
ClinicalTrials.gov Identifier: NCT00034086 - Active, not recruiting
HIV Infections
- Comparison of GW433908/Ritonavir to Nelfinavir When Used with Abacavir and Lamivudine in Patients That Have Not Taken Antiretroviral Drugs
ClinicalTrials.gov Identifier: NCT00009061 - Active, not recruiting
HIV Infections
- Lamivudine and Therapeutic Vaccine Evaluation in Senegalese Patients with Chronic Hepatitis B Infection
ClinicalTrials.gov Identifier: NCT00120796 - Recruiting
Hepatitis B
- Safety of and Immune Response to Cyclosporine A in Combination with Abacavir Sulfate, Lamivudine, and Zidovudine and Lopinavir/Ritonavir in Adults with Acute HIV Infection
ClinicalTrials.gov Identifier: NCT00084149 - Active, not recruiting
HIV Infections
- PI Vs. NNRTI Based Therapy for HIV Advanced Disease
ClinicalTrials.gov Identifier: NCT00162643 - Recruiting
Acquired Immunodeficiency Syndrome
- Trial of UK-427,857 in Combination with Zidovudine/Lamivudine versus Efavirenz in Combination with Zidovudine/Lamivudine for the Treatment of HIV-1 Infected Subjects
ClinicalTrials.gov Identifier: NCT00098293 - Active, not recruiting
HIV Infection
- Telbivudine versus Lamivudine in Adults with Decompensated Chronic Hepatitis B and Evidence of Cirrhosis
ClinicalTrials.gov Identifier: NCT00076336 - Active, not recruiting
Hepatitis; Hepatitis B, Chronic; Cirrhosis
- Efavirenz Or Atazanazir/Ritonavir Given with Emtricitabine/Tenofovir Disoproxil Fumarate Or Abacavir/Lamivudine in HIV Infected Treatment-Naive Adults
ClinicalTrials.gov Identifier: NCT00118898 - Active, not recruiting
HIV Infections
- Study Comparing the Safety of Switching From Lamivudine to Adefovir Dipivoxil Versus Overlapping Lamivudine and Adefovir Before Adefovir Dipivoxil Monotherapy in Patients With Chronic Hepatitis B
ClinicalTrials.gov Identifier: NCT00307242 - Recruiting
Chronic Hepatitis B
- Study of Zidovudine/Lamivudine and Nevirapine for Reduction of Mother-to-Child HIV Transmission During Breastfeeding
ClinicalTrials.gov Identifier: NCT00146380 - Recruiting
HIV Infections
- A Randomized, Prospective Study of the Efficacy, Safety and Tolerability of Two Doses of GW433908Ritonavir Given With Abacavir/Lamivudine Fixed Dose Combination
ClinicalTrials.gov Identifier: NCT00335270 - Active, not recruiting
HIV
- Abacavir/Lamivudine Versus Emtricitabine/Tenofovir Both In Combination With Lopinavir/Ritonavir For The Treatment Of HIV
ClinicalTrials.gov Identifier: NCT00244712 - Active, not recruiting
HIV Infections
- Efavirenz and Lamivudine/Zidovudine for Treatment-Naive HIV Infected Adults and Adolescents in Senegal
ClinicalTrials.gov Identifier: NCT00100568 - Not yet recruiting
HIV Infections
- A Study to Investigate Whether the Immediate Use or Deferred Use of an Anti-Viral Drug Lamivudine Will Help to Better Safe-Guard the Delivery of Chemotherapy in Patients With Cancer Who Are Also Hepatitis B Carriers
ClinicalTrials.gov Identifier: NCT00516945 - Active, not recruiting
Hepatitis B; Neoplasms
- An Extension Study of Telbivudine, Lamivudine or Telbivudine Plus Lamivudine in Patients With Chronic Hepatitis B
ClinicalTrials.gov Identifier: NCT00124241 - Completed
Hepatitis B
- Induction/Simplification With Atazanavir + Ritonavir + Abacavir/Lamivudine Fixed-Dose Combination In HIV-1 Infection
ClinicalTrials.gov Identifier: NCT00440947 - Active, not recruiting
HIV Infection
- Different Regimens of Pegylated Interferon and Lamivudine Combination Therapy in Chronic Hepatitis B Patients
ClinicalTrials.gov Identifier: NCT00226447 - Active, not recruiting
Chronic Hepatitis B
- A Trial To Study The Effect Of Lamivudine In Adult Patients Who Suffer From Chronic Hepatitis B Alone
ClinicalTrials.gov Identifier: NCT00354653 - Active, not recruiting
Chronic Hepatitis B
- Safety and Effectiveness of an Anti-HIV Drug Combination Taken Twice Daily
ClinicalTrials.gov Identifier: NCT00002241 - Active, not recruiting
HIV Infections
- Bioavailability Study of a New Pediatric Formulation of Zidovudine/Lamivudine in Adult Volunteers
ClinicalTrials.gov Identifier: NCT00470041 - Recruiting
Healthy
- NRTI-Sparing Pilot Study
ClinicalTrials.gov Identifier: NCT00143689 - Active, not recruiting
HIV; Mitochondrial Toxicity
- Switching Therapy from Lamivudine to Telbivudine Vs Continued Lamivudine in Adults with Chronic Hepatitis B
ClinicalTrials.gov Identifier: NCT00132652 - Completed
Chronic Hepatitis B
- Comparison of Elvucitabine/Efavirenz/Tenofovir Versus Lamivudine/Efavirenz/Tenofovir in HIV-1 Infected, Treatment Naive Subjects
ClinicalTrials.gov Identifier: NCT00350272 - Active, not recruiting
HIV Infections
- Comparison of Three Different Initial Treatments Without Protease Inhibitors for HIV Infection
ClinicalTrials.gov Identifier: NCT00013520 - Completed
HIV Infections
- Treatment with Combinations of Several Antiviral Drugs in Infants and Young Children with HIV Infection
ClinicalTrials.gov Identifier: NCT00000872 - Active, not recruiting
HIV Infections
- Treatment with Interleukin-2 (IL-2) Plus Combination Anti-HIV-Drug Therapy (HAART) for Patients Formerly in ACTG 328
ClinicalTrials.gov Identifier: NCT00000923 - Active, not recruiting
HIV Infections
- A Study of the Safety and Effectiveness of Treating Advanced AIDS Patients between Ages 4 and 22 with 7 Drugs, Some at Higher than Usual Doses
ClinicalTrials.gov Identifier: NCT00001108 - Active, not recruiting
HIV Infections
- Anti-HIV Drugs for Treating Infants Who Acquired HIV Infection at Birth
ClinicalTrials.gov Identifier: NCT00102960 - Active, not recruiting
HIV Infections
- Use of Combined Antiretroviral Therapy to Determine Sites of Persistent HIV Infection
ClinicalTrials.gov Identifier: NCT00001644 - Active, not recruiting
HIV Infection
- Comparing the Safety, Effectiveness, and Tolerability of Three Anti-HIV Drug Regimens for Treatment-Naive Patients
ClinicalTrials.gov Identifier: NCT00050895 - Active, not recruiting
HIV Infections
- Once-Daily HAART Regimen Administration in HIV-1 Infected Children in Burkina Faso
ClinicalTrials.gov Identifier: NCT00122538 - Active, not recruiting
HIV Infection; AIDS
- A Comparison of Two Anti-HIV Drug Regimens for Youth Who Have Failed Prior Therapy
ClinicalTrials.gov Identifier: NCT00102206 - Active, not recruiting
HIV Infections
- A Study on the Management of Combination Anti-HIV Drug Therapy in HIV-Positive Children with Prior Treatment
ClinicalTrials.gov Identifier: NCT00000902 - Active, not recruiting
HIV Infections
- A Study of ABT-378/Ritonavir in HIV-Infected Patients
ClinicalTrials.gov Identifier: NCT00004578 - Active, not recruiting
HIV Infections
- Five-Drug Anti-HIV Treatment Followed by Treatment Interruption in Patients Who Have Recently Been Infected with HIV
ClinicalTrials.gov Identifier: NCT00000940 - Active, not recruiting
HIV Infections
- Once-Daily PI/NNRTI Therapy Combinations for Treatment Naive, HIV Infected Patients in Resource-limited Conditions
ClinicalTrials.gov Identifier: NCT00084136 - Active, not recruiting
HIV Infections
- A Study of Ritonavir (an Anti-HIV Drug) in HIV-Positive Infants and Children
ClinicalTrials.gov Identifier: NCT00000952 - Active, not recruiting
HIV Infections
- Compare the Efficacy and Safety of 48-Week Treatment With Clevudine 30mg Versus Lamivudine 100mg for CHB Infection
ClinicalTrials.gov Identifier: NCT00362635 - Recruiting
Hepatitis B
- Anti-HIV Treatment Interruptions in HIV Infected Adults in South Africa
ClinicalTrials.gov Identifier: NCT00100646 - Active, not recruiting
HIV Infections
- Effectiveness of Treating HIV-Positive Patients with an HIV Vaccine (Remune)
ClinicalTrials.gov Identifier: NCT00005002 - Active, not recruiting
HIV Infections
- HIV Study Of GW433908 Versus Kaletra, Both With Abacavir/lamivudine In Therapy-Naive Patients
ClinicalTrials.gov Identifier: NCT00085943 - Active, not recruiting
HIV Infections
- Comparison of GW433908 and Nelfinavir in HIV Patients Who Have Not Had Antiretroviral Therapy
ClinicalTrials.gov Identifier: NCT00008554 - Active, not recruiting
HIV Infections
- Long-Term Lamivudine Therapy for Chronic Hepatitis B
ClinicalTrials.gov Identifier: NCT00120354 - Completed
- Treatment with Nelfinavir or Efavirenz of HIV-Infected Patients Who Have Never Received Anti-HIV Drugs
ClinicalTrials.gov Identifier: NCT00005000 - Active, not recruiting
HIV Infections
- Effectiveness of Directly Observed Therapy in Combined HIV and Tuberculosis Treatment in Resource-limited Settings
ClinicalTrials.gov Identifier: NCT00091936 - Active, not recruiting
HIV Infections; Tuberculosis
- A Randomized Study Comparing Lamivudine Versus Adefovir Dipivoxil for Prevention of zHBV Reactivation in HBsAg Seropositive Patients Undergoing Cytotoxic Chemotherapy
ClinicalTrials.gov Identifier: NCT00489151 - Recruiting
Hepatitis B
- Treatment of Hepatitis B Virus (HBV) Before Beginning Anti-HIV Drugs in Patients with Both HBV and HIV
ClinicalTrials.gov Identifier: NCT00051090 - Active, not recruiting
HIV Infections; Hepatitis B
- Drug Levels of Tablet and Liquid Forms of Lamivudine, Nevirapine, and Stavudine in HIV Infected Thai Children
ClinicalTrials.gov Identifier: NCT00312091 - Recruiting
HIV Infections
- Safety and antiviral study of ACH126, 433 (b-L-Fd4C) in adults with lamivudine-resistant chronic hepatitis B
ClinicalTrials.gov Identifier: NCT00040144 - Active, not recruiting
Chronic Hepatitis B
- 3TC (Lamivudine; GR109714X) Open-Label Program
ClinicalTrials.gov Identifier: NCT00002108 - Completed
HIV Infections
- MEDICLAS Study (Metabolic Effects of Different Classes of AntiretroviralS)
ClinicalTrials.gov Identifier: NCT00122226 - Active, not recruiting
HIV Infections; HIV-Associated Lipodystrophy Syndrome
- Adding Adefovir Dipivoxil Versus Switching to Entecavir in Patients With Lamivudine-Resistant Chronic Hepatitis B
ClinicalTrials.gov Identifier: NCT00531167 - Recruiting
Chronic Hepatitis B
- A Study of PEGASYS® (Peginterferon Alfa-2a (40KD)) in Patients With Lamivudine Resistant HBeAg-Negative Chronic Hepatitis B.
ClinicalTrials.gov Identifier: NCT00460850 - Recruiting
Hepatitis B, Chronic
- A Study in Korea of Entecavir Versus Lamivudine in Adults With Chronic Hepatitis B Infection
ClinicalTrials.gov Identifier: NCT00393484 - Recruiting
Chronic Hepatitis B
- Lamivudine as an Adjuvant Therapy After Radiofrequency Ablation for Hepatocellular Carcinoma
ClinicalTrials.gov Identifier: NCT00555334 - Recruiting
Hepatocellular Carcinoma; Liver Cancer
- A Study to Compare the Safety and Effectiveness of Two Dosing Schedules of Lamivudine in Combination with Two Other Anti-HIV Drugs
ClinicalTrials.gov Identifier: NCT00002442 - Completed
HIV Infections
- A Comparison of Three Anti-HIV Drug Combinations in HIV-Infected Patients
ClinicalTrials.gov Identifier: NCT00005106 - Completed
HIV Infections
- Comparing FTC and Lamivudine in HIV-Infected Patients on a Stable Anti-HIV Drug Combination
ClinicalTrials.gov Identifier: NCT00002416 - Completed
HIV Infections
- Once a Day (QD) - Twice a Day (BID) Clinical Trial: Didanosine, Lamivudine and Efavirenz Versus Zidovudine, Lamivudine and Efavirenz in the Starting Treatment of HIV
ClinicalTrials.gov Identifier: NCT00256828 - Completed
HIV Infections
- Tenofovir Disoproxil Fumarate (DF)/Emtricitabine/Efavirenz Versus Combivir/Efavirenz in Antiretroviral-Naive HIV-1 Infected Subjects
ClinicalTrials.gov Identifier: NCT00112047 - Active, not recruiting
HIV Infections
- Effectiveness and Safety of Epivir/Ziagen/Zerit (3TC/ABC/d4T) Versus Epivir/Ziagen/Sustiva (3TC/ABC/EFV) Versus Epivir/Ziagen/Agenerase/Norvir (3TC/ABC/APV/RTV) in HIV Patients Who Have Never Received Treatment
ClinicalTrials.gov Identifier: NCT00005017 - Active, not recruiting
HIV Infections
- Lamivudine Plus Interferon Versus Lamivudine For The Treatment Of HBeAg Positive Chronic Hepatitis B Virus (HBV)
ClinicalTrials.gov Identifier: NCT00140725 - Completed
HBeAg positive chronic hepatitis B patients with active disease
- The STEAL Study
ClinicalTrials.gov Identifier: NCT00192634 - Recruiting
HIV
- Effectiveness of Adding Interleukin-2 to Anti-HIV Drugs in Patients Recently Infected with HIV
ClinicalTrials.gov Identifier: NCT00006441 - Recruiting
HIV Infections
- A Study of Increased Lactic Acid and Abnormal Fat Distribution in HIV-Positive Patients
ClinicalTrials.gov Identifier: NCT00005764 - Completed
HIV Infections; Lipodystrophy
- When to Start Anti-HIV Drugs in Children Infected With HIV
ClinicalTrials.gov Identifier: NCT00234091 - Recruiting
HIV Infections
- Potent Antiviral Therapy for Critically Ill HIV Infected Patients Admitted to Intensive Care
ClinicalTrials.gov Identifier: NCT00028327 - Completed
HIV Infections
- Evaluation of Four Anti-HIV Treatment Strategies in Resource-Limited South African Communities
ClinicalTrials.gov Identifier: NCT00255840 - Active, not recruiting
HIV Infections
- Early Versus Standard Start of Anti-HIV Therapy for Treatment-Naive Adults in Haiti
ClinicalTrials.gov Identifier: NCT00120510 - Recruiting
HIV Infections; Tuberculosis
- The Safety and Effectiveness of Lamivudine Plus Zidovudine, Used with and without 1592U89, in HIV-1 Infected Patients Who Have Never Taken Anti-HIV Drugs
ClinicalTrials.gov Identifier: NCT00002389 - Completed
HIV Infections
- The Safety and Effectiveness of Zidovudine Plus Lamivudine, Used with and without 1592U89, in HIV-1 Infected Children Who Have Taken Anti-HIV-1 Drugs
ClinicalTrials.gov Identifier: NCT00002391 - Completed
HIV Infections
- Randomized, Double Blind Trial of LdT (Telbivudine) versus Lamivudine in Adults with Compensated Chronic Hepatitis B
ClinicalTrials.gov Identifier: NCT00057265 - Completed
Chronic Hepatitis B
- Comparison of Three Anti-HIV Regimens to Prevent Nevirapine Resistance in Women who Take Nevirapine During Pregnancy
ClinicalTrials.gov Identifier: NCT00099632 - Recruiting
HIV Infections
- Entecavir Plus Adefovir Versus Entecavir or Adefovir Monotherapy for Chronic Hepatitis B Infected Subjects With Lamivudine-Resistant Virus
ClinicalTrials.gov Identifier: NCT00410202 - Recruiting
Hepatitis B, Chronic
- A Comparison of Zidovudine Plus Lamivudine Versus ddI Used Alone or in Combination with Zidovudine in HIV-1 Infected Children
ClinicalTrials.gov Identifier: NCT00001066 - Completed
HIV Infections
- A Comparison of BMS-232632 with Efavirenz, Each in Combination with Zidovudine-Lamivudine
ClinicalTrials.gov Identifier: NCT00013897 - Completed
HIV Infections
- Simplified Drug Regimens for HIV Patients in ACTG 388 or Patients Who Responded to A First Potent Combination Regimen
ClinicalTrials.gov Identifier: NCT00014937 - Completed
HIV Infections
- The Safety and Effectiveness of Nevirapine Plus Lamivudine Plus Other Anti-HIV Drugs
ClinicalTrials.gov Identifier: NCT00002368 - Completed
HIV Infections
- Preventing Sexual Transmission of HIV With Anti-HIV Drugs
ClinicalTrials.gov Identifier: NCT00074581 - Completed
HIV Infections; HIV Seronegativity
- Efavirenz and Lamivudine/Zidovudine for Treatment-Naive HIV Infected People in Wenxi County, Shanxi Province, China
ClinicalTrials.gov Identifier: NCT00100594 - Completed
HIV Infections
- A Study of Three Treatment Combinations Using Zidovudine Plus Lamivudine Plus Indinavir in HIV-Infected Patients
ClinicalTrials.gov Identifier: NCT00001084 - Completed
HIV Infections
- Comparing the Effectiveness of a Triple Nucleoside Reverse Transcriptase Inhibitor Regimen Versus a Protease Inhibitor-Based Regimen In the Prevention of Mother-to-Child Transmission of HIV
ClinicalTrials.gov Identifier: NCT00270296 - Recruiting
HIV Infections
- Anti-HIV Drugs for Ugandan Patients With HIV and Tuberculosis
ClinicalTrials.gov Identifier: NCT00078247 - Recruiting
HIV Infections; Tuberculosis
- A Study of Saquinavir Soft Gelatin Capsules Plus Zidovudine Plus Lamivudine in the Treatment of HIV-1 Infected Patients Who Have Never Taken Anti-HIV Drugs
ClinicalTrials.gov Identifier: NCT00002367 - Completed
HIV Infections
- The Effectiveness of Indinavir Plus Zidovudine Plus Lamivudine in HIV-Infected Patients with No Symptoms of Infection
ClinicalTrials.gov Identifier: NCT00002179 - Completed
HIV Infections
- A Study to Evaluate Various Combinations of Anti-HIV Medications to Treat Early HIV Infection
ClinicalTrials.gov Identifier: NCT00000919 - Completed
HIV Infections
- Combination Treatment With and Without Protease Inhibitors for Women Who Begin Therapy for HIV Infection During Pregnancy
ClinicalTrials.gov Identifier: NCT00017719 - Completed
HIV Infections; Pregnancy

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