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Eplerenone |
Inspra |
Eplerenone Systematic (IUPAC) name pregn-4-ene-7,21-dicarboxylic acid, 9,11-epoxy-17-hydroxy-3-oxo, γ-lactone, methyl ester (7α, 11α, 17α) Identifiers CAS number 107724-20-9 ATC code C03DA04 PubChem 5282131 DrugBank APRD00707 Chemical data Formula C24H30O6 Mol. weight 414.49 Pharmacokinetic data Bioavailability 69% Metabolism hepatic (CYP3A4) Half life 3–5 hours Excretion 67% renal 32% biliary Therapeutic considerations Pregnancy cat. B3 (Aust) ...
Wikipedia - [full article]
Eplerenone Clinical Trials
- Effectiveness of Eplerenone to Improve Target Organ Damage in Patients with Resistant Arterial Hypertension
ClinicalTrials.gov Identifier: NCT00138944 - Recruiting
Essential Hypertension
- A Comparison Of The Endpoints Of Death From A Cardiovascular Cause and Hospitalization For Worsening Heart Failure, In Patients Who Have NYHA Class II Heart Failure When They Are Treated With Eplerenone Or Placebo In Addition To Standard Heart Failure Med
ClinicalTrials.gov Identifier: NCT00232180 - Recruiting
Heart Failure
- Compare Effectiveness of Eplerenone Vs Atenolol in Reversing the Remodelling Resistance Arteries in Subjects with HT
ClinicalTrials.gov Identifier: NCT00147563 - Completed
Hypertension
- The Long-Term Study to Evaluate the Safety of Eplerenone in the Treatment of Hypertension in Children Aged 6 to 16 Years
ClinicalTrials.gov Identifier: NCT00147615 - Completed
Hypertension
- A Study to Evaluate the Efficacy and Safety of Eplerenone in the Treatment of Hypertension in Children.
ClinicalTrials.gov Identifier: NCT00147589 - Completed
Hypertension
- Effects of Eplerenone on Left Ventricular Remodelling Following Heart Attack
ClinicalTrials.gov Identifier: NCT00132093 - Completed
Myocardial Infarction
- Eplerenone, ACE Inhibition and Albuminuria
ClinicalTrials.gov Identifier: NCT00315016 - Recruiting
Diabetic Nephropathy
- EWISE: Study of Eplerenone in Women With Chest Pain, Coronary Vascular Dysfunction and Evidence of Myocardial Ischemia
ClinicalTrials.gov Identifier: NCT00187889 - Recruiting
Ischemic Heart Disease
- Eplerenone on Cardiac Remodeling in Patients with Left Ventricular Systolic Dysfunction and Mild to Moderate Heart Failure
ClinicalTrials.gov Identifier: NCT00082589 - Completed
Congestive Heart Failure
- The Effect of Eplerenone and Atorvastatin on Markers of Collagen Turnover in Diastolic Heart Failure
ClinicalTrials.gov Identifier: NCT00505336 - Recruiting
Diastolic Heart Failure
- CMR to Assess Fibrosis in Cardiomyopathy Using Eplerenone
ClinicalTrials.gov Identifier: NCT00401856 - Not yet recruiting
Cardiomyopathy
- PREDICT: Eplerenone in Reversing Endothelial and Diastolic Dysfunction and Improving Collagen Turnover in Diastolic Heart Failure
ClinicalTrials.gov Identifier: NCT00293150 - Recruiting
Diastolic Heart Failure
- Effect of Eplerenone on Endothelial Function in Patients With Stable Coronary Heart Disease
ClinicalTrials.gov Identifier: NCT00427284 - Suspended
Coronary Artery Disease
Resources
- Eplerenone (Drug Digest)
- Inspra (Drug Digest)
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