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Effect of Zinc Carnosine on Intestinal Permeability in Healthy Volunteers - Article


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Clinical Trial: Effect of Zinc Carnosine on Intestinal Permeability in Healthy Volunteers

This study is currently recruiting patients.
Verified by Imperial College London September 2005

Sponsors and Collaborators: Imperial College London
Wexham GI Trust
Information provided by: Imperial College London
ClinicalTrials.gov Identifier: NCT00149149

Purpose

Zinc carnosine is a food supplement which is available in the health food shops. We wish to see if it can reduce intestinal swelling in people who take non steroidal anti-inflammatory (anti-swelling) drugs (NSAIDS).
Condition Intervention Phase
Reduction in NSAID related gut damage
  Drug: Zinc carnosine
 Phase I

MedlinePlus consumer health information 

Study Type: Interventional
Study Design: Prevention, Randomized, Double-Blind, Placebo Control, Crossover Assignment, Safety/Efficacy Study

Official Title: Use of Zinc Carnosine on Intestinal Permeability in Healthy Volunteers Taking Non Steroidal Anti Inflammatory Drugs (NSAIDS):

Further Study Details: 
Primary Outcomes: Effect of Zinc Carnosine in reducing the gut damage caused by non steroidal anti inflammatory drugs
Secondary Outcomes: Differences in dyspepsia score; Differences in faecal calprotectin
Expected Total Enrollment:  12

Study start: May 2005

Eligibility

Ages Eligible for Study:  18 Years   -   35 Years,  Genders Eligible for Study:  Both

Accepts Healthy Volunteers

Criteria

Inclusion Criteria:

  • Age 18-35

Exclusion Criteria:

  • Conditions known to alter intestinal permeability eg previous bowel surgery, caeliac disease

Conditions where NSAIDs are contraindicated eg asthma, renal failure, heart failure

Diabetes

Any other serious ilness

Location and Contact Information

Please refer to this study by ClinicalTrials.gov identifier  NCT00149149

Asif Mahmood, MD      02083838067    asif.mahmood@imperial.ac.uk

United Kingdom
      Imperial College, London,  W12 0NN,  United Kingdom; Recruiting
Asif Mahmood, MD  02083838067    asif.mahmood@imperial.ac.uk 
Asif Mahmood, MRCP,  Sub-Investigator
Raymond Playford, FRCP PhD,  Principal Investigator

Study chairs or principal investigators

Raymond Playford, MD PhD,  Principal Investigator,  Imperial College   

More Information

Study ID Numbers:  05/Q0408/19
Last Updated:  September 7, 2005
Record first received:  September 7, 2005
ClinicalTrials.gov Identifier:  NCT00149149
Health Authority: United Kingdom: Medicines and Healthcare Products Regulatory Agency
ClinicalTrials.gov processed this record on 2005-09-13


Source: ClinicalTrials.gov
Cache Date: September 14, 2005

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Page Updated: June 1, 2005
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