This project examines experimental pain and chronic pain in the mouth, specifically the condition called atypical odontalgia (AO:atypical toothpain). In 16 patients with AO and 16 healthy persons, capsaicin (chili-pepper) is applied to the gingiva to cause pain. This pain is evaluated by the participants. In three sessions, 3 different medications are tested for effect on the pain. The medications are fentanyl, S-ketamine and placebo-treatment (saline). The aim is to know more about pain mechanisms in AO in order to develop an effective treatment.

Condition	Intervention	Phase
Odontalgia	Drug: fentanyl  Drug: S-ketamine	Phase IV

Further Study Details: 

Primary Outcomes: Pain; Sensitivity to heat and cold; Sensitivity to mechanical stimuli

Ages Eligible for Study:  18 Years and above,  Genders Eligible for Study:  Both

Accepts Healthy Volunteers

Criteria

Inclusion Criteria:

• Atypical odontalgia

Exclusion Criteria:

• BMI > 30
• Heart conditions
• Lung disease
• Diseases of the liver or kidneys
• Hypertension, untreated

Please refer to this study by ClinicalTrials.gov identifier  NCT00115102

Lene Baad-Hansen, DDS      +45 89424167    lbhansen@odont.au.dk

Denmark
      Danish Pain Research Center, Aarhus,  DK-8000,  Denmark; Recruiting

Study chairs or principal investigators

Troels Staehelin Jensen, MD, PhD, Dr.Sci,  Study Chair,  Aarhus University Hospital   

Study ID Numbers:  AO1
Record last reviewed:  March 2004
Last Updated:  June 30, 2005
Record first received:  June 20, 2005
ClinicalTrials.gov Identifier:  NCT00115102
Health Authority: Denmark: Danish Medicines Agency
ClinicalTrials.gov processed this record on 2005-07-05