Zalcitabine |
ddC; dideoxycytidine; Hivid |
Zalcitabine Systematic (IUPAC) name 4-amino-1-[5-(hydroxymethyl) tetrahydrofuran-2-yl]- 1H-pyrimidin-2-one Identifiers CAS number 7481-89-2 ATC code J05AF03 PubChem 24066 DrugBank APRD00562 Chemical data Formula C9H13N3O3 Mol. weight 211.218 g/mol Pharmacokinetic data Bioavailability ? Protein binding <4% Metabolism Renal elimination (ca.80%) Half life 2 hours Excretion ? Therapeutic considerations Pregnancy cat. C (USA) D (Aus) L ...
Wikipedia - [full article]
Zalcitabine Clinical Trials
- A Prospective, Randomized, Open-Label, Comparative Trial of Dideoxyinosine (ddI) Versus Dideoxycytidine (ddC) in HIV-Infected Patients Who Are Intolerant of or Who Have Failed Zidovudine (AZT) Therapy
ClinicalTrials.gov Identifier: NCT00000969 - Active, not recruiting
HIV Infections
- A Study on the Management of Combination Anti-HIV Drug Therapy in HIV-Positive Children with Prior Treatment
ClinicalTrials.gov Identifier: NCT00000902 - Active, not recruiting
HIV Infections
- A Study of Saquinavir and Zalcitabine, Used Alone and Together, in the Treatment of Advanced HIV Infection in Patients Who Stopped Taking or Who Cannot Take Zidovudine
ClinicalTrials.gov Identifier: NCT00002333 - Completed
HIV Infections
- An Open-Label Safety Program for the Use of Zalcitabine (Dideoxycytidine; ddC) in Pediatric Patients With Symptomatic HIV Infection Who Have Failed or Are Intolerant to AZT Monotherapy, or Who Have Completed Other ddC Protocols, or Are Ineligible for Othe
ClinicalTrials.gov Identifier: NCT00002118 - Completed
HIV Infections
- A Comparison of Zidovudine (AZT) Used Alone or in Combination with Didanosine (ddI) or Dideoxycytidine (ddC) in HIV-Infected Patients
ClinicalTrials.gov Identifier: NCT00001022 - Active, not recruiting
HIV Infections
- Comparison of Ro 31-8959 Plus Zidovudine (AZT) Versus AZT Plus Zalcitabine (ddC) Versus Ro 31-8959 Plus AZT Plus ddC
ClinicalTrials.gov Identifier: NCT00001040 - Completed
HIV Infections
- A Multicenter Dose Ranging Clinical Trial of 2',3'-Dideoxycytidine in the Treatment of Patients With AIDS and Advanced ARC.
ClinicalTrials.gov Identifier: NCT00000704 - Completed
HIV Infections
- A Comparison of Three Treatments for Advanced HIV Disease in Patients Who Have Received Nucleoside Therapy in the Past
ClinicalTrials.gov Identifier: NCT00001029 - Completed
HIV Infections
- A Study of ddC in Patients with AIDS or Advanced AIDS-Related Complex (ARC) Who Have Not Had Success with Zidovudine (AZT)
ClinicalTrials.gov Identifier: NCT00002279 - Completed
HIV Infections
- The Safety and Effectiveness of Three Anti-HIV Drug Combinations in HIV-Infected Patients Who Have Taken AZT
ClinicalTrials.gov Identifier: NCT00002436 - Completed
HIV Infections
- Dideoxycytidine ( Ro 24-2027 ). A Treatment Protocol for the Use of Dideoxycytidine ( ddC ) in Patients with AIDS or Advanced ARC who Cannot be Maintained on Zidovudine ( AZT ) Therapy.
ClinicalTrials.gov Identifier: NCT00002256 - Completed
HIV Infections
- A Study of Dideoxycytidine in HIV-Infected Patients
ClinicalTrials.gov Identifier: NCT00000997 - Completed
HIV Infections
- Open-Label Program of Dideoxycytidine ( ddC ) to be Used in Combination With Zidovudine ( AZT ) for Treatment of Advanced HIV Disease
ClinicalTrials.gov Identifier: NCT00002081 - Completed
HIV Infections
- The Safety and Effectiveness of Retrovir Plus HIVID Combined with Either Nevirapine or Invirase in the Treatment of HIV Infection
ClinicalTrials.gov Identifier: NCT00002347 - Completed
HIV Infections
- An Open-Label, Multicenter Study to Evaluate the Safety and Tolerability of Dideoxycytidine (ddC) in Patients With AIDS or Advanced ARC Who Previously Demonstrated Intolerance to Zidovudine (AZT) in Protocol N3300 or N3492
ClinicalTrials.gov Identifier: NCT00002265 - Completed
HIV Infections
- A Trial of Alternating 2',3'-Dideoxycytidine and Zidovudine in the Treatment of Patients With Advanced HIV Disease
ClinicalTrials.gov Identifier: NCT00000719 - Completed
HIV Infections
- (Ro 24-2027) A Randomized, Double-Blind, Comparative Study of Dideoxycytidine (ddC) versus Zidovudine (AZT) in Patients With AIDS or Advanced ARC
ClinicalTrials.gov Identifier: NCT00000679 - Completed
HIV Infections
- A Clinical Trial of Alternating and Intermittent Regimens of 2',3'-Dideoxycytidine and 3'-Azido-3'-Deoxythymidine in the Treatment of Patients With AIDS and Advanced ARC
ClinicalTrials.gov Identifier: NCT00000718 - Completed
HIV Infections
- A Randomized, Open-Label Study of Alternative Treatment Combinations of Dideoxycytidine (HIVID; ddC) and Zidovudine (AZT) in Patients With HIV Infection
ClinicalTrials.gov Identifier: NCT00002117 - Completed
HIV Infections
- A Trial of Two Doses of 2',3'-Dideoxycytidine (ddC) in the Treatment of Children With Symptomatic HIV Infection Who Are Intolerant of AZT and/or Who Show Progressive Disease While on AZT
ClinicalTrials.gov Identifier: NCT00000653 - Completed
HIV Infections
- A Randomized, Parallel Arm, Comparative, Open Label, Multicenter Study of the Activity and Safety of Two Formulations of Saquinavir in Combination With Other Antiretroviral Drugs
ClinicalTrials.gov Identifier: NCT00002162 - Completed
HIV Infections
- A Study of Zidovudine (AZT) Used Alone or in Combination with Other Anti-HIV Drugs in HIV-Infected Patients with Little or No Previous Treatment
ClinicalTrials.gov Identifier: NCT00002334 - Completed
HIV Infections
- A Study of Dideoxycytidine Plus Zidovudine in the Treatment of AIDS or Advanced AIDS Related Complex (ARC)
ClinicalTrials.gov Identifier: NCT00000978 - Completed
HIV Infections
- A Randomized, Unblinded Trial of Zidovudine Versus ddC in the Treatment of Patients Status Post PCP Who Received Long-Term Zidovudine Therapy in Protocol ACTG 002
ClinicalTrials.gov Identifier: NCT00000682 - Completed
HIV Infections
- The Safety and Effectiveness of a Two-Drug Combination in the Treatment of Patients with Hepatitis C Plus Advanced HIV Infections
ClinicalTrials.gov Identifier: NCT00001035 - Completed
HIV Infections; Hepatitis C
- A Randomized, Double-Blind, Four-Arm Study Comparing Combination Nucleoside, Alternating Nucleoside, and Triple-Drug Therapy for the Treatment of Advanced HIV Disease (CD4 <= 50/mm3)
ClinicalTrials.gov Identifier: NCT00000781 - Completed
HIV Infections
- The Antiviral Efficacy of Concurrent Zidovudine and 2',3'-dideoxyinosine or 2',3'-dideoxycytidine in Patients with Human Immunodeficiency Virus Disease
ClinicalTrials.gov Identifier: NCT00002001 - Completed
HIV Infections
- A Phase I Concentration-Targeted Multidose Study of Atevirdine Mesylate ( U-87201E ), AZT, and ddI or ddC
ClinicalTrials.gov Identifier: NCT00000753 - Completed
HIV Infections
- A Randomized, Double-Blind Phase II/III Trial of Monotherapy vs. Combination Therapy With Nucleoside Analogs in HIV-Infected Persons With CD4 Cells of 200-500/mm3
ClinicalTrials.gov Identifier: NCT00000625 - Completed
HIV Infections
- A Study of Dideoxycytidine Plus Zidovudine (AZT) in HIV-Infected Children Who Have Taken AZT
ClinicalTrials.gov Identifier: NCT00001032 - Completed
HIV Infections
- Effect of Indinavir Plus Two Other Anti-HIV Drugs on Blood Clotting in HIV-Positive Males with Hemophilia
ClinicalTrials.gov Identifier: NCT00002386 - Completed
HIV Infections; Hemophilia A
- A Study of Chemotherapy Plus ddI or ddC in the Treatment of AIDS-Related Kaposi's Sarcoma
ClinicalTrials.gov Identifier: NCT00000954 - Completed
Sarcoma, Kaposi; HIV Infections
- Dideoxycytidine ( Ro 24-2027 ) A Randomized, Open-Label, Comparative Study of Dideoxycytidine ( ddC ) versus Zidovudine ( AZT ) in Patients With AIDS or Advanced ARC Who Have Received Long-Term AZT Therapy.
ClinicalTrials.gov Identifier: NCT00000678 - Completed
HIV Infections
- A Randomized, Double Blind, Comparative Study of Dideoxycytidine (ddC) Alone or ddC/AZT Combination Versus Zidovudine (ZDV) Alone in Patients With HIV Infection Who Have Received Prior ZDV Therapy
ClinicalTrials.gov Identifier: NCT00000651 - Completed
HIV Infections
- Double-Blind Study of Timunox (Thymopentin) in Asymptomatic HIV-Infected Patients Receiving Either Mono (AZT or ddI) or Combination (AZT / ddI or AZT / ddC) Anti-Retroviral Therapy
ClinicalTrials.gov Identifier: NCT00002109 - Completed
HIV Infections
- The Effectiveness of Nelfinavir and Efavirenz, Used Alone or Together, Combined with Other Anti-HIV Drugs in Patients Who Have Taken Anti-HIV Drugs
ClinicalTrials.gov Identifier: NCT00001087 - Completed
HIV Infections
- A Randomized Trial to Evaluate the Safety and Efficacy of Combination Therapy With Retrovir ( AZT ) and HIVID ( ddC ) Versus Retrovir, HIVID, and Wellferon ( Interferon alfa-n1 ) for the Treatment of HIV Infection
ClinicalTrials.gov Identifier: NCT00002086 - Completed
HIV Infections
- Comparison of Anti HIV Drugs Used Alone or in Combination with Cytosine Arabinoside to Treat Progressive Multifocal Leukoencephalopathy (PML) in HIV-Infected Patients
ClinicalTrials.gov Identifier: NCT00001048 - Completed
HIV Infections; Leukoencephalopathy, Progressive Multifocal
- A Randomized Phase II Study of Two Doses of Interferon alfa-2a (IFN alfa-2a) in Combination With Zidovudine (AZT) and Dideoxycytidine (ddC) Versus AZT and ddC Only in Patients With HIV Infection and Less Than 400 CD4 Cells/mm3
ClinicalTrials.gov Identifier: NCT00000754 - Completed
HIV Infections

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