Ibritumomab tiuxetan

Zevalin

Ibritumomab tiuxetan, also sold under the trade name Zevalin®, is a monoclonal antibody radioimmunotherapy treatment for some forms of B cell non-Hodgkin's lymphoma, a myeloproliferative disorder of the lymphatic system. The drug uses the monoclonal mouse IgG1 antibody ibritumomab in conjunction with the chelator tiuxetan, to which a radioactive isotope (either yttrium-90 or indium-111) is added. Mechanism of action The antibody binds to the CD20 antigen found on the surface of normal a ...