Ibritumomab tiuxetan |
Zevalin |
Ibritumomab tiuxetan, also sold under the trade name ZevalinĀ®, is a monoclonal antibody radioimmunotherapy treatment for some forms of B cell non-Hodgkin's lymphoma, a myeloproliferative disorder of the lymphatic system. The drug uses the monoclonal mouse IgG1 antibody ibritumomab in conjunction with the chelator tiuxetan, to which a radioactive isotope (either yttrium-90 or indium-111) is added. Mechanism of action The antibody binds to the CD20 antigen found on the surface of normal a ...
Wikipedia - [full article]
Ibritumomab tiuxetan Clinical Trials
- Ibritumomab Tiuxetan for Treatment of Non-Follicular CD20+ Indolent Lymphomas
ClinicalTrials.gov Identifier: NCT00493454 - Active, not recruiting
Lymphoma
- Ibritumomab Tiuxetan + Rituximab Maintenance
ClinicalTrials.gov Identifier: NCT00582166 - Recruiting
Non-Hodgkin's Lymphoma
- Ibritumomab Tiuxetan for Early Stage Indolent Lymphomas
ClinicalTrials.gov Identifier: NCT00493467 - Recruiting
Lymphoma
- Rituximab and Combination Chemotherapy Combined With Yttrium Y 90 Ibritumomab Tiuxetan in Treating Older Patients With Previously Untreated B-Cell Lymphoma
ClinicalTrials.gov Identifier: NCT00058422 - Recruiting
noncontiguous stage II adult diffuse large cell lymphoma; stage III adult diffuse large cell lymphoma; stage IV adult diffuse large cell lymphoma
- Rituximab and Chemotherapy Followed by Ibritumomab Tiuxetan as Treatment for Low Grade Follicular Non-Hodgkin's Lymphoma
ClinicalTrials.gov Identifier: NCT00193440 - Active, not recruiting
Non-Hodgkins Lymphoma
- Yttrium Y 90 Ibritumomab Tiuxetan, Etoposide, Cyclophosphamide, and an Autologous Stem Cell Transplant in Treating Patients With Non-Hodgkin Lymphoma
ClinicalTrials.gov Identifier: NCT00562978 - Active, not recruiting
Lymphoma
- Yttrium Y 90 Ibritumomab Tiuxetan, Fludarabine, and Radiation Therapy in Treating Patients Who Are Undergoing a Donor Stem Cell Transplant for Relapsed Or Refractory Non-Hodgkin''s Lymphoma
ClinicalTrials.gov Identifier: NCT00119392 - Recruiting
adult non-Hodgkin''s lymphoma
- CpG 7909, Rituximab, and Yttrium Y 90 Ibritumomab Tiuxetan in Treating Patients With Non-Hodgkin's Lymphoma That is Recurrent or Did Not Respond to Previous Treatment
ClinicalTrials.gov Identifier: NCT00438880 - Active, not recruiting
Lymphoma
- Rituximab and Yttrium Y 90 Ibritumomab Tiuxetan in Treating Patients With Non-Hodgkin's Lymphoma
ClinicalTrials.gov Identifier: NCT00110149 - Recruiting
grade 1 follicular lymphoma; grade 2 follicular lymphoma; marginal zone lymphoma; Small Lymphocytic Lymphoma
- Iodine I 131 Tositumomab or Yttrium Y 90 Ibritumomab Tiuxetan in Treating Patients With Non-Hodgkin's Lymphoma
ClinicalTrials.gov Identifier: NCT00416312 - Recruiting
Lymphoma
- Yttrium Y 90 Ibritumomab Tiuxetan and Rituximab in Treating Patients With Previously Untreated Marginal Zone Lymphoma
ClinicalTrials.gov Identifier: NCT00453102 - Recruiting
Lymphoma
- Motexafin Gadolinium, Rituximab, and Yttrium Y 90 Ibritumomab Tiuxetan in Treating Patients With Stage II, Stage III, or Stage IV Relapsed or Refractory Non-Hodgkin's Lymphoma
ClinicalTrials.gov Identifier: NCT00089284 - Recruiting
adult non-Hodgkin's lymphoma; indolent or aggressive adult non-Hodgkin's lymphoma
- Yttrium Y 90 Ibritumomab Tiuxetan in Treating Patients With Waldenstrom's Macroglobulinemia
ClinicalTrials.gov Identifier: NCT00060294 - Completed
Waldenstrom's Macroglobulinemia
- Bortezomib, Rituximab, and Yttrium Y 90 Ibritumomab Tiuxetan in Treating Patients With Relapsed or Refractory Follicular Non-Hodgkin's Lymphoma
ClinicalTrials.gov Identifier: NCT00372905 - Recruiting
Lymphoma
- Rituximab, Fludarabine, Cyclophosphamide, and Yttrium Y 90 Ibritumomab Tiuxetan in Treating Patients With Relapsed B-Cell Non-Hodgkin's Lymphoma
ClinicalTrials.gov Identifier: NCT00397800 - Recruiting
Lymphoma
- Radioimmunotherapy in Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma
ClinicalTrials.gov Identifier: NCT00005592 - Active, not recruiting
recurrent diffuse small lymphocytic/marginal zone lymphoma; recurrent adult diffuse small cleaved cell lymphoma; ...
- Rituximab, Combination Chemotherapy, and Yttrium Y 90 Ibritumomab Tiuxetan in Treating Patients With Stage I or Stage II Lymphoma
ClinicalTrials.gov Identifier: NCT00088881 - Recruiting
stage I adult diffuse large cell lymphoma; stage II adult diffuse large cell lymphoma
- Bortezomib, Rituximab, and Yttrium Y 90 Ibritumomab Tiuxetan in Treating Patients With Relapsed or Refractory Low-Grade, Follicular, or Mantle Cell Non-Hodgkin's Lymphoma
ClinicalTrials.gov Identifier: NCT00334438 - Recruiting
Lymphoma
- Treatment With [90]Y-Ibritumomab Tiuxetan Versus no Treatment in Patients With Follicular Non Hodgkin Lymphoma (Stage III or IV) Having Achieved a Partial or Complete Remission After First Line Chemotherapy
ClinicalTrials.gov Identifier: NCT00185393 - Active, not recruiting
Non Hodgkin Lymphoma
- Yttrium Y 90 Ibritumomab Tiuxetan and Rituximab in Treating Patients With Relapsed or Refractory Diffuse Large B-Cell Non-Hodgkin's Lymphoma
ClinicalTrials.gov Identifier: NCT00073957 - Recruiting
recurrent adult diffuse large cell lymphoma; recurrent adult immunoblastic large cell lymphoma; anaplastic large cell lymphoma
- Rituximab, Prednisone, Cyclophosphamide, Doxorubicin, Vincristine, and Yttrium Y 90 Ibritumomab Tiuxetan in Treating Patients With Previously Untreated Mantle Cell Lymphoma
ClinicalTrials.gov Identifier: NCT00070447 - Active, not recruiting
contiguous stage II mantle cell lymphoma; noncontiguous stage II mantle cell lymphoma; stage III mantle cell lymphoma; stage IV mantle cell lymphoma
- Melphalan, Yttrium Y 90 Ibritumomab Tiuxetan, and Rituximab Followed by Autologous Stem Cell Transplant in Treating Older Patients With Non-Hodgkin's Lymphoma That Has Relapsed or Not Responded to Previous Treatment
ClinicalTrials.gov Identifier: NCT00392691 - Recruiting
Lymphoma
- Radioimmunotherapy With 90Y-Ibritumomab Tiuxetan as Part of a Dose Reduced Conditioning Regimen for Allogeneic Hematopoietic Cell Transplantation for the Treatment of Non-Hodgkin Lymphoma
ClinicalTrials.gov Identifier: NCT00302757 - Recruiting
Non-Hodgkin Lymphoma
- Yttrium Y 90 Ibritumomab Tiuxetan, Rituximab, Fludarabine, Melphalan, and Donor Stem Cell Transplant in Treating Patients With B-Cell Non-Hodgkin Lymphoma
ClinicalTrials.gov Identifier: NCT00577278 - Recruiting
Graft Versus Host Disease; Leukemia; Lymphoma
- Rituximab and Yttrium Y 90 Ibritumomab Tiuxetan in Treating Patients With Recurrent Primary CNS Lymphoma
ClinicalTrials.gov Identifier: NCT00082836 - Completed
primary central nervous system lymphoma
- Rituximab, Yttrium Y 90 Ibritumomab Tiuxetan, Melphalan, and Autologous Peripheral Stem Cell Transplant in Treating Patients With Previously Treated Multiple Myeloma
ClinicalTrials.gov Identifier: NCT00477815 - Recruiting
Multiple Myeloma and Plasma Cell Neoplasm
- Cyclophosphamide, Doxorubicin, Vincristine, Prednisone, and Radiation Therapy Followed By Rituximab and Yttrium Y 90 Ibritumomab Tiuxetan in Treating Patients With Stage I or Stage II Non-Hodgkin's Lymphoma
ClinicalTrials.gov Identifier: NCT00070018 - Recruiting
adult Burkitt's lymphoma; adult diffuse large cell lymphoma; adult non-Hodgkin's lymphoma; anaplastic large cell lymphoma; Mantle Cell Lymphoma
- 90Y-IBRITUMOMAB Tiuxetan and AHCI With HD Chemotherapy and Autologous Transplantation for Relapsed or Resistant NHL
ClinicalTrials.gov Identifier: NCT00186589 - Completed
Lymphoma, Non-Hodgkin
- Yttrium Y 90 Ibritumomab Tiuxetan and Rituximab in Treating Patients With Non-Hodgkin's Lymphoma
ClinicalTrials.gov Identifier: NCT00062114 - Completed
recurrent adult diffuse large cell lymphoma; recurrent adult diffuse mixed cell lymphoma; recurrent adult immunoblastic large cell lymphoma
- Yttrium Y 90 Ibritumomab Tiuxetan and Rituximab in Treating Patients With Post-Transplant Lymphoproliferative Disorder
ClinicalTrials.gov Identifier: NCT00064246 - Completed
adult Burkitt's lymphoma; adult diffuse large cell lymphoma; indolent, adult non-Hodgkin's lymphoma; post-transplant lymphoproliferative disorder
- Radiolabeled Monoclonal Antibody With or Without Peripheral Stem Cell Transplantation in Treating Children With Recurrent or Refractory Lymphoma
ClinicalTrials.gov Identifier: NCT00036855 - Completed
AIDS-Related Lymphoma; childhood large cell lymphoma; childhood lymphoblastic lymphoma; childhood small noncleaved cell lymphoma; ...
- Radiolabeled Monoclonal Antibody in Treating Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma
ClinicalTrials.gov Identifier: NCT00033423 - Active, not recruiting
grade 1 follicular lymphoma; grade 2 follicular lymphoma; grade 3 follicular lymphoma; marginal zone lymphoma; Small Lymphocytic Lymphoma
- Study Of Yttrium-ibritumomab (Zevalin) For the Treatment Of Patients With Relapsed And Refractory Mantle Cell Lymphoma
ClinicalTrials.gov Identifier: NCT00038623 - Active, not recruiting
Lymphoma, Mantle-Cell
- Radiolabeled Monoclonal Antibody Therapy and High-Dose Chemotherapy Followed By Autologous Peripheral Stem Cell Transplantation in Treating Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma
ClinicalTrials.gov Identifier: NCT00058292 - Active, not recruiting
adult non-Hodgkin's lymphoma
- Comparative Trial between Bexxar and Zevalin
ClinicalTrials.gov Identifier: NCT00078676 - Not yet recruiting
Follicular Lymphoma; Diffuse Large Cell Lymphoma
- Monoclonal Antibody Therapy and Peripheral Stem Cell Transplantation in Treating Patients With Non-Hodgkin's Lymphoma
ClinicalTrials.gov Identifier: NCT00017381 - Recruiting
adult non-Hodgkin's lymphoma; indolent or aggressive adult non-Hodgkin's lymphoma
- Yttrium-90 Ibritumomab Tiuxetan (Zevalin) with BEAM in Relapsed Low Grade B-Cell Lymphoma
ClinicalTrials.gov Identifier: NCT00138086 - Completed
B Cell Lymphoma
- Radiolabeled Monoclonal Antibody Plus Rituximab With and Without Filgrastim and Interleukin-11 in Treating Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma
ClinicalTrials.gov Identifier: NCT00012298 - Recruiting
grade 1 follicular lymphoma; grade 2 follicular lymphoma; grade 3 follicular lymphoma; indolent, adult non-Hodgkin's lymphoma; marginal zone lymphoma; ...
- Monoclonal Antibody Therapy in Treating Patients With Non-Hodgkin's Lymphoma That Has Relapsed After High-Dose Chemotherapy and Autologous Stem Cell Transplantation
ClinicalTrials.gov Identifier: NCT00031642 - Completed
adult non-Hodgkin's lymphoma
- Safety and Efficacy of Zevalin in the Treatment of Non-Hodgkin's Lymphoma
ClinicalTrials.gov Identifier: NCT00057343 - Terminated
Non-Hodgkin's Lymphoma

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