To determine if platelet dysfunction and/or pharmacologic drug interaction occurs in patients taking both AZT and ibuprofen, which might account for enhanced bleeding tendency.

Ages Eligible for Study:  12 Years and above,  Genders Eligible for Study:  Both

Criteria

Inclusion Criteria

Patients must have:

• Hemophilia.
• HIV-seropositivity confirmed by Western Blot. Prior Medication: Required:

AZT for study patients. Allowed:

Ibuprofen.

Exclusion Criteria

Co-existing Condition: Patients with the following symptoms and conditions are excluded: Hospitalization for opportunistic infection, bacterial infection or malignancy. Concurrent Medication: Excluded:

• AZT (for control group).
• Antibiotics or other medication for opportunistic infection, bacterial infection, or malignancy. Patients with the following prior conditions are excluded: Hospitalization for opportunistic infection, bacterial infection, or malignancy. Required:
• Ibuprofen.
• AZT 1-2 gm daily (for study patient) or not taking AZT (for control).