Article: Ifosfamide

Ifosfamide
Systematic (IUPAC) name
3-(2-chloroethyl)-2 -[(2-chloroethyl)amino]tetrahydro -2H-1,3,2-oxazaphosphorine 2-oxide
Identifiers
CAS number	?
ATC code	??
PubChem	?
DrugBank	?
Chemical data
Formula	C7H15Cl2N2O2P
Mol. weight	261.1
Pharmacokinetic data
Bioavailability	100%
Metabolism	Hepatic
Half life	60-80% in 72 hours
Excretion	Renal
Therapeutic considerations
Pregnancy cat.	?
Legal status	?
Routes	intravenously

Ifosfamide (pronounced eye.fos'.fa.mide) (also marketed as Mitoxana and Ifex) is is a white powder which, when prepared for use in chemotherapy becomes a clear, colorless fluid. The delivery is intravenous, and is given as a treatment for a variety of cancers, including:

• Testicular cancer
• Breast cancer
• Lymphoma (Non-Hodgkin)
• Soft tissue sarcoma
• Osteogenic sarcoma
• Lung cancer
• Cervical cancer
• Ovarian cancer
• Bone cancer

Ifosfamide is often used in conjunction with mesna to avoid internal bleeding in the patient.