Ifosfamide |
Ifex |
Clinical Trial: Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Metastatic Testicular Cancer
This study is no longer recruiting patients.
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Purpose
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
PURPOSE: Phase II trial to study the effectiveness of combining paclitaxel, ifosfamide, and cisplatin in treating patients who have metastatic testicular cancer that has recurred following treatment.
| Condition | Treatment or Intervention | Phase |
|---|---|---|
| Testicular Cancer Reproductive Cancer | Drug: cisplatin Drug: ifosfamide Drug: paclitaxel Procedure: chemotherapy | Phase II |
MedlinePlus related topics: Testicular Cancer
Study Type: Interventional
Study Design: Treatment
Official Title: Phase II Study of Paclitaxel, Ifosfamide, and Cisplatin in Patients With Metastatic Nonseminomatous Germ Cell Tumor of the Testis in First Relapse Following First Line Treatment With Bleomycin, Etoposide, and Cisplatin
OBJECTIVES:
- Determine the feasibility of combining paclitaxel, ifosfamide, and cisplatin induction in patients with metastatic nonseminomatous germ cell tumor of the testis in first relapse following first line treatment with bleomycin, etoposide, and cisplatin.
- Determine the response rates to this regimen in these patients
OUTLINE: This is a multicenter study.
Patients receive paclitaxel IV over 3 hours and ifosfamide IV and cisplatin IV daily for 5 days. Patients with stable or responding disease repeat treatment every 3 weeks for 4 courses in the absence of disease progression or unacceptable toxicity.
PROJECTED ACCRUAL: A minimum of 25 patients will be accrued for this study.
Eligibility
Ages Eligible for Study: 16 Years - 64 Years, Genders Eligible for Study: Both
Criteria
DISEASE CHARACTERISTICS:
- Metastatic nonseminomatous germ cell tumor of the testis
- In first relapse following first line treatment with bleomycin, etoposide, and cisplatin
- Biopsy proven germ cell tumor OR
- Rising tumor markers (alpha fetoprotein and/or human chorionic gonadotropin)
- No brain metastases
PATIENT CHARACTERISTICS: Age:
- 16 to 64
Performance status:
- 0-2
Life expectancy:
- Not specified
Hematopoietic:
- Not specified
Hepatic:
- Not specified
Renal:
- Glomerular filtration rate greater than 50 mL/min
Other:
- No other prior malignancy except curatively treated nonmelanomatous skin cancer or superficial bladder cancer
PRIOR CONCURRENT THERAPY: Biologic therapy:
- Not specified
Chemotherapy:
- See Disease Characteristics
Endocrine therapy:
- Not specified
Radiotherapy:
- Not specified
Surgery:
- Not specified
Other:
- No prior experimental drugs
Location Information
United Kingdom, Wales
Velindre Hospital, Cardiff, Wales, CF14 2TL, United Kingdom
Malcolm D. Mason, MD, Study Chair, Velindre Hospital
More Information
Clinical trial summary from the National Cancer Institute's PDQ® database
Record last reviewed: May 2003
Last Updated: October 13, 2004
Record first received: December 10, 1999
ClinicalTrials.gov Identifier: NCT00004077
Health Authority: Unspecified
ClinicalTrials.gov processed this record on 2005-04-08
Source: ClinicalTrials.gov
Cache Date: April 9, 2005
Resources
- Ifex (Drug Digest)
- Ifosfamide (Drug Digest)

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