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Indomethacin |
Indocin |
Indometacin Systematic (IUPAC) name 1-(4-chlorobenzoyl)-5-methoxy- 2-methyl-1-H-indole-3-acetic acid Identifiers CAS number 53-86-1 ATC code C01EB03 M01AB01, M02AA23, S01BC01 PubChem 3715 DrugBank APRD00109 Chemical data Formula C19H16NClO4 Mol. weight 357.79 g.mol-1 Pharmacokinetic data Bioavailability ~100% (oral), 80–90% (rectal) Protein binding 99% Metabolism Hepatic Half life 4.5 hours Excretion Renal 60%, faecal 33% Therapeutic considera ...
Wikipedia - [full article]
Indomethacin Clinical Trials
- Indomethacin Germinal Matrix Hemorrhage/Intraventricular Hemorrage (GMH/IVH) Prevention Trial
ClinicalTrials.gov Identifier: NCT00033917 - Active, not recruiting
intraventricular hemorrhage (IVH); bleeding in the brain; prematurity; very low birth weight infants
- Indomethacin vs. Placebo in Women With PPROM
ClinicalTrials.gov Identifier: NCT00466128 - Recruiting
Preterm Premature Rupture of Membranes
- Indomethacin Versus Nifedipine for Preterm Labor Tocolysis
ClinicalTrials.gov Identifier: NCT00486824 - Recruiting
Obstetric Labor, Premature
- The Effect of Indomethacin in Monosymptomatic Enuresis Nocturnal
ClinicalTrials.gov Identifier: NCT00226122 - Recruiting
Enuresis
- A Study Evaluating the Effect of of Etoricoxib and Indomethacin in the Treatment of Acute Gout.
ClinicalTrials.gov Identifier: NCT00142558 - Active, not recruiting
acute gout
- Comparison of 2 Different Indomethacin Dosing Protocols to Treat Infants Delivered at <28 Weeks Gestation With a Persistent Patent Ductus Arteriosus
ClinicalTrials.gov Identifier: NCT00187447 - Recruiting
Patent Ductus Arteriosus
- Mechanisms of Human Cutaneous Microcirculation in Healthy Volunteers
ClinicalTrials.gov Identifier: NCT00152724 - Recruiting
Healthy volunteers
- Trial of Indomethacin Prophylaxis in Preterm Infants (TIPP)
ClinicalTrials.gov Identifier: NCT00009646 - Completed
Infant, very low birth weight; Infant, Premature; Ductus Arteriosus, Patent
- Comparing Ibuprofen And Indomethacin For The Treatment Of The Patent Ductus Arteriosus in Very Premature Babies
ClinicalTrials.gov Identifier: NCT00470743 - Not yet recruiting
Ductus Arteriosus, Patent; Prematurity
- Indomethacin Plus Biological Therapy in Treating Patients With Advanced Melanoma
ClinicalTrials.gov Identifier: NCT00002535 - Completed
stage III melanoma; Stage IV Melanoma; Recurrent Melanoma
- Ibuprofen vs. Continuous Indomethacin in the Treatment of PDA
ClinicalTrials.gov Identifier: NCT00485160 - Completed
Patent Ductus Arteriosus
- Magnesium Sulfate versus Indomethacin for Preterm Labor
ClinicalTrials.gov Identifier: NCT00116623 - Terminated
Labor, Premature
- Effect of Indomethacin on the Progression of Alzheimer's Disease
ClinicalTrials.gov Identifier: NCT00432081 - Completed
Alzheimer Disease
- Fluorouracil, Phenylbutyrate, Indomethacin, and Interferon Gamma in Treating Patients With Advanced Colorectal Cancer
ClinicalTrials.gov Identifier: NCT00002796 - Completed
stage IV colon cancer; Stage IV rectal cancer; recurrent colon cancer; recurrent rectal cancer; adenocarcinoma of the colon; ...
- Effects of Indomethacin on Retinal and Choroidal Blood Flow in Healthy Volunteers
ClinicalTrials.gov Identifier: NCT00275730 - Completed
Ocular Physiology; Regional Blood Flow
- The Use of B-Type Natriuretic Peptide (BNP) to Predict Closure of a Patent Ductus Arteriosus (PDA) in Premature Infants
ClinicalTrials.gov Identifier: NCT00500305 - Completed
Indomethacin Therapy; Patent Ductus Arteriosus
- INFLUENCE OF TOPICAL INDOMETHACIN ON HYPOTHENSIVE EFFECT OF BRIMONIDINE
ClinicalTrials.gov Identifier: NCT00347035 - Terminated
Glaucoma
- Management of Patent Ductus in Premature Infants
ClinicalTrials.gov Identifier: NCT00000494 - Completed
Cardiovascular Diseases; Defect, Congenital Heart; Ductus Arteriosus, Patent; Heart Diseases
Resources
- Indocin (Drug Digest)
- Indomethacin (Drug Digest)
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