Memantine |
Namenda |
Memantine Systematic (IUPAC) name 1-amino-3,5-dimethyl-adamantane Identifiers CAS number 19982-08-2 ATC code N06DX01 PubChem 4054 DrugBank APRD00221 Chemical data Formula C12H21N Mol. weight 179.3 g/mol Pharmacokinetic data Bioavailability ~100% Metabolism Hepatic (<10%) Half life 60–100 hours Excretion Renal Therapeutic considerations Pregnancy cat. B2 (Au), B (U.S.) Legal status S4 (Au), POM (UK), ℞-only (U.S.) Routes Oral Memantine ...
Wikipedia - [full article]
Memantine Clinical Trials
- Vitamin E and Namenda (Memantine) for the Treatment of Patients With Mild to Moderate Alzheimer''s Disease on Aricept (Donepezil)
ClinicalTrials.gov Identifier: NCT00235716 - Recruiting
Alzheimer''s Disease
- Memantine for the Prevention of Negative Symptomatology
ClinicalTrials.gov Identifier: NCT00148590 - Recruiting
Schizophrenia
- Effectiveness of Memantine in Treating Cocaine-Dependent Individuals - 2
ClinicalTrials.gov Identifier: NCT00134901 - Active, not recruiting
Cocaine-Related Disorders
- Memantine for the Treatment of Negative Symptomatology
ClinicalTrials.gov Identifier: NCT00148616 - Recruiting
Chronic schizophrenia
- Effectiveness of Memantine in Treating Heroin-Dependent Individuals - 1
ClinicalTrials.gov Identifier: NCT00126711 - Recruiting
Heroin Dependence
- Effect of Memantine Versus Bupropion on Smoking Relapse in Nicotine-Dependent Individuals - 3
ClinicalTrials.gov Identifier: NCT00136786 - Not yet recruiting
Tobacco Use Disorder
- Memantine Augmentation in Obsessive-Compulsive Disorder
ClinicalTrials.gov Identifier: NCT00264238 - Recruiting
Obsessive-Compulsive Disorder [F03.080.600]
- Memantine Augmentation of Antidepressants
ClinicalTrials.gov Identifier: NCT00344682 - Recruiting
Depressive Disorder
- Study of Memantine in Assessment of Selected Measures of Volumetric Magnetic Resonance Imaging (MRI) and Cognition in Moderate AD (Alzheimer’s Disease)
ClinicalTrials.gov Identifier: NCT00334906 - Active, not recruiting
Alzheimer's Disease
- Evaluation of the Safety and Efficacy of Memantine as Adjunctive Treatment in Schizophrenia Patients
ClinicalTrials.gov Identifier: NCT00097942 - Completed
Schizophrenia
- A Study of the Safety and Efficacy of Memantine in Moderate to Severe Alzheimer's Disease
ClinicalTrials.gov Identifier: NCT00322153 - Active, not recruiting
Alzheimer's Disease
- Memantine Versus Donepezil in Early Stages of Alzheimer's Disease
ClinicalTrials.gov Identifier: NCT00505167 - Recruiting
Dementia, Alzheimer Type
- Clinical Trial of Memantine for Major Depression
ClinicalTrials.gov Identifier: NCT00040261 - Completed
Depression
- The Effect of Memantine on Functional Outcomes and Motor Neuron Degeneration in ALS
ClinicalTrials.gov Identifier: NCT00409721 - Recruiting
Amyotrophic Lateral Sclerosis
- Magnetic Resonance Spectroscopy Study of Memantine in Alzheimer's Disease
ClinicalTrials.gov Identifier: NCT00551161 - Recruiting
Alzheimer Disease
- Memantine Treatment for Improving Rehabilitation Outcomes and Preventing Depression in Older Adults
ClinicalTrials.gov Identifier: NCT00183729 - Recruiting
Depression
- An Evaluation of the Safety and Efficacy of Memantine in Agitated Patients with Moderate to Severe Alzheimer's Disease
ClinicalTrials.gov Identifier: NCT00097916 - Completed
Alzheimer's Disease
- Memantine and Constraint-Induced Language Therapy in Chronic Poststroke Aphasia:A Randomized Controlled Trial
ClinicalTrials.gov Identifier: NCT00196703 - Recruiting
Aphasia; Stroke
- An Evaluation of the Safety and Efficacy of Memantine in Patients with Acute Mania Associated with Bipolar I Disorder
ClinicalTrials.gov Identifier: NCT00106405 - Completed
Bipolar Disorder
- Memantine or Riluzole Prophylaxis for Corticosteroid-Induced Mood and Declarative Memory Changes
ClinicalTrials.gov Identifier: NCT00283309 - Recruiting
Mood; Memory Deficit
- Memantine for Agitation in Dementia
ClinicalTrials.gov Identifier: NCT00371059 - Recruiting
Dementia
- Memantine as an Adjunctive Agent to Reduce Neurocognitive Deficits Following Unilateral ECT for the Treatment of a Severe Major Depressive Episode
ClinicalTrials.gov Identifier: NCT00186498 - Recruiting
Major Depressive Disorder
- The Effect of Memantine on Brain Structure and Chemistry in Alzheimer's Disease Patients
ClinicalTrials.gov Identifier: NCT00255086 - Recruiting
Alzheimer's Disease
- Trial of Memantine for Cognitive Impairment in Multiple Sclerosis
ClinicalTrials.gov Identifier: NCT00300716 - Recruiting
Multiple Sclerosis; Cognition Disorders
- Memantine Augmentation of Lamotrigine Incomplete-Response in Bipolar Depression
ClinicalTrials.gov Identifier: NCT00305578 - Recruiting
Bipolar Depression
- Effect of Memantine on Functional Communication in Patients With Alzheimer's Disease
ClinicalTrials.gov Identifier: NCT00469456 - Recruiting
Alzheimer's Disease
- Memantine and Down's Syndrome
ClinicalTrials.gov Identifier: NCT00240760 - Recruiting
Down's Syndrome; Dementia; Learning Disabilities
- A Pilot Clinical Trial Of Memantine for Essential Tremor
ClinicalTrials.gov Identifier: NCT00439699 - Recruiting
Essential Tremor
- Developing Medication For Tobacco Addiction - 1
ClinicalTrials.gov Identifier: NCT00136747 - Recruiting
Tobacco Use Disorder
- Memantine in Patients with Chronic Glaucoma
ClinicalTrials.gov Identifier: NCT00141882 - Completed
Open-Angle Glaucoma
- Memantine as a Supplement to Naltrexone in Treating Heroin Dependence
ClinicalTrials.gov Identifier: NCT00476242 - Recruiting
Opioid Dependence; Heroin Dependence
- A 10 Week Open-Label Pilot Study to Evaluate the Effectiveness and Safety of Memantine(Namenda) as Augmentation Therapy in Patients With Generalized Anxiety Disorder
ClinicalTrials.gov Identifier: NCT00411398 - Recruiting
General Anxiety Disorder, Social Anxiety Disorder
- Double-Blind, Parallel Group, Placebo-Controlled Trial of the Efficacy and Tolerability of Memantine (20 Mg) in Frontotemporal Dementia (FTD) Patients.
ClinicalTrials.gov Identifier: NCT00200538 - Recruiting
Patients with frontotemporal dementia
- Memantine for Disability in Amyotrophic Lateral Sclerosis (MEDALS)
ClinicalTrials.gov Identifier: NCT00353665 - Recruiting
Amyotrophic Lateral Sclerosis
- Memantine in Systemic Lupus Erythematosus
ClinicalTrials.gov Identifier: NCT00181298 - Not yet recruiting
Systemic Lupus Erythematosus
- A Study to Evaluate the Use of Memantine In Combination with Anti-HIV Drugs to Treat AIDS Dementia Complex (ADC)
ClinicalTrials.gov Identifier: NCT00000867 - Completed
AIDS Dementia Complex; HIV Infections
- Memantine (10mg BID) for the Frontal and Temporal Subtypes of Frontotemporal Dementia
ClinicalTrials.gov Identifier: NCT00545974 - Recruiting
Frontal Lobe Dementia; Frontotemporal Lobe Dementia; Semantic Dementia
- Memantine for Treatment of Cognitive Impairment in Patients With Parkinson's Disease and Dementia
ClinicalTrials.gov Identifier: NCT00294554 - Recruiting
Parkinson's Disease; Cognitive Impairment; Dementia
- Memantine for Agitation and Aggression in Severe Alzheimer's Disease
ClinicalTrials.gov Identifier: NCT00401167 - Not yet recruiting
Alzheimer's Disease
- Memantine in Preventing Side Effects in Patients Undergoing Whole-Brain Radiation Therapy for Brain Metastases From Solid Tumors
ClinicalTrials.gov Identifier: NCT00566852 - Not yet recruiting
Brain and Central Nervous System Tumors; Cognitive/Functional Effects; Neurotoxicity; Unspecified Adult Solid Tumor, Protocol Specific
- Memantine for Corticosteroid-Induced Mood and Declarative Memory Changes
ClinicalTrials.gov Identifier: NCT00280774 - Completed
Physiological Effects of Drugs
- Memantine in Patients With Chronic Glaucoma
ClinicalTrials.gov Identifier: NCT00168350 - Completed
Open-Angle Glaucoma
- Safety and Tolerability of Rivastigmine With Add-on Memantine in Patients With Probable Alzheimer's Disease
ClinicalTrials.gov Identifier: NCT00305903 - Completed
Alzheimer's Disease
- Efficacy Study of Memantine Hydrochloride and Escitalopram for the Treatment of Co-Morbid Depression and Alcoholism.
ClinicalTrials.gov Identifier: NCT00368862 - Completed
Alcoholism; Depression
- Rivastigmine Monotherapy and Combination Therapy With Memantine in Patients With Moderately Severe Alzheimer's Disease Who Failed to Benefit From Previous Cholinesterase Inhibitor Treatment
ClinicalTrials.gov Identifier: NCT00234637 - Completed
Alzheimer's Disease
- Parkinson's Disease Evaluated by PET and the Effect of Memantine
ClinicalTrials.gov Identifier: NCT00375778 - Completed
Parkinson's Disease
- A Placebo-Controlled Trial of Memantine for Alcohol Dependence
ClinicalTrials.gov Identifier: NCT00246415 - Completed
Alcohol Dependence (Primary Condition); Alcohol Abuse
- A 52 Week Open Label Trial of Memantine for Frontotemporal Lobar Degeneration
ClinicalTrials.gov Identifier: NCT00187525 - Completed
Frontotemporal Lobar Degeneration
- Testing the Effectiveness of Medications Used to Treat Heroin Dependence - 1
ClinicalTrials.gov Identifier: NCT00125515 - Completed
Heroin Dependence
- An Open-Label Trial of Memantine in the Treatment of Binge Eating Disorder
ClinicalTrials.gov Identifier: NCT00330655 - Completed
Binge Eating Disorder
- Prophylactic Effect of Memantine in Chronic Tension-Type Headache
ClinicalTrials.gov Identifier: NCT00315666 - Completed
Tension-Type Headache

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