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Mercaptopurine |
6-MP; Purinethol |
Mercaptopurine Systematic (IUPAC) name 3,7-dihydropurine-6-thione Identifiers CAS number 50-44-2 ATC code L01BB02 PubChem 667490 DrugBank APRD01096.txt Chemical data Formula C5H4N4S Mol. weight 152.181 Pharmacokinetic data Bioavailability 5-37% Metabolism ? Half life 60-120 min., longer for its active metabolites Excretion Renal Therapeutic considerations Pregnancy cat. ?,(Increased Risk of Abortion) Legal status ? Routes Oral Mercapt ...
Wikipedia - [full article]
Mercaptopurine Clinical Trials
- A Multicenter Phase II Study in Adults with Untreated Acute Lymphoblastic Leukemia
ClinicalTrials.gov Identifier: NCT00136435 - Recruiting
Acute Lymphoblastic Leukemia
- Phase II Study of Carmustine, Streptozocin, and Mercaptopurine for Refractory or Recurrent Brain Neoplasms
ClinicalTrials.gov Identifier: NCT00004688 - Active, not recruiting
Anaplastic Astrocytoma; Anaplastic Oligodendroglioma; Mixed Gliomas; Glioblastoma Multiforme; Recurrent Brain Tumor
- Tretinoin, Cytarabine, and Daunorubicin With or Without Arsenic Trioxide Followed by Tretinoin With or Without Mercaptopurine and Methotrexate in Treating Patients With Acute Promyelocytic Leukemia
ClinicalTrials.gov Identifier: NCT00003934 - Active, not recruiting
untreated adult acute myeloid leukemia; untreated childhood acute myeloid leukemia and other myeloid malignancies; ...
- Combination Chemotherapy With or Without Gemtuzumab Followed By Tretinoin, Mercaptopurine, and Methotexate or Observation in Treating Patients With Acute Promyelocytic Leukemia
ClinicalTrials.gov Identifier: NCT00492856 - Recruiting
Leukemia
- Chemotherapy in Treating Patients With Acute Lymphoblastic Leukemia and Diffuse Non-Hodgkin's Lymphoma
ClinicalTrials.gov Identifier: NCT00018954 - Active, not recruiting
Lymphoma; Leukemia
- Combination Chemotherapy With or Without Bone Marrow Transplantation in Treating Patients With Previously Untreated Acute Lymphocytic Leukemia
ClinicalTrials.gov Identifier: NCT00002665 - Active, not recruiting
Thrombocytopenia; Leukemia, Lymphocytic; Neutropenia
- Combination Chemotherapy in Treating Children With Newly Diagnosed Acute Lymphoblastic Leukemia
ClinicalTrials.gov Identifier: NCT00005596 - Active, not recruiting
untreated childhood acute lymphoblastic leukemia
- Combination Chemotherapy in Treating Children With Newly Diagnosed Acute Lymphocytic Leukemia
ClinicalTrials.gov Identifier: NCT00003671 - Active, not recruiting
B-cell childhood acute lymphocytic leukemia; untreated childhood acute lymphocytic leukemia
- Combination Chemotherapy in Treating Patients With Newly Diagnosed Acute Lymphoblastic Leukemia
ClinicalTrials.gov Identifier: NCT00016302 - Active, not recruiting
untreated childhood acute lymphoblastic leukemia; T-cell childhood acute lymphoblastic leukemia
- Combination Chemotherapy in Treating Children With Acute Lymphoblastic Leukemia
ClinicalTrials.gov Identifier: NCT00005603 - Active, not recruiting
childhood acute lymphoblastic leukemia in remission; B-cell childhood acute lymphoblastic leukemia
- Combination Chemotherapy in Treating Children With Acute Lymphoblastic Leukemia
ClinicalTrials.gov Identifier: NCT00005585 - Active, not recruiting
childhood acute lymphoblastic leukemia in remission; B-cell childhood acute lymphoblastic leukemia
- Randomized Controlled Trial to Test Efficacy of High-Dose MTX for Adult Acute Lymphoblastic Leukemia (ALL)
ClinicalTrials.gov Identifier: NCT00131027 - Recruiting
Acute Lymphoblastic Leukemia
- Combination Chemotherapy and Radiation Therapy in Treating Children With Acute Lymphoblastic Leukemia
ClinicalTrials.gov Identifier: NCT00004034 - Active, not recruiting
L2 childhood acute lymphoblastic leukemia; untreated childhood acute lymphoblastic leukemia; cardiac toxicity; ...
- Combination Chemotherapy in Treating Adults With Acute Lymphocytic Leukemia
ClinicalTrials.gov Identifier: NCT00002531 - Active, not recruiting
non-T, non-B adult acute lymphoblastic leukemia; untreated adult acute lymphoblastic leukemia; B-cell adult acute lymphoblastic leukemia; ...
- Combination Chemotherapy in Treating Children With Very High Risk Acute Lymphocytic Leukemia
ClinicalTrials.gov Identifier: NCT00003783 - Active, not recruiting
L2 childhood acute lymphoblastic leukemia; untreated childhood acute lymphoblastic leukemia; L1 childhood acute lymphoblastic leukemia; ...
- Phase 2 Study of Applying Pediatric Regimens to Younger Adult Patients with Acute Lymphoblastic Leukemia (ALL)
ClinicalTrials.gov Identifier: NCT00131053 - Recruiting
Acute Lymphoblastic Leukemia
- Hormone Therapy Plus Chemotherapy in Treating Children With Acute Lymphocytic Leukemia
ClinicalTrials.gov Identifier: NCT00003437 - Active, not recruiting
recurrent childhood acute lymphoblastic leukemia; untreated childhood acute lymphoblastic leukemia
- Combination Chemotherapy in Treating Patients With Untreated Acute Lymphoblastic Leukemia
ClinicalTrials.gov Identifier: NCT00003700 - Active, not recruiting
L1 adult acute lymphoblastic leukemia; L2 adult acute lymphoblastic leukemia; untreated adult acute lymphoblastic leukemia
- Combination Chemotherapy in Treating Children or Adolescents With Newly Diagnosed Lymphoblastic Lymphoma
ClinicalTrials.gov Identifier: NCT00004228 - Active, not recruiting
stage I childhood lymphoblastic lymphoma; stage II childhood lymphoblastic lymphoma; stage III childhood lymphoblastic lymphoma; ...
- Radiation Therapy to the Head or Intrathecal Chemotherapy Plus High Dose Cytarabine in Preventing CNS Disease in Children With Acute Lymphoblastic Leukemia
ClinicalTrials.gov Identifier: NCT00019409 - Active, not recruiting
L2 childhood acute lymphoblastic leukemia; untreated childhood acute lymphoblastic leukemia; L1 childhood acute lymphoblastic leukemia; ...
- Comparison of Different Combination Chemotherapy Regimens in Treating Children With Acute Lymphoblastic Leukemia
ClinicalTrials.gov Identifier: NCT00005945 - Active, not recruiting
untreated childhood acute lymphoblastic leukemia; L1 childhood acute lymphoblastic leukemia; L2 childhood acute lymphoblastic leukemia; ...
- Radiation Therapy and Chemotherapy in Treating Children With CNS Relapse From Acute Lymphoblastic Leukemia
ClinicalTrials.gov Identifier: NCT00002704 - Active, not recruiting
B-cell childhood acute lymphocytic leukemia; TdT positive childhood acute lymphocytic leukemia; recurrent childhood acute lymphocytic leukemia; ...
- Comparison of Different Combination Chemotherapy Regimens in Treating Infants With Acute Lymphoblastic Leukemia
ClinicalTrials.gov Identifier: NCT00015873 - Active, not recruiting
untreated childhood acute lymphoblastic leukemia
- Combination Chemotherapy in Treating Children With Non-Hodgkin's Lymphoma
ClinicalTrials.gov Identifier: NCT00003650 - Active, not recruiting
stage I childhood lymphoblastic lymphoma; stage II childhood lymphoblastic lymphoma; stage III childhood lymphoblastic lymphoma; ...
- Comparison of Two Combination Chemotherapy Regimens in Treating Adults With Previously Untreated Leukemia or Lymphoma
ClinicalTrials.gov Identifier: NCT00002766 - Active, not recruiting
Philadelphia chromosome positive chronic myelogenous leukemia; adult acute lymphoblastic leukemia; adult lymphoblastic lymphoma; ...
- Combination Chemotherapy With or Without Bone Marrow Transplantation in Treating Patients With Acute Promyelocytic Leukemia
ClinicalTrials.gov Identifier: NCT00002701 - Active, not recruiting
untreated adult acute myeloid leukemia; adult acute promyelocytic leukemia (M3)
- Comparison of Two Combination Chemotherapy Regimens With Either Vincristine or Vinblastine in Treating Patients With Advanced Anaplastic Large Cell Lymphoma
ClinicalTrials.gov Identifier: NCT00059839 - Recruiting
anaplastic large cell lymphoma
- Alemtuzumab With or Without Methotrexate and Mercaptopurine in Treating Young Patients With Relapsed Acute Lymphoblastic Leukemia
ClinicalTrials.gov Identifier: NCT00089349 - Completed
recurrent childhood acute lymphoblastic leukemia
- Alemtuzumab and Combination Chemotherapy in Treating Patients With Untreated Acute Lymphoblastic Leukemia
ClinicalTrials.gov Identifier: NCT00061945 - Active, not recruiting
B-cell adult acute lymphoblastic leukemia; L1 adult acute lymphoblastic leukemia; L2 adult acute lymphoblastic leukemia; ...
- Donor Stem Cell Transplantation With or Without Chemotherapy in Treating Children With Primary Myelodysplastic Syndrome
ClinicalTrials.gov Identifier: NCT00047268 - Active, not recruiting
atypical chronic myeloid leukemia; Chronic Myelomonocytic Leukemia; juvenile myelomonocytic leukemia; myelodysplastic and myeloproliferative disease; ...
- Combination Chemotherapy in Treating Children With Non-Hodgkin's Lymphoma
ClinicalTrials.gov Identifier: NCT00003423 - Active, not recruiting
stage I childhood large cell lymphoma; stage III childhood lymphoblastic lymphoma; stage III childhood large cell lymphoma; ...
- Combination Chemotherapy With or Without Donor Bone Marrow Transplantation in Treating Infants With Previously Untreated Acute Lymphoblastic Leukemia
ClinicalTrials.gov Identifier: NCT00022126 - Active, not recruiting
untreated childhood acute lymphoblastic leukemia; L1 childhood acute lymphoblastic leukemia; L2 childhood acute lymphoblastic leukemia; ...
- Combination Chemotherapy and Alemtuzumab in Treating Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia
ClinicalTrials.gov Identifier: NCT00262925 - Recruiting
Recurrent Adult Acute Lymphoblastic Leukemia
- Combination Chemotherapy in Treating Pediatric Patients With Advanced-Stage Large Cell Lymphoma
ClinicalTrials.gov Identifier: NCT00002618 - Active, not recruiting
stage III childhood large cell lymphoma; stage IV childhood large cell lymphoma; childhood diffuse large cell lymphoma; ...
- Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Lymphoblastic Leukemia
ClinicalTrials.gov Identifier: NCT00103285 - Recruiting
untreated childhood acute lymphoblastic leukemia; B-cell childhood acute lymphoblastic leukemia
- Chemotherapy With or Without Bone Marrow Transplantation in Treating Patients With Acute Lymphoblastic Leukemia
ClinicalTrials.gov Identifier: NCT00002700 - Active, not recruiting
untreated adult acute lymphoblastic leukemia; stage I adult lymphoblastic lymphoma; stage III adult lymphoblastic lymphoma; ...
- Combination Chemotherapy With or Without Peripheral Stem Cell Transplantation in Treating Children With Acute Lymphoblastic Leukemia
ClinicalTrials.gov Identifier: NCT00022737 - Active, not recruiting
recurrent childhood acute lymphoblastic leukemia; childhood acute lymphoblastic leukemia in remission
- Combination Chemotherapy in Treating Patients With Newly Diagnosed Acute Lymphoblastic Leukemia
ClinicalTrials.gov Identifier: NCT00109837 - Recruiting
L1 adult acute lymphoblastic leukemia; L2 adult acute lymphoblastic leukemia; untreated adult acute lymphoblastic leukemia
- Combination Chemotherapy and Radiation Therapy in Treating Patients With Acute Lymphoblastic Leukemia That Has Relapsed in the CNS or Testes
ClinicalTrials.gov Identifier: NCT00096135 - Recruiting
recurrent childhood acute lymphoblastic leukemia; B-cell childhood acute lymphoblastic leukemia; T-cell childhood acute lymphoblastic leukemia; ...
- Combination Chemotherapy Plus Steroid Therapy in Treating Children With Acute Lymphoblastic Leukemia or Lymphoblastic Non-Hodgkin's Lymphoma
ClinicalTrials.gov Identifier: NCT00003728 - Recruiting
acute undifferentiated leukemia; childhood acute lymphoblastic leukemia; childhood lymphoblastic lymphoma
- Study to Assess Compliance to Long-Term MercaptopurineTreatment in Young Patients With Acute Lymphoblastic Leukemia in Remission
ClinicalTrials.gov Identifier: NCT00268528 - Recruiting
Long-Term Effects Secondary to Cancer Therapy in Children; Psychosocial Effects/Treatment; Childhood Acute Lymphoblastic Leukemia in Remission
- Dexamethasone Compared With Prednisone During Induction Therapy and Methotrexate With or Without Leucovorin During Maintenance Therapy in Treating Patients With Newly Diagnosed High-Risk Acute Lymphoblastic Leukemia
ClinicalTrials.gov Identifier: NCT00075725 - Recruiting
untreated childhood acute lymphoblastic leukemia; B-cell childhood acute lymphoblastic leukemia; untreated adult acute lymphoblastic leukemia; ...
- Combination Chemotherapy, Bone Marrow Transplantation, and Radiation Therapy in Treating Infants With Acute Lymphoblastic Leukemia
ClinicalTrials.gov Identifier: NCT00002785 - Completed
untreated childhood acute lymphoblastic leukemia
- Induction Intensification in Treating Infants With Newly Diagnosed Acute Lymphoblastic Leukemia
ClinicalTrials.gov Identifier: NCT00002756 - Completed
untreated childhood acute lymphoblastic leukemia; acute undifferentiated leukemia
- Combination Chemotherapy in Treating Children With Newly Diagnosed Acute Lymphoblastic Leukemia
ClinicalTrials.gov Identifier: NCT00002744 - Completed
L1 childhood acute lymphocytic leukemia; L2 childhood acute lymphocytic leukemia; untreated childhood acute lymphocytic leukemia
- Combination Chemotherapy in Treating Children With Acute Lymphocytic Leukemia
ClinicalTrials.gov Identifier: NCT00002812 - Completed
L2 childhood acute lymphoblastic leukemia; untreated childhood acute lymphoblastic leukemia; L1 childhood acute lymphoblastic leukemia
- Stem Cell Transplantation Compared With Standard Chemotherapy in Treating Patients With Acute Lymphoblastic Leukemia in First Remission
ClinicalTrials.gov Identifier: NCT00002514 - Completed
adult acute lymphoblastic leukemia in remission
Resources
- Mercaptopurine (Drug Digest)
- Purinethol (Drug Digest)
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