Methotrexate |
Rheumatrex; Trexall |
Methotrexate Systematic (IUPAC) name (S)-2-(4-(((2,4-diaminopteridin-6-yl) methyl)methylamino)benzamido) pentanedioic acid Identifiers CAS number 59-05-2 ATC code L01BA01 L04AX03 PubChem 126941 DrugBank APRD00353 Chemical data Formula C20H22N8O5 Mol. weight 454.44 g/mol Pharmacokinetic data Bioavailability 17–90% Metabolism hepatic Half life 3–15 hours (dose dependent) Excretion renal 48–100% Therapeutic considerations Pregnancy cat. D(AU) X(US ...
Wikipedia - [full article]
Methotrexate News Headlines
- Phase III ACTEMRA(TM) (tocilizumab) Study Results Demonstrate Significant Improvement In Signs And Symptoms Of Patients With Rheumatoid Arthritis
MedicalNewsToday - Thu, 25 Jan 2007 08:00 EST
- Predicting The Risk Of Rheumatoid Arthritis For Early Arthritis Patients
ScienceDaily - Tue, 30 Jan 2007 04:00 EST
- First Actemra Multinational Phase III Trial Demonstrates Significant Improvement In Signs And Symptoms Of Rheumatoid Arthritis
MedicalNewsToday - Mon, 29 Jan 2007 08:00 EST
- "Biologic" rheumatoid drugs safe for heart
Reuters - Fri, 01 Dec 2006 10:22 EST
- Early Aggressive Treatment May Alter Course Of Rheumatoid Arthritis
MedicalNewsToday - Mon, 13 Nov 2006 08:00 EST
- Window Of Opportunity: Early Doses Of Methotrexate May Stop Certain Forms Of Arthritis Before They Start
MedicalNewsToday - Mon, 13 Nov 2006 08:00 EST
- Anti-TNF Golimumab (CNTO 148) Continues To Show Promise In Phase 2 Rheumatoid Arthritis Study
MedicalNewsToday - Tue, 14 Nov 2006 08:00 EST
- Orencia Efficacy In Adults With Rheumatoid Arthritis, Two-year Data
MedicalNewsToday - Sat, 11 Nov 2006 08:00 EST
- Two-Year Data For ORENCIA(R) (abatacept) Demonstrate Continued Efficacy In Adults With Rheumatoid Arthritis
MedicalNewsToday - Fri, 10 Nov 2006 08:00 EST
- New Phase III Data Show Abbott's HUMIRA ® (adalimumab) Was Statistically Superior To Methotrexate In Patients With Psoriasis
MedicalNewsToday - Fri, 06 Oct 2006 07:00 EST
- Many Australian Physicians Not Applying For Permission To Import Mifepristone; Using Alternative Combination
MedicalNewsToday - Thu, 21 Sep 2006 07:00 EST
- No Increased Risk Of Lymphoma Or Tumors Associated With Anti-TNF Therapy Over Methotrexate Use Among Rheumatoid Arthritis Patients, Study Finds
MedicalNewsToday - Mon, 04 Sep 2006 07:00 EST
- Tumor Necrosis Factor Blockers May Not Cause Cancer After All
ScienceDaily - Fri, 01 Sep 2006 03:00 EST
- Tanabe Seiyaku Launches New Anti-rheumatic
MedicalNewsToday - Sat, 29 Jul 2006 06:00 EST
- Methotrexate boosts UV therapy for psoriasis
Reuters - Fri, 23 Jun 2006 08:58 EST
- Rheumatoid Arthritis Patients Benefit From Enbrel In Combination With Methotrexate
MedicalNewsToday - Sun, 25 Jun 2006 06:00 EST
- Rheumatoid Arthritis Patients Can Benefit From Enbrel In Combination With Methotrexate
MedicalNewsToday - Sun, 25 Jun 2006 06:00 EST
- New Study Reveals Tocilizumab In Monotherapy Significantly Improves Signs And Symptoms Of Active RA
MedicalNewsToday - Tue, 27 Jun 2006 01:00 EST
- Better Inhibition Of Radiographic Progression In RA Patients
MedicalNewsToday - Tue, 27 Jun 2006 02:00 EST
- Rituxan® Plus Methotrexate Reduced Joint Damage In Rheumatoid Arthritis Patients Who Respond Inadequately To TNF Antagonist Therapies
MedicalNewsToday - Mon, 26 Jun 2006 06:00 EST
- New Two-Year Orencia ® (abatacept) Aim Data Presented At Annual Eular Congress
MedicalNewsToday - Mon, 26 Jun 2006 06:00 EST
- New Two-Year ORENCIA(R) (abatacept) AIM Data Presented At Annual EULAR Congress
MedicalNewsToday - Sat, 24 Jun 2006 06:00 EST
- Abatacept Treatment Yields Better Inhibition Of Radiographic Progression Over 2 Years In Rheumatoid Arthritis Patients, New Long-Term Data
MedicalNewsToday - Sun, 25 Jun 2006 06:00 EST
- Analysis Of Phase III Study Showed Rituxan(R) Plus Methotrexate Reduced Joint Damage In Rheumatoid Arthritis Patients Who Respond Inadequately To TNF
MedicalNewsToday - Fri, 23 Jun 2006 06:00 EST
- Rheumatoid Arthritis Treatment With Methotrexate Effective The Second Time
MedicalNewsToday - Mon, 27 Feb 2006 04:00 EST
- Methotrexate Fights Rheumatoid Arthritis Second Time Around
MedicineNet - Fri, 24 Feb 2006 06:00 EST
- Arthritis drug may work better second time around
Reuters - Thu, 02 Mar 2006 08:40 EST
- FDA Approves Rituxan® - The First Targeted B-Cell Therapy For Treatment Of Moderate-To-Severe Rheumatoid Arthritis
MedicalNewsToday - Sun, 05 Mar 2006 11:00 EST
- Rheumatoid Arthritis - Genentech, Biogen Get Added Rituxan OK
MedicalNewsToday - Thu, 02 Mar 2006 08:00 EST
- Two drugs better than one for RA: study
Reuters - Fri, 30 Dec 2005 05:44 EST
- FDA Approves Orencia® (Abatacept) For Rheumatoid Arthritis Treatment
MedicalNewsToday - Mon, 26 Dec 2005 11:00 EST
- Long-standing rheumatoid arthritis - Adalimumab plus methotrexate effective
MedicalNewsToday - Tue, 16 Aug 2005 06:00 EST
- Treatment For Rare Liver Disease Increases Mortality Risk
ScienceDaily - Wed, 24 Aug 2005 02:00 EST
- Treatment for rare liver disease increases mortality risk
MedicalNewsToday - Wed, 24 Aug 2005 07:00 EST
- Rheumatoid Arthritis - Early Therapy With Humira® and Methotrexate May Affect Long-Term Disease
MedicalNewsToday - Thu, 09 Jun 2005 05:00 EST
- Methotrexate Still Best for Juvenile RA
WebMD - Wed, 20 Apr 2005 10:47 EST

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