The purpose of this study is to demonstrate superiority in survival in favor of TLK286 as compared to active control therapy with Doxil/Caelyx or Hycamtin in the intent-to-treat (ITT) populations.

Condition	Treatment or Intervention	Phase
Ovarian Neoplasms	Drug: TLK286 HCl for injection  Drug: topotecan hydrochloride for injection  Drug: doxorubicin HCl liposome injection	Phase III

Further Study Details: 

Expected Total Enrollment:  440

Ages Eligible for Study:  18 Years and above,  Genders Eligible for Study:  Female

Criteria

Inclusion criteria include:

• Considered platinum refractory or resistant according to standard criteria
• Progressed during or following completion of one second-line treatment with Doxil/Caelyx or Hycamtin
• Histologically or cytologically confirmed diagnosis of epithelial cancer of the ovary, fallopian tube, or primary peritoneal cancer
• Measurable disease according to RECIST criteria with documented tumor progression

Exclusion criteria include:

• Treatment with second-line chemotherapy other than Doxil/Caelyx or Hycamtin
• History of whole pelvis radiation therapy within 12 months of enrollment
• Clinically significant cardiac disease
• Evidence of gross hematuria at the time of study entry
• Any signs of intestinal obstruction interfering with nutrition at the time of study entry
• Pregnant or lactating women

Arkansas
      Little Rock Hematology Oncology Associates, Little Rock,  Arkansas,  72205,  United States
      University of Arkansas for Medical Sciences, Little Rock,  Arkansas,  72205,  United States
California
      Southwest Cancer Care, Poway,  California,  92064,  United States
      David Geffen School of Medicine at UCLA, Los Angeles,  California,  90095,  United States
      Loma Linda University Medical Center, Loma Linda,  California,  92354,  United States
      Gyncologic Oncology Associates, Newport Beach,  California,  92663,  United States
      Southwest Cancer Care, Escondido,  California,  92025,  United States
      Southwest Cancer Care, Murrieta,  California,  92562,  United States
      Sharp Healthcare Clinical Oncology Research, San Diego,  California,  92123,  United States
      Bay Area Research Cancer Group, Concord,  California,  94520,  United States
      Gynecologic Oncology Associates, La Jolla,  California,  92037,  United States
      Kaiser Permanente Oncology Clinical Trials Program, Vallejo,  California,  94589,  United States
      Kaiser Permanente Oncology Clinical Trials Program, Oakland,  California,  94611,  United States
      Kaiser Permanente Oncology Clinical Trials Program, Sacramento,  California,  95825,  United States
      Kaiser Permanente Oncology Clinical Trials Program, San Francisco,  California,  94115,  United States
      Kaiser Permanente Oncology Clinical Trials Program, Santa Clara,  California,  95051,  United States
      Kaiser Permanente Oncology Clinical Trails Program, Santa Teresa,  California,  95119,  United States
      Kaiser Permanente Oncology Clinial Trials Program, Walnut Creek,  California,  94596,  United States
      Kaiser Permanente Oncology Clinical Trials Program, Hayward,  California,  94545,  United States
      Kaiser Permanente Oncology Clinical Trials Program, Roseville,  California,  95661,  United States
      Kaiser Permanente Oncology Clinical Trials Program, San Rafael,  California,  94903,  United States
      Kaiser Permanente Oncology Clinical Trials Program, Santa Rosa,  California,  95403,  United States
      Kaiser Permanente Oncology Clinical Trials Program, South San Francisco,  California,  94080,  United States
      Kaiser Permanente Oncology Clinical Trials Program, Redwood City,  California,  94063,  United States
      Sharp Memorial Hospital, San Diego,  California,  92123,  United States
      Grossmont Hospital, La Mesa,  California,  91942,  United States
      Sharp Rees-Stealy, San Diego,  California,  92123,  United States
      Sharp Rees-Stealy, La Mesa,  California,  91942,  United States
      Medical Oncology Associates-SD, San Diego,  California,  92123,  United States
      Rosalba Rodriguez, M. D., Chula Vista,  California,  91911,  United States
      Marilyn Norton, M. D., Chula Vista,  California,  91911,  United States
      N. County Oncology Medical, Oceanside,  California,  92056,  United States
      LLU Faculty Medical Offices, Loma Linda,  California,  92354,  United States
      Southern California Permanente Medical Group, San Diego,  California,  92120,  United States
      Southern California Permanente Medical Group, Baldwin Park,  California,  91706,  United States
      California Oncology of the Central Valley, Fresno,  California,  93710,  United States
      Loma Linda University Medical Center, Loma Linda,  California,  92354,  United States
      LLU Faculty Meidical Offices, Loma Linda,  California,  92354,  United States
      Women's Cancer Center - Community Hospital Los Gatos, Los Gatos,  California,  95032,  United States
      Providence Saint Joseph Medical Center, Burbank,  California,  91505-4866,  United States
Connecticut
      Whittingham Cancer Center at Norwalk Hospital, Norwalk,  Connecticut,  06856,  United States
      Hematology Oncology, P.C., Stamford,  Connecticut,  06902,  United States
Florida
      Gynecologic Oncology, Orlando,  Florida,  32804,  United States
      Women's Cancer Research Foundation, Inc., S. Miami,  Florida,  33143,  United States
      Sheridan Clinical Research, Inc., Hollywood,  Florida,  33021,  United States
      University of Florida Health Science Center/Jacksonville, Jacksonville,  Florida,  32209,  United States
      Florida Hospital, Orlando,  Florida,  32803,  United States
      Memorial Regional Hospital, Hollywood,  Florida,  33021,  United States
      Gynecologic Oncology Associates, Pembroke Pines,  Florida,  33028,  United States
      Palm Beach Cancer Institute, West Palm Beach,  Florida,  33401,  United States
      Palm Beach Cancer Institute, Palm Beach Gardens,  Florida,  33410,  United States
      Palm Beach Cancer Institute, Wellington,  Florida,  33414,  United States
      Sheridan Clinical Research, Inc., Hollywood,  Florida,  33021,  United States
      Memorial Regional Hospital, Hollywood,  Florida,  33021,  United States
      Gynecologic Oncology Associates, Pembroke Pines,  Florida,  33028,  United States
      The Center for Hematology-Oncology, Boca Raton,  Florida,  33486,  United States
      The Center for Hematology-Oncology, Delray Beach,  Florida,  33484,  United States
      Hematology/Oncology Associates of Treasure Coast, Port St. Lucie,  Florida,  34952,  United States
      Florida Hospital Memorial Division, Cancer Care Center, Ormond Beach,  Florida,  32174,  United States
      Florida Hospital Memorial Division, Ormond Beach,  Florida,  32174,  United States
Georgia
      Suburban Hematology-Oncology Associates, Lawrenceville,  Georgia,  30045,  United States
      Memorial Health University Medical Center, Savannah,  Georgia,  31404,  United States
      Suburban Hematology Oncology, Snellville,  Georgia,  30078,  United States
      Suburban Hematology Oncology, Duluth,  Georgia,  30096,  United States
Hawaii
      Univ. of Hawaii, Kapiolani Medical Center for Women and Children, Honolulu,  Hawaii,  96826,  United States
      Straub Clinic and Hospital, Honolulu,  Hawaii,  96826,  United States
      Kaiser Permanente - Moanalua Medical Center, Honolulu,  Hawaii,  96819,  United States
Illinois
      MacNeal Cancer Center, Berwyn,  Illinois,  60402,  United States
      Cancer Care Specialists of Central IL, Decatur,  Illinois,  62526,  United States
      Cancer Care Specialists of Central IL-Crossroads Cancer Care Center, Effingham,  Illinois,  62401,  United States
      Decatur Memorial Hospital, Decatur,  Illinois,  62526,  United States
      Joliet Oncology-Hematology Associates, Ltd., Joliet,  Illinois,  60435,  United States
      Joliet Oncology-Hematology Associates, Ltd., Morris,  Illinois,  60450,  United States
      Joliet Oncology-Hematology Associates, Ltd., Flossmoor,  Illinois,  60422,  United States
      Hematology Oncology Associates of Illinois (HOAI), Chicago,  Illinois,  60657,  United States
      Hematology Oncology Associates of Illinois (HOAI), Skokie,  Illinois,  60076,  United States
      Swedish Covenant Cancer Center, Chicago,  Illinois,  60625,  United States
      North Shore Oncology Hematology Associates - Deerpath Medical Associates, Lake Forest,  Illinois,  60045,  United States
      North Shore Oncology Hematology Associates, Barrington,  Illinois,  60010,  United States
      North Shore Oncology Hematology Associates, Libertyville,  Illinois,  60048,  United States
      North Shore Oncology Hematology Associates, McHenry,  Illinois,  60050,  United States
      Midwest Cancer Research Group, Inc., Skokie,  Illinois,  60077,  United States
Indiana
      Indiana University Medical Center, Indianapolis,  Indiana,  46202,  United States
      St. Joseph's Regional, South Bend,  Indiana,  46617,  United States
      St. Vincent Gynecologic Oncology, Indianapolis,  Indiana,  46260,  United States
      Michiana Hematology Oncology, Elkhart,  Indiana,  46514,  United States
      St. Vincent Hospital and Health Care Center, Indianapolis,  Indiana,  46260,  United States
      Indiana Cancer Pavilion, Indianapolis,  Indiana,  46202,  United States
      Saint Joseph's Regional, South Bend,  Indiana,  46634,  United States
      Elkhart General Hospital, Elkhart,  Indiana,  46514,  United States
      Michiana Hematology Oncology, South Bend,  Indiana,  46617,  United States
      St. Vincent Hospital and Helath Care Center, Indianapolis,  Indiana,  46260,  United States
Iowa
      University of Iowa, Iowa City,  Iowa,  52242,  United States
      University of Iowa Hospitals and Clinics, Iowa City,  Iowa,  52242,  United States
Kansas
      Associates in Women's Health, Wichita,  Kansas,  67214,  United States
      Research Support Personnel, LLC, Wichita,  Kansas,  67208,  United States
Kentucky
      Oncology/Hematology Care, Inc., Crestview,  Kentucky,  41017,  United States
      Univ. of Louisville, Div. of Gynecologic Oncology, Louisville,  Kentucky,  40202,  United States
Louisiana
      LSU Health Sciences Center, Shreveport,  Louisiana,  71103,  United States
      Ochsner Clinic Foundation, New Orleans,  Louisiana,  70121,  United States
      Hematology and Oncology Specialists, LLC, New Orleans,  Louisiana,  70115,  United States
      Hematology and Oncology Specialists, LLC, Covington,  Louisiana,  70433,  United States
      OncRx (Pharmacy), Metairie,  Louisiana,  70002,  United States
Maryland
      Center for Cancer and Blood Disorders, Bethesda,  Maryland,  20817,  United States
      Sinai Cancer Institute, Baltimore,  Maryland,  21205,  United States
Massachusetts
      St. Elizabeth's Med. Ctr., Boston,  Massachusetts,  02135,  United States
Michigan
      Sparrow Regional Cancer Center, Lansing,  Michigan,  48909,  United States
      St. Joseph Mercy Hospital, Ann Arbor,  Michigan,  48106,  United States
Minnesota
      St. Mary's Duluth Clinic, Duluth,  Minnesota,  55805,  United States
Missouri
      Gynecology & Oncology Consultants, PC, St. Louis,  Missouri,  63141,  United States
      Ellis Fischel Cancer Center, Columbia,  Missouri,  65203,  United States
      St. Louis University, Dept. of Ob-Gyn and Women's Health, St. Louis,  Missouri,  63117,  United States
      Saint John's Mercy Hospital, St. Louis,  Missouri,  63141,  United States
Montana
      Hematology & Oncology Centers Northern Rockies, Billings,  Montana,  59101,  United States
      Deaconess Billings Clinic, Billings,  Montana,  59101,  United States
      Hematology Oncology Centers of the Northern Rockies, Butte,  Montana,  59701,  United States
      Hematology Oncology Centers of the Northern Rockies, Butte,  Montana,  59701,  United States
Nebraska
      Horizon's West Medical Group, Scottsbluff,  Nebraska,  69361,  United States
Nevada
      Nevada Cancer Center, Las Vegas,  Nevada,  89109,  United States
New Jersey
      The Cancer Institute of New Jersey, New Brunswick,  New Jersey,  08901,  United States
      Jersey Shore University Medical Center, Neptune,  New Jersey,  07754,  United States
      Robert Wood Johnson University Hospital, New Brunswick,  New Jersey,  08903,  United States
New Mexico
      UNM Cancer Research and Treatment Center, Albuquerque,  New Mexico,  87131,  United States
New York
      The Mary Imogene Bassett Hospital, Cooperstown,  New York,  13326,  United States
      NYU School of Medicine, New York,  New York,  10016,  United States
      The Union State Bank Cancer Center at Nyack Hospital, Nyack,  New York,  10960,  United States
      Med-Onc/Hem, Malone,  New York,  12953,  United States
      Gynecologic-Oncology, Rochester,  New York,  14620,  United States
      Memorial Sloan Kettering Cancer Center, New York,  New York,  11021,  United States
      Good Samaritan Hospital Medical Center, West Islip,  New York,  11795,  United States
      Benjamin Schwartz, M.D., Babylon,  New York,  11702,  United States
      South Bay OB/GYN, West Islip,  New York,  11795,  United States
      Hematology-Oncology Associates of Rockland, New City,  New York,  10956,  United States
      Comprehensive Cancer Center Medical Practice Offices, New York,  New York,  10016,  United States
      Bellevue Hospital Center, New York,  New York,  10016,  United States
      North Shore-Long Island Jewish Health System/Medical Center, New Hyde Park,  New York,  11040,  United States
      New York University Medical Center - Tisch Hospital, New York,  New York,  10016,  United States
      Long Island Jewish Medical Center, New Hyde Park,  New York,  11040,  United States
North Carolina
      Piedmont Hematology Oncology Assoc., PA-Salem Research Group, Winston Salem,  North Carolina,  27103,  United States
      Wake Forest University School of Medicine, Winston Salem,  North Carolina,  27157,  United States
      Blumenthal Cancer Center, Charlotte,  North Carolina,  28203,  United States
      Salem Research Group, Inc., Winston Salem,  North Carolina,  27103,  United States
      Presbyterian Hospital Center for Cancer Research, Charlotte,  North Carolina,  28204,  United States
      Presbyterian Gynecologic Oncology, Charlotte,  North Carolina,  28204,  United States
North Dakota
      Dakota Cancer Institute, Fargo,  North Dakota,  58103,  United States
      Mid Dakota Clinic, Bismarck,  North Dakota,  58501,  United States
      Odyssey Research Services, Bismarck,  North Dakota,  58501,  United States
      Odyssey Research Services, Fargo,  North Dakota,  58104,  United States
Ohio
      Gynecologic Oncology, Columbus,  Ohio,  43222,  United States
      Mid-Ohio Oncology Hematology, Columbus,  Ohio,  43213,  United States
      Mid-Ohio Oncology Hematology St. Anne's, Columbus,  Ohio,  43081,  United States
      Oncology/Hematology Care, Inc., Cincinnati,  Ohio,  45242,  United States
      Oncology/Hematology Care, Inc., Cincinnati,  Ohio,  45236,  United States
      Oncology/Hematology Care, Inc., Cincinnati,  Ohio,  45013,  United States
      Oncology/Hematology Care, Inc., Cincinnati,  Ohio,  45230,  United States
      Oncology/Hematology Care, Inc., Cincinnati,  Ohio,  45219,  United States
      Wright State Univ. School of Medicine, Dayton,  Ohio,  45409,  United States
      MetroHealth Medical Center, Cleveland,  Ohio,  44109,  United States
      University Hospital, Cincinnati,  Ohio,  45219,  United States
      Hillcrest Hospital Cancer Center, Mayfield Heights,  Ohio,  44124,  United States
      Barrett Cancer Center, Cincinnati,  Ohio,  45219,  United States
      UC Physician's Medical Arts Bldg., Cincinnati,  Ohio,  45219,  United States
      Mount Carmel Health, Columbus,  Ohio,  43222,  United States
      Mid Ohio Oncology Hematology, Columbus,  Ohio,  43213,  United States
      Metro Health Medical Center, Cleveland,  Ohio,  44109,  United States
Oklahoma
      University of Oklahoma Health Sciences Center, Oklahoma City,  Oklahoma,  73104,  United States
      OU Medical Center - Everett Tower, Oklahoma City,  Oklahoma,  73104,  United States
      Presbyterian, Oklahoma City,  Oklahoma,  73104,  United States
      OU Physicians' Bldg., Oklahoma City,  Oklahoma,  73104,  United States
Oregon
      Oregon Health Science University, Portland,  Oregon,  97239,  United States
      Kaiser Permanente Nw, Oncology Research, Portland,  Oregon,  97227,  United States
      Oregon Health & Science University, Portland,  Oregon,  97239-3098,  United States
Pennsylvania
      Hematology & Oncology Associates of NEPA, Dunmore,  Pennsylvania,  18512,  United States
      Magee-Womens Hospital, Pittsburgh,  Pennsylvania,  15213,  United States
      Abington Mem. Hospita/Rosenfield Cancer Center, Abington,  Pennsylvania,  19001,  United States
      Mercy Health Partners, Scranton,  Pennsylvania,  18510,  United States
      Moses Taylor Hospital, Scranton,  Pennsylvania,  18510,  United States
      Community Medical Center, Scranton,  Pennsylvania,  18510,  United States
      Viewmont Medical Services, Scranton,  Pennsylvania,  18508,  United States
      Advanced Imaging, Dunmore,  Pennsylvania,  18512,  United States
      Associates in Hematology-Oncology, P.C., Upland,  Pennsylvania,  19013,  United States
South Carolina
      Gynecologic Oncology Research and Development, Greenville,  South Carolina,  29605,  United States
      Carolina Center of Gynecologic Oncology, PA, Charleston,  South Carolina,  29407,  United States
      Gynecologic Oncology Research and Development, Spartanburg,  South Carolina,  29303,  United States
      South Carolina Oncology Associates, PA, Columbia,  South Carolina,  29201,  United States
South Dakota
      Sioux Calley Clinic OBGYN Ltd., Sioux Falls,  South Dakota,  57105,  United States
      Sioux Valley Clinic Clinical Research Center, Sioux Falls,  South Dakota,  57104,  United States
      Sioux Valley Clinic Oncology, Sioux Falls,  South Dakota,  57104,  United States
      Sioux Valley Hospital - North Center Radiology, Sioux Falls,  South Dakota,  57104,  United States
Tennessee
      The Consultant Group, Nashville,  Tennessee,  37205,  United States
      Fort Sanders Parkwest Medical Center, Knoxville,  Tennessee,  37923,  United States
      The Sarah Cannon Cancer Center/Tennessee Oncology, PLLC, Nashville,  Tennessee,  37203,  United States
      The Sarah Cannon Cancer Center/Tennessee Oncology, PLLC, Nashville,  Tennessee,  37211,  United States
      The Sarah Cannon Cancer Center/Tennessee Oncology, PLLC, Hermitage,  Tennessee,  37076,  United States
      The Sarah Cannon Cancer Center/Tennessee Oncology, PLLC, Nashville,  Tennessee,  37207,  United States
      The Sarah Cannon Cancer Center/Tennessee Oncology, PLLC, Murfreesboro,  Tennessee,  37130,  United States
      The Sarah Cannon Cancer Center/Tennessee Oncology, PLLC, Nashville,  Tennessee,  37205,  United States
      The Sarah Cannon Cancer Center/Tennessee Oncology, PLLC, Gallatin,  Tennessee,  37066,  United States
      The Sarah Cannon Cancer Center/Tennessee Oncology, PLLC, Lebanon,  Tennessee,  37087,  United States
      The Sarah Cannon Cancer Center/Tennessee Oncology, PLLC, Smyma,  Tennessee,  37167,  United States
      Memorial Hospital, Chattanooga,  Tennessee,  37404,  United States
      Chattanooga Oncology & Hematology Associates, P.C., Chattanooga,  Tennessee,  37404,  United States
      Saint Mary's Health System, Inc., Knoxville,  Tennessee,  37917,  United States
      Hall and Martin, M.D.'s, P.C., Knoxville,  Tennessee,  37920,  United States
      The Consultant Group, Franklin,  Tennessee,  37067,  United States
Texas
      Arlington Cancer Center, Arlington,  Texas,  76012,  United States
      Univ. of TX, MD Anderson Cancer Center, Houston,  Texas,  77030,  United States
      Texas Cancer Associates, Dallas,  Texas,  75231,  United States
      Texas Oncology, PA, Fort Worth,  Texas,  76104,  United States
      Southwest Fort Worth Cancer Center, Fort Worth,  Texas,  76132,  United States
      Amarillo Cancer Center, Amarillo,  Texas,  79106,  United States
      Dallas Oncology Consultants, Dallas,  Texas,  75201,  United States
Virginia
      Danville Hematology and Oncology, Inc., Danville,  Virginia,  24541,  United States
Washington
      Western Washington Oncology, Olympia,  Washington,  98502,  United States
      MultiCare Health System - Medical Oncology, Tacoma,  Washington,  98405,  United States
      Western Washington Oncology, Olympia,  Washington,  98506,  United States
      Western Washington Oncology, Centralia,  Washington,  98531,  United States
      Western Washington Oncology, Shelton,  Washington,  98584,  United States
      Western Washington Oncology, Aberdeen,  Washington,  98520,  United States
      Allenmore Hospital - Hematology Oncology Clinic, Tacoma,  Washington,  98405,  United States
      Covington Multicare - Oncology Clinic, Covington,  Washington,  98042,  United States
Wisconsin
      Medical Consultants, Ltd., Milwaukee,  Wisconsin,  53215,  United States
      Marshfield Clinic Research Foundation, Marshfield,  Wisconsin,  54449,  United States
      Saint Joseph's Hospital, Marshfield,  Wisconsin,  54449,  United States
      Chippewa Falls Cancer Center, Chippewa Falls,  Wisconsin,  54729,  United States
      Merrill Cancer Center, Merrill,  Wisconsin,  54452,  United States
      Wausau Cancer Center, Wausau,  Wisconsin,  54401,  United States
      Wisconsin Rapid Cancer Center, Marshfield,  Wisconsin,  54494,  United States
      Regional Cancer Center, Eau Claire,  Wisconsin,  54701,  United States
      Saint Michael Hospital, Stevens Point,  Wisconsin,  54481,  United States
      Marshfield Clinic - Indianhead Center, Rice Lake,  Wisconsin,  54868,  United States
      Marshfield Clinc - Lakeland Center, Minocqua,  Wisconsin,  54548,  United States
      Marshfield Clinic - Lakeland Center, Minocqua,  Wisconsin,  54548,  United States
      Marshfield Clinic - Lakeland Center, Minocqua,  Wisconsin,  54548,  United States
      Diagnostic Radiology Associates, Rice Lake,  Wisconsin,  54868,  United States
      Lakeview Medical Center, Rice Lake,  Wisconsin,  54868,  United States
Wyoming
      Hematology Oncology Centers of the Northern Rockies, Cody,  Wyoming,  82414,  United States
      Hematology Oncology of the Northern Rockies, Sheridan,  Wyoming,  82801,  United States
Argentina
      Sociedad de Beneficencia Hospital Italiano, Cordoba,  Argentina
      Hospital Donacion Francisco Santojanni, Buenos Aires,  1408,  Argentina
      Complejo Medico de la Policia Federal Argentina "Churruca-Visca", Buenos Aires,  1437,  Argentina
      Sanatorio Municipal Dr. Julio Mendez, Buenos Aires,  C1405CNF,  Argentina
      Complejo Medico de la Policia Federal Argentina "Churruca-Visca", Buenos Aires,  C1437JCP,  Argentina
      Hospital General de Agudos "Carlos G. Durand", Buenos Aires,  C1405DCS,  Argentina
      Hospital Italiano de Buenos Aires, Buenos Aires,  C1181ACH,  Argentina
      Policlinica Privada Instituto de Medicina Nuclear, Buenos Aires,  Argentina
      Hospital de Oncologia Maria Curie, Buenos Aires,  Argentina
Argentina, Buenos Aires
      Hospital General de Agudos Donacion F. Santojanni, Capital Federal,  Buenos Aires,  1408,  Argentina
      Hospital Universitario Austral, Pilar,  Buenos Aires,  B1629AHJ,  Argentina
      Hospital Italiano Regional del Sur, Bahia Blanca,  Buenos Aires,  B8001HXM,  Argentina
Argentina, Santa Fe
      ISIS Clinica Especializada, Sante Fe,  Santa Fe,  03000,  Argentina
Belgium
      Cliniques Universitaires Saint-Luc, Brussels,  B 1200,  Belgium
      Universitair Ziekenhuis Gent., Gent,  9000,  Belgium
      AZ-VUB Dienst Oncologie, Brussels,  1090,  Belgium
      Centre Hospitalier Regional de la Citadelle, LIEGE,  4000,  Belgium
Belgium, Antwerpen
      Algemeen Ziekenhuis Antwerpen, Lindedreef,  Antwerpen,  2020,  Belgium
Belgium, Edegem
      Universitaire Ziekenhuis Antwerpen, Wilrijkstraat,  Edegem,  2650,  Belgium
Belgium, Leuven
      University Hospital Gasthuisberg, Herestraat,  Leuven,  49,  Belgium
Brazil
      INCA Hospital de Oncologia Clinica, Rio de Janeiro,  20220-410,  Brazil
      Instituto de Saude e Bem Estar da Mulher, Sao Paolo,  Brazil
      Hospital do Cancer - A.C. Camargo, Sao Paolo,  01509,  Brazil
      UNIFESP/EPM, Sao Paulo,  04024-002,  Brazil
Brazil, CE
      Instituto do Cancer do Ceara, Fortaleza,  CE,  60430-230,  Brazil
Brazil, MG
      Hospital Luxemburgo, Belo Horizonte,  MG,  32380,  Brazil
      Hospital Vera Cruz, Belo Horizonte,  MG,  30190-130,  Brazil
Brazil, PR
      Hospital de Clinicas da Universidade Federal do Parana, Curitiba,  PR,  Brazil
      Centro de Tratamento Oncologico de Londrina, Londrina,  PR,  86010-640,  Brazil
Brazil, Porto Alegre
      Hospital de Clinicas de Porto Alegre, Bairro Bom Fim,  Porto Alegre,  90035-003,  Brazil
Brazil, SP
      Hospital das Clinicas de Sao Paulo-FMUSP, Sao Paolo,  SP,  05403,  Brazil
      Instituto Arnaldo Vieira de Carvalho, Sao Paolo,  SP,  01223,  Brazil
Chile
      Clinica Santa Maria, Santiago de Chile,  Chile
Chile, Santiago
      Servicio de Oncologia-Hospital Clinico Unversidad de Chile, Independencia,  Santiago,  Santos Dumontt 999,  Chile
Czech Republic
      Masarykuv Onkologicky Ustav, Brno,  656 53,  Czech Republic
      Fakultni nemocnice, Onkologicka klinika, Plzen,  Czech Republic
Czech Republic, Olomouc
      Fakultni nemocnice Olomouc, Onkologicka klinika, Pardubice,  Olomouc,  77520,  Czech Republic
Czech Republic, Pardubice
      Krajska nemocnice Pardubice, Oddeleni radiacni onklogie, Kyjevska 44,  Pardubice,  53203,  Czech Republic
Czech Republic, Plzen
      Fakultni Nemocnice - Onkologicka Klinika, Doudlevecka 69,  Plzen,  301 31,  Czech Republic
Czech Republic, Praha
      Vseobecna Fakultni Nemocnice - Onkologicka Klinika, Unemocnice,  Praha,  12808,  Czech Republic
Czech Republic, Zlin
      Batova krajska nemocnice Zlin, prispevkova organizace, Onkologicke oddeleni, Havlickovo nabrezi 600,  Zlin,  76001,  Czech Republic
      Batova krajska nemocnice Zlin, prispevkova organizace, Radiodiagnosticke oddeleni, Havlickovo nabrezi,  Zlin,  76001,  Czech Republic
Germany
      St. Vincentius Kliniken - Frauenkinik, Karlsruhe,  D76137,  Germany
      Klinikum GroBhadern-Zentrum fur Frauenheilkunde, Munich,  D81377,  Germany
      Klinikum GroBhadern-Institut fur Radiologie, Munich,  D-81377,  Germany
      St. Vincentius Kliniken - Radiology, Karlsruhe,  D76137,  Germany
      Universitaets-Frauenklinik Ulm, Ulm,  D89075,  Germany
      Dr. Horst-Schmidt-Kliniken GmbH, Wiesbaden,  D65199,  Germany
      Universitatsklinikum Charite - Campus Virchow-Klinikum, Berlin,  D13353,  Germany
      St. Vincentius Kliniken, Karlsruhe,  D-76137,  Germany
Hungary
      SZTE, Department of Oncotherapy, Szeged,  6720,  Hungary
      Faculty of Gynaecologycal Oncology/Univ. of Debrecen, Debrecen,  4032,  Hungary
      Baranya County Hospital, Pecs,  7632,  Hungary
      Uzsoki Street Hospital Dept. of Radiooncology, Budapest,  H-1145,  Hungary
      Semmelweis University, 1st Dept. of Obstetrics and Gynaecology, Baross,  H-1088,  Hungary
      Baranya County Hospital - Department of Oncology, Rakoczi,  Hungary
      Baranya County Hospital - Department of Radiology, Rakoczi,  Hungary
Ireland
      Oncology Dept., University Floor, Belfast City Hospital, Belfast,  BT9 7AB,  Ireland
Netherlands
      Vrije Universiteit Medical Centre (VUMC), HV Amsterdam,  1081,  Netherlands
      University Medical Centre Nijmegen (UMCN), Nijmegen,  6525,  Netherlands
South Africa
      Eastern Cape Oncology Research Centre, Port Elizabeth,  6001,  South Africa
South Africa, Cape Town
      Panorama Medical Centre, Panorama,  Cape Town,  7500,  South Africa
South Africa, Durban
      Hopelands Cancer Centre, Overport,  Durban,  4091,  South Africa
South Africa, Johannesburg
      Rosebank Oncology Centre, Saxonwold,  Johannesburg,  2196,  South Africa
      Medical and Dental Centre, Rosebank,  Johannesburg,  2196,  South Africa
South Africa, Pretoria
      Wilgers Oncology Centre, Die Wilgers x14,  Pretoria,  41,  South Africa
Spain
      Servicio de Oncologia, Madrid,  28007,  Spain
      Hospital Clinic i Provincial, Barcelona,  8035,  Spain
      Hospital General de Guadalajara, Guadalajara,  Spain
      Instituto Valenciano de Oncologia (IVO) Servicio de Oncologia, Valencia,  46009,  Spain
      Instituto Valenciano de Oncologia (IVO) Servicio de Radiologia, Valencia,  46009,  Spain
      Hospital Clinic i Provincial de Barcelona - Servicio de Oncologia Medica, Barcelona,  08036,  Spain
Spain, Barcelona
      Servicio Oncologia Hospital General Vall d'HebronPaseo, Vall d'Hebron,  Barcelona,  119-129,  Spain
Spain, Valencia
      Instituto Valenciano de Oncologia (IVO), Profesor Beltran Baguena,  Valencia,  46009,  Spain
United Kingdom
      Department of Medical Oncology, Christie Hospital, Manchester,  M20 4BX,  United Kingdom
      St. Chad's Outpatients Unit, City Hospital, Birmingham,  B18 7QH,  United Kingdom
      Beatson Oncology Centre, Glasgow,  G11 6NT,  United Kingdom
      Medical Oncology (NCCT) - Newcastle General Hospital, Newcastle upon Tyne,  NE4 6BE,  United Kingdom
      Medical Oncology - Guy's and St. Thomas' Hospital, London,  SE1 9RT,  United Kingdom
      Dorset Cancer Centre - Poole Hospital, Poole,  BH15 2JB,  United Kingdom
      Beatson Oncology Unit, Glasgow,  G11 6NT,  United Kingdom
      United Bristol Healthcare Trust - Bristol Oncology Centre, Bristol,  BS2 8ED,  United Kingdom
      Velindre NHS Trust - Velindre Hospital, Wales,  CFT142TL,  United Kingdom
      Department of Medicine-Royal Marsden Hospital, London,  SW3 6JJ,  United Kingdom
United Kingdom, Dundee
      Department of Cancer Medicine - Ninewells Hospital & Medical School, Scotland,  Dundee,  DD1 9SY,  United Kingdom
United Kingdom, Surrey
      Dept. of Med. Oncology/The Royal Marsden Hospital, Sutton,  Surrey,  SMT 5PT,  United Kingdom

Study ID Numbers:  TLK286.3017
Record last reviewed:  February 2005
Last Updated:  February 8, 2005
Record first received:  April 7, 2003
ClinicalTrials.gov Identifier:  NCT00057720
Health Authority: United States: Food and Drug Administration
ClinicalTrials.gov processed this record on 2005-04-08