Naloxone Injection |
Narcan |
Naloxone Systematic (IUPAC) name 17-allyl-4,5α-epoxy- 3,14-dihydroxymorphinan-6-one Identifiers CAS number 465-65-6 ATC code V03AB15 PubChem 4425 DrugBank APRD00025 Chemical data Formula C19H21NO4 Mol. weight 327.27 Pharmacokinetic data Bioavailability 2% (90% absorption but high first-pass metabolism) Metabolism Liver Half life 1-1.5 hours Excretion Urine, Biliary Therapeutic considerations Pregnancy cat. B (USA) B1 (Aus) Legal status Schedu ...
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Naloxone Injection Clinical Trials
- Buprenorphine/Naloxone for Treatment of Opiate Dependence - 9
ClinicalTrials.gov Identifier: NCT00000344 - Active, not recruiting
Opioid-Related Disorders
- Buprenorphine/Naloxone - Facilitated Rehabilitation for Opioid Dependent Adolescents - 1
ClinicalTrials.gov Identifier: NCT00078130 - Active, not recruiting
Opioid-Related Disorders
- Abuse Potential of Parenteral Buprenorphine/Naloxone in Non-Dependent Opioid Abusers - 3
ClinicalTrials.gov Identifier: NCT00134875 - Active, not recruiting
Opioid-Related Disorders
- Buprenorphine/Naloxone Versus Clonidine for Inpatient Opiate Detoxification - 1
ClinicalTrials.gov Identifier: NCT00032955 - Active, not recruiting
Heroin Dependence; Morphine Dependence; Substance Withdrawal Syndrome
- Buprenorphine/Naloxone Versus Clonidine for Outpatient Opiate Detoxification - 1
ClinicalTrials.gov Identifier: NCT00032968 - Active, not recruiting
Heroin Dependence; Morphine Dependence; Substance Withdrawal Syndrome
- Buprenorphine/Naloxone in the Treatment of Heroin Dependence - 14
ClinicalTrials.gov Identifier: NCT00015340 - Active, not recruiting
Heroin Dependence; Substance-Related Disorders
- Naloxone in Treating Constipation in Patients Who Are Receiving Opioids for Chronic Pain
ClinicalTrials.gov Identifier: NCT00020605 - Active, not recruiting
constipation, impaction, and bowel obstruction; unspecified adult solid tumor, protocol specific
- Oxycodone-Naloxone in Relieving Opioid-Related Constipation
ClinicalTrials.gov Identifier: NCT00412152 - Active, not recruiting
Pain
- Oxycodone-Naloxone Prolonged Release Tablets in Relieving Opioid-Related Constipation
ClinicalTrials.gov Identifier: NCT00412100 - Active, not recruiting
Pain
- TLK286 (Telcyta) vs. Doxil/Caelyx or Hycamtin in Platinum Refractory or Resistant Ovarian Cancer
ClinicalTrials.gov Identifier: NCT00057720 - Active, not recruiting
Ovarian Neoplasms
- Evaluation of PF-00572778 and Alprazolam on Naloxone Challenge in Healthy Subjects
ClinicalTrials.gov Identifier: NCT00580190 - Active, not recruiting
Healthy People
- Drug Treatment Combined With Drug and Risk Reduction Counseling in the Prevention of HIV Infection Among Injection Drug Users
ClinicalTrials.gov Identifier: NCT00270257 - Not yet recruiting
HIV Infections; Opioid-Related Disorders
- Optimal Dose of Prophylactic Naloxone in Reducing Opioid-Induced Side Effects in Children/Adolescents
ClinicalTrials.gov Identifier: NCT00330343 - Recruiting
Pain; Nausea; Pruritus
- Suboxone: (Buprenorphine/Naloxone) Comparison of Two Taper Schedules - 1
ClinicalTrials.gov Identifier: NCT00078117 - Active, not recruiting
Opioid-Related Disorders
- Determine the safety of a sublingual tablet formulation of buprenorphine and naloxone by extending the combination tablet availability to physicians in office-based practice
ClinicalTrials.gov Identifier: NCT00007527 - Completed
Opiate Dependence
- Penile Injection Anxiety
ClinicalTrials.gov Identifier: NCT00582231 - Recruiting
Penile Injection Therapy; Erectile Dysfunction; Radical Pelvic Surgery
- Safety of KAI-9803 for Injection with Angioplasty following Heart Attack
ClinicalTrials.gov Identifier: NCT00093197 - Active, not recruiting
Myocardial Infarction
- A Study to Evaluate the Effects of Two Vitamin D Analogs, Zemplar® Injection and Hectorol® Injection, on Intestinal Absorption of Calcium in Patients With Stage 5 Chronic Kidney Disease
ClinicalTrials.gov Identifier: NCT00257920 - Recruiting
Stage 5 Chronic Kidney Disease (CKD); Secondary Hyperparathyroidism
- The Acute and Protracted Blockade Efficacy of Buprenorphine/Naloxone - 2
ClinicalTrials.gov Identifier: NCT00134888 - Completed
Opioid-Related Disorders
- Effects of Buprenorphine/Naloxone - 4
ClinicalTrials.gov Identifier: NCT00134914 - Active, not recruiting
Opioid-Related Disorders
- Study of TLK199 HCl Liposomes for Injection in Myelodysplastic Syndrome
ClinicalTrials.gov Identifier: NCT00035867 - Active, not recruiting
Myelodysplastic Syndromes
- Buprenorphine and Naloxone Combination Study - 10
ClinicalTrials.gov Identifier: NCT00015288 - Completed
Heroin Dependence; Opioid-Related Disorders
- Preoperative Injection of Bevacizumab Prior to Vitreoretinal Surgery in Diabetic Tractional Retinal Detachment
ClinicalTrials.gov Identifier: NCT00548197 - Recruiting
Intravitreal Bevacizumab Injection; Pars Plana Vitrectomy; Tractional Retinal Detachment; Diabetic Retinopathy
- Adverse Drug Reactions of Different Brands of Ceftazidime Injection
ClinicalTrials.gov Identifier: NCT00173901 - Active, not recruiting
Infection
- Topical Amethocaine Gel for Intramuscular Injection in Term Neonates
ClinicalTrials.gov Identifier: NCT00267111 - Active, not recruiting
Pain
- Buprenorphine and Naloxone for the Treatment of Opiate Dependence - 1
ClinicalTrials.gov Identifier: NCT00015171 - Completed
Heroin Dependence; Substance-Related Disorders
- Validation of Self-Reported Needle Sharing Among Injection Drug Users
ClinicalTrials.gov Identifier: NCT00341081 - Active, not recruiting
Viral Infection
- EPC by Intracoronary Injection in Patients With Chronic Stable Angina
ClinicalTrials.gov Identifier: NCT00384514 - Active, not recruiting
Coronary Artery Disease
- A Effectiveness and Safety Study of AQUAVAN® Injection (AQUAVAN; Fospropofol Disodium) for Sedation During Colonoscopy
ClinicalTrials.gov Identifier: NCT00125424 - Active, not recruiting
Colonoscopy; Colon Polyps; Endoscopic sedation; Endoscopic outcomes; Endoscopy
- Buprenorphine/Naloxone for Opiate-Dependence Treatment - 1
ClinicalTrials.gov Identifier: NCT00015028 - Completed
Opioid-Related Disorders; Substance-Related Disorders
- Trial of Buprenorphine/Naloxone for Opiate Dependence - 2
ClinicalTrials.gov Identifier: NCT00000353 - Completed
Opioid-Related Disorders; Substance-Related Disorders
- The Necessity of an Injection-Meal-Interval in Patients With Type 2 Diabetes Mellitus and Therapy With Human Insulin
ClinicalTrials.gov Identifier: NCT00529165 - Recruiting
Diabetes Mellitus Type 2; Injection to Meal Time; Human Insulin
- Comparison Between Type A Botulinum Toxin Injection and Corticosteroid Injection in the Treatment of Tennis Elbow
ClinicalTrials.gov Identifier: NCT00395616 - Recruiting
Type A Botulinum Toxin; Tennis Elbow
- Safety and Effects of Implanted (Autologous) Skeletal Myoblasts (MyoCell) Using an Injection Catheter = SEISMIC Trial
ClinicalTrials.gov Identifier: NCT00375817 - Active, not recruiting
Myocardial Infarction; Heart Failure, Congestive
- Study of MEDI-522 Administered by Subcutaneous Injection to Adults With Plaque Psoriasis
ClinicalTrials.gov Identifier: NCT00192517 - Active, not recruiting
Psoriasis
- A 2-Year Study of Patients With Schizophrenia Who Are Treated With Long-Acting Risperidone Injection.
ClinicalTrials.gov Identifier: NCT00246194 - Active, not recruiting
Schizophrenia
- IOP Reduction After Anecortave Acetate Injection in Glaucoma Patients
ClinicalTrials.gov Identifier: NCT00533962 - Active, not recruiting
Glaucoma; Intraocular Pressure
- A Study Comparing Oxycodone to Oxycodone/Naloxone in Moderate to Severe, Chronic Cancer Pain
ClinicalTrials.gov Identifier: NCT00513656 - Not yet recruiting
Cancer; Pain; Constipation
- Behavioral Intervention for HIV and HCV-Uninfected Injection Drug Users
ClinicalTrials.gov Identifier: NCT00164372 - Active, not recruiting
HIV Infections; Hepatitis C
- Comparison of Efficacy Between Silicone Ahmed Glaucoma Valves With and Without Intravitreal Triamcinolone Injection
ClinicalTrials.gov Identifier: NCT00491712 - Active, not recruiting
Neovascular Glaucoma
- A Trial to Reduce Hepatitis C Among Injection Drug Users - 1
ClinicalTrials.gov Identifier: NCT00218192 - Active, not recruiting
HCV Negative Status; HCV Risk Behavior
- A Phase I/II Study of Chondrogen Delivered by Intra-Articular Injection Following Meniscectomy
ClinicalTrials.gov Identifier: NCT00225095 - Active, not recruiting
Recovery Following Partial Medial Meniscectomy
- Multicenter Study Of CPX-1 (Irinotecan HCl: Floxuridine) Liposome Injection In Patients With Advanced Colorectal Cancer
ClinicalTrials.gov Identifier: NCT00361842 - Active, not recruiting
Colorectal Neoplasms
- Doxorubicin HCI Liposome Injection Versus Weekly Docetaxel in Patients First Relapse Metastatic Breast Cancer
ClinicalTrials.gov Identifier: NCT00193037 - Active, not recruiting
Breast Cancer
- Vitamin K Injections for the Treatment of Painful Menstruation
ClinicalTrials.gov Identifier: NCT00104546 - Active, not recruiting
Dysmenorrhea
- Injection Of AJCC Stage IIB, IIC, III And IV Melanoma Patients With A Multi-Epitope Peptide Vaccine Using GM-CSF DNA As An Adjuvant: A Pilot Trial To Assess Safety And Immunity
ClinicalTrials.gov Identifier: NCT00580060 - Active, not recruiting
Melanoma
- Randomized Study of Interventions to Enhance Adherence to Isoniazid Prevention Therapy for Tuberculosis in Injection Drug Users
ClinicalTrials.gov Identifier: NCT00004740 - Active, not recruiting
Tuberculosis
- Safety and Efficacy of Doxorubicin Adsorbed to Magnetic Beads
ClinicalTrials.gov Identifier: NCT00054951 - Active, not recruiting
Hepatocellular Carcinoma
- Study of Pasireotide Long Acting Release (LAR) Injection in Patients With Acromegaly and Patients With Carcinoid Disease
ClinicalTrials.gov Identifier: NCT00446082 - Active, not recruiting
Carcinoid Tumor; Acromegaly
- Abuse Potential of Buprenorphine/Naloxone - 7
ClinicalTrials.gov Identifier: NCT00149539 - Terminated
Opioid Dependence
- Patients Preference With Self-Injection: The PRISM Study
ClinicalTrials.gov Identifier: NCT00253396 - Recruiting
Bruises
- Safety and Efficacy of PolyHeme(R) in Hemorrhagic Shock Following Traumatic Injuries Beginning in the Pre-Hospital Setting
ClinicalTrials.gov Identifier: NCT00076648 - Active, not recruiting
Hemorrhagic Shock
- Fluocinolone Acetonide Implant Compared to Sham Injection in Patients With Diabetic Macular Edema
ClinicalTrials.gov Identifier: NCT00344968 - Active, not recruiting
Diabetic Macular Edema
- Injection Site Study In Patients With Type 2 Diabetes Mellitus (T2DM) And Healthy Volunteers
ClinicalTrials.gov Identifier: NCT00394030 - Active, not recruiting
Type 2 Diabetes Mellitus
- Study of Taxoprexin Injection vs. Dacarbazine in Patients with Metastatic Malignant Melanoma
ClinicalTrials.gov Identifier: NCT00087776 - Active, not recruiting
Malignant Melanoma
- Insulin Glargine Injection Treatment in Place of Thiazolidinedione (TZD), Sulfonylurea, or Metformin in Triple Agent Therapy for Type 2 Diabetes Mellitus (T2DM) Adult Subjects With Unsatisfactory Control
ClinicalTrials.gov Identifier: NCT00283049 - Active, not recruiting
Diabetes Mellitus, Type 2
- Study of TPI 287 in Patients with Advanced Malignancies
ClinicalTrials.gov Identifier: NCT00113724 - Active, not recruiting
Neoplasms
- A Study to Determine the Effectiveness and Safety of Risperidone in the Prevention of Bipolar Mood Episodes
ClinicalTrials.gov Identifier: NCT00132678 - Active, not recruiting
Bipolar Disorder
- Azithromycin/Bicillin for treatment of early syphilis
ClinicalTrials.gov Identifier: NCT00031499 - Active, not recruiting
Syphilis
- Treating High Risk Leukemia with CD40 Ligand & IL-2 Gene Modified Tumor Vaccine.
ClinicalTrials.gov Identifier: NCT00058799 - Active, not recruiting
Leukemia
- Intraocular Pressure Immediately Following Intravitreous Injection of Ranibizumab
ClinicalTrials.gov Identifier: NCT00417703 - Recruiting
Choroidal Neovascularization
- Botulinum Toxin Injection for the Management of BPH
ClinicalTrials.gov Identifier: NCT00451191 - Recruiting
Benign Prostatic Hyperplasia
- Dysport® Injection in the Treatment of Chronic Lateral Epicondylitis
ClinicalTrials.gov Identifier: NCT00497913 - Recruiting
Tennis Elbow
- A Phase 2 open-label clinical study using intravenous Paxceed™ to treat patients with rheumatoid arthritis
ClinicalTrials.gov Identifier: NCT00055133 - Active, not recruiting
Rheumatoid Arthritis
- ATX-101 (Sodium Deoxycholate for Injection) for the Treatment of Superficial Lipomas
ClinicalTrials.gov Identifier: NCT00422188 - Recruiting
Lipoma
- The ORIGIN Trial (Outcome Reduction with Initial Glargine Intervention)
ClinicalTrials.gov Identifier: NCT00069784 - Active, not recruiting
Diabetes Mellitus, Non-Insulin-Dependent
- Does a Single Steroid Injection Reduce the Formation of Postmastectomy Seroma
ClinicalTrials.gov Identifier: NCT00307606 - Recruiting
Breast Neoplasms; Mastectomy
- To Find the Best Dose of pVGI.1(VEGF2) to Benefit Angina Patients when given with an Experimental Injection Catheter
ClinicalTrials.gov Identifier: NCT00090714 - Active, not recruiting
Angina Pectoris
- Safety and Effectiveness of SeeMore (EVP 1001-1 Injection) for MRI in Heart Patients
ClinicalTrials.gov Identifier: NCT00340925 - Recruiting
Myocardial Infarction
- Sentinel Lymph Node Biopsy Using Peritumoral Injection With Blue Dye Confirmation
ClinicalTrials.gov Identifier: NCT00575744 - Recruiting
Breast Cancer
- An Observational Study Evaluating SYMLIN® (Pramlintide Acetate) Injection Use in Insulin Using Patients With Type 2 and Type 1 Diabetes
ClinicalTrials.gov Identifier: NCT00229658 - Active, not recruiting
Type 1 Diabetes Mellitus; Type 2 Diabetes Mellitus
- Impact of Low Dose Naloxone on Fentanyl Requirements in Pediatric ICU Patients
ClinicalTrials.gov Identifier: NCT00286052 - Completed
Opioid Tolerance
- A Study to Evaluate Nutropin AQ for the Treatment of Growth Restriction in Children with Cystic Fibrosis
ClinicalTrials.gov Identifier: NCT00079742 - Active, not recruiting
Cystic Fibrosis
- Injection Methods in Finding the Sentinel Lymph Node During Lymphatic Mapping and Sentinel Lymph Node Biopsy in Patients With Invasive Breast Cancer
ClinicalTrials.gov Identifier: NCT00438477 - Active, not recruiting
Breast Cancer
- Comparison Study of Operation and Percutaneous Ethanol Injection Therapy for Small, Solitary HCC
ClinicalTrials.gov Identifier: NCT00357422 - Recruiting
Hepatocellular Carcinoma
- Comparison Study of Transarterial Chemoembolization and Percutaneous Ethanol Injection for Multiple, Small HCCs
ClinicalTrials.gov Identifier: NCT00357474 - Recruiting
Hepatocellular Carcinoma
- Safety Study of IHL-305 (Irinotecan Liposome Injection) to Treat Advanced Solid Tumors
ClinicalTrials.gov Identifier: NCT00364143 - Recruiting
Cancer
- The Impact of an Epidural Ropivacaine-Neostigmine Injection for Perineal Analgesia at the End of Labor.
ClinicalTrials.gov Identifier: NCT00407290 - Recruiting
Pregnancy; Vaginal Delivery
- Sub-Tenon’s Injection of Triamcinolone and Ciprofloxacin in a Controlled-Release System for Cataract Surgery
ClinicalTrials.gov Identifier: NCT00431028 - Recruiting
Inflammation; Bacterial Infections
- This is a Prospective, Randomized, Double-Blind Study Comparing Intravesical Injection of Botox® to Placebo.
ClinicalTrials.gov Identifier: NCT00479596 - Recruiting
Overactive Bladder
- Phase I/II Dose Escalation Study of VELCADE® and Docetaxel in Patients with Advanced Androgen-Independent Prostate Cancer
ClinicalTrials.gov Identifier: NCT00064610 - Active, not recruiting
Prostatic Neoplasms
- Safety and Efficacy Study of Myobloc in the Treatment of Sialorrhea (Drooling) in Patients with ALS
ClinicalTrials.gov Identifier: NCT00125203 - Active, not recruiting
Amyotrophic Lateral Sclerosis; Sialorrhea
- Intramyocardial Injection of Autologous Aldehyde Dehydrogenase-Bright Stem Cells for Therapeutic Angiogenesis
ClinicalTrials.gov Identifier: NCT00314366 - Recruiting
Coronary Artery Disease
- Corticosteroid Injection for Common Upper Extremity Problems
ClinicalTrials.gov Identifier: NCT00438672 - Recruiting
Lateral Elbow Pain; deQuervain’s Tendonitis; CMC Arthritis
- Injection of ex Vivo Amplified G-CSF Mobilised Autologous Peripheral Blood Stem Cell Transplantation
ClinicalTrials.gov Identifier: NCT00461955 - Recruiting
Multiple Myeloma
- A Phase 1 Safety Study of Single and Repeated Doses of JSM6427 (Intravitreal Injection) to Treat AMD
ClinicalTrials.gov Identifier: NCT00536016 - Recruiting
Macular Degeneration
- Hyaluronan Versus NaCl 20 Ml Versus Placebo in Knee Osteoarthritis
ClinicalTrials.gov Identifier: NCT00144820 - Active, not recruiting
Osteoarthritis, Knee
- Phase 2b Study of VELCADE Alone and VELCADE plus Irinotecan in Patients with Relapsed or Refractory Colorectal Carcinoma
ClinicalTrials.gov Identifier: NCT00051987 - Active, not recruiting
Colorectal Carcinoma
- Safety Study of MBP-426 (Liposomal Oxaliplatin Suspension for Injection) to Treat Advanced or Metastatic Solid Tumors
ClinicalTrials.gov Identifier: NCT00355888 - Recruiting
Cancer
- Feasibility Study of the Effect of Intra-Dermal Insulin Injection on Blood Glucose Levels After Eating
ClinicalTrials.gov Identifier: NCT00553488 - Recruiting
Diabetes Mellitus, Type 1
- Factors Predicting Efficacy of Allergen Injection Immunotherapy for Grass Pollen Hayfever: a Pilot Study.
ClinicalTrials.gov Identifier: NCT00135629 - Active, not recruiting
Seasonal Allergic Rhinoconjunctivitis
- Valganciclovir in Patients with CMV Retinitis and AIDS Who Cannot Take Drugs by Injection
ClinicalTrials.gov Identifier: NCT00017784 - Active, not recruiting
Cytomegalovirus Retinitis; HIV Infections
- Vincristine, DOXIL® (Doxorubicin HCl Liposome Injection) and Dexamethasone vs. Vincristine, Doxorubicin, and Dexamethasone in Patients With Newly Diagnosed Multiple Myeloma
ClinicalTrials.gov Identifier: NCT00344422 - Active, not recruiting
M-Protein; Multiple Myeloma; Myeloma; Myeloma Proteins
- Depo-Provera: Evaluation of BMDensity and Total Body Ca Adolescent DP150CI Users and Non-Hormonal Contraception
ClinicalTrials.gov Identifier: NCT00139685 - Active, not recruiting
Contraception; Bone Density
- Evaluation of the Effects of L-Carnitine Injection in Patients Undergoing Hemodialysis
ClinicalTrials.gov Identifier: NCT00173706 - Recruiting
Cardiac Complications; Signs and Symptoms; Muscle Weakness; Anemia; Hypotension
- Thal/Dex (Thalidomide and Dexamethasone) vs. Dd-T (Doxil, Dexamethasone and Thalidomide) in Multiple Myeloma Patients
ClinicalTrials.gov Identifier: NCT00097981 - Active, not recruiting
Multiple Myeloma
- Treatment of Chronic Lymphocytic B-Leukemia with IL-2 and CD-40 Autologous Tumor Cells
ClinicalTrials.gov Identifier: NCT00058786 - Active, not recruiting
Chronic Lymphocytic B-Leukemia
- EUS-Guided Pancreatic Injection of Cyst (EPIC) Trial
ClinicalTrials.gov Identifier: NCT00233038 - Recruiting
Pancreatic Cystadenoma.
- Pore Excision, Curettage, and Injection of Cymetra for Pilonidal Disease
ClinicalTrials.gov Identifier: NCT00493493 - Recruiting
Pilonidal Sinus
- One Time Injection of Bacteria to Treat Solid Tumors That Have Not Responded to Standard Therapy
ClinicalTrials.gov Identifier: NCT00358397 - Recruiting
Tumors

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