Not Signed In -
Naloxone Injection |
Narcan |
Clinical Trial: Abuse Potential of Parenteral Buprenorphine/Naloxone in Non-Dependent Opioid Abusers - 3
This study has been completed.
Purpose
Buprenorphine, a treatment for opioid dependence, can be mixed with naloxone to limit the parenteral abuse potential of the combination product. Parenteral administration of buprenorphine/nalxone causes withdrawal symptoms in opioid dependent individuals. However naloxone would not cause withdrawal symptoms in a non-dependent opioid abuser. This study investigates whether nalxone decreases the opioid agonist effect from injected buprenorphine, hence decreasing the abuse potential of buprenorphine/naloxone in non-dependent opioid abusers.
| Condition | Intervention |
|---|---|
| Opioid-Related Disorders | Drug: Buprenorphine/naloxone |
MedlinePlus related topics: Drug Abuse
Study Type: Interventional
Study Design: Treatment, Randomized, Double-Blind, Active Control, Pharmacodynamics Study
Official Title: Abuse Potential of Parenteral Buprenorphine/Naloxone in Non-Dependent Opioid Abusers-0016
Further Study Details:
Expected Total Enrollment: 9
Study start: December 2000; Study completion: June 2006
Last follow-up: December 2002; Data entry closure: December 2002
Eligibility
Ages Eligible for Study: 18 Years - 55 Years, Genders Eligible for Study: Both
Accepts Healthy Volunteers
Criteria
non-dependent male and females actively abusing opioids by injection.
Exclusion Criteria:
diagnosis of opioid dependence, signs or symptoms of opioid withdrawal once admitted to residential unit
Location Information
Maryland
Johns Hopkins University (BPRU) Bayview Campus, Baltimore, Maryland, 21224 6823, United States
Study chairs or principal investigators
Eric C Strain, M.D., Principal Investigator, Johns Hopkins University
More Information
Study ID Numbers: NIDA-08045-3; R01-08045-3
Last Updated: August 24, 2005
Record first received: August 23, 2005
ClinicalTrials.gov Identifier: NCT00134875
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2005-08-30
Last Updated: August 24, 2005
Record first received: August 23, 2005
ClinicalTrials.gov Identifier: NCT00134875
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2005-08-30
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