Naltrexone |
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Naltrexone Systematic (IUPAC) name 17-(cyclopropylmethyl)-4,5α-epoxy- 3,14-dihydroxymorphinan-6-one Identifiers CAS number 16590-41-3 ATC code N07BB04 PubChem 5360515 DrugBank APRD00005 Chemical data Formula C20H23NO4 Mol. weight 341.401 g/mol Physical data Melt. point 169°C (336°F) Pharmacokinetic data Bioavailability 5-40% Protein binding 21% Metabolism hepatic Half life 4 hours (naltrexone), 13 hours (6-β-naltrexol) Excretion renal Therapeu ...
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Naltrexone Clinical Trials
- Managing Alcoholism in People who Do Not Respond to Naltrexone
ClinicalTrials.gov Identifier: NCT00115037 - Active, not recruiting
Alcoholism
- Behavioral Naltrexone Therapy (BNT) for Promoting Adherence to Oral Naltrexone (BNT-Oral) vs Extended Release Injectable Depot Naltrexone (Depot-BNT); a Randomized Trial. A Free Treatment for Opiate Abuse.
ClinicalTrials.gov Identifier: NCT00577408 - Recruiting
Opiate Dependence; Heroin Dependence
- Opiate Dependence: Combined Naltrexone/Behavior Therapy - 1
ClinicalTrials.gov Identifier: NCT00238914 - Active, not recruiting
Behavior Therapy; Naltrexone; Opioid Dependence
- Effectiveness of Gabapentin When Used With Naltrexone to Treat Alcohol Dependence Compared to Placebo and Naltrexone Alone
ClinicalTrials.gov Identifier: NCT00183196 - Recruiting
Alcohol Dependence
- Effectiveness of Disulfiram and Naltrexone Used in Combination to Treat Individuals Diagnosed with Both Cocaine and Alcohol Dependence - 1
ClinicalTrials.gov Identifier: NCT00142844 - Active, not recruiting
Alcohol-Related Disorders; Alcoholism; Cocaine-Related Disorders
- Place of Low-Dose Naltrexone in Opiate Detoxification - 1
ClinicalTrials.gov Identifier: NCT00135759 - Active, not recruiting
Heroin Dependence; Opioid-Related Disorders; Substance-Related Disorders
- Efficacy of Naltrexone in Women''s Smoking Cessation
ClinicalTrials.gov Identifier: NCT00271024 - Recruiting
Smoking; Smoking Cessation
- Oral and Depot Naltrexone - 1
ClinicalTrials.gov Identifier: NCT00218426 - Recruiting
Heroin Dependence
- Naltrexone Effects on Alcohol Intake
ClinicalTrials.gov Identifier: NCT00254670 - Active, not recruiting
Social Drinker
- Naltrexone Implants as Relapse Prevention
ClinicalTrials.gov Identifier: NCT00269607 - Active, not recruiting
Opioid Dependency
- Naltrexone Implants vs. MMT Among Inmates in the Norwegian Correctional Services
ClinicalTrials.gov Identifier: NCT00204243 - Active, not recruiting
Opiate Addiction
- Efficacy of Naltrexone Treatment as Augmentation to SSRI in OCD Patients
ClinicalTrials.gov Identifier: NCT00234689 - Active, not recruiting
Obsessive Compulsive Disorder
- Treatment for Alcoholism and Post-Traumatic Stress Disorder (naltrexone)
ClinicalTrials.gov Identifier: NCT00006489 - Recruiting
Alcoholism; Post-Traumatic Stress Disorder
- Targeted Naltrexone for Problem Drinkers
ClinicalTrials.gov Identifier: NCT00369408 - Active, not recruiting
Alcoholism; Alcohol Drinking; Alcohol Dependence
- Behavioral Naltrexone Therapy: A Novel Treatment for Heroin Dependence
ClinicalTrials.gov Identifier: NCT00332228 - Active, not recruiting
Opiate Dependence
- Trial for the Treatment of Alcohol Dependence
ClinicalTrials.gov Identifier: NCT00120601 - Active, not recruiting
Alcoholism
- Naltrexone Implants - a Treatment Alternative for Heroin Dependent Prisoners?
ClinicalTrials.gov Identifier: NCT00520793 - Active, not recruiting
Heroin Dependence; Criminal Behaviour
- A Study of Naltrexone SR/Bupropion SR and Placebo in Obese Subjects Participating in a Behavior Modification Program
ClinicalTrials.gov Identifier: NCT00456521 - Active, not recruiting
Obesity
- An Open-Label Evaluation of the Independent Effects of Coadministration of a High-Fat Meal and Naltrexone Blockade on the Pharmacokinetic Profile of Dilaudid OROS (Hydromorphone HCI) 16mg
ClinicalTrials.gov Identifier: NCT00399295 - Active, not recruiting
Analgesia
- Naltrexone in Borderline Personality Disorder
ClinicalTrials.gov Identifier: NCT00124839 - Recruiting
Borderline Personality Disorder
- Naltrexone Implants - a Randomised Study
ClinicalTrials.gov Identifier: NCT00521157 - Recruiting
Opiate Dependence
- Naltrexone and Patch for Smokers
ClinicalTrials.gov Identifier: NCT00018213 - Completed
Smoking
- Naltrexone for Early Problem Drinkers
ClinicalTrials.gov Identifier: NCT00000455 - Completed
Alcoholism
- Naltrexone for Relapse Prevention
ClinicalTrials.gov Identifier: NCT00000442 - Completed
Alcoholism
- Naltrexone, Craving, and Drinking
ClinicalTrials.gov Identifier: NCT00006203 - Completed
Alcoholism
- Use of Naltrexone in a Clinical Setting
ClinicalTrials.gov Identifier: NCT00000445 - Completed
Alcoholism
- Naltrexone and Varenicline: Weight Gain and Tolerability in Cigarette Smokers
ClinicalTrials.gov Identifier: NCT00502216 - Recruiting
Smoking; Nicotine Dependence
- Augmenting Zyprexa With Naltrexone to Ameliorate Metabolic Side-Effects
ClinicalTrials.gov Identifier: NCT00567034 - Recruiting
Schizophrenia; Psychotic Disorders
- Injectable Versus Oral Naltrexone Treatment of Alcohol Dependence In Serious Mental Illness (SMI)
ClinicalTrials.gov Identifier: NCT00453804 - Active, not recruiting
Bipolar Disorders; Schizophrenia; Schizoaffective Disorders; Alcohol Dependence
- Drug Treatment for Pathologic Gambling Disorder
ClinicalTrials.gov Identifier: NCT00053677 - Active, not recruiting
Impulse Control Disorders
- Naltrexone in Two Models of Psychosocial Treatments for Cocaine and Alcohol Dependence - 1
ClinicalTrials.gov Identifier: NCT00218660 - Active, not recruiting
Alcoholism; Cocaine Abuse, Cocaine-Related Disorders; Cocaine Dependence
- Naltrexone Treatment of Alcohol Abuse in Schizophrenia
ClinicalTrials.gov Identifier: NCT00145847 - Recruiting
Schizophrenia; Mental Disorders; Alcohol Abuse; Alcoholism; Alcohol-Related Disorders
- Modafinil and Naltrexone for the Treatment of Cocaine and Alcohol Dependence - 3
ClinicalTrials.gov Identifier: NCT00142818 - Recruiting
Alcohol-Related Disorders; Alcoholism; Cocaine Abuse, Cocaine-Related Disorders; alcohol & drug use
- Drug Therapy for Alcohol Dependence in Alaska Natives (naltrexone/sertraline)
ClinicalTrials.gov Identifier: NCT00000451 - Completed
Alcoholism
- Self-Injury: Diagnosis and Treatment
ClinicalTrials.gov Identifier: NCT00065936 - Active, not recruiting
Self-Injurious Behavior; Mental Retardation
- Naltrexone Maintenance Treatment of Alcoholism
ClinicalTrials.gov Identifier: NCT00000450 - Completed
Alcoholism
- Sertraline and Naltrexone for Alcohol Dependence
ClinicalTrials.gov Identifier: NCT00000440 - Completed
Alcoholism
- Study of Bupropion Versus Bupropion + Naltrexone for Smoking Cessation
ClinicalTrials.gov Identifier: NCT00419731 - Recruiting
Tobacco Use Disorder
- A Study of Two Doses of Naltrexone SR/Bupropion SR and Placebo in Obese Subjects
ClinicalTrials.gov Identifier: NCT00532779 - Recruiting
Obesity
- Naltrexone Treatment of Alcohol Dependence
ClinicalTrials.gov Identifier: NCT00000452 - Completed
Alcoholism
- Effectiveness of Naltrexone Versus Placebo to Reduce Craving for Alcohol With Evaluation of Genetic Variability.
ClinicalTrials.gov Identifier: NCT00366626 - Recruiting
Alcohol Dependence
- Combined Pharmacotherapies for Alcoholism (naltrexone/ondansetron)
ClinicalTrials.gov Identifier: NCT00027079 - Completed
Alcoholism
- Naltrexone in the Treatment of Pyromania
ClinicalTrials.gov Identifier: NCT00467454 - Recruiting
Pyromania; Fire Setting
- Effects of Low Dose Naltrexone in Fibromyalgia
ClinicalTrials.gov Identifier: NCT00568555 - Recruiting
Fibromyalgia
- COMBINE (acamprosate/naltrexone)
ClinicalTrials.gov Identifier: NCT00006206 - Completed
Alcoholism
- Naltrexone Treatment for Alcoholism
ClinicalTrials.gov Identifier: NCT00000438 - Completed
Alcoholism
- Post-Treatment Effects of Naltrexone
ClinicalTrials.gov Identifier: NCT00006449 - Completed
Alcoholism
- Double-Blind Naltrexone in Kleptomania
ClinicalTrials.gov Identifier: NCT00332579 - Recruiting
Kleptomania
- Drug Treatment for Depressed Alcoholics (naltrexone/fluoxetine)
ClinicalTrials.gov Identifier: NCT00006204 - Completed
Alcoholism; Depression
- This Study Aims to Evaluate Naltrexone, Lofexidine and Their Combination in Conjuction with Psychosocial Treatment to Prevent Relapse in Detoxified Heroin Addicts in Russia - 1
ClinicalTrials.gov Identifier: NCT00142948 - Recruiting
- Naltrexone Treatment for Alcoholic Women
ClinicalTrials.gov Identifier: NCT00000448 - Completed
Alcoholism; Eating Disorder
- Naltrexone in Treating Women With Metastatic Breast Cancer That Did Not Respond to Hormone Therapy
ClinicalTrials.gov Identifier: NCT00379197 - Recruiting
Breast Cancer
- A Safety and Efficacy Study Comparing Naltrexone SR/Bupropion SR and Placebo in Obese Type 2 Diabetics
ClinicalTrials.gov Identifier: NCT00474630 - Recruiting
Obesity; Diabetes Mellitus, Type 2
- Behavior and Naltrexone Treatment for Alcoholics
ClinicalTrials.gov Identifier: NCT00000449 - Completed
Alcoholism
- Naltrexone & SSRI in Alcoholics With Depression/PTSD
ClinicalTrials.gov Identifier: NCT00338962 - Recruiting
Alcoholism; Depression; PTSD
- A Safety and Efficacy Study of Naltrexone SR/Bupropion SR in Obesity
ClinicalTrials.gov Identifier: NCT00567255 - Recruiting
Obesity
- Targeted Interventions for Weight-Concerned Smokers
ClinicalTrials.gov Identifier: NCT00105482 - Recruiting
Nicotine Dependence
- Long-Acting Injectable Naltrexone Treatment of Alcohol Dependence in Primary Care vs. in Specialized Chemical Dependence Treament: A Pilot Trial
ClinicalTrials.gov Identifier: NCT00461890 - Recruiting
Alcohol Dependence; Veterans
- A Study of Naltrexone SR/ Bupropion SR in Overweight and Obese Subjects Who Are Nicotine-Dependent
ClinicalTrials.gov Identifier: NCT00563563 - Recruiting
Nicotine Dependence; Overweight; Obesity
- Naltrexone for Bipolar Disorder and Alcohol Dependence
ClinicalTrials.gov Identifier: NCT00223275 - Active, not recruiting
Bipolar Disorder; Alcohol Dependence
- Behavioral/Drug Therapy for Alcohol-Nicotine Dependence (naltrexone/nicotine patch)
ClinicalTrials.gov Identifier: NCT00000447 - Completed
Alcoholism; Smoking
- N-Acetyl Cysteine Plus Naltrexone in Methamphetamine Dependence
ClinicalTrials.gov Identifier: NCT00332605 - Recruiting
Methamphetamine Dependence
- Memantine as a Supplement to Naltrexone in Treating Heroin Dependence
ClinicalTrials.gov Identifier: NCT00476242 - Recruiting
Opioid Dependence; Heroin Dependence
- Long-Term Safety Study of Naltrexone Long Acting Injection in Alcohol Dependent Adults
ClinicalTrials.gov Identifier: NCT00156923 - Completed
Alcoholism
- Tobacco Dependence in Alcoholism Treatment (nicotine patch/naltrexone)
ClinicalTrials.gov Identifier: NCT00000437 - Completed
Alcoholism; Smoking
- Treatment of Alcoholism with Cocaine Dependence
ClinicalTrials.gov Identifier: NCT00136162 - Active, not recruiting
Alcoholism; Alcohol-Related Disorders; Cocaine-Related Disorders
- Effects of a Range of Naltrexone Doses in Combination With Smoked Marijuana
ClinicalTrials.gov Identifier: NCT00403117 - Not yet recruiting
Marijuana Use
- Naltrexone in Treatment of Cocaine Dependence - 5
ClinicalTrials.gov Identifier: NCT00015080 - Completed
Cocaine-Related Disorders
- Testing the Effectiveness of Low-Dose Naltrexone Combined with Bupropion to Stop Smoking With Less Weight Gain
ClinicalTrials.gov Identifier: NCT00129246 - Completed
Smoking; Nicotine Dependence
- Behavioral Therapy Plus Naltrexone for Alcoholism
ClinicalTrials.gov Identifier: NCT00000456 - Completed
Alcoholism
- Effectiveness of Lofexidine to Prevent Stress-Related Opiate Relapse During Naltrexone Treatment - 1
ClinicalTrials.gov Identifier: NCT00142909 - Recruiting
Opioid-Related Disorders
- Naltrexone for Heavy Drinking in Young Adults
ClinicalTrials.gov Identifier: NCT00568958 - Not yet recruiting
Alcohol Consumption; Alcoholic Intoxication; Alcoholism; Alcohol-Induced Disorders
- Double-Blind Naltrexone in Compulsive Sexual Behavior
ClinicalTrials.gov Identifier: NCT00467558 - Recruiting
Compulsive Sexual Behavior
- Employment-Based Incentives to Motivate Naltrexone Ingestion and Drug Abstinence in the Treatment of Drug Addiction. - 1
ClinicalTrials.gov Identifier: NCT00149669 - Not yet recruiting
Behavior Therapy; Cocaine; Cocaine (IV); Cocaine Abuse; Cocaine Dependence; Contingency management; HIV risk behaviors; Heroin; Heroin Dependence; ...
- Effects of Yohimbine and Naltrexone on Sexual Function
ClinicalTrials.gov Identifier: NCT00042536 - Completed
Erectile Dysfunction
- Screening Medications for Cocaine Cessation and Relapse Prevention - 7
ClinicalTrials.gov Identifier: NCT00218023 - Recruiting
Cocaine Abuse; Cocaine-Related Disorders
- Long-Term Safety Study of Naltrexone Long Acting Injection in Alcohol or Opiate Dependent Adults.
ClinicalTrials.gov Identifier: NCT00156936 - Completed
Alcoholism; Opiate Dependence
- Naltrexone as Adjunct in Alcoholic Cocaine Dependent Patients - 4
ClinicalTrials.gov Identifier: NCT00000307 - Completed
Alcohol-Related Disorders; Cocaine-Related Disorders
- Injectable Naltrexone Treatment of Alcohol Dependence in Serious Mental Illness (SMI)
ClinicalTrials.gov Identifier: NCT00453609 - Not yet recruiting
Schizophrenia; Schizoaffective Disorder; Bipolar Disorder; Alcohol Dependence
- Trial of Low-Dose Naltrexone for Children With Pervasive Developmental Disorder (PDD)
ClinicalTrials.gov Identifier: NCT00318162 - Not yet recruiting
Pervasive Developmental Disorder
- Effects of Naltrexone on Nicotine Reinforcement
ClinicalTrials.gov Identifier: NCT00270231 - Completed
Tobacco Dependence
- Naltrexone Augmentation of Nicotine Patch Therapy - 1
ClinicalTrials.gov Identifier: NCT00218153 - Completed
Tobacco Use Disorder
- A Randomized Placebo-Controlled, Crossover-Design Study of the Effects of Low Dose Naltrexone
ClinicalTrials.gov Identifier: NCT00501696 - Completed
Multiple Sclerosis
- Effectiveness of Naltrexone and/or Ondansetron to Reduce Craving for Alcohol and Drinking
ClinicalTrials.gov Identifier: NCT00183222 - Completed
Alcohol Dependence
- Effectiveness of Naltrexone and Lofexidine in Treating Detoxified Heroin Addicts - 1
ClinicalTrials.gov Identifier: NCT00218530 - Completed
Heroin Dependence
- Naltrexone in Two Models of Psychosocial Treatments for Cocaine and Alcohol Dependence
ClinicalTrials.gov Identifier: NCT00167232 - Completed
Cocaine Dependence; Alcoholism
- Comparative Trial Of Disulfiram, Naltrexone And Acamprosate In The Treatment Of Alcohol Dependence
ClinicalTrials.gov Identifier: NCT00435435 - Completed
Alcohol Dependence
- Treating Alcohol Use In Older Adults With Depression
ClinicalTrials.gov Identifier: NCT00018824 - Completed
Alcoholism; Depression
- Sertraline for Alcohol Dependence and Depression
ClinicalTrials.gov Identifier: NCT00004554 - Completed
Alcoholism; Depression
- Rapid Opiate Detoxification and Naltrexone Induction Using Buprenorphine - 2
ClinicalTrials.gov Identifier: NCT00000299 - Completed
Opioid-Related Disorders
- Neurobiology of Opioid Dependence: 4 - 4
ClinicalTrials.gov Identifier: NCT00000195 - Completed
Opioid-Related Disorders
- Neurobiology of Opioid Dependence: 5 - 5
ClinicalTrials.gov Identifier: NCT00000196 - Completed
Opioid-Related Disorders
- Naltrexone in the Treatment of Concurrent Alcohol Dependence and Pathological Gambling
ClinicalTrials.gov Identifier: NCT00326807 - Completed
Concurrent Alcohol Dependence and Pathological Gambling

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