Pentostatin |
Nipent |
Image:Pentostatin.png Pentostatin Systematic (IUPAC) name 8-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]- 4,6,8,10- tetrazabicyclo[5.3.0] deca-4,9,11-trien-2-ol Identifiers CAS number 53910-25-1 ATC code L01XX08 PubChem 40926 DrugBank APRD00202 Chemical data Formula C11H16N4O4 Mol. weight 268.269 g/mol Pharmacokinetic data Bioavailability ? Protein binding 4% Metabolism ? Half life ? Excretion ? Therapeutic considerations ...
Wikipedia - [full article]
Pentostatin Clinical Trials
- Pentostatin for High Risk and Refractory Chronic Graft Versus Host Disease in Children
ClinicalTrials.gov Identifier: NCT00144430 - Recruiting
Graft vs Host Disease
- Pentostatin, Cyclophosphamide, and Rituximab in Treating Patients With Chronic Lymphocytic Leukemia or Other B-cell Cancers
ClinicalTrials.gov Identifier: NCT00003658 - Active, not recruiting
adult non-Hodgkin's lymphoma; Chronic Lymphocytic Leukemia; indolent or aggressive adult non-Hodgkin's lymphoma
- Phase I/II Study of Pentostatin Combined With Tacrolimus and Mini-Methotrexate for GVHD Prevention After MUD BMT
ClinicalTrials.gov Identifier: NCT00506922 - Active, not recruiting
Leukemia; Lymphoma
- Pentostatin and Donor White Blood Cells in Preventing Graft Rejection in Cancer Patients Who Have Undergone Donor Stem Cell Transplantation
ClinicalTrials.gov Identifier: NCT00096161 - Recruiting
Cancer; Graft Versus Host Disease
- Alemtuzumab and Pentostatin In T-Cell Neoplasms
ClinicalTrials.gov Identifier: NCT00453193 - Recruiting
Lymphoma; Leukemia
- Chemotherapy With Cordycepin Plus Pentostatin in Treating Patients With Refractory Acute Lymphocytic or Chronic Myelogenous Leukemia
ClinicalTrials.gov Identifier: NCT00003005 - Active, not recruiting
recurrent adult acute lymphocytic leukemia; TdT positive adult acute lymphocytic leukemia; blastic phase chronic myelogenous leukemia
- Pentostatin, Cyclophosphamide, and Rituximab Followed By Alemtuzumab in Treating Patients With Relapsed or Refractory B-Cell Chronic Lymphocytic Leukemia
ClinicalTrials.gov Identifier: NCT00074282 - Recruiting
refractory chronic lymphocytic leukemia; B-cell Chronic Lymphocytic Leukemia
- Etanercept, Mycophenolate Mofetil, Denileukin Diftitox, or Pentostatin Combined With Prednisone or Methylprednisolone in Treating Patients With Acute Graft-Versus-Host Disease Who Have Undergone a Previous Donor Stem Cell Transplant
ClinicalTrials.gov Identifier: NCT00253656 - Recruiting
Cancer; Graft Versus Host Disease
- Combination of Etanercept, Mycophenolate Mofetil (MMF), Denileukin Diftitox (Ontak), and Pentostatin With Steroids
ClinicalTrials.gov Identifier: NCT00474149 - Recruiting
Graft-Versus-Host Disease
- Pentostatin, and Rituximab With and Without Cyclophosphamide for Previously Untreated B-Chronic Lymphocytic Leukemia
ClinicalTrials.gov Identifier: NCT00201721 - Active, not recruiting
B-Chronic Lymphocytic Leukemia
- Pentostatin and Rituximab With or Without Cyclophosphamide in Treating Patients With Previously Untreated B-Cell Chronic Lymphocytic Leukemia
ClinicalTrials.gov Identifier: NCT00423423 - Recruiting
Leukemia
- Pentostatin, Cyclophosphamide, and Rituximab in Treating Patients With Previously Untreated Chronic Lymphocytic Leukemia
ClinicalTrials.gov Identifier: NCT00541034 - Recruiting
Leukemia; Lymphoma
- Pentostatin, Cyclophosphamide, Rituximab, and Mitoxantrone in Treating Patients With Chronic Lymphocytic Leukemia or Other Low-Grade B-Cell Cancer
ClinicalTrials.gov Identifier: NCT00546377 - Recruiting
Leukemia; Lymphoma
- Phase II Trial of Pentostatin and Targeted Busulfan
ClinicalTrials.gov Identifier: NCT00496340 - Not yet recruiting
Hematologic Malignancies
- A Trial of Extracorporeal Photopheresis, Pentostatin, and Total Body Irradiation in Patients Undergoing Reduced Intensity Allogeneic Stem Cell Transplantation for the Treatment of Malignancies
ClinicalTrials.gov Identifier: NCT00402714 - Recruiting
Hematologic Malignancies
- Pentostatin and Alemtuzumab as a Preparative Regimen for Allogeneic Peripheral Blood Stem Cell Transplantation
ClinicalTrials.gov Identifier: NCT00543283 - Recruiting
Leukemia; Lymphoma; Hodgkin's Disease; Hematologic Neoplasms; Multiple Myeloma; Carcinoma, Renal Cell
- Pentostatin and Rituximab in Treating Patients With Low-Grade Non-Hodgkin's Lymphoma or Chronic Lymphocytic Leukemia
ClinicalTrials.gov Identifier: NCT00026351 - Completed
Leukemia; Lymphoma
- Combination Chemotherapy and Rituximab in Treating Patients With Chronic Lymphocytic Leukemia or Lymphocytic Lymphoma
ClinicalTrials.gov Identifier: NCT00049413 - Active, not recruiting
adult non-Hodgkin's lymphoma; Chronic Lymphocytic Leukemia
- Safety and Efficacy of Pentostatin and Low Dose TBI With Allogenic Peripheral Blood Stem Cell Transplant
ClinicalTrials.gov Identifier: NCT00571662 - Recruiting
Acute Myelogenous Leukemia; Acute Lymphocytic Leukemia; Chronic Myelogenous Leukemia; Chronic Lymphocytic Leukemia; Myelodysplastic Syndromes; Multiple Myeloma; Non-Hodgkins Lymphoma; Hodgkins Disease; Peripheral T-Cell Lymphoma
- Reduced-Intensity Regimen Before Allogeneic Bone Marrow Transplantation in Treating Patients With Relapsed Non-Hodgkin's or Hodgkin's Lymphoma
ClinicalTrials.gov Identifier: NCT00057954 - Active, not recruiting
adult Hodgkin's lymphoma; adult T-cell leukemia and lymphoma; adult non-Hodgkin's lymphoma; anaplastic large cell lymphoma; ...
- A Study Of Deoxycoformycin(DCF)/Pentostatin In Lymphoid Malignancies
ClinicalTrials.gov Identifier: NCT00038025 - Completed
Peripheral T-Cell Lymphoma; Cutaneous T-Cell Lymphoma; Chronic Lymphocytic Leukemia
- Dose-finding study using pentostatin for injection in the treatment of steroid-refractory aGvHD
ClinicalTrials.gov Identifier: NCT00032773 - Terminated
Acute Graft Versus Host Disease
- Reduced-Intensity Regimen Before Donor Bone Marrow Transplantation in Treating Patients With Myelodysplastic Syndromes
ClinicalTrials.gov Identifier: NCT00045305 - Recruiting
atypical chronic myeloid leukemia; Chronic Myelomonocytic Leukemia; myelodysplastic and myeloproliferative disease; Myelodysplastic Syndromes
- Pentostatin Followed by Peripheral Stem Cell Transplantation in Treating Patients With Advanced Kidney Cancer
ClinicalTrials.gov Identifier: NCT00006968 - Completed
stage III renal cell cancer; Stage IV Renal Cell Cancer; recurrent renal cell cancer
- Pentostatin in Treating Patients With Refractory Chronic Graft-Versus-Host Disease
ClinicalTrials.gov Identifier: NCT00074035 - Suspended
Breast Cancer; Endocrine Cancer; female reproductive cancer; Graft Versus Host Disease; hematopoietic and lymphoid cancer; Neuroblastoma
- Phase II Trial of Pentostatin in Steroid Refractory Acute Graft Versus Host Disease
ClinicalTrials.gov Identifier: NCT00201786 - Suspended
Graft-Versus-Host Disease

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