The purposes of this study are to determine:

• The effectiveness of olanzapine as compared to quetiapine in treating and preventing the recurrence of a variety of symptoms of schizophrenia and schizoaffective disorder in patients who are obese or overweight.
• The safety of olanzapine as compared to quetiapine.

Condition	Treatment or Intervention	Phase
Schizophrenia	Drug: Olanzapine  Drug: Quetiapine	Phase IV

Ages Eligible for Study:  18 Years   -   75 Years,  Genders Eligible for Study:  Both

Criteria

Inclusion Criteria:

• You must be 18-75 years of age and be diagnosed with schizophrenia or schizoaffective disorder
• You must be able to visit the doctor's office thirteen (13) times over a twenty-six (26) week period

Exclusion Criteria:

• You are a woman and are pregnant or breastfeeding
• You have an acute or unstable medical illness, such as heart, liver, or kidney disease, or you have a seizure disorder. (Note: If you are uncertain about a particular condition, please discuss it with your physician.)
• You have a history of allergic reaction or intolerance to olanzapine (Zyprexa) or quetiapine (Seroquel)

"There may be multiple sites in this clinical trial."      1-877-CTLILLY (1-877-285-4559) 

California
      "For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at (1-877-285-4559) or speak with your personal physician, La Mesa,  California,  United States; Recruiting
      "For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at (1-877-285-4559) or speak with your personal physician, San Diego,  California,  United States; Recruiting
      "For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at (1-877-285-4559) or speak with your personal physician, Garden Grove,  California,  United States; Recruiting
District of Columbia
      "For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at (1-877-285-4559) or speak with your personal physician, Washington,  District of Columbia,  United States; Recruiting
Florida
      "For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at (1-877-285-4559) or speak with your personal physician, Miami,  Florida,  United States; Recruiting
      "For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at (1-877-285-4559) or speak with your personal physician, Winter Park,  Florida,  United States; Recruiting
Illinois
      "For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at (1-877-285-4559) or speak with your personal physician, Granite City,  Illinois,  United States; Recruiting
Indiana
      "For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at (1-877-285-4559) or speak with your personal physician, Lafayette,  Indiana,  United States; Recruiting
Louisiana
      "For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at (1-877-285-4559) or speak with your personal physician, Lake Charles,  Louisiana,  United States; Recruiting
Maryland
      "For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at (1-877-285-4559) or speak with your personal physician, Baltimore,  Maryland,  United States; Recruiting
Nebraska
      "For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at (1-877-285-4559) or speak with your personal physician, Omaha,  Nebraska,  United States; Recruiting
New Hampshire
      "For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at (1-877-285-4559) or speak with your personal physician, Nashua,  New Hampshire,  United States; Recruiting
New Jersey
      "For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at (1-877-285-4559) or speak with your personal physician, Princeton,  New Jersey,  United States; Recruiting
      "For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at (1-877-285-4559) or speak with your personal physician, Kenilworth,  New Jersey,  United States; Recruiting
      For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician., Neptune,  New Jersey,  United States; Recruiting
New York
      "For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at (1-877-285-4559) or speak with your personal physician, Rochester,  New York,  United States; Recruiting
      "For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at (1-877-285-4559) or speak with your personal physician, Brooklyn,  New York,  United States; Recruiting
      "For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at (1-877-285-4559) or speak with your personal physician, Olean,  New York,  United States; Recruiting
      "For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at (1-877-285-4559) or speak with your personal physician, New York,  New York,  United States; Recruiting
Ohio
      "For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at (1-877-285-4559) or speak with your personal physician, Cleveland,  Ohio,  United States; Recruiting
Oregon
      For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician., Springfield,  Oregon,  United States; Recruiting
Pennsylvania
      For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician., Paoli,  Pennsylvania,  United States; Recruiting
South Carolina
      For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician., Columbia,  South Carolina,  United States; Recruiting
Texas
      "For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at (1-877-285-4559) or speak with your personal physician, Conroe,  Texas,  United States; Recruiting
      "For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at (1-877-285-4559) or speak with your personal physician, Waco,  Texas,  United States; Recruiting
Utah
      For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician., Salt Lake City,  Utah,  United States; Recruiting
Washington
      For additional information regarding investigative sites for this trial, contact the Clinical Trials Support Center at 1-877-CTLILLY (1-877-285-4559) or speak with your personal physician., Tacoma,  Washington,  United States; Recruiting

Study ID Numbers:  8894
Record last reviewed:  January 2005
Last Updated:  January 21, 2005
Record first received:  August 18, 2004
ClinicalTrials.gov Identifier:  NCT00090012
Health Authority: United States: Food and Drug Administration
ClinicalTrials.gov processed this record on 2005-04-08