Not Signed In -
Rocuronium |
Zemuron |
Article: Rocuronium
| Image:Rocuronium.png | |
| Rocuronium | |
| Systematic (IUPAC) name | |
| [3-hydroxy-10,13-dimethyl-2-morpholin-4-yl-16-(1-prop-2-enyl-2,3,4,5-tetrahydropyrrol- 1-yl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren- 17-yl] acetate | |
| Identifiers | |
| CAS number | 119302-91-9 |
| ATC code | M03AC09 |
| PubChem | 7980535 |
| DrugBank | APRD01221 |
| Chemical data | |
| Formula | C32H53N2O4+ |
| Mol. weight | 529.774 g/mol |
| Pharmacokinetic data | |
| Bioavailability | 100% (IV) |
| Protein binding | ~30% |
| Metabolism | some de-acetylation |
| Half life | 66-80 minutes |
| Excretion | unchanged in bile & urine |
| Therapeutic considerations | |
| Pregnancy cat. | ? |
| Legal status | POM (UK) |
| Routes | IV |
Rocuronium is an aminosteroid non-depolarizing (that is, it does not cause initial stimulation of muscles before weakening them) neuromuscular blocker or muscle relaxant used in modern anaesthesia, to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation.
It is a more recent member of a family of similar drugs. It has rapid onset, and intermediate duration of action. It is marketed under the trade name of Zemuron ® in the United States and Esmeron ® in most other countries.
There is considered to be some risk of allergic reaction to the drug in occasional patients, but, a similar incidence of allergic reactions has been observed by using other members of the drug class (non-depolarizing neuromuscular blocking drugs). The drug is commonly used in modern anaesthesia.
 | This biochemistry article is a stub. You can help Wikipedia by expanding it. |
Categories: Biochemistry stubs | Muscle relaxants | Anesthesia | Intensive care medicine
email this page
print this page
bookmark this page
feedback on this page
