Stavudine |
d4T; Zerit |
Stavudine Systematic (IUPAC) name 1-[5-(hydroxymethyl)- 2,5-dihydrofuran-2-yl] -5-methyl-1H-pyrimidine-2,4-dione Identifiers CAS number 3056-17-5 ATC code J05AF04 PubChem 18283 DrugBank APRD00440 Chemical data Formula C10H12N2O4 Mol. weight 224.213 g/mol Pharmacokinetic data Bioavailability ? Protein binding Negligible Metabolism Renal elimination (ca.40%) Half life 0.8-1.5 hours (in adults) Excretion ? Therapeutic considerations Pregnan ...
Wikipedia - [full article]
Stavudine Clinical Trials
- A Study to Evaluate the Safety and Tolerance of Stavudine (d4T) in Combination with Lamivudine (3TC) in HIV-Positive Pregnant Women and Their Infants
ClinicalTrials.gov Identifier: NCT00000878 - Active, not recruiting
HIV Infections; Pregnancy
- Safety and Effectiveness of Giving Indinavir Plus Stavudine Plus Lamivudine to HIV-Infected Children
ClinicalTrials.gov Identifier: NCT00000901 - Active, not recruiting
HIV Infections
- Differences Between Women and Men Taking a Combination of Indinavir, Ritonavir, Enteric-Coated Didanosine, and Stavudine Who Previously Took Anti-HIV Drugs
ClinicalTrials.gov Identifier: NCT00006397 - Active, not recruiting
HIV Infections
- Safety and Effectiveness of Giving Indinavir, Ritonavir, Stavudine, and Lamivudine to HIV-Infected Patients Who Have Never Received Anti-HIV Drugs
ClinicalTrials.gov Identifier: NCT00002451 - Active, not recruiting
HIV Infections
- A Comparison of Emtricitabine and Stavudine Used with Didanosine Plus Efavirenz in HIV-Infected Patients Who Have Not Taken Anti-HIV Drugs
ClinicalTrials.gov Identifier: NCT00006208 - Active, not recruiting
HIV Infections
- Study of Treatment of Antiretroviral-Naive, HIV-1-Infected Patients Comparing Tenofovir Disoproxil Fumarate Administered in Combination with Lamivudine and Efavirenz Vs. Stavudine, Lamivudine and Efavirenz.
ClinicalTrials.gov Identifier: NCT00158821 - Active, not recruiting
HIV-1
- Evaluation of Viral Efficacy and Safety of a Reduced Dose of Stavudine (d4T): THE PHOENIX STUDY
ClinicalTrials.gov Identifier: NCT00235222 - Active, not recruiting
HIV
- A Study of HIV-Disease Development in Aging
ClinicalTrials.gov Identifier: NCT00006144 - Active, not recruiting
HIV Infections
- Safety and Effectiveness of an Anti-HIV Drug Combination Taken Twice Daily
ClinicalTrials.gov Identifier: NCT00002241 - Active, not recruiting
HIV Infections
- A Study to Compare Two Different Anti-HIV Drug Regimens
ClinicalTrials.gov Identifier: NCT00000924 - Active, not recruiting
HIV Infections
- Safety and Effectiveness of a Three-Drug Combination Treatment for Recently Infected or Converted HIV Patients
ClinicalTrials.gov Identifier: NCT00007202 - Active, not recruiting
HIV Infections
- Treatment with Combinations of Several Antiviral Drugs in Infants and Young Children with HIV Infection
ClinicalTrials.gov Identifier: NCT00000872 - Active, not recruiting
HIV Infections
- Treatment with Interleukin-2 (IL-2) Plus Combination Anti-HIV-Drug Therapy (HAART) for Patients Formerly in ACTG 328
ClinicalTrials.gov Identifier: NCT00000923 - Active, not recruiting
HIV Infections
- A Study of the Safety and Effectiveness of Treating Advanced AIDS Patients between Ages 4 and 22 with 7 Drugs, Some at Higher than Usual Doses
ClinicalTrials.gov Identifier: NCT00001108 - Active, not recruiting
HIV Infections
- Comparing the Safety, Effectiveness, and Tolerability of Three Anti-HIV Drug Regimens for Treatment-Naive Patients
ClinicalTrials.gov Identifier: NCT00050895 - Active, not recruiting
HIV Infections
- A Study to Compare Anti-HIV Drugs Given Twice a Day or Once a Day, With or Without Direct Observation
ClinicalTrials.gov Identifier: NCT00036452 - Active, not recruiting
HIV Infections
- A Study on the Management of Combination Anti-HIV Drug Therapy in HIV-Positive Children with Prior Treatment
ClinicalTrials.gov Identifier: NCT00000902 - Active, not recruiting
HIV Infections
- A Study of ABT-378/Ritonavir in HIV-Infected Patients
ClinicalTrials.gov Identifier: NCT00004578 - Active, not recruiting
HIV Infections
- Five-Drug Anti-HIV Treatment Followed by Treatment Interruption in Patients Who Have Recently Been Infected with HIV
ClinicalTrials.gov Identifier: NCT00000940 - Active, not recruiting
HIV Infections
- Anti-HIV Treatment Interruptions in HIV Infected Adults in South Africa
ClinicalTrials.gov Identifier: NCT00100646 - Active, not recruiting
HIV Infections
- A Pilot Study to Compare the Antiviral and Immunologic Effects of Stavudine ( d4T ) Versus Placebo in Subjects With Evidence of Recent HIV Infection.
ClinicalTrials.gov Identifier: NCT00002349 - Completed
HIV Infections
- Effects of Uridine Supplementation on Metabolic Side Effects of Stavudine and Zidovudine
ClinicalTrials.gov Identifier: NCT00471614 - Recruiting
HIV Infections; Insulin Resistance; Hyperlactatemia
- Treatment with Nelfinavir or Efavirenz of HIV-Infected Patients Who Have Never Received Anti-HIV Drugs
ClinicalTrials.gov Identifier: NCT00005000 - Active, not recruiting
HIV Infections
- Effectiveness and Safety of Two Forms of Stavudine in HIV-Infected Patients
ClinicalTrials.gov Identifier: NCT00005918 - Completed
HIV Infections
- Drug Levels of Tablet and Liquid Forms of Lamivudine, Nevirapine, and Stavudine in HIV Infected Thai Children
ClinicalTrials.gov Identifier: NCT00312091 - Recruiting
HIV Infections
- Safety and Efficacy of Switching From Stavudine or Zidovudine to Tenofovir DF in HIV-1 Infected Children (Ages 2- <12)
ClinicalTrials.gov Identifier: NCT00528957 - Recruiting
HIV Infections
- Rollover Study for Zerit (Stavudine) ER Studies (-096, -099)
ClinicalTrials.gov Identifier: NCT00116298 - Completed
HIV Infections; AIDS
- Study of Anti-HIV Therapy Intensification
ClinicalTrials.gov Identifier: NCT00034086 - Active, not recruiting
HIV Infections
- A Study of Stavudine in HIV-Infected Patients Who Have Not Had Success with Other Anti-HIV Drugs
ClinicalTrials.gov Identifier: NCT00002308 - Completed
HIV Infections
- When to Start Anti-HIV Drugs in Patients with Opportunistic Infections
ClinicalTrials.gov Identifier: NCT00055120 - Active, not recruiting
HIV Infections; AIDS-Related Opportunistic Infections
- A Randomized, Comparative Trial of Zidovudine (AZT) Versus 2',3'-Didehydro-3'-deoxythymidine (Stavudine; d4T) in Children With HIV Infection
ClinicalTrials.gov Identifier: NCT00000789 - Completed
HIV Infections
- Comparison of Stavudine Used Alone or in Combination with Didanosine in HIV-Infected Children
ClinicalTrials.gov Identifier: NCT00000851 - Completed
HIV Infections
- A Comparison of Two Dose Levels of Didanosine Used in Combination with Stavudine in HIV-Infected Patients
ClinicalTrials.gov Identifier: NCT00002207 - Completed
HIV Infections
- Effectiveness and Safety of Epivir/Ziagen/Zerit (3TC/ABC/d4T) Versus Epivir/Ziagen/Sustiva (3TC/ABC/EFV) Versus Epivir/Ziagen/Agenerase/Norvir (3TC/ABC/APV/RTV) in HIV Patients Who Have Never Received Treatment
ClinicalTrials.gov Identifier: NCT00005017 - Active, not recruiting
HIV Infections
- Safety and Effectiveness of Combining Hydroxyurea (HU) with Didanosine (ddI) and Stavudine (d4T) for Treatment of HIV-Infected Adults
ClinicalTrials.gov Identifier: NCT00002427 - Completed
HIV Infections
- Evaluation of Four Anti-HIV Treatment Strategies in Resource-Limited South African Communities
ClinicalTrials.gov Identifier: NCT00255840 - Active, not recruiting
HIV Infections
- A Randomized, Placebo-Controlled Study of the Safety and Efficacy of Efavirenz, Didanosine, and Stavudine in Combination With or Without Hydroxyurea in Antiretroviral Naive or Experienced HIV-Infected Patients
ClinicalTrials.gov Identifier: NCT00002230 - Completed
HIV Infections
- Emtricitabine Given Once A Day with Other Anti-HIV Drugs in Children with HIV
ClinicalTrials.gov Identifier: NCT00017992 - Recruiting
HIV Infections
- The Safety and Effectiveness of Nevirapine Plus Nelfinavir in HIV-1 Infected Patients Who Have Taken Stavudine
ClinicalTrials.gov Identifier: NCT00002381 - Completed
HIV Infections
- A Comparison of Zidovudine (AZT) and Stavudine in HIV-Infected Patients
ClinicalTrials.gov Identifier: NCT00002307 - Completed
HIV Infections
- The Safety and Effectiveness of Lamivudine Plus Stavudine or Zidovudine in HIV-Infected Patients Who Have Taken Zidovudine
ClinicalTrials.gov Identifier: NCT00002371 - Completed
HIV Infections
- A Study of Efavirenz in Combination with Stavudine and Didanosine
ClinicalTrials.gov Identifier: NCT00002225 - Completed
HIV Infections
- A Pilot Open Label Trial of HIV Therapy with d4T (Stavudine), ddI (Didanosine), Nelfinavir and Hydroxyurea in Subjects with Early Asymptomatic HIV Infection
ClinicalTrials.gov Identifier: NCT00002176 - Completed
HIV Infections
- Antiviral Activity of and Resistance to Lamivudine in Combination with Zidovudine, Stavudine, or Didanosine
ClinicalTrials.gov Identifier: NCT00000838 - Completed
HIV Infections
- A Pilot Open Label Trial of HIV Therapy with d4T (Stavudine), ddI (Didanosine), Nelfinavir and Hydroxyurea in Subjects with Recent HIV Infection
ClinicalTrials.gov Identifier: NCT00002177 - Completed
HIV Infections
- Virologic and Immunologic Activity of Continued Lamivudine (3TC) vs Delavirdine (DLV) in Combination with Indinavir (IDV) and Zidovudine (ZDV) or Stavudine (d4T) in 3TC-Experienced Subjects
ClinicalTrials.gov Identifier: NCT00000882 - Completed
HIV Infections
- The Safety and Effectiveness of Adefovir Dipivoxil Plus Indinavir Combined with Zidovudine or Lamivudine or Stavudine in HIV-Infected Patients Who Have Not Taken Anti-HIV Drugs
ClinicalTrials.gov Identifier: NCT00002379 - Completed
HIV Infections
- A Study of Indinavir Sulfate Given Together with Stavudine to HIV-Positive Patients
ClinicalTrials.gov Identifier: NCT00002354 - Completed
HIV Infections
- A Study to Compare the Safety and Effectiveness of Indinavir Combined with Stavudine and Lamivudine
ClinicalTrials.gov Identifier: NCT00002424 - Suspended
HIV Infections
- A Study to Evaluate the Use of Stavudine (d4T) to Treat AIDS Dementia Complex
ClinicalTrials.gov Identifier: NCT00002246 - Completed
AIDS Dementia Complex; HIV Infections
- A Study to Evaluate the Use of a Protease Inhibitor and of Interleukin-2 (IL-2) in the Treatment of Early HIV Infection
ClinicalTrials.gov Identifier: NCT00006154 - Not yet recruiting
HIV Infections
- The Safety and Effectiveness of Didanosine Plus Stavudine Plus Nevirapine Combined with MKC-442 in HIV-Infected Patients Who Have Not Had Success with Protease Inhibitors
ClinicalTrials.gov Identifier: NCT00002418 - Terminated
HIV Infections
- The Safety and Effectiveness of Didanosine Plus Stavudine Plus Delavirdine Mesylate Plus MKC-442 in HIV-Infected Patients Who Have Not Had Success with Protease Inhibitors
ClinicalTrials.gov Identifier: NCT00002420 - Terminated
HIV Infections
- 2NN & CHARM Long-Term Follow-Up Study
ClinicalTrials.gov Identifier: NCT00127972 - Completed
HIV-1
- Study Comparing Reducing the Dose of Stavudine Versus Switching to Tenofovir in HIV-Infected Patients Receiving Antiretroviral Therapy
ClinicalTrials.gov Identifier: NCT00312832 - Completed
HIV Infections; Lipoatrophy
- Virologic Responses To New Nucleoside Regimens After Prolonged ZDV or ddI Monotherapy
ClinicalTrials.gov Identifier: NCT00000831 - Completed
HIV Infections
- A Study of MKC-442 in Combination with Other Anti-HIV Drugs
ClinicalTrials.gov Identifier: NCT00002412 - Completed
HIV Infections
- A Study to Compare the Effectiveness of Two Anti-HIV Drug Combinations
ClinicalTrials.gov Identifier: NCT00002430 - Completed
HIV Infections
- A Comparison of Two Triple-Drug Combinations in Patients Who Have Never Been Treated with Anti-HIV Drugs
ClinicalTrials.gov Identifier: NCT00002411 - Completed
HIV Infections
- Study of a New Protease Inhibitor, BMS-232632, in Combination with Other Anti-HIV Drugs
ClinicalTrials.gov Identifier: NCT00002240 - Completed
HIV Infections
- A Pilot Study of the Immunologic Reconstitution in HIV-1 Infected Children Receiving Highly Active Antiretroviral Therapy with Combination Ritonavir, Nevirapine and Stavudine
ClinicalTrials.gov Identifier: NCT00001688 - Completed
HIV Infection
- A Comparison of Two Anti-HIV Triple-Drug Combinations in HIV-Infected Patients
ClinicalTrials.gov Identifier: NCT00002168 - Completed
HIV Infections
- A Study of BMY-27857 in Patients with AIDS or AIDS Related Complex
ClinicalTrials.gov Identifier: NCT00000988 - Completed
HIV Infections
- A Comparison of Epivir Plus Crixivan Combined with Zerit or Retrovir in HIV-Infected Patients Who Have Never Taken Anti-HIV Drugs
ClinicalTrials.gov Identifier: NCT00002369 - Completed
HIV Infections
- A Comparison of Two Drug Combinations Used in HIV-Infected Patients Who Never Have Taken Anti-HIV Drugs
ClinicalTrials.gov Identifier: NCT00005573 - Completed
HIV Infections
- Safety and Effectiveness of Four Anti-HIV Drug Combinations in HIV-Infected Children and Teens
ClinicalTrials.gov Identifier: NCT00001091 - Completed
HIV Infections
- A Study of an Adherence Plan to Help HIV-Positive Patients Take Their First Anti-HIV Medications Correctly
ClinicalTrials.gov Identifier: NCT00001122 - Completed
HIV Infections
- A Study of Three Drug Combination Therapies in HIV-Infected Patients Who Have Never Been Treated with Anti-HIV Drugs
ClinicalTrials.gov Identifier: NCT00002407 - Completed
HIV Infections
- A Study on the Effect of Chemotherapy Combined with Anti-HIV Drugs in HIV-Positive Patients
ClinicalTrials.gov Identifier: NCT00000899 - Completed
HIV Infections
- The Safety and Effects of 1592U89 Used Alone or in Combination with Other Anti-HIV Drugs in HIV-Infected Infants and Children
ClinicalTrials.gov Identifier: NCT00000865 - Completed
HIV Infections
- A Study to Compare the Effectiveness of Different Anti-HIV Drug Regimens in Keeping Levels of HIV in the Blood as Low as Possible
ClinicalTrials.gov Identifier: NCT00000939 - Completed
HIV Infections
- The Effectiveness of HIV RNA Viral Load Testing in Determining Treatment Type in HIV-Infected Patients
ClinicalTrials.gov Identifier: NCT00002376 - Completed
HIV Infections
- Comparison of Two Anti-HIV Regimens that Include One of Two Forms of Didanosine (ddI)
ClinicalTrials.gov Identifier: NCT00002224 - Completed
HIV Infections
- The Effectiveness of Three Drug Combinations in HIV-Infected Patients Who Have Taken Zidovudine for More than 12 Weeks
ClinicalTrials.gov Identifier: NCT00001063 - Completed
HIV Infections
- A Study of Three Anti-HIV Drug Combinations in Patients Who Have Taken Amprenavir
ClinicalTrials.gov Identifier: NCT00001095 - Completed
HIV Infections
- A Study to Compare the Safety and Effectiveness of Two Dosing Schedules of Lamivudine in Combination with Two Other Anti-HIV Drugs
ClinicalTrials.gov Identifier: NCT00002442 - Completed
HIV Infections
- A Randomized, Parallel Arm, Comparative, Open Label, Multicenter Study of the Activity and Safety of Two Formulations of Saquinavir in Combination With Other Antiretroviral Drugs
ClinicalTrials.gov Identifier: NCT00002162 - Completed
HIV Infections
- Safety and Effectiveness of Giving Combinations of Three or Four Anti-HIV Drugs to HIV-Infected Patients
ClinicalTrials.gov Identifier: NCT00002211 - Completed
HIV Infections
- A Comparison of Three Anti-HIV Drug Combinations in HIV-Infected Patients
ClinicalTrials.gov Identifier: NCT00005106 - Completed
HIV Infections
- A Study of Saquinavir Soft Gelatin Capsules Combined with Other Anti-HIV Drugs in HIV-1 Infected Patients
ClinicalTrials.gov Identifier: NCT00002374 - Completed
HIV Infections
- A Study to determine how and why HIV-Infected subjects on anti-viral treatment develop Lipodystrophy
ClinicalTrials.gov Identifier: NCT00006190 - Completed
HIV Infections; Lipodystrophy
- A Study of Efavirenz in HIV-Infected Patients Who Have Never Taken Anti-HIV Drugs
ClinicalTrials.gov Identifier: NCT00002227 - Completed
HIV Infections
- Effects of Ribavirin on Zidovudine or Stavudine
ClinicalTrials.gov Identifier: NCT00021632 - Completed
HIV Infections; Hepatitis C
- Comparison of New Anti-HIV Drug Combinations in HIV-Infected Children Who Have Taken Anti-HIV Drugs
ClinicalTrials.gov Identifier: NCT00001083 - Completed
HIV Infections
- The Effectiveness of Three Anti-HIV Drug Combinations in HIV-Infected Patients Who Have Never Used Anti-HIV Drugs
ClinicalTrials.gov Identifier: NCT00001067 - Completed
HIV Infections
- Effects of Two Anti-HIV Drug Combinations on the Immune Systems of HIV-Infected Patients Who Have Never Received Anti-HIV Drugs
ClinicalTrials.gov Identifier: NCT00004855 - Completed
HIV Infections
- Immunologic and Virologic Consequences of Long-Term Highly Active Antiretroviral Therapy (HAART) in Subjects with Moderately Advanced HIV-1 Disease: A Follow-Up Study to ACTG 315
ClinicalTrials.gov Identifier: NCT00000891 - Completed
HIV Infections
- Effectiveness of Anti-HIV Therapy (HAART) in HIV-Infected Patients with Tuberculosis
ClinicalTrials.gov Identifier: NCT00004736 - Completed
HIV Infections; Tuberculosis
- DART II - Study of 3 Antiretroviral Medicines in Combination, in HIV Patients who Have Not Been Previously Treated with Antiretroviral Therapy
ClinicalTrials.gov Identifier: NCT00116116 - Completed
HIV Infections; AIDS
- A Comparison of Three Anti-HIV Drug Combinations Containing Saquinavir Soft Gelatin Capsules Used in HIV-1 Infected Patients
ClinicalTrials.gov Identifier: NCT00002378 - Completed
HIV Infections
- A Study to Evaluate the Long-Term Effectiveness of Three Anti-HIV Drug Treatments in HIV-Positive Patients Who Have Never Been Exposed to Highly Active Antiretroviral Therapy (HAART)
ClinicalTrials.gov Identifier: NCT00000922 - Completed
HIV Infections
- Effectiveness of Anti-HIV Drugs in Patients Who Have Not Received Previous Anti-HIV Drugs During Different Stages of HIV Infection
ClinicalTrials.gov Identifier: NCT00006443 - Completed
HIV Infections
- Effect of Indinavir Plus Two Other Anti-HIV Drugs on Blood Clotting in HIV-Positive Males with Hemophilia
ClinicalTrials.gov Identifier: NCT00002386 - Completed
HIV Infections; Hemophilia A
- Simplified Drug Regimens for HIV Patients in ACTG 388 or Patients Who Responded to A First Potent Combination Regimen
ClinicalTrials.gov Identifier: NCT00014937 - Completed
HIV Infections
- Strategies for Delivering Anti-HIV Therapy in South Africa
ClinicalTrials.gov Identifier: NCT00080522 - Completed
HIV Infections
- A Study to Compare the Effectiveness of a Four Drug Anti-HIV Regimen Given Alone or in Combination with GM-CSF or IL-12 to HIV-Positive Patients
ClinicalTrials.gov Identifier: NCT00000896 - Completed
HIV Infections
- Preventing Sexual Transmission of HIV With Anti-HIV Drugs
ClinicalTrials.gov Identifier: NCT00074581 - Completed
HIV Infections; HIV Seronegativity
- A Study of Three Treatment Combinations Using Zidovudine Plus Lamivudine Plus Indinavir in HIV-Infected Patients
ClinicalTrials.gov Identifier: NCT00001084 - Completed
HIV Infections
- Treatment Success and Failure in HIV-Infected Subjects Receiving Indinavir in Combination with Nucleoside Analogs: A Rollover Study for ACTG 320
ClinicalTrials.gov Identifier: NCT00000885 - Completed
HIV Infections
- Evaluation of an Anti-HIV Drug Combination That Includes a Coated Form of Didanosine (ddI EC) Compared to a Typical Anti-HIV Drug Regimen
ClinicalTrials.gov Identifier: NCT00002429 - Completed
HIV Infections

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