Tramadol and Acetaminophen |
Ultracet |
Tramadol Systematic (IUPAC) name rac-(1R,2R)-2-(dimethylaminomethyl)-1- (3-methoxyphenyl)-cyclohexanol Identifiers CAS number 27203-92-5 ATC code N02AX02 PubChem 33741 DrugBank APRD00028 Chemical data Formula C16H25NO2 Mol. weight 263.4 g/mol Pharmacokinetic data Bioavailability 68-72% Increases with repeated dosing. Metabolism Hepatic demethylated & glucuronidated Half life 5-7 hours Excretion Renal Therapeutic considerations Pregnancy cat. ...
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Tramadol and Acetaminophen Clinical Trials
- An Open Label Study to Evaluate Safety, Tolerability and Clinical Utility of ULTRACET® (37.5mg Tramadol Hydrochloride/325mg Acetaminophen) for the Treatment of Breakthrough Pain in Cancer Patients
ClinicalTrials.gov Identifier: NCT00576173 - Active, not recruiting
Pain
- A Study of the Efficacy and Safety of Tramadol HCl/Acetaminophen, Hydrocodone Bitartrate/Acetaminophen and Placebo in Patients With Pain From an Ankle Sprain With a Partial Torn Ligament
ClinicalTrials.gov Identifier: NCT00236535 - Completed
Pain; Sprains and Strains
- A Comparison of the Effectiveness and Safety of ULTRACET® (Tramadol Hydrochloride/Acetaminophen) Versus ULTRAM® (Tramadol Hydrochloride) Versus Placebo in Patients With Pain After Oral Surgery
ClinicalTrials.gov Identifier: NCT00236483 - Completed
Pain, Postoperative; Surgery, Oral
- Opioid Withdrawal Suppression with Tramadol - 1
ClinicalTrials.gov Identifier: NCT00142896 - Active, not recruiting
Opioid Dependence
- A Study Comparing the Effectiveness and Safety of Tramadol HCl/Acetaminophen Versus Placebo for the Treatment of Painful Neuropathy in Diabetic Patients
ClinicalTrials.gov Identifier: NCT00210847 - Completed
Diabetic Neuropathies
- Pain Relief - Tramadol versus Ibuprofen
ClinicalTrials.gov Identifier: NCT00111046 - Active, not recruiting
Choroidal melanoma; Melanoma; Eye Neoplasms
- ULTRACET® (Tramadol Hydrochloride and Acetaminophen) for the Treatment of Rheumatoid Arthritis Pain.
ClinicalTrials.gov Identifier: NCT00246168 - Completed
Arthritis, Rheumatoid
- A Study Comparing the Effectiveness and Safety of ULTRACET® (Tramadol HCl/Acetaminophen) Versus Placebo for the Treatment of Acute Pain From a Migraine Headache
ClinicalTrials.gov Identifier: NCT00297375 - Completed
Head Pain; Headache; Migraine
- Ibuprofen Alone and in Combination With Acetaminophen for Treatment of Fever
ClinicalTrials.gov Identifier: NCT00267293 - Recruiting
Fever
- Comparison of Tramadol Vs Remifentanyl Patient Controlled Analgesia for Second Trimester Abortions
ClinicalTrials.gov Identifier: NCT00361686 - Recruiting
Abortion,Induced
- Study To Determine The Effects Of Doses Of Relacatib On The Metabolism Of Acetaminophen, Ibuprofen And Atorvastatin
ClinicalTrials.gov Identifier: NCT00411190 - Active, not recruiting
Osteoporosis; Osteoarthritis
- Comparison Between Tramadol Hcl and Other Analgesics in the Treatment of Renal Colic
ClinicalTrials.gov Identifier: NCT00310908 - Recruiting
Renal Calculus
- Assessment of Tramadol as a Treatment for Opioid Addiction
ClinicalTrials.gov Identifier: NCT00301210 - Recruiting
Opioid-Related Disorders
- Acetaminophen for Cancer Pain
ClinicalTrials.gov Identifier: NCT00152854 - Recruiting
Cancer; Pain
- A Study of Rizatriptan Co-Administered With Acetaminophen for the Treatment of Acute Migraine
ClinicalTrials.gov Identifier: NCT00300924 - Active, not recruiting
Migraine
- Study of the Efficacy and Safety of Intravenous vs Oral Acetaminophen for Treatment of Fever in Healthy Adult Males
ClinicalTrials.gov Identifier: NCT00564629 - Active, not recruiting
Fever
- AVIS - Acetaminophen Before Vaccines for Infants Study
ClinicalTrials.gov Identifier: NCT00325819 - Recruiting
Fever
- Adding a Second Drug for Febrile Children Treated With Acetaminophen
ClinicalTrials.gov Identifier: NCT00389272 - Recruiting
Fever
- A Trial Comparing Combination Therapy of Acetaminophen Plus Ibuprofen Versus Tylenol #3 for the Treatment of Pain After Outpatient Surgery
ClinicalTrials.gov Identifier: NCT00245375 - Active, not recruiting
Laparoscopic Cholecystectomy; Inguinal Hernia; Abdominal Hernia; Umbilical Hernia
- Effect of Sulfur Amino Acid Depletion and Acetaminophen on Plasma Glutatione
ClinicalTrials.gov Identifier: NCT00228644 - Recruiting
Healthy
- Tramadol iv. : Influence of Dose and Dose Intervals on Therapeutic Accuracy and Side Effects When Used for Postoperative Pain Relief in Ambulatory Surgery
ClinicalTrials.gov Identifier: NCT00333346 - Recruiting
Ambulatory Surgery
- Safety and Pharmacokinetic Study of Intravenous Acetaminophen Administration in Pediatric Inpatients
ClinicalTrials.gov Identifier: NCT00493246 - Recruiting
Pain and Fever
- A Study of the Effectiveness and Safety of Tramadol HCl/Acetaminophen Compared to Placebo in Treating Acute Low Back Pain
ClinicalTrials.gov Identifier: NCT00210561 - Terminated
Low Back Pain; Back Pain
- RCT on Ketorolac and Tramadol in Bone Fractures Pain of Child
ClinicalTrials.gov Identifier: NCT00560443 - Not yet recruiting
Fracture; Pain
- The Effect of Paracetamol in the Treatment of Non-Severe Malaria in Children in Guinea-Bissau
ClinicalTrials.gov Identifier: NCT00137566 - Active, not recruiting
Malaria, Falciparum
- Acetaminophen-Induced Hepatotoxicity in Chronic Alcohol Abusers
ClinicalTrials.gov Identifier: NCT00137059 - Completed
hepatotoxicity
- Cytokines Polymorphisms and Acetaminophen Toxicity
ClinicalTrials.gov Identifier: NCT00166608 - Recruiting
Drug Toxicity
- Chiropractic Care, Medication, and Self-Care for Neck Pain
ClinicalTrials.gov Identifier: NCT00029770 - Active, not recruiting
Neck Pain
- Study of the Analgesic Efficacy & Safety of Intravenous Acetaminophen Versus Placebo for the Treatment of Postoperative Pain After Abdominal Laparoscopic Surgery
ClinicalTrials.gov Identifier: NCT00564486 - Recruiting
Pain
- Norspan® Patches Versus Tramadol in Subjects With Chronic, Moderate to Severe Osteoarthritis Pain in the Hip and/or Knee
ClinicalTrials.gov Identifier: NCT00426647 - Not yet recruiting
Osteoarthritis; Pain
- Tramadol and Pain Sensitization
ClinicalTrials.gov Identifier: NCT00487175 - Not yet recruiting
Pain
- Effects of Acetaminophen on Hurt Feelings
ClinicalTrials.gov Identifier: NCT00561288 - Not yet recruiting
Emotional Pain
- Measurement of Nitrotyrosine and Cytokines in Acetaminophen Overdose Patients
ClinicalTrials.gov Identifier: NCT00147407 - Recruiting
Liver Dysfunction
- Switching From Morphine to Oral Methadone Plus Acetaminophen in the Treatment of Cancer Pain
ClinicalTrials.gov Identifier: NCT00525967 - Recruiting
Cancer; Pain; Palliative Care
- Acetaminophen Versus Ibuprofen for the Control of Immediate and Delayed Pain Following Orthodontic Separator Placement
ClinicalTrials.gov Identifier: NCT00484744 - Recruiting
Orthodontic Pain
- Effect of Imatinib Mesylate and the Pharmacokinetics of Acetaminophen/Paracetamol in Patients With Newly Diagnosed, Previously Untreated Chronic Myeloid Leukemia in Chronic Phase (CML-CP)
ClinicalTrials.gov Identifier: NCT00428909 - Recruiting
Chronic Myeloid Leukemia (CML)
- Combination Chemotherapy in Treating Patients With Stage III or Stage IV Melanoma
ClinicalTrials.gov Identifier: NCT00003346 - Active, not recruiting
stage III melanoma; Stage IV Melanoma; Recurrent Melanoma
- Acetaminophen for Fetal Tachycardia: a Randomized Pilot Trial
ClinicalTrials.gov Identifier: NCT00377832 - Not yet recruiting
Fever; Heart Rate, Fetal
- Comparison of Butorphanol and Tramadol Associated PCA After Hysterectomy
ClinicalTrials.gov Identifier: NCT00510666 - Completed
Postoperative Pain
- The Discriminative Effects of Tramadol in Humans
ClinicalTrials.gov Identifier: NCT00499746 - Not yet recruiting
Opioid Abuse; Opioid Addiction; Stimulant Abuse; Stimulant Addiction
- Evaluation of the Interaction Between Acetaminophen and Zidovudine
ClinicalTrials.gov Identifier: NCT00000731 - Completed
HIV Infections
- A Randomised Open Controlled Parallel Group Study Comparing Norspan and Tramadol
ClinicalTrials.gov Identifier: NCT00399178 - Completed
Osteoarthritis
- A Study Comparing the Effectiveness and Safety of Extended Release Tramadol Versus Placebo for the Treatment of Osteoarthritis (OA) of the Knee
ClinicalTrials.gov Identifier: NCT00348010 - Completed
Chronic Pain
- A Study Comparing the Effectiveness and Safety of Extended-Release Tramadol Versus Placebo in the Treatment of Chronic Low Back Pain
ClinicalTrials.gov Identifier: NCT00347724 - Completed
Chronic Pain
- A Study Comparing the Effectiveness and Safety of Varying Dose Strengths (100, 200, 300 and 400 Mg) of Extended-Release Tramadol HCl With Placebo for the Treatment of Osteoarthritis(OA) of the Knee and/or Hip
ClinicalTrials.gov Identifier: NCT00325858 - Completed
Chronic Pain
- A One-Year, Open-Label Study to Assess the Safety and Effectiveness of Extended Release Tramadol HCl in the Treatment of Chronic, Non-Malignant Pain.
ClinicalTrials.gov Identifier: NCT00347685 - Completed
Chronic Pain
- Acetaminophen Concentration in Cerebrospinal Fluid in Infants
ClinicalTrials.gov Identifier: NCT00389454 - Completed
Fever
- Platelet Inhibition by Aspirin, Acetaminophen and NSAID
ClinicalTrials.gov Identifier: NCT00536068 - Completed
Hemostasis
- Continuous Infusion of Dexamethasone Plus Tramadol Adjunct to Morphine PCA After Abdominal Hysterectomy
ClinicalTrials.gov Identifier: NCT00564603 - Completed
Postoperative Pain; Post Operative Analgesia; Patient-Controlled Analgesia; Abdominal Surgeries
- Celebrex vs Tramadol in the Treatment of Chronic Lower Back Pain.
ClinicalTrials.gov Identifier: NCT00290901 - Completed
Back Pain
- Comparison of Acetaminophen With Codeine and Ibuprofen for Children With Injuries
ClinicalTrials.gov Identifier: NCT00474721 - Completed
Pain
- Hepatic Function During and Following Three Days of Acetaminophen Dosing in Alcoholics
ClinicalTrials.gov Identifier: NCT00402571 - Completed
Alcohol Related Disorders
- Hepatic Function in Alcoholics Following 5 Days of Acetaminophen Dosing
ClinicalTrials.gov Identifier: NCT00427206 - Completed
Alcohol Related Disorders
- A Study Comparing the Effectiveness and Safety of Extended Release Tramadol HCl at 100 Mg, 200 Mg and 300 Mg Doses to Placebo for the Treatment of Moderate to Severe Pain Due to Osteoarthritis (OA)
ClinicalTrials.gov Identifier: NCT00348452 - Completed
Chronic Pain
- An Effectiveness and Safety Study of Acetaminophen Extended Release Caplets in Treating Muscle Aches and Soreness That Occur After a Marathon Race
ClinicalTrials.gov Identifier: NCT00240851 - Completed
Pain
- A Study Comparing the Analgesic Efficacy and Safety of Extended Release Hydrocodone/Acetaminophen (Vicodin® CR)and Placebo in Subjects With Osteoarthritis
ClinicalTrials.gov Identifier: NCT00404183 - Completed
Pain
- Effects of Therapeutic Doses of Acetaminophen in Moderate Drinkers
ClinicalTrials.gov Identifier: NCT00400621 - Completed
Moderate Alcohol Consumption (1-3 Drinks Per Day)
- An Effectiveness and Safety Study of Acetaminophen Extended Release Caplets in the Treatment of Osteoarthritis of the Hip or Knee.
ClinicalTrials.gov Identifier: NCT00240799 - Completed
Osteoarthritis
- A Study of Extended-Release Hydrocodone/Acetaminophen (Vicodin CR®) in Subjects With Acute Pain Following Bunionectomy
ClinicalTrials.gov Identifier: NCT00402792 - Completed
Pain
- An Effectiveness and Safety Study of Two Doses of Acetaminophen Extended Release Caplets in the Treatment of Osteoarthritis of the Hip or Knee
ClinicalTrials.gov Identifier: NCT00240786 - Completed
Osteoarthritis
- Safety of Intravenous Acetaminophen Versus Placebo for the Treatment of Endotoxin-Induced Fever in Healthy Adult Males
ClinicalTrials.gov Identifier: NCT00493311 - Completed
Fever
- Efficacy and Safety of IV Acetaminophen Over 48 Hours for the Treatment of Post-Operative Pain After Gynecologic Surgery
ClinicalTrials.gov Identifier: NCT00399568 - Completed
Postoperative Pain; Hysterectomy
- A Study Comparing the Analgesic Activity of Extended Release Hydrocodone/Acetaminophen (Vicodin® CR) and Placebo in Subjects With Pain Following Bunionectomy Surgery
ClinicalTrials.gov Identifier: NCT00404391 - Completed
Pain
- Toward Better Outcomes in Osteoarthritis
ClinicalTrials.gov Identifier: NCT00000425 - Completed
Osteoarthritis
- An Effectiveness and Safety Study of Acetaminophen 1000 mg and Ibuprofen 400 mg in Postoperative Dental Pain.
ClinicalTrials.gov Identifier: NCT00240825 - Completed
Pain
- An Effectiveness and Safety Study of Acetaminophen 1000 mg and Ibuprofen 400 mg in Postoperative Dental Pain
ClinicalTrials.gov Identifier: NCT00240864 - Completed
Pain
- A Four-Week Study Comparing Acetaminophen Extended Release and Rofecoxib in the Treatment of Osteoarthritis of the Knee
ClinicalTrials.gov Identifier: NCT00568295 - Completed
Osteoarthritis of the Knee
- An Effectiveness and Safety Study Comparing Acetaminophen (3900 mg/Day) to Ibuprofen (1200 mg/Day) in the Treatment of Post-Race Muscle Soreness.
ClinicalTrials.gov Identifier: NCT00240838 - Completed
Pain
- A Safety and Effectiveness Study of Acetaminophen Extended Release (3900 mg/Day) and Ibuprofen (1200 mg/Day) in the Treatment of Pain Associated With Ankle Sprains.
ClinicalTrials.gov Identifier: NCT00261560 - Completed
Sprains and Strains; Pain
- Acetaminophen or Fluvastatin Compared to Placebo on the Transient Post-Dose Symptoms (PDS) Following an Intravenous (i.v.) Infusion of a Single Dose of Zoledronic Acid 5mg, in Post-Menopausal Women With Low Bone Mass
ClinicalTrials.gov Identifier: NCT00489424 - Completed
Low Bone Mass
- Pain Management and Behavioral Outcomes in Patients with Dementia
ClinicalTrials.gov Identifier: NCT00012857 - Completed
Dementia; Alzheimer Disease; Pain
- Glucosamine Unum In Die [Once A Day] Efficacy (GUIDE) Trial: Glucosamine Sulfate in Patients with Knee Osteoarthritis
ClinicalTrials.gov Identifier: NCT00110474 - Completed
Knee Osteoarthritis
- A Safety and Effectiveness Study of Acetaminophen (4000 mg/Day) and Naproxen (750 mg/Day) in the Treatment of Osteoarthritis of the Hip or Knee
ClinicalTrials.gov Identifier: NCT00240773 - Completed
Osteoarthritis, Knee; Osteoarthritis, Hip
- Randomized Study of Acetylcysteine in Patients with Acute Liver Failure Not Caused by Acetaminophen
ClinicalTrials.gov Identifier: NCT00004467 - Completed
Acute Liver Failure
- Controlled Clinical Trial of Antiviral Cytotoxic T Lymphocyte (CTL) Infusion Following Combination Antiretroviral Drug Therapy for Asymptomatic HIV-1 Infection
ClinicalTrials.gov Identifier: NCT00000875 - Terminated
HIV Infections

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