Coenzyme Q-10 Clinical Trials

• Coenzyme Q10 in Relieving Treatment-Related Fatigue in Women With Breast Cancer
  ClinicalTrials.gov Identifier: NCT00096356 - Recruiting
  Breast Cancer; Fatigue
  
• The Efficacy of Coenzyme Q10 And Curcumin in Patients With Myelodysplastic Syndromes
  ClinicalTrials.gov Identifier: NCT00247026 - Not yet recruiting
  Myelodysplastic Syndrome
  
• Phase III Trial of Coenzyme Q10 in Mitochondrial Disease
  ClinicalTrials.gov Identifier: NCT00432744 - Recruiting
  Mitochondrial Diseases
  
• Anti-Oxidant Treatment of Alzheimer''s Disease
  ClinicalTrials.gov Identifier: NCT00117403 - Active, not recruiting
  Alzheimer''s Disease
  
• New Combination Inhaler (FlutiForm HFA MDI 100/10 µg and 250/10 µg) in Patients With Asthma
  ClinicalTrials.gov Identifier: NCT00394121 - Active, not recruiting
  Asthma
  
• 10-Propargyl-10-Deazaaminopterin in Treating Patients With Recurrent or Refractory Non-Hodgkin's Lymphoma or Hodgkin's Lymphoma
  ClinicalTrials.gov Identifier: NCT00052442 - Active, not recruiting
  adult Hodgkin's lymphoma; adult non-Hodgkin's lymphoma
  
• An Open-label Pilot Study of Coenzyme Q10 in Steroid-Treated Duchenne Muscular Dystrophy
  ClinicalTrials.gov Identifier: NCT00033189 - Completed
  Muscular Dystrophy, Duchenne
  
• Effects of Coenzyme Q10 in Progressive Supranuclear Palsy (PSP)
  ClinicalTrials.gov Identifier: NCT00382824 - Recruiting
  Progressive Supranuclear Palsy; Atypical Parkinsonism
  
• Oral Vitamin K for Warfarin Associated Coagulopathy
  ClinicalTrials.gov Identifier: NCT00143715 - Active, not recruiting
  ...
  
• Vytorin (10/20 Or 10/40) Compared to Atorvastatin (10mg or 20mg) in Patients With Coronary Artery Disease
  ClinicalTrials.gov Identifier: NCT00442897 - Recruiting
  Hypercholesterolemia
  
• Parkinson's disease treatment with coenzyme Q10
  ClinicalTrials.gov Identifier: NCT00004731 - Completed
  Parkinson's Disease
  
• Effects of Coenzyme Q10 on Charcot-Marie-Tooth Disease
  ClinicalTrials.gov Identifier: NCT00541164 - Recruiting
  Charcot Marie Tooth Disease
  
• New Combination Inhaler (Flutiform HFA MDI 100/10 µg and 250/10 µg) Versus Fluticasone and Formoterol Administered Alone, and Placebo in Patients With Moderate to Severe Asthma
  ClinicalTrials.gov Identifier: NCT00393952 - Recruiting
  Asthma
  
• Dolastatin 10 in Treating Patients With Advanced Kidney Cancer
  ClinicalTrials.gov Identifier: NCT00003914 - Active, not recruiting
  Stage IV Renal Cell Cancer; recurrent renal cell cancer
  
• Telmisartan/Amlodipine (80/10) vs. Telmisartan/Amlodipine (40/10) vs. amlodipine10 in Resistant Hypertension
  ClinicalTrials.gov Identifier: NCT00553267 - Recruiting
  Hypertension
  
• 10-Propargyl-10-Deazaaminopterin in Treating Patients With Stage IIIB or Stage IV Non-small Cell Lung Cancer
  ClinicalTrials.gov Identifier: NCT00004238 - Active, not recruiting
  stage IV non-small cell lung cancer; stage IIIB non-small cell lung cancer; recurrent non-small cell lung cancer; Quality of Life
  
• Effects of Coenzyme Q10 in PSP and CBD
  ClinicalTrials.gov Identifier: NCT00532571 - Completed
  Progressive Supranuclear Palsy; Neurological Disorders
  
• Long Term Safety of SL77.0499-10 (Alfuzosin) in Patients With BPH
  ClinicalTrials.gov Identifier: NCT00347061 - Active, not recruiting
  Benign Prostatic Hyperplasia
  
• Bimetric-10: Investigation of Patients Who Have Underwent Total Hip Arthroplasty With a Cemented Bi-Metric Stem
  ClinicalTrials.gov Identifier: NCT00192699 - Active, not recruiting
  Osteoarthrosis
  
• Dolastatin 10 in Treating Patients With Metastatic Pancreatic Cancer
  ClinicalTrials.gov Identifier: NCT00003677 - Active, not recruiting
  recurrent pancreatic cancer; stage IVA pancreatic cancer; stage IVB pancreatic cancer; adenocarcinoma of the pancreas
  
• Long Term Immunogenicity Study of Engerix-B Vaccine in 10 Year Old Children and the Effect of Booster Injections
  ClinicalTrials.gov Identifier: NCT00169858 - Active, not recruiting
  Hepatitis B; Vaccination
  
• Inactivated Influenza Vaccine in Infants 10-22 Weeks of Age
  ClinicalTrials.gov Identifier: NCT00231920 - Active, not recruiting
  Influenza
  
• US 10 mL Biologic Lung Volume Reduction (BLVR) Phase 1 Emphysema Study
  ClinicalTrials.gov Identifier: NCT00347659 - Active, not recruiting
  Pulmonary Emphysema
  
• Monotherapy Versus Placebo Over 10 Days in Integrase Naive HIV-1 Infected Adults
  ClinicalTrials.gov Identifier: NCT00398125 - Active, not recruiting
  HIV Infections
  
• US 10 mL Biologic Lung Volume Reduction (BLVR) Phase 2 Emphysema Study
  ClinicalTrials.gov Identifier: NCT00435253 - Active, not recruiting
  Pulmonary Emphysema
  
• E3810-A001-313: Efficacy and Safety of 10 Mg Rabeprazole for Treating Heartburn in Frequent Sufferers
  ClinicalTrials.gov Identifier: NCT00236184 - Active, not recruiting
  Heartburn
  
• E3810-A001-312: Efficacy and Safety of 10 Mg Rabeprazole for Treating Heartburn in Frequent Sufferers
  ClinicalTrials.gov Identifier: NCT00236197 - Active, not recruiting
  Heartburn
  
• Safety and Immunogenicity Study of GlaxoSmithKline (GSK) Biologicals’ 10-Valent Pneumococcal Conjugate Vaccine
  ClinicalTrials.gov Identifier: NCT00344318 - Active, not recruiting
  Pneumococcal Infections
  
• Immunogenicity and Safety Study of GlaxoSmithKline (GSK) Biologicals’ 10-Valent Pneumococcal Conjugate Vaccine
  ClinicalTrials.gov Identifier: NCT00345358 - Active, not recruiting
  Pneumococcal Infections
  
• Study to Evaluate the Safety and Immunogenicity of a 10-Valent Pneumococcal Conjugate Vaccine in Preterm Infants
  ClinicalTrials.gov Identifier: NCT00390910 - Active, not recruiting
  Pneumococcal Infections
  
• Immunogenicity and Safety of GSK Biologicals' HPV Vaccine 580299 in Healthy Japanese Females 10-15 Years of Age
  ClinicalTrials.gov Identifier: NCT00492544 - Active, not recruiting
  Papillomavirus Infections; Cervical Cancer
  
• Safety and Immunogenicity of Meningococcal ACWY Conjugate Versus Polysaccharide Vaccine in Children 2 to 10 Years of Age
  ClinicalTrials.gov Identifier: NCT00329849 - Active, not recruiting
  Meningococcal Disease
  
• Immunogenicity and Safety of GSK's Meningococcal Vaccine vs. Menactra in Healthy Adolescent/Adults Aged 10-25 Years
  ClinicalTrials.gov Identifier: NCT00454909 - Active, not recruiting
  Meningococcal Infections
  
• MODULA-Study: Modul 10: Benefit of CRT-Therapy in CRT-Patients With QRS-Complex of 120 - 150 Ms
  ClinicalTrials.gov Identifier: NCT00180401 - Active, not recruiting
  Heart Failure
  
• LT FU Studies at Y6,7 8,9,10: 2 Formulations of Combined hepatitisA/B Vaccine Compared in Subjects Aged 12-15 y
  ClinicalTrials.gov Identifier: NCT00197119 - Active, not recruiting
  Hepatitis A; Hepatitis B
  
• Evaluate the Safety & Immunogenicity of GSK Biologicals’ 10-Valent Pneumococcal Conjugate Vaccine When Administered as a 2-Dose Schedule
  ClinicalTrials.gov Identifier: NCT00307034 - Active, not recruiting
  Pneumococcal Infections
  
• Comparison of New Combination Inhaler (FlutiForm HFA MDI 100/10 µg) Versus Fluticasone & Formoterol Administered Alone in Patients With Asthma
  ClinicalTrials.gov Identifier: NCT00394199 - Active, not recruiting
  Asthma
  
• Comparative Study of Oestradiol Suppression: Zoladex 10.8mg/3 Month vs. 3.6mg/Month in ER +ve EBC Pre-Menopausal Patients
  ClinicalTrials.gov Identifier: NCT00303524 - Active, not recruiting
  Breast Cancer
  
• Efficacy, Safety and Tolerability of Topical 10% Terbinafine Hydrogen Chloride Versus 5% Amorolfine Nail Lacquer in Patients With Mild to Moderate Toenail Onychomycosis
  ClinicalTrials.gov Identifier: NCT00459537 - Active, not recruiting
  Onychomycosis
  
• Safety Study of Herpes Simplex Vaccine in HSV Seronegative and Seropositive Females Between 10 and 17 Years Old
  ClinicalTrials.gov Identifier: NCT00224484 - Active, not recruiting
  Herpes Simplex
  
• Efficacy and Safety of SL77.0499-10 (Alfuzosin) Versus Placebo and Tamsulosin in Japanese Patients With Benign Prostatic Hyperplasia
  ClinicalTrials.gov Identifier: NCT00399464 - Active, not recruiting
  Prostatic Hyperplasia
  
• Dolastatin 10 in Treating Patients With Metastatic Or Recurrent Liver, Bile Duct, or Gallbladder Cancer
  ClinicalTrials.gov Identifier: NCT00003557 - Active, not recruiting
  recurrent adult primary liver cancer; advanced adult primary liver cancer; cholangiocarcinoma of the gallbladder; ...
  
• Coenzyme Q10 Supplementation and Development of Preeclampsia
  ClinicalTrials.gov Identifier: NCT00300937 - Completed
  Preeclampsia
  
• Efficacy and Safety of Aliskiren 300mg Compared to Irbesartan 300mg and Ramipril 10 mg in the Setting of a Missed Dose for Patients With Essential Hypertension.
  ClinicalTrials.gov Identifier: NCT00343551 - Active, not recruiting
  Essential Hypertension
  
• A 10-12 Week Study to Evaluate the Safety and Efficacy of 320 mg Valsartan and 80 mg Simvastatin in Combination and as Monotherapies in Treating Hypertension and Hypercholesterolemia
  ClinicalTrials.gov Identifier: NCT00171093 - Active, not recruiting
  Hypertension; Hypercholesterolemia
  
• Dolastatin 10 in Treating Patients With Refractory or Relapsed Acute Leukemia, Myelodysplastic Syndrome, or Chronic Myelogenous Leukemia
  ClinicalTrials.gov Identifier: NCT00003693 - Active, not recruiting
  Previously Treated Myelodysplastic Syndrome; recurrent adult acute myeloid leukemia; refractory anemia with excess blasts in transformation; ...
  
• A Study of the Safety and Efficacy of Infliximab (Remicade) in Subjects with Fistulizing Crohn''s Disease
  ClinicalTrials.gov Identifier: NCT00207766 - Active, not recruiting
  Crohn Disease
  
• H5 Aventis Children 2 - 10
  ClinicalTrials.gov Identifier: NCT00133536 - Active, not recruiting
  Influenza
  
• Rasagiline 1 mg and 2 mg Added to Aricept 10 mg Daily in Patients with Mild to Moderate Alzheimer's Disease (AD)
  ClinicalTrials.gov Identifier: NCT00104273 - Active, not recruiting
  Dementia, Alzheimer Type
  
• Transjugular Intrahepatic Portosystemic Shunt With 8- or 10-mm Covered Stents
  ClinicalTrials.gov Identifier: NCT00401895 - Recruiting
  Cirrhosis
  
• Safety and Efficacy of Adefovir Dipivoxil in Children and Adolescents with Chronic Hepatitis B
  ClinicalTrials.gov Identifier: NCT00095121 - Active, not recruiting
  Chronic Hepatitis B
  
• A Study on the Efficacy of 10 Mg Oral Mifepristone for the Treatment of Symptomatic Uterine Leiomyomas
  ClinicalTrials.gov Identifier: NCT00219778 - Recruiting
  Leiomyoma
  
• 10 Year Registry of Children (Ages 2-17 Years) With Eczema That Have Used Pimecrolimus
  ClinicalTrials.gov Identifier: NCT00568997 - Recruiting
  Atopic Dermatitis
  
• Predicom, Determination Of Predictive Factors Allowing To An Additional 10% Reduction Of Intra-Ocular Pressure
  ClinicalTrials.gov Identifier: NCT00230763 - Recruiting
  Glaucoma
  
• A Dose Response Trial Using 5 and 10 Mg of Midodrine Hydrochloride
  ClinicalTrials.gov Identifier: NCT00426842 - Recruiting
  Spinal Cord Injury; Orthostatic Hypotension
  
• Immunogenicity & Reactogenicity of Boostrix 10 Years After Previous Booster Vaccination.
  ClinicalTrials.gov Identifier: NCT00548171 - Recruiting
  Diphtheria; Tetanus; Pertussis
  
• A Study to Compare Tenofovir Versus Hepsera (Adefovir) for the Treatment of HBeAg Negative Chronic Hepatitis B
  ClinicalTrials.gov Identifier: NCT00117676 - Active, not recruiting
  Chronic Hepatitis B
  
• A Study to Compare Tenofovir versus Hepsera (adefovir) for the Treatment of Hepatitis Be Antigen (HBeAg) Positive Chronic Hepatitis B
  ClinicalTrials.gov Identifier: NCT00116805 - Active, not recruiting
  Chronic Hepatitis B
  
• Funen Anorexia Nervosa Study - Retrospective Cohort Study and 10 Year Follow-Up Study
  ClinicalTrials.gov Identifier: NCT00267228 - Active, not recruiting
  Anorexia Nervosa; Eating Disorder
  
• Spanish Validation Of Quality of Life Questionnaire (QOLIE-10) For Epilepsy
  ClinicalTrials.gov Identifier: NCT00264680 - Recruiting
  Epilepsy
  
• Ig NextGen 10% in ITP Patients
  ClinicalTrials.gov Identifier: NCT00362349 - Recruiting
  Idiopathic Thrombocytopenic Purpura (ITP)
  
• Coenzyme Q10 as a Symptomatic Treatment in Parkinson's Disease
  ClinicalTrials.gov Identifier: NCT00180037 - Completed
  Parkinson's Disease
  
• PV-10 Chemoablation of Recurrent Breast Carcinoma
  ClinicalTrials.gov Identifier: NCT00237354 - Recruiting
  Breast Cancer
  
• Phase 2 Study of Intralesional PV-10 for Metastatic Melanoma
  ClinicalTrials.gov Identifier: NCT00521053 - Recruiting
  Melanoma
  
• The Influence of FP-10 on the Eradication Rates of H. Pylori by a Triple Therapy
  ClinicalTrials.gov Identifier: NCT00281047 - Recruiting
  Helicobacter Pylori
  
• Topical PH-10 Aqueous Hydrogel and Photodynamic Therapy for Psoriasis
  ClinicalTrials.gov Identifier: NCT00555646 - Recruiting
  Plaque Psoriasis
  
• Improving Diabetic Foot Ulcers with atorvaStatin
  ClinicalTrials.gov Identifier: NCT00134550 - Active, not recruiting
  Diabetes Mellitus; Foot Ulcer
  
• Non-Inferiority of Meningococcal Vaccine GSK134612 Versus Mencevax™ in 2-10 Year Old Subjects
  ClinicalTrials.gov Identifier: NCT00514904 - Recruiting
  Meningococcal Disease
  
• Comparison of Intravenous and Subcutaneous Administration of IGIV, 10% in PID Subjects
  ClinicalTrials.gov Identifier: NCT00546871 - Recruiting
  Primary Immunodeficiency (PID)
  
• Comparison of New Combination Inhaler (FlutiForm HFA MDI 100/10 µg) Versus Fluticasone and Formoterol Administered Alone, and Placebo, in Patients With Asthma
  ClinicalTrials.gov Identifier: NCT00393991 - Recruiting
  Asthma
  
• Phase IV, 9 Weeks Comparison Between MICARDIS 80 mg and Amlodipine 10 mg on Biological PPAR Gamma Activities
  ClinicalTrials.gov Identifier: NCT00242814 - Recruiting
  Hypertension; Metabolic Syndrome X
  
• A Study To Assess If 10 mg Vardenafil (BAY 38-9456) Taken Twice Daily For 6 Weeks Has An Effect On Bladder Function
  ClinicalTrials.gov Identifier: NCT00478881 - Recruiting
  Overactive Bladder; Detrusor Overactivity
  
• Comparative Efficacy, Safety, and Tolerability of Rivastigmine 10 and 15 cm2 Patch in Patients With Alzheimer's Disease (AD) Showing Cognitive Decline
  ClinicalTrials.gov Identifier: NCT00506415 - Recruiting
  Alzheimer Disease
  
• Immunogenicity and Safety of GlaxoSmithKline Biologicals' HPV Vaccine 580299 in Healthy Females 10 - 25 Years of Age.
  ClinicalTrials.gov Identifier: NCT00481767 - Recruiting
  HPV-16/18 Infections; Cervical Neoplasia
  
• Adrenal Function and Use of Intralesional Triamcinolone Acetonide 10 mg/mL in Patients With Alopecia Areata
  ClinicalTrials.gov Identifier: NCT00484679 - Recruiting
  Alopecia Areata
  
• 5-Fluorouracil Combined With CoFactor (5-10 Methylenetetrahydrofolate) in Treating Advanced Breast Cancer Patients
  ClinicalTrials.gov Identifier: NCT00434369 - Recruiting
  Breast Cancer
  
• Evaluation of Topical 10% Metronidazole Ointment for the Treatment of Active Perianal Crohn's Disease
  ClinicalTrials.gov Identifier: NCT00509639 - Recruiting
  Crohn's Disease
  
• CESA 5.10 Investigation to Compare the Efficacy and Safety of the Adacolumn® Apheresis Device in Patients With Active Ulcerative Colitis
  ClinicalTrials.gov Identifier: NCT00366925 - Recruiting
  Ulcerative Colitis
  
• Efficacy, Safety and PK of Once or Twice Daily Bilastine (10 or 20 mg) Compared With Placebo in the Symptomatic Treatment of SAR
  ClinicalTrials.gov Identifier: NCT00574379 - Recruiting
  Seasonal Allergic Rhinitis; Hay Fever; Allergic Conjunctivitis; Hypersensitivity
  
• Pulmonary Function Changes in 10 Pack Year Smokers With Chronic Bronchitis
  ClinicalTrials.gov Identifier: NCT00454675 - Recruiting
  Chronic Bronchitis; COPD
  
• Clinical Effectiveness of 10 cm2 Rivastigmine Patch in Patients With Alzheimer's Disease
  ClinicalTrials.gov Identifier: NCT00561392 - Recruiting
  Alzheimer's Disease
  
• Vaccine Therapy With or Without Sargramostim in Treating Patients With High-Risk or Metastatic Melanoma
  ClinicalTrials.gov Identifier: NCT00037037 - Active, not recruiting
  stage III melanoma; Stage IV Melanoma; Recurrent Melanoma
  
• This Study Offers Narrowband UVB Light Therapy to Patients With Dark Skin Types Who Have 10% of Their Body Involved With Psoriasis Vulgaris.
  ClinicalTrials.gov Identifier: NCT00220025 - Recruiting
  Psoriasis Vulgaris
  
• Study About Safety and Efficacy of Coenzyme Q10 in Progressive Supranuclear Palsy
  ClinicalTrials.gov Identifier: NCT00328874 - Completed
  Progressive Supranuclear Palsy
  
• A Randomized, Double-Blind, Placebo Controlled, Parallel Group Trial of Cyclamen Europaeum Extract Nasal Spray 10% (v/v) in the Treatment of Subjects With Acute Sinusitis
  ClinicalTrials.gov Identifier: NCT00552773 - Recruiting
  ACUTE SINUSITIS
  
• Clinical and Molecular Correlations in Spinocerebellar Ataxia Type 10 (SCA10)
  ClinicalTrials.gov Identifier: NCT00004306 - Recruiting
  Hereditary Ataxia
  
• A 10-Week Study Evaluating the Efficacy And Safety of PD 0332334 for the Treatment of Generalized Anxiety Disorder
  ClinicalTrials.gov Identifier: NCT00542685 - Recruiting
  Generalized Anxiety Disorder
  
• Clinical Study to Evaluate the Efficacy and Safety of Octagam 10% in Idiopathic Thrombocytopenic Purpura in Adults
  ClinicalTrials.gov Identifier: NCT00426270 - Recruiting
  Idiopathic Thrombocytopenic Purpura
  
• A 10 Week Open-Label Pilot Study to Evaluate the Effectiveness and Safety of Memantine(Namenda) as Augmentation Therapy in Patients With Generalized Anxiety Disorder
  ClinicalTrials.gov Identifier: NCT00411398 - Recruiting
  General Anxiety Disorder, Social Anxiety Disorder
  
• Fludeoxyglucose F 18 PET Scan, CT Scan, and Ferumoxtran-10 MRI Scan Before Chemotherapy and Radiation Therapy in Finding Lymph Node Metastasis in Patients With Locally Advanced Cervical Cancer
  ClinicalTrials.gov Identifier: NCT00416455 - Recruiting
  Cervical Cancer
  
• Efficacy and Safety of Levetiracetam in the Inpatient Treatment of Alcohol Withdrawal Syndrome
  ClinicalTrials.gov Identifier: NCT00146471 - Not yet recruiting
  alcohol dependence according to DSM-IV/ICD-10; Withdrawal Symptoms; inpatient
  
• BREAST-10: Three-Weekly Versus Weekly First-Line Chemotherapy for Metastatic or Locally Advanced Breast Cancer
  ClinicalTrials.gov Identifier: NCT00540800 - Recruiting
  Breast Cancer
  
• Open Label Phase 3 Study of NABI-IGIV 10% [(HUMAN)] In Subjects With Primary Immune Deficiency Disorders (PIDD)
  ClinicalTrials.gov Identifier: NCT00538915 - Recruiting
  Primary Immune Deficiency Disorders; Antibody Deficiency Syndromes
  
• 10-Propargyl-10-Deazaaminopterin Plus Probenecid in Treating Patients With Advanced Solid Tumors
  ClinicalTrials.gov Identifier: NCT00024245 - Completed
  unspecified adult solid tumor, protocol specific
  
• Comparison of 23 mg Donepezil Sustained Release (SR) to 10 mg Donepezil Immediate Release (IR) in Patients With Moderate to Severe Alzheimer's Disease
  ClinicalTrials.gov Identifier: NCT00478205 - Recruiting
  Alzheimer's Disease
  
• Telmisartan/Amlodipine (80/5) vs. Telmisartan/Amlodipine (40/5) vs. Amlodipine 10 or 5 in Resistant Hypertension
  ClinicalTrials.gov Identifier: NCT00558428 - Recruiting
  Hypertension
  
• Ig NextGen 10% in Patients With Primary Immune Deficiency (PID)
  ClinicalTrials.gov Identifier: NCT00405184 - Recruiting
  Primary Immune Deficiency (PID)
  
• The Effects of Ezetimibe/Simvastatin Tablet 10/20 mg Versus Doubling the Dose of Simvastatin 20 mg [Simvastatin 40 mg] in High Cholesterol and Coronary Heart Disease (Study P04039)
  ClinicalTrials.gov Identifier: NCT00423579 - Recruiting
  Hypercholesterolemia; Coronary Disease
  
• IMPROVE-IT: Examining Outcomes in Subjects with Acute Coronary Syndrome:Vytorin (Ezetimibe/Simvastatin) Vs Simvastatin
  ClinicalTrials.gov Identifier: NCT00202878 - Recruiting
  Hypercholesterolemia; Myocardial Infarction
  
• A Multicenter, Randomized, Open Label Study to Evaluate the Lipid Lowering Efficacy and Safety of Vytorin 10/20 vs. Atorvastatin 10mg in Hypercholesterolemia Patients With Metabolic Syndrome in Korea
  ClinicalTrials.gov Identifier: NCT00496730 - Not yet recruiting
  Hypercholesterolemia