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The Efficacy of Coenzyme Q10 And Curcumin in Patients With Myelodysplastic Syndromes - Article


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Coenzyme Q-10

Co Q 10; Mitoquinone; Q 10; Ubidecarenone; Ubiquinone; Vitamin Q

Clinical Trial: The Efficacy of Coenzyme Q10 And Curcumin in Patients With Myelodysplastic Syndromes

This study is not yet open for patient recruitment.
Verified by Hadassah Medical Organization October 2005

Sponsored by: Hadassah Medical Organization
Information provided by: Hadassah Medical Organization
ClinicalTrials.gov Identifier: NCT00247026

Purpose

To determine the clinical effects of coenzyme Q10 and Curcumin in improving the cytopenias of patients with myelodysplastic syndromes. we propose to explore the efficacy of the natural compounds curcumin and CoQ10 in MDS because these two agents possess many of the effects that are desirable in MDS.
Condition Intervention Phase
Myelodysplastic Syndrome
  Drug: curcumin; coenzyme q10
 Phase I
Phase II

MedlinePlus related topics:  Anemia;   Blood and Blood Disorders;   Bone Marrow Diseases;   Cancer;   Cancer Alternative Therapies

Study Type: Interventional
Study Design: Treatment, Non-Randomized, Open Label, Historical Control, Single Group Assignment, Efficacy Study

Official Title: A Pilot Study to Determine the Clinical Efficacy of Coenzyme Q10 And Curcumin in Patients With Myelodysplastic Syndromes

Further study details as provided by Hadassah Medical Organization:
Primary Outcomes: major hematologic improvement in any lineage
Secondary Outcomes: • Time to disease progression; • Overall and progression-free survival; • Cytogenetic response
Expected Total Enrollment:  50

Study start: February 2006

Eligibility

Ages Eligible for Study:  16 Years and above,  Genders Eligible for Study:  Both
Criteria

Inclusion Criteria:

 MDS patients with RA, RARS or RAEB will be eligible for treatment with CoQ10 as long as their IPSS score ≤ 1.5.

Exclusion Criteria:

 Pregnant women and nursing women will be excluded.

 History of clinically significant liver or kidney disease.

 ECOG>2

 IPSS score >1.5

 Poorly controlled diabetes mellitus, hypertension, or other serious medical or psychiatric illness that could potentially interfere with the completion of treatment according to the protocol.

Location and Contact Information

Please refer to this study by ClinicalTrials.gov identifier  NCT00247026

moshe e gatt, dr      972-50-7874854    gatt@md.huji.ac.il

Israel
      Hadassah Medical Organization, Jerusalem,  Israel
arik Tzukert, DMD  00 972 2 6776095    lhadas@hadassah.org.il 
moshe e gatt, dr,  Principal Investigator

Study chairs or principal investigators

moshe e gatt, dr,  Principal Investigator,  hadassah hebrew university medical center   

More Information

Study ID Numbers:  385-mds 1-HMO-CTIL; mds 1
Last Updated:  December 8, 2005
Record first received:  October 31, 2005
ClinicalTrials.gov Identifier:  NCT00247026
Health Authority: Israel: Israeli Health Ministry Pharmaceutical Administration
ClinicalTrials.gov processed this record on 2006-01-10


Source: ClinicalTrials.gov
Cache Date: January 11, 2006


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Page Updated: June 1, 2005
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