RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development of cancer. It is not yet known which regimen of selenium and/or vitamin E may be more effective in preventing prostate cancer.

PURPOSE: Randomizedphase III trial to determine the effectiveness of selenium and vitamin E, either alone or together, in preventing prostate cancer.

Condition	Treatment or Intervention	Phase
Prostate Cancer	Drug: selenium  Drug: vitamin E  Procedure: biologically based therapies  Procedure: cancer prevention intervention  Procedure: chemoprevention of cancer  Procedure: complementary and alternative therapy  Procedure: nutritional supplementation	Phase III

Further Study Details: 

OBJECTIVES:

• Compare the effect of selenium and vitamin E administered alone vs in combination on the clinical incidence of prostate cancer.
• Compare the effect of these prevention regimens on the incidence of lung cancer, colorectal cancer, and all cancers combined in participants on this study.
• Compare the effect of these prevention regimens on prostate cancer-free survival, lung cancer-free survival, colorectal cancer-free survival, cancer-free survival, overall survival, and serious cardiovascular events in these participants.
• Compare the quality of life of participants treated with these regimens.
• Determine the association of biological molecular markers with the risk of prostate cancer, lung cancer, and colon cancer in these participants.
• Determine the relationship between the effects of these regimens on prostate cancer risk and genetic factors in these participants.
• Determine whether the effects of these regimens on prostate cancer risk are conditional upon pre-study use of these supplements by these participants.
• Determine whether the effects of these regimens are conditional upon intake of other nutrients, foods, and dietary supplements by these participants.
• Determine the effect of other dietary nutrients and dietary patterns on prostate cancer risk in these participants.
• Determine the effects of these regimens on the reduction of Alzheimer's disease incidence in these participants.
• Determine whether these regimens reduce the risk of age-related macular degeneration or cataract in these participants.

OUTLINE: This is a randomized, double-blind, multicenter study. Participants are randomized to one of four prevention arms.

• Arm I: Participants receive 2 different oral placebos once daily.
• Arm II: Participants receive oral selenium and oral placebo once daily.
• Arm III: Participants receive oral vitamin E and oral placebo once daily.
• Arm IV: Participants receive oral selenium and oral vitamin E once daily. Treatment continues for 7-12 years in the absence of unacceptable toxicity or diagnosis of prostate cancer.

Quality of life is assessed at baseline and then at 1, 3, 5, and 7 years.

Participants are followed annually.

PROJECTED ACCRUAL: A total of 32,400 participants (8,100 per prevention arm) will be accrued for this study within 5 years.

Ages Eligible for Study:  50 Years and above,  Genders Eligible for Study:  Both

Accepts Healthy Volunteers

Criteria

DISEASE CHARACTERISTICS:

• Males age 55 and over (African American males age 50 and over)
• Digital rectal examination (DRE) deemed not suspicious for prostate cancer performed within 364 days prior to study entry
• Participants with a suspicious DRE are ineligible even if a recent or subsequent biopsy is negative for cancer
• Total prostate-specific antigen ≤ 4.0 ng/mL within 364 days prior to study entry
• No prior prostate cancer or high-grade (grade 2-3) prostatic intraepithelial neoplasia

PATIENT CHARACTERISTICS: Age:

• See Disease Characteristics

Performance status:

• Not specified

Life expectancy:

• Not specified

Hematopoietic:

• Not specified

Hepatic:

• Not specified

Renal:

• Not specified

Cardiovascular:

• Systolic blood pressure < 160 mm Hg
• Diastolic blood pressure < 90 mm Hg
• No history of hemorrhagic stroke

Other:

• No malignancies within the past 5 years except basal cell or squamous cell skin cancer
• No uncontrolled medical illness
• No retinitis pigmentosa

PRIOR CONCURRENT THERAPY: Biologic therapy

• Not specified

Chemotherapy

• Not specified

Endocrine therapy

• Not specified

Radiotherapy

• Not specified

Surgery

• Not specified

Other

• At least 7 years since prior randomization to SWOG-9217, with completion of end-of-study biopsy requirement
• No additional concurrent selenium or vitamin E (contained in individual supplements, antioxidant mix, or multivitamin)
• Concurrent multivitamins allowed (supplied on study)
• No concurrent anticoagulation therapy (e.g., warfarin)
• Concurrent prophylactic aspirin (average daily dose no greater than 175 mg/day) allowed
• Concurrent daily aspirin dose ≤ 81 mg for participants receiving clopidrogel
• Concurrent anti-hypertension medication allowed
• No concurrent participation in another study involving a medical, surgical, nutritional, or life-style intervention (unless no longer receiving the intervention and are in the follow-up phase only)

Alabama
      MBCCOP - Gulf Coast, Mobile,  Alabama,  36652-2144,  United States
      Northeast Alabama Regional Medical Center, Anniston,  Alabama,  36207,  United States
      Veterans Affairs Medical Center - Tuscaloosa, Tuscaloosa,  Alabama,  35404,  United States
Alaska
      Alaska Oncology and Hematology, LLC, Anchorage,  Alaska,  99508,  United States
      Fairbanks Cancer Treatment Center at Fairbanks Memorial Hospital, Fairbanks,  Alaska,  99701,  United States
      Providence Alaska Medical Center, Anchorage,  Alaska,  99519-6604,  United States
Arizona
      Arizona Cancer Center at University of Arizona Health Sciences Center, Tucson,  Arizona,  85724,  United States
      Chandler Regional Hospital, Chandler,  Arizona,  85224,  United States
      Mayo Clinic Scottsdale, Scottsdale,  Arizona,  85259,  United States
      Mesa Lutheran Hospital, Mesa,  Arizona,  85201-3202,  United States
      Sun Health Research Institute, Sun City,  Arizona,  85351-3004,  United States
      Veterans Affairs Medical Center - Phoenix (Carl T. Hayden), Phoenix,  Arizona,  85012,  United States
      Veterans Affairs Medical Center - Tucson, Tucson,  Arizona,  85723,  United States
Arkansas
      Arkansas Cancer Research Center at University of Arkansas for Medical Sciences, Little Rock,  Arkansas,  72205,  United States
      Veterans Affairs Medical Center - Little Rock (McClellan), Little Rock,  Arkansas,  72205,  United States
California
      CCOP - Bay Area Tumor Institute, Oakland,  California,  94609-3305,  United States
      CCOP - Santa Rosa Memorial Hospital, Santa Rosa,  California,  95403,  United States
      City of Hope Comprehensive Cancer Center, Duarte,  California,  91010-3000,  United States
      Glendale Memorial Hospital and Health Center, Glendale,  California,  91204,  United States
      Huntington Cancer Center at Huntington Hospital, Pasadena,  California,  91105,  United States
      Jonsson Comprehensive Cancer Center, UCLA, Los Angeles,  California,  90095-1781,  United States
      Kaiser Permanente Medical Center - Oakland, Oakland,  California,  94612,  United States
      Kaiser Permanente Medical Center/Kaiser Foundation Hospital - San Diego, San Diego,  California,  92120,  United States
      Lionel B. Katchem, Ontario,  California,  91764,  United States
      Loma Linda University Cancer Institute at Loma Linda University Medical Center, Loma Linda,  California,  92354,  United States
      Naval Medical Center - San Diego, San Diego,  California,  92134-3202,  United States
      Rebecca and John Moores UCSD Cancer Center, La Jolla,  California,  92093-0658,  United States
      Santa Clara Valley Medical Center, San Jose,  California,  95128,  United States
      Sierra Nevada Cancer Center at Sierra Nevada Memorial Hospital, Grass Valley,  California,  95945,  United States
      Stanford Cancer Center at Stanford University Medical Center, Stanford,  California,  94305,  United States
      Sutter Cancer Center, Sacramento,  California,  95816,  United States
      Todd Cancer Institute at Long Beach Memorial Medical Center, Long Beach,  California,  90806,  United States
      UCSF Comprehensive Cancer Center, San Francisco,  California,  94143-0128,  United States
      University of California San Diego, Chula Vista,  California,  91910,  United States
      USC/Norris Comprehensive Cancer Center and Hospital, Los Angeles,  California,  90089,  United States
      Veterans Affairs Medical Center - Loma Linda (Pettis), Loma Linda,  California,  92354,  United States
      Veterans Affairs Medical Center - Long Beach, Long Beach,  California,  90822,  United States
      Veterans Affairs Medical Center - Palo Alto, Palo Alto,  California,  94304-1290,  United States
      Veterans Affairs Medical Center - San Diego, San Diego,  California,  92161,  United States
      Veterans Affairs Outpatient Clinic - Martinez, Martinez,  California,  94553,  United States
Colorado
      Boulder Community Hospital, Boulder,  Colorado,  80301-9019,  United States
      CCOP - Colorado Cancer Research Program, Incorporated, Denver,  Colorado,  80224,  United States
      Front Range Cancer Specialists, Fort Collins,  Colorado,  80524-4038,  United States
      Longmont United Hospital, Longmont,  Colorado,  80501,  United States
      Medical Center of Aurora - South Campus, Aurora,  Colorado,  80012-0000,  United States
      Penrose Cancer Center, Colorado Springs,  Colorado,  80933,  United States
      Porter Adventist Hospital, Denver,  Colorado,  80210,  United States
      Presbyterian - St. Luke's Medical Center, Denver,  Colorado,  80218,  United States
      Rocky Mountain Cancer Centers - Rose, Denver,  Colorado,  80220,  United States
      Rocky Mountain Cancer Centers, Thornton,  Colorado,  80260,  United States
      Sky Ridge Medical Center, Lone Tree,  Colorado,  80124,  United States
      St. Joseph Hospital, Denver,  Colorado,  80218-1191,  United States
      St. Mary-Corwin Regional Medical Center, Pueblo,  Colorado,  81004,  United States
      Swedish Medical Center, Englewood,  Colorado,  80112,  United States
Connecticut
      Hematology Oncology, P.C., Stamford,  Connecticut,  06902,  United States
      Lawrence and Memorial Hospital, New London,  Connecticut,  06320,  United States
      New Britain General Hospital, New Britain,  Connecticut,  06050,  United States
      University of Connecticut Comprehensive Cancer Center at University of Connecticut Health Center, Farmington,  Connecticut,  06360-3805,  United States
Delaware
      Beebe Medical Center, Lewes,  Delaware,  19958,  United States
      Helen F. Graham Cancer Center at Christiana Care Health System, Newark,  Delaware,  19718-6001,  United States
      Nanticoke Memorial Hospital, Seaford,  Delaware,  19973,  United States
District of Columbia
      George Washington University Medical Center, Washington,  District of Columbia,  20037,  United States
      Sibley Memorial Hospital, Washington,  District of Columbia,  20060,  United States
      Veterans Affairs Medical Center - Washington, DC, Washington,  District of Columbia,  20422,  United States
      Walter Reed Army Medical Center, Washington,  District of Columbia,  20307-5000,  United States
Florida
      Baptist Regional Cancer Institute - Jacksonville, Jacksonville,  Florida,  32207-8560,  United States
      Boca Raton Community Hospital, Boca Raton,  Florida,  33486,  United States
      Broward General Medical Center, Fort Lauderdale,  Florida,  33316,  United States
      CCOP - Mount Sinai Medical Center, Miami Beach,  Florida,  33140,  United States
      H. Lee Moffitt Cancer Center and Research Institute, Tampa,  Florida,  33612-9497,  United States
      Martin Memorial Cancer Center, Stuart,  Florida,  34995-9010,  United States
      Memorial Regional Cancer Center at Memorial Regional Hospital, Hollywood,  Florida,  33021,  United States
      Palm Beach Cancer Institute, West Palm Beach,  Florida,  33401,  United States
      Sacred Heart Cancer Center at Sacred Heart Hospital, Pensacola,  Florida,  32513-7000,  United States
      University of Miami Sylvester Cancer Center, Miami,  Florida,  33136,  United States
      Veterans Affairs Medical Center - Gainesville, Gainesville,  Florida,  32608-1197,  United States
      Veterans Affairs Medical Center - Tampa (Haley), Tampa,  Florida,  33612,  United States
Georgia
      CCOP - Atlanta Regional, Atlanta,  Georgia,  30342-1701,  United States
      Charles B. Eberhart Cancer Center at DeKalb Medical Center, Decatur,  Georgia,  30033,  United States
      Gwinnett Hospital System, Lawrenceville,  Georgia,  30045,  United States
      Kaiser Permanente Medical Center - Crescent Centre, Tucker,  Georgia,  30084,  United States
      Midtown Urology, Atlanta,  Georgia,  30308,  United States
      Northside Hospital, Atlanta,  Georgia,  30342-1611,  United States
      Piedmont Hospital Incorporated, Atlanta,  Georgia,  30309-1285,  United States
      Southern Regional Medical Center, Riverdale,  Georgia,  30274-2600,  United States
      Val Oak Professional Corp, Valdosta,  Georgia,  31602,  United States
      Wellstar Kennestone Hospital, Marietta,  Georgia,  30060,  United States
Hawaii
      MBCCOP - Hawaii, Honolulu,  Hawaii,  96813,  United States
Idaho
      North Idaho Cancer Center, Coeur D Alene,  Idaho,  83814,  United States
      Saint Alphonsus Regional Medical Center, Boise,  Idaho,  83706,  United States
      St. Luke's Regional Medical Center, Boise,  Idaho,  83712,  United States
Illinois
      Cardinal Bernardin Cancer Center at Loyola University Medical Center, Maywood,  Illinois,  60153,  United States
      Carle Foundation Hospital - Carle Cancer Center, Urbana,  Illinois,  61801,  United States
      CCOP - Central Illinois, Decatur,  Illinois,  62526,  United States
      CCOP - Illinois Oncology Research Association, Peoria,  Illinois,  61602,  United States
      Chicago Consortium For SELECT, Chicago,  Illinois,  60616,  United States
      Decatur Memorial Hospital, Decatur,  Illinois,  62526-4163,  United States
      Evanston Northwestern Health Care - Evanston Hospital, Evanston,  Illinois,  60201-1781,  United States
      Ingalls Memorial Hospital, Harvey,  Illinois,  60426,  United States
      Louis A. Weiss Memorial Hospital, Chicago,  Illinois,  60640,  United States
      Lutheran General Cancer Care Center, Park Ridge,  Illinois,  60068-1174,  United States
      MacNeal Cancer Center at MacNeal Hospital, Berwyn,  Illinois,  60402,  United States
      MBCCOP - University of Illinois at Chicago, Chicago,  Illinois,  60612-7323,  United States
      Memorial Medical Center, Springfield,  Illinois,  62781,  United States
      Midwest Center for Hematology/Oncology, Joliet,  Illinois,  60432,  United States
      Mount Sinai Hospital Medical Center, Chicago,  Illinois,  60608,  United States
      Northwestern University Medical School, Chicago,  Illinois,  60611,  United States
      Resurrection Medical Center, Chicago,  Illinois,  60631-3746,  United States
      Robert H. Lurie Comprehensive Cancer Center at Northwestern University, Chicago,  Illinois,  60611-3013,  United States
      Rush Cancer Institute at Rush University Medical Center, Chicago,  Illinois,  60612,  United States
      Saint Anthony Medical Center, Rockford,  Illinois,  61108,  United States
      Sherman Hospital, Elgin,  Illinois,  60120-2198,  United States
      Trinity Medical Center - West, Rock Island,  Illinois,  61201,  United States
      Veterans Affairs Medical Center - Chicago (Westside Hospital), Chicago,  Illinois,  60612,  United States
      Veterans Affairs Medical Center - Hines (Hines Junior VA Hospital), Hines,  Illinois,  60141,  United States
      West Suburban Center for Cancer Care, River Forest,  Illinois,  60305,  United States
Indiana
      CCOP - Northern Indiana CR Consortium, South Bend,  Indiana,  46601,  United States
      Fort Wayne Medical Oncology and Hematology, Incorporated, Fort Wayne,  Indiana,  46885-5099,  United States
      Indiana University Cancer Center, Indianapolis,  Indiana,  46202-5289,  United States
      Methodist Cancer Center at Methodist Hospital, Indianapolis,  Indiana,  46206-1367,  United States
      Oncology and Hematology Associates, Indianapolis,  Indiana,  46227,  United States
      Oncology Institute of Greater Lafayette, Lafayette,  Indiana,  70506,  United States
      Oncology/Hematology Associates, Indianaoplis,  Indiana,  46227,  United States
      Saint Anthony Memorial Health Centers, Michigan City,  Indiana,  46360-4358,  United States
Iowa
      CCOP - Cedar Rapids Oncology Project, Cedar Rapids,  Iowa,  52403,  United States
      Genesis Regional Cancer Center at Genesis Medical Center, Davenport,  Iowa,  52804,  United States
      Iowa Lutheran Hospital, Des Moines,  Iowa,  50316-2301,  United States
      Iowa Oncology Research Association, Des Moines,  Iowa,  50309-1016,  United States
      John Stoddard Cancer Center at Iowa Methodist Medical Center, Des Moines,  Iowa,  50309,  United States
      Mary Greeley Medical Center, Ames,  Iowa,  50010,  United States
      Mercy Cancer Center at Mercy Medical Center-Des Moines, Des Moines,  Iowa,  50314,  United States
      Mercy Cancer Center at Mercy Medical Center - North Iowa, Mason City,  Iowa,  50401,  United States
      Ottumwa Regional Health Center, Ottumwa,  Iowa,  52501,  United States
      Siouxland Hematology-Oncology, Sioux City,  Iowa,  51101-1733,  United States
      Veterans Affairs Medical Center - Iowa City, Iowa City,  Iowa,  52246-2208,  United States
Kansas
      CCOP - Wichita, Wichita,  Kansas,  67214-3882,  United States
      Cotton - O'Neil Clinic, P.A., Topeka,  Kansas,  66606,  United States
      Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center, Kansas City,  Kansas,  66160-7357,  United States
      Veterans Affairs Medical Center - Leavenworth, Leavenworth,  Kansas,  66048,  United States
      Veterans Affairs Medical Center - Topeka (O'Neil), Topeka,  Kansas,  66622-0001,  United States
Kentucky
      Baptist Hospital East - Louisville, Louisville,  Kentucky,  40207,  United States
      Cancer Care at Our Lady of Bellefonte Hospital, Ashland,  Kentucky,  41101,  United States
      Central Baptist Hospital, Lexington,  Kentucky,  40503-9985,  United States
      Veterans Affairs Medical Center - Louisville, Louisville,  Kentucky,  40206-1499,  United States
Louisiana
      Baton Rouge General Medical Center, Baton Rouge,  Louisiana,  70821-2511,  United States
      CCOP - Ochsner, New Orleans,  Louisiana,  70121,  United States
      Louisiana Oncology Associates - Lafayette, Lafayette,  Louisiana,  70506,  United States
      Louisiana State University School of Medicine, Shreveport,  Louisiana,  71130-3932,  United States
      MBCCOP - LSU Health Sciences Center, New Orleans,  Louisiana,  70112,  United States
      Ochsner Clinic of Baton Rouge, Baton Rouge,  Louisiana,  70809-3679,  United States
      Our Lady of the Lake Regional Medical Center, Baton Rouge,  Louisiana,  70808,  United States
      Terrebonne Parish General Hospital, Houma,  Louisiana,  70360,  United States
      Thibodaux Regional Medical Center, Thibodaux,  Louisiana,  70301,  United States
      Tulane Cancer Center at Tulane University Hospital and Clinic, New Orleans,  Louisiana,  70118,  United States
      Veterans Affairs Medical Center - Shreveport, Shreveport,  Louisiana,  71130,  United States
Maine
      Maine General Medical Center - Waterville, Waterville,  Maine,  04901,  United States
Maryland
      Anne Arundel Medical Center, Annapolis,  Maryland,  21401,  United States
      Greater Baltimore Medical Center and Cancer Center, Baltimore,  Maryland,  21204,  United States
      Memorial Hospital at Easton, Easton,  Maryland,  21601,  United States
      Peninsula Regional Medical Center, Salisbury,  Maryland,  21801,  United States
      Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore,  Maryland,  21205,  United States
      St. Joseph Medical Center, Towson,  Maryland,  21204,  United States
Massachusetts
      Berkshire Hematology Oncology, P.C., Pittsfield,  Massachusetts,  01201,  United States
      Beth Israel Deaconess Medical Center, Boston,  Massachusetts,  02215,  United States
      Cancer Research Center at Boston Medical Center, Boston,  Massachusetts,  02118-2307,  United States
      Lahey Clinic Medical Center - Burlington, Burlington,  Massachusetts,  01805-0001,  United States
      Veterans Affairs Medical Center - Boston (Jamaica Plain), Jamaica Plain,  Massachusetts,  02130,  United States
Michigan
      Barbara Ann Karmanos Cancer Institute, Detroit,  Michigan,  48201-1379,  United States
      Breslin Cancer Center at Ingham Regional Medical Center, Lansing,  Michigan,  48910,  United States
      Cancer Center St. Joseph Mercy Hospital, Ann Arbor,  Michigan,  48106,  United States
      CCOP - Grand Rapids, Grand Rapids,  Michigan,  49503,  United States
      CCOP - Kalamazoo, Kalamazoo,  Michigan,  49007-3731,  United States
      Detroit-Macomb Hospital Corporation, Detroit,  Michigan,  48236,  United States
      Genesys Regional Medical Center, Grand Blanc,  Michigan,  48439-8066,  United States
      Hurley Medical Center, Flint,  Michigan,  48503,  United States
      Josephine Ford Cancer Center at Henry Ford Hospital, Detroit,  Michigan,  48202,  United States
      Lakeland Cancer Care Center at Lakeland Hospital - St. Joseph, Saint Joseph,  Michigan,  49085,  United States
      Marquette General Hospital, Marquette,  Michigan,  49855,  United States
      Monroe Clinic, Monroe,  Michigan,  48162,  United States
      Munson Medical Center, Traverse City,  Michigan,  49684,  United States
      Northern Michigan Hospital, Petoskey,  Michigan,  49770,  United States
      Oakwood Hospital and Medical Center, Dearborn,  Michigan,  48123-2500,  United States
      Providence Cancer Institute at Providence Hospital, Southfield,  Michigan,  48075,  United States
      Saint Mary's Seton Cancer Institute, Saginaw,  Michigan,  48601,  United States
      St. John Macomb Hospital, Warren,  Michigan,  48093-3494,  United States
      St. Joseph Mercy Hospital, Pontiac,  Michigan,  48341-2985,  United States
      St. Lawrence Hospital, Lansing,  Michigan,  48909-7980,  United States
      University of Michigan Comprehensive Cancer Center, Ann Arbor,  Michigan,  48109-0752,  United States
      William Beaumont Hospital - Royal Oak, Royal Oak,  Michigan,  48073,  United States
Minnesota
      CCOP - Duluth, Duluth,  Minnesota,  55805,  United States
      CCOP - Metro-Minnesota, Saint Louis Park,  Minnesota,  55416,  United States
      Mayo Clinic - Jacksonville, Rochester,  Minnesota,  55905,  United States
      Veterans Affairs Medical Center - Minneapolis, Minneapolis,  Minnesota,  55417,  United States
Mississippi
      Delta Health Center, Mound Bayou,  Mississippi,  38762,  United States
      Mid Delta Family Practice, Cleveland,  Mississippi,  38732,  United States
      University of Mississippi Medical Center, Jackson,  Mississippi,  39216-4505,  United States
      Veterans Affairs Medical Center - Biloxi, Biloxi,  Mississippi,  39531-2410,  United States
Missouri
      Associated Urologists PC, Columbia,  Missouri,  65201,  United States
      CCOP - Cancer Research for the Ozarks, Springfield,  Missouri,  65807,  United States
      CCOP - Kansas City, Kansas City,  Missouri,  64131,  United States
      Freeman Cancer Institute at Freeman Health System, Joplin,  Missouri,  64804-3599,  United States
      Missouri Baptist Cancer Center, Saint Louis,  Missouri,  63131,  United States
      Phelps County Regional Medical Center, Rolla,  Missouri,  65401,  United States
      St. John's Regional Health Center, Springfield,  Missouri,  65804-2263,  United States
      St. John's Regional Medical Center, Joplin,  Missouri,  64804,  United States
      Veterans Affairs Medical Center - Kansas City, Kansas City,  Missouri,  64128-2295,  United States
      Veterans Affairs Medical Center - Saint Louis, Saint Louis,  Missouri,  63106-1697,  United States
      Washington Universtiy Urologic, Saint Louis,  Missouri,  63141,  United States
Montana
      CCOP - Montana Cancer Consortium, Billings,  Montana,  59101,  United States
      Montana Cancer Institute - Benefis Healthcare, Great Falls,  Montana,  59405,  United States
Nebraska
      Alegent Health - Immanuel Medical Center, Omaha,  Nebraska,  68122,  United States
      Bergan Mercy Medical Center, Omaha,  Nebraska,  68124,  United States
      Cancer Center at the Good Samaritan Health Systems, Kearney,  Nebraska,  68848-1990,  United States
      Cancer Resource Center - Lincoln, Lincoln,  Nebraska,  68510-4844,  United States
      Methodist Hospital Cancer Center at Nebraska Methodist Hospital - Omaha, Omaha,  Nebraska,  68114-4199,  United States
      Midlands Cancer Center at Midlands Community Hospital, Papillion,  Nebraska,  68128-4157,  United States
      Midwest Urology Associates, Omaha,  Nebraska,  68122,  United States
      UNMC Eppley Cancer Center at the University of Nebraska Medical Center, Omaha,  Nebraska,  68198-7680,  United States
      Veterans Affairs Medical Center - Omaha, Omaha,  Nebraska,  68105,  United States
Nevada
      CCOP - Southern Nevada Cancer Research Foundation, Las Vegas,  Nevada,  89106,  United States
      Veterans Affairs Medical Center - Southern Nevada, Las Vegas,  Nevada,  89036,  United States
      Veterans Affairs Medical Center - Las Vegas, Las Vegas,  Nevada,  89106,  United States
      Washoe Cancer Services at Washoe Medical Center - Reno, Reno,  Nevada,  89520-0109,  United States
New Hampshire
      New Hampshire Oncology-Hematology, PA - Hooksett, Hooksett,  New Hampshire,  03106,  United States
New Jersey
      Atlantic City Medical Center, Hackensack,  New Jersey,  07601,  United States
      Booker Cancer Center at Riverview Medical Center, Red Bank,  New Jersey,  07701-9871,  United States
      Capital Health System at Mercer, Trenton,  New Jersey,  08618,  United States
      Community Medical Center, Toms River,  New Jersey,  08755-6432,  United States
      Cooper Cancer Institute at Cooper University Hospital, Voorhees,  New Jersey,  08043,  United States
      Cooper University Hospital, Camden,  New Jersey,  08103,  United States
      Fox Chase Cancer Center at St. Francis Medical Center, Trenton,  New Jersey,  08629,  United States
      Fox Chase Virtua Health Cancer Program at Virtua West Jersey, Voorhees,  New Jersey,  08043,  United States
      Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital, Marlton,  New Jersey,  08053,  United States
      Hunterdon Regional Cancer Center, Flemington,  New Jersey,  08822,  United States
      Ocean Medical Center at Meridian Health System, Brick,  New Jersey,  08724,  United States
      Shore Memorial Hospital, Somers Point,  New Jersey,  08244,  United States
      Somerset Medical Center, Somerville,  New Jersey,  08876,  United States
      Trinitas Hospital - Jersey Street Campus, Elizabeth,  New Jersey,  07201,  United States
      Valley Hospital, Paramus,  New Jersey,  07652-2509,  United States
      Veterans Affairs Medical Center - East Orange, East Orange,  New Jersey,  07018-1095,  United States
      Warren Hospital, Phillipsburg,  New Jersey,  08865,  United States
New Mexico
      MBCCOP - University of New Mexico HSC, Albuquerque,  New Mexico,  87131,  United States
      University of New Mexico Cancer Research and Treatment Center, Albuquerque,  New Mexico,  87131-5636,  United States
New York
      CCOP - North Shore University Hospital, Manhasset,  New York,  11030,  United States
      CCOP - Syracuse Hematology-Oncology Associates of Central New York, P.C., Syracuse,  New York,  13217,  United States
      Dickstein Cancer Treatment Center at White Plains Hospital Center, White Plains,  New York,  10601,  United States
      Elmhurst Hospital Center, Elmhurst,  New York,  11373,  United States
      Faxton - St. Luke's Healthcare, Utica,  New York,  13502-5475,  United States
      James P. Wilmot Cancer Center at University of Rochester Medical Center, Rochester,  New York,  14642,  United States
      New York Methodist Hospital, Brooklyn,  New York,  11215-3609,  United States
      NYU School of Medicine's Kaplan Comprehensive Cancer Center, New York,  New York,  10016,  United States
      Queens Cancer Center of Queens Hospital, Jamaica,  New York,  11432,  United States
      SUNY Downstate Medical Center, Brooklyn,  New York,  11203,  United States
      Union State Bank Cancer Center at Nyack Hospital, Nyack,  New York,  10960-1998,  United States
      Veterans Affairs Medical Center - Albany, Albany,  New York,  12208,  United States
      Veterans Affairs Medical Center - Bath, Bath,  New York,  14810,  United States
      Veterans Affairs Medical Center - Buffalo, Buffalo,  New York,  14215,  United States
      Veterans Affairs Medical Center - Northport, Northport,  New York,  11768,  United States
      Veterans Affairs Medical Center - Syracuse, Syracuse,  New York,  13210,  United States
      Western New York Urology Associates, Orchard Park,  New York,  14127,  United States
North Carolina
      Cape Fear Valley Health System, Fayetteville,  North Carolina,  28302-2000,  United States
      CCOP - Southeast Cancer Control Consortium, Winston Salem,  North Carolina,  27104-4241,  United States
      Duke Comprehensive Cancer Center, Durham,  North Carolina,  27710,  United States
      FirstHealth Moore Regional Hospital, Pinehurst,  North Carolina,  28374,  United States
      Forsyth Medical Center, Winston Salem,  North Carolina,  27103,  United States
      Lenoir Memorial Hospital Cancer Center, Kinston,  North Carolina,  28503-1678,  United States
      Mission Hospitals, Asheville,  North Carolina,  28801,  United States
      New Hanover Regional Medical Center, Wilmington,  North Carolina,  28402-9025,  United States
      NorthEast Oncology Associates, Concord,  North Carolina,  28025,  United States
      Pardee Memorial Hospital, Hendersonville,  North Carolina,  28791-3525,  United States
      Piedmont Hematology-Oncology Associates, Winston Salem,  North Carolina,  27103,  United States
      Presbyterian Hospital, Charlotte,  North Carolina,  28233-3549,  United States
      Raleigh Hematology/Oncology Associates, P.A. - Cary Practice, Cary,  North Carolina,  27511-6118,  United States
      Veterans Affairs Medical Center - Asheville, Asheville,  North Carolina,  28805,  United States
      Veterans Affairs Medical Center - Durham, Durham,  North Carolina,  27705,  United States
      Veterans Affairs Medical Center - Salisbury, Salisbury,  North Carolina,  28144,  United States
      Wayne Memorial Hospital, Inc., Goldsboro,  North Carolina,  27533,  United States
North Dakota
      CCOP - Merit Care Hospital, Fargo,  North Dakota,  58122,  United States
      Veterans Affairs Medical Center - Fargo, Fargo,  North Dakota,  58102,  United States
Ohio
      Akron City Hospital, Akron,  Ohio,  44304,  United States
      Arthur G. James Cancer Hospital - Ohio State University, Columbus,  Ohio,  43210-1240,  United States
      Aultman Hospital Cancer Center at Aultman Health Foundation, Canton,  Ohio,  44710-1799,  United States
      CCOP - Columbus, Columbus,  Ohio,  43206,  United States
      CCOP - Dayton, Dayton,  Ohio,  45429,  United States
      CCOP - Toledo Community Hospital, Toledo,  Ohio,  43623-3456,  United States
      Charles M. Barrett Cancer Center at University Hospital, Cincinnati,  Ohio,  45267-0589,  United States
      Cleveland Clinic Taussig Cancer Center, Cleveland,  Ohio,  44195-5236,  United States
      Firelands Regional Medical Center, Sandusky,  Ohio,  44870,  United States
      Flower Hospital - ProMedica Health System, Sylvania,  Ohio,  43560,  United States
      Fulton County Health Center, Wauseon,  Ohio,  43567,  United States
      Lima Memorial Hospital, Lima,  Ohio,  45804,  United States
      Medical College of Ohio Cancer Institute, Toledo,  Ohio,  43614,  United States
      MetroHealth's Cancer Care Center at MetroHealth Medical Center, Cleveland,  Ohio,  44106-5065,  United States
      St. Charles Mercy Hospital, Oregon,  Ohio,  43616,  United States
      St. Luke's Hospital, Maumee,  Ohio,  43537,  United States
      St. Vincent Mercy Medical Center, Toledo,  Ohio,  43608,  United States
      Toledo Clinic, Incorporated, Toledo,  Ohio,  43623,  United States
      Toledo Hospital, Toledo,  Ohio,  43606,  United States
      Tri-Health Good Samaritan Hospital, Cincinnati,  Ohio,  45207-2489,  United States
      Veterans Affairs Medical Center - Cleveland, Cleveland,  Ohio,  44106,  United States
Oklahoma
      Comanche County Memorial Hospital, Lawton,  Oklahoma,  73505-8320,  United States
      Integris Oncology Services, Oklahoma City,  Oklahoma,  73112-4481,  United States
      Mercy Health Center, Oklahoma City,  Oklahoma,  73120-8362,  United States
      Muskogee Regional Medical Center, Muskogee,  Oklahoma,  74401-5075,  United States
      Oklahoma University Medical Center at University of Oklahoma Health Sciences Center, Oklahoma City,  Oklahoma,  73104,  United States
      Saint Francis Hospital, Tulsa,  Oklahoma,  74136,  United States
      St. John Health System, Tulsa,  Oklahoma,  74104,  United States
      University of Oklahoma, Oklahoma City,  Oklahoma,  73104,  United States
      Veterans Affairs Medical Center - Oklahoma City, Oklahoma City,  Oklahoma,  73104-5028,  United States
Oregon
      Cancer Institute at Oregon Health and Science University, Portland,  Oregon,  97239-3098,  United States
      CCOP - Columbia River Oncology Program, Portland,  Oregon,  97225,  United States
      Kaiser Permanente Medical Office - Interstate Medical Office Central, Portland,  Oregon,  97227,  United States
      St. Charles Medical Center, Bend,  Oregon,  97701,  United States
      Willamette Valley Cancer Center - Eugene, Eugene,  Oregon,  97401-2234,  United States
Pennsylvania
      Abington Memorial Hospital, Abington,  Pennsylvania,  19001-3788,  United States
      Abramson Cancer Center at University of Pennsylvania Medical Center, Philadelphia,  Pennsylvania,  19104-4283,  United States
      Bryn Mawr Hospital, Bryn Mawr,  Pennsylvania,  19010,  United States
      Cancer Center at Paoli Memorial Hospital, Paoli,  Pennsylvania,  19301,  United States
      Cancer Center at Phoenixville Hospital, Phoenixville,  Pennsylvania,  19460,  United States
      CCOP - MainLine Health, Wynnewood,  Pennsylvania,  19096,  United States
      Central Montgomery Medical Center, Lansdale,  Pennsylvania,  19446-1200,  United States
      Central Pennsylvania Hematology and Medical Oncology Associates, PC, Lemoyne,  Pennsylvania,  17043-1440,  United States
      Chester County Hospital, West Chester,  Pennsylvania,  19380,  United States
      Chestnut Hill Healthcare, Philadelphia,  Pennsylvania,  19118-9914,  United States
      Conemaugh Memorial Hospital, Johnstown,  Pennsylvania,  15905,  United States
      Delaware County Memorial Hospital, Drexel Hill,  Pennsylvania,  19026-1186,  United States
      Doylestown Hospital, Doylestown,  Pennsylvania,  18901-2597,  United States
      Easton Hospital, Easton,  Pennsylvania,  18042-3892,  United States
      Eastwick Primary, Philadelphia,  Pennsylvania,  19153,  United States
      Geisinger Medical Center, Danville,  Pennsylvania,  17822-2001,  United States
      Grand View Hospital, Sellersville,  Pennsylvania,  18960,  United States
      Jennersville Regional Hospital, West Grove,  Pennsylvania,  19390-9499,  United States
      John and Dorothy Morgan Cancer Center at Lehigh Valley Hospital, Allentown,  Pennsylvania,  18105-1556,  United States
      Kimmel Cancer Center at Thomas Jefferson University - Philadelphia, Philadelphia,  Pennsylvania,  19107-5563,  United States
      Lancaster General Hospital, Lancaster,  Pennsylvania,  17604-3555,  United States
      Mercy Fitzgerald Hospital, Darby,  Pennsylvania,  19023,  United States
      Norristown Regional Cancer Center, Norristown,  Pennsylvania,  19401,  United States
      Penn State Cancer Institute at Milton S. Hershey Medical Center, Hershey,  Pennsylvania,  17033-0850,  United States
      Pinnacle Health Regional Cancer Center at Pinnacle Health System, Harrisburg,  Pennsylvania,  17110,  United States
      Pottstown Memorial Regional Cancer Center, Pottstown,  Pennsylvania,  19464,  United States
      Reading Hospital and Medical Center, Reading,  Pennsylvania,  19612-6052,  United States
      Regional Cancer Center - Erie, Erie,  Pennsylvania,  16505,  United States
      Riddle Memorial Hospital, Media,  Pennsylvania,  19063,  United States
      Sacred Heart Hospital, Allentown,  Pennsylvania,  18102-3490,  United States
      Saint Mary Regional Cancer Center, Langhorne,  Pennsylvania,  19047,  United States
      St. Joseph Medical Center, Reading,  Pennsylvania,  19603,  United States
      St. Luke's Hospital Cancer Center, Bethlehem,  Pennsylvania,  18015,  United States
&nb

More Information

Clinical trial summary from the National Cancer Institute's PDQ® database

Publications

Goodman PJ, Lippman S, Klein E, et al.: Design of the selenium and vitamin E chemoprevention trial(SELECT). [Abstract] Proceedings of the Society for Clinical Trials A11, 2000.

Klein EA, Thompson IM, Lippman SM, Goodman PJ, Albanes D, Taylor PR, Coltman C. SELECT: the next prostate cancer prevention trial. Selenum and Vitamin E Cancer Prevention Trial. J Urol. 2001 Oct;166(4):1311-5.

Hoque A, Albanes D, Lippman SM, Spitz MR, Taylor PR, Klein EA, Thompson IM, Goodman P, Stanford JL, Crowley JJ, Coltman CA, Santella RM. Molecular epidemiologic studies within the Selenium and Vitamin E Cancer Prevention Trial (SELECT). Cancer Causes Control. 2001 Sep;12(7):627-33.

Source: ClinicalTrials.gov
Cache Date: April 9, 2005