Medium-chain acyl-coenzyme A dehydrogenase deficiency

ACADM deficiency; MCAD deficiency; MCADD; MCADH deficiency

Medium-chain acyl-coenzyme A dehydrogenase deficiency is one of a group of conditions that is associated with inborn errors of metabolism in fatty acid oxidation. It is due to defects in the enzyme complex known as medium chain acyl dehydrogenase (MCAD) and reduced activity of this complex. It is recognised as one of the causes of sudden infant death syndrome (SIDS, "cot death" or "crib death"). MCAD deficiency is considered sufficient explanation for sudden death. This condition is better ...