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A Test to Predict the Hemolytic Potential of Drugs in G6PD Deficiency - Article


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General Topics A-Z

Very long-chain acyl-coenzyme A dehydrogenase deficiency

ACADVL; acyl-CoA dehydrogenase very long chain deficiency; VLCAD deficiency; VLCAD-C; VLCAD-H

Clinical Trial: A Test to Predict the Hemolytic Potential of Drugs in G6PD Deficiency

This study is currently recruiting patients.

Sponsored by: Walter Reed Army Institute of Research (WRAIR)
Information provided by: Walter Reed Army Institute of Research (WRAIR)

Purpose

This study will evaluate a new and safe testing method for identifying medicines that can cause problems in glucose-6-phosphate dehydrogenase (G6PD) deficient individuals. We are looking for volunteers with G6PD deficiency who would be willing to donate blood samples.

Condition Treatment or Intervention
Glucosephosphate Dehydrogenase Deficiency
Favism
  Drug: Primaquine

MedlinePlus related topics:  Anemia;   Food Contamination and Poisoning;   Genetic Disorders;   Metabolic Disorders;   Poisoning

Study Type: Interventional
Study Design: Prevention, Non-Randomized, Open Label, Uncontrolled, Single Group Assignment, Pharmacodynamics Study

Further Study Details: 

Expected Total Enrollment:  14

Study start: December 2003

Eligibility

Ages Eligible for Study:  18 Years   -   60 Years,  Genders Eligible for Study:  Both

Accepts Healthy Volunteers

Criteria

  • Not pregnant or planning pregnancy
  • Have not taken any anti-malarial medication in past month
  • Negative blood tests for HIV and specific types of hepatitis
  • Not allergic to primaquine
  • Need both G6PD-deficient volunteers and G6PD-normal volunteers

Location and Contact Information


Maryland
      Walter Reed Army Institute of Research, Silver Spring,  Maryland,  20910,  United States; Recruiting
Felicia L Breedy  866-856-3259    clinical2@na.amedd.army.mil 
Oman Q Salazar  866-856-3259    clinical2@na.amedd.army.mil 
In-Kyu Yoon, M.D.,  Principal Investigator

More Information

Recruitment page for G6PD study

Study ID Numbers:  G6PD; 992
Record last reviewed:  March 2004
Last Updated:  October 13, 2004
Record first received:  January 20, 2004
ClinicalTrials.gov Identifier:  NCT00076323
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2005-04-08


Source: ClinicalTrials.gov
Cache Date: April 9, 2005


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October 8, 2008


Page Updated: September 6, 2005
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