Factor V Leiden thrombophilia

APC resistance, Leiden type; Hereditary resistance to activated protein C; Thrombophilia due to deficiency of cofactor for activated protein C, Leiden type

Factor V Leiden (sometimes Factor VLeiden) is the name given to a variant of human factor V that causes a hypercoagulability disorder. In this disorder the Leiden variant of factor V, cannot be inactivated by activated protein C. Factor V Leiden is the most common hereditary hypercoagulability disorder amongst Eurasians. It is named after the city Leiden (The Netherlands), where it was first identified in 1994 by Prof R. Bertina et al. Pathophysiology In the normal person, factor V funct ...