RATIONALE: Thalidomide may stop the growth of soft tissue sarcoma by stopping blood flow to the tumor. Radiation therapy uses high-energy x-rays to damage tumor cells. Drugs used in chemotherapy, such as doxorubicin, ifosfamide, and dacarbazine, work in different ways to stop tumor cells from dividing so they stop growing or die. Giving thalidomide together with radiation therapy and/or chemotherapy before surgery may shrink the tumor so that it can be removed.

PURPOSE: This phase II trial is studying how well giving preoperative (before surgery) thalidomide together with radiation therapy works in treating patients with low-grade primary soft tissue sarcoma, and how well giving thalidomide together with radiation therapy, doxorubicin, ifosfamide, and dacarbazine works in treating patients with high-grade or intermediate-grade primary soft tissue sarcoma of the arm, leg, chest wall, or abdominal wall.

Condition	Treatment or Intervention	Phase
stage I adult soft tissue sarcoma stage II adult soft tissue sarcoma stage III adult soft tissue sarcoma recurrent adult soft tissue sarcoma	Drug: dacarbazine  Drug: doxorubicin  Drug: filgrastim  Drug: ifosfamide  Drug: thalidomide  Procedure: adjuvant therapy  Procedure: anti-cytokine therapy  Procedure: antiangiogenesis therapy  Procedure: biological response modifier therapy  Procedure: chemotherapy  Procedure: colony-stimulating factor therapy  Procedure: conventional surgery  Procedure: cytokine therapy  Procedure: growth factor antagonist therapy  Procedure: neoadjuvant therapy  Procedure: radiation therapy  Procedure: surgery	Phase II

Further Study Details: 

OBJECTIVES:

• Determine the treatment delivery and toxicity of the combination of thalidomide and radiotherapy in patients with low-grade primary soft tissue sarcoma of the extremity or body wall.
• Determine the treatment delivery and toxicity of the combination of thalidomide and doxorubicin, ifosfamide, dacarbazine, and radiotherapy in patients with high- or intermediate-grade primary soft tissue sarcoma of the extremity or body wall and compare these results with those of patients treated on RTOG-9514.
• Determine the feasibility of using specific tissue and circulating biomarkers of antiangiogenic response in patients treated with these regimens, in a multi-institutional setting.
• Determine the quantitative changes and patient variabilities of these biomarkers before, during, and after therapy with these regimens.
• Determine the baseline data sets of biomarkers, particularly circulating endothelial cells, in patients treated with these regimens.
• Determine the tolerance to long-term post-operative thalidomide in these patients.
• Determine the clinical response to pre-operative therapy in these patients.
• Correlate local control and disease-free survival with surrogate biological endpoints in patients treated with these regimens.

OUTLINE: This is a pilot, cohort study. Patients with high- or intermediate-grade tumors ≥ 8 cm in diameter are assigned to cohort A and patients with low-grade tumors > 5 cm in diameter are assigned to cohort B.

• Cohort A: Patients receive doxorubicin, ifosfamide, and dacarbazine IV continuously on days 1-3, 22-24, and 43-45. Patients receive filgrastim (G-CSF) subcutaneously beginning on days 4, 25, and 46 and continuing until blood counts recover. Patients undergo radiotherapy once daily on days 7-11, 14-18, 21, 28-32, 35-39, and 42. Patients receive oral thalidomide once daily on days 7-21 and 26-42. Patients undergo surgical resection between days 84 and 98. Beginning 2 weeks after surgery, patients receive oral thalidomide once daily for 12 months in the absence of unacceptable toxicity.
• Cohort B: Patients receive oral thalidomide once daily beginning on day 1 and continuing until 1 week before surgery. Patients undergo radiotherapy once daily, 5 days a week, on weeks 1-5. Patients undergo surgical resection between days 77 and 91. Beginning 2 weeks after surgery, patients receive oral thalidomide once daily for 6 months in the absence of unacceptable toxicity. Patients are followed every 3 months for 2 years and then every 6 months for 4 years.

PROJECTED ACCRUAL: A total of 44 patients (22 per cohort) will be accrued for this study within 17 months.

Ages Eligible for Study:  16 Years and above,  Genders Eligible for Study:  Both

Criteria

DISEASE CHARACTERISTICS:

• Diagnosis of primary soft tissue sarcoma
• T2a or T2b disease
• Superficial or deep tumor
• Grade 1, 2, 3, or 4
• Tumor located on the upper extremity (including shoulder), lower extremity (including hip), or trunk
• Meets 1 of the following criteria:
• Tumor ≥ 8 cm in maximal diameter and grade 3 or 4 (intermediate or high grade) (cohort A)
• Tumor > 5 cm in maximal diameter and grade 1 or 2 (low grade) (cohort B)
• Locally recurrent disease allowed provided there has been no prior radiotherapy to the primary tumor
• No histologically confirmed rhabdomyosarcoma, extraosseous Ewing's primitive neuroectodermal tumors, osteosarcoma or chondrosarcoma, Kaposi's sarcoma, angiosarcoma, desmoid tumors, or dermatofibrosarcoma protuberans
• No overt evidence of lung metastases (CT scan evidence of small incidental lesions without histologic diagnosis allowed)
• No evidence of other metastases
• No sarcoma of the head, neck, intra-abdominal, or retroperitoneal region

PATIENT CHARACTERISTICS: Age

• 16 and over

Performance status

• Zubrod 0-1

Life expectancy

• At least 2 years

Hematopoietic

• Absolute neutrophil count ≥ 1,500/mm^3
• Platelet count ≥ 120,000/mm^3
• Hemoglobin ≥ 8.0 g/dL (cohort A)
• No known hypercoagulable disorders, such as the following:
• APC resistance (factor V Leiden)
• Protein S deficiency
• Protein C deficiency
• Antithrombin III deficiency
• Hyperhomocystinemia
• Dysplasminogenemia
• High plasminogen activator inhibitor
• Dysfibrinogenemia
• Antiphospholipid syndrome
• Thrombocythemia
• Dysproteinemia
• Fibrin split products < 2 times upper limit of normal (ULN)
• Fibrinogen > 200 mg/dL

Hepatic

• Bilirubin ≤ 1.5 mg/dL (1.0 mg/dL for patients with Gilbert's syndrome)
• AST and ALT ≤ 2.0 times ULN
• PT and PTT < 1.25 times ULN (except in patients treated with anticoagulants for unrelated medical conditions [e.g., atrial fibrillation])
• No history of hepatic cirrhosis

Renal

• Creatinine ≤ 1.5 mg/dL OR
• Creatinine clearance > 60 mL/min

Cardiovascular

• No atherosclerotic coronary artery disease that required bypass surgery within the past year
• No uncompensated coronary artery disease by ECG or physical examination
• No myocardial infarction within the past 6 months
• No severe or unstable angina within the past 6 months
• No uncompensated congestive heart failure
• No New York Heart Association class II-IV heart disease
• No symptomatic peripheral vascular disease
• No history of deep vein thrombosis
• Cohort A only:
• EF ≥ 50% within the past 6 months
• LVEF > 50%

Pulmonary

• No pulmonary embolus except if caused directly by foreign body implants (e.g., central venous catheters or portacaths)

Neurologic

• No global neurocognitive symptomatology
• No fatigue ≥ grade 2
• No history of uncontrolled seizures or uncontrolled seizure disorder
• No sensory neuropathy ≥ grade 2 except for localized neuropathy due to mechanical cause or trauma

Other

• No other malignancies within the past 3 years except non-invasive malignancies (e.g., carcinoma of the cervix, breast, or oral cavity) or squamous or basal cell skin cancer
• No history of uncontrolled myxedema
• No hypothyroidism ≥ grade 3
• No active uncontrolled bacterial, viral, or fungal infection
• No other significant illness that would preclude surgery
• No other major illness or psychiatric impairment that would preclude study therapy
• No known AIDS
• Not pregnant or nursing
• Negative pregnancy test
• Fertile patients must use 2 effective barrier methods of contraception for 4 weeks before, during, and for at least 4 weeks after study treatment

PRIOR CONCURRENT THERAPY: Biologic therapy

• No prior thalidomide
• No prior biologic therapy for this tumor

Chemotherapy

• No prior chemotherapy for this tumor

Endocrine therapy

• Not specified

Radiotherapy

• See Disease Characteristics
• No prior radiotherapy for this tumor

Surgery

• See Cardiovascular

Other

• No other concurrent investigational drugs
• No concurrent sedating drugs
• No concurrent illegal sedating "recreational" drugs
• No concurrent alcohol intake of more than 1 drink per day

Indiana
      St. Francis Hospital and Health Centers, Beech Grove,  Indiana,  46107,  United States; Recruiting
Louisiana
      Tulane Cancer Center at Tulane University Hospital and Clinic, New Orleans,  Louisiana,  70112-2699,  United States; Recruiting
Ohio
      Akron City Hospital at Summa Health System, Akron,  Ohio,  44304,  United States; Recruiting
      CCOP - Dayton, Dayton,  Ohio,  45429,  United States; Recruiting
      Charles F. Kettering Memorial Hospital, Kettering,  Ohio,  45429,  United States; Recruiting
      Good Samaritan Hospital, Dayton,  Ohio,  45406-1891,  United States; Recruiting
      Grandview Hospital, Dayton,  Ohio,  45405,  United States; Recruiting
      Miami Valley Hospital, Dayton,  Ohio,  45409,  United States; Recruiting
      Middletown Regional Hospital, Middletown,  Ohio,  45044-4898,  United States; Recruiting
      Ruth G. McMillan Cancer Center at Greene Memorial Hospital, Xenia,  Ohio,  45385,  United States; Recruiting
      Samaritan North Cancer Care Center, Dayton,  Ohio,  45415,  United States; Recruiting
      UVMC Cancer Care Center at Upper Valley Medical Center, Troy,  Ohio,  45373-1300,  United States; Recruiting
      Veterans Affairs Medical Center - Dayton, Dayton,  Ohio,  45428-1002,  United States; Recruiting
Pennsylvania
      John and Dorothy Morgan Cancer Center at Lehigh Valley Hospital, Allentown,  Pennsylvania,  18105-1556,  United States; Recruiting

Study chairs or principal investigators

Burton L. Eisenberg, MD,  Study Chair,  Norris Cotton Cancer Center   
Thomas F. DeLaney, MD,  Massachusetts General Hospital   
William G. Kraybill, MD, FACS,  Roswell Park Cancer Institute   
John M. Kane, MD,  Roswell Park Cancer Institute   
David C. Harmon, MD,  Massachusetts General Hospital   
David S. Ettinger, MD,  Sidney Kimmel Cancer Center   

Study ID Numbers:  CDR0000365499; RTOG-0330; NCT00089544
Record last reviewed:  November 2004
Last Updated:  April 5, 2005
Record first received:  August 6, 2004
ClinicalTrials.gov Identifier:  NCT00089544
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2005-04-08